EKS-MEG-00220

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00220

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	448.5	7.8E-135	200	488	289

Status

Unreviewed

Ensembl Protein

ENSMGAP00000013587

UniProt Accession

G1NJQ3;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000012880	ENSMGAP00000013587	ENSMGAT00000014499

Organism

Meleagris gallopavo

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

MVGQGRWAGC CRSTARPVLT EPCVAGLQCV CQLCEHTNFT CQTEGACWAS VMLTNGKEEV 60

IKSCVSLPEL NAQVFCHSSK NITKTECCYT DFCNNITLRL PVASESPGRA AVGPVVLAAT 120

VAVPICVLSL VAVLAACGCQ GRRCARGRTK PPNVEEPLSE CNLVSAGKTL KDLIYDMTTS 180

GSGSEPGLPL LVQRTIARTI VLQEIVGKGR FGEVWRGKWC GEDVAVKIFS SRDERSWFRE 240

AEIYQTVMLR HENILGFIAA DNKDNGTWTQ LWLVSEYHEQ GSLFDYLNRG TVTAEGMVRL 300

ALSIASGLAH LHMEIVGTQA GKPAIAHRDL KSKNILVKRN ESCAIADLGL AVKHDSVLNT 360

IDIPQNPRVG TRRYMAPEIL DDAMNTNIFE SFKRADIYSL GLVYWEIARR CCVGGITEEY 420

QLPYYDVVPS DPSIEDMRRV VCEQKLRPNI PNQWQSCEAL RVMGRIMREC WYANGAARLT 480

ALRIKKTISQ LCVQEDSKT 499

Nucleotide Sequence
(FASTA)

ATGGTGGGGC AGGGCAGGTG GGCGGGGTGC TGCAGGAGCA CCGCTCGCCC TGTCCTCACA 60

GAACCGTGTG TTGCAGGGCT CCAGTGCGTG TGCCAGCTGT GCGAGCACAC CAACTTCACC 120

TGCCAGACGG AGGGAGCGTG CTGGGCCTCG GTCATGCTGA CCAACGGCAA GGAGGAGGTG 180

ATCAAATCCT GCGTGTCCCT CCCGGAGCTC AACGCTCAGG TCTTCTGCCA CAGCTCCAAG 240

AACATCACCA AGACCGAGTG CTGCTACACC GACTTCTGCA ACAACATCAC CCTCCGCCTG 300

CCCGTAGCCT CCGAGTCCCC CGGTCGTGCC GCCGTGGGTC CCGTGGTGCT GGCAGCGACA 360

GTGGCCGTGC CCATCTGCGT CCTGTCCCTC GTGGCAGTGC TGGCTGCCTG CGGCTGCCAG 420

GGCCGGCGCT GCGCCCGCGG CAGGACGAAG CCGCCCAACG TGGAGGAGCC GCTCTCCGAG 480

TGCAACCTGG TCAGCGCGGG CAAGACGCTC AAGGACCTCA TTTACGACAT GACGACGTCT 540

GGCTCCGGCT CTGAACCAGG CTTACCTCTG CTCGTACAGA GAACCATTGC GAGGACCATC 600

GTTCTGCAGG AGATCGTAGG GAAGGGCCGC TTCGGAGAAG TGTGGCGTGG GAAGTGGTGC 660

GGGGAGGACG TGGCTGTGAA AATCTTCTCC TCGAGAGACG AGCGGTCCTG GTTCCGGGAG 720

GCAGAGATTT ATCAGACGGT TATGCTGAGA CATGAGAACA TCCTGGGCTT TATTGCTGCT 780

GATAACAAGG ACAACGGGAC CTGGACCCAG CTGTGGCTCG TCTCCGAGTA CCACGAGCAG 840

GGCTCCCTGT TTGATTACCT GAACAGGGGC ACGGTGACGG CGGAGGGCAT GGTGAGGCTG 900

GCACTGTCCA TCGCCAGCGG CCTGGCACAC CTGCACATGG AGATCGTGGG CACGCAGGCA 960

GGCAAACCGG CGATCGCTCA CAGGGACCTG AAGTCCAAGA ACATCCTGGT GAAGAGGAAC 1020

GAGAGCTGTG CCATCGCAGA CCTGGGGCTG GCAGTGAAGC ACGACTCCGT GCTCAACACC 1080

ATCGACATCC CCCAGAACCC GCGGGTGGGG ACGAGGAGGT ACATGGCTCC CGAGATACTG 1140

GATGACGCGA TGAACACCAA CATCTTTGAG TCCTTCAAGC GTGCGGACAT CTACTCTCTT 1200

GGGCTGGTGT ACTGGGAGAT AGCACGGAGG TGTTGTGTTG GAGGGATCAC TGAGGAGTAC 1260

CAGCTGCCTT ACTACGACGT CGTGCCTTCT GATCCCTCGA TAGAAGATAT GAGAAGGGTG 1320

GTTTGTGAGC AGAAGCTCCG ACCAAATATT CCAAACCAGT GGCAGAGCTG TGAGGCACTG 1380

CGGGTGATGG GCCGGATCAT GCGGGAGTGC TGGTACGCCA ATGGTGCGGC ACGGCTCACT 1440

GCTCTGCGCA TCAAGAAGAC CATTTCACAG CTCTGTGTGC AGGAGGACTC CAAAACCTAA 1500

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++k+ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 200   IVLQEIVGKGRFGEVWRGKWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  259

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe+gsL+dyL+r t+++e ++rlals+asGlahLH+eivgt+

Q: 260   ADNKDNGTWTQLWLVSEYHEQGSLFDYLNRGTVTAEGMVRLALSIASGLAHLHMEIVGTQ  319

         **********************************************************98

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

            KpaiaHRDlkskNilvk++++c+iaDlGLa+k+++  +++d+ +n +vGt+RYmaPE

Q: 320   A-GKPAIAHRDLKSKNILVKRNESCAIADLGLAVKHDSVLNTIDIPQNPRVGTRRYMAPE  378

         7.9*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l++a+n++ fe+fkraD+YslgLv+WE+a+Rc   ++++eey+lp+++vv+sdPs+e+m

Q: 379   ILDDAMNTNIFESFKRADIYSLGLVYWEIARRCCV-GGITEEYQLPYYDVVPSDPSIEDM  437

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 438   RRVVCEQKLRPNIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  488

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWRGKW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE QGSLFDYLNR GTVTAEGMVR LALSIASGLA HLHMEIVGTQ 120

AGKPAIAHRD LKSKNILVKR NESCAIADLG LAVKHDSVLN TIDIPQNPRV GTRRYMAPEI 180

LDDAMNTNIF ESFKRADIYS LGLVYWEIAR RCCVGGITEE YQLPYYDVVP SDPSIEDMRR 240

VVCEQKLRPN IPNQWQSCEA LRVMGRIMRE CWYANGAARL TALRIKKTI 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030154	; P:cell differentiation
GO:0019915	; P:lipid storage
GO:0008285	; P:negative regulation of cell proliferation
GO:0046676	; P:negative regulation of insulin secretion
GO:0038092	; P:nodal signaling pathway
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0009749	; P:response to glucose stimulus
GO:0032868	; P:response to insulin stimulus

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013