EKS-MEG-00221

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00221

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	444.0	1.8E-133	208	494	287

Status

Unreviewed

Ensembl Protein

ENSMGAP00000013597

UniProt Accession

G1NJR2;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000012891	ENSMGAP00000013597	ENSMGAT00000014509

Organism

Meleagris gallopavo

Functional Description

Protein Length

508

Protein Sequence
(FASTA)

VTDGAMALPL LLLLLALPSR SVQDEELKLN ECVCEGMSCG NGDRCQGQQC FASLSINDGA 60

KVYQKGCFQV YEQGKMTCKT PPSPDQAVEC CQGYLCNMNI TAKLPSSKGQ TLQGEAAGYS 120

METLIVVILA PVVVLVVFSV VAVLIIRRIQ KNHMERLNSR DAEYGTIEGL IASNVGDSTL 180

ADLLDHSCTS GSGSGLPFLV QRTVARQITL VECVGKGRYG EVWRGQWQGE NVAVKIFSSR 240

DEKSWFRETE LYNTVLLRHE NILGFIASDM TSRNSSTQLW LITHYHEMGS LYDYLQLTTL 300

DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AISHRDLKSK NILVKKNGQC CIADLGLAVM 360

HSQSTNQLDV GNNPVGTKRY MAPEVLDETI QADCFDSYKR VDIWAFGLVL WEVARRMVSN 420

GIVEDYKPPF YDLVPNDPSF EDMRKVVCVD QQRPNIPNRW FSDPTLTSLA KLMKECWYQN 480

PSARLTALRI KKTLTKIDNS LDKLKADC 508

Nucleotide Sequence
(FASTA)

GTGACAGATG GAGCCATGGC TCTCCCCCTG CTGCTGCTGC TGCTGGCCCT GCCCTCCCGC 60

AGCGTGCAAG ACGAGGAGCT GAAGCTAAAT GAATGTGTGT GTGAAGGCAT GTCATGTGGG 120

AATGGAGACC GCTGCCAGGG CCAGCAGTGC TTTGCCTCCC TGAGCATTAA CGATGGTGCT 180

AAAGTTTACC AGAAAGGCTG CTTCCAAGTC TATGAACAAG GGAAAATGAC GTGCAAAACC 240

CCGCCGTCTC CTGACCAAGC TGTGGAGTGC TGCCAAGGAT ACCTGTGCAA CATGAACATC 300

ACTGCGAAGC TGCCCTCTTC TAAAGGGCAA ACCCTGCAAG GGGAAGCTGC AGGTTACAGC 360

ATGGAAACAC TAATCGTCGT TATACTGGCT CCCGTGGTAG TGCTGGTAGT TTTCTCTGTG 420

GTAGCTGTGC TCATCATCCG GAGAATCCAG AAGAACCACA TGGAGAGACT CAATTCTAGA 480

GATGCAGAAT ATGGCACAAT TGAGGGACTC ATTGCTTCAA ATGTTGGAGA CAGTACATTG 540

GCAGATTTAT TGGACCATTC CTGCACATCT GGAAGTGGAT CTGGACTTCC ATTCTTGGTG 600

CAAAGAACGG TGGCTCGCCA GATCACGCTT GTGGAGTGTG TAGGAAAGGG CCGTTATGGA 660

GAAGTCTGGA GGGGTCAGTG GCAAGGAGAA AATGTTGCTG TGAAGATCTT CTCTTCTAGG 720

GATGAAAAAT CCTGGTTCAG GGAAACTGAA TTGTATAACA CTGTATTGCT GCGGCATGAA 780

AATATTTTAG GTTTTATTGC ATCCGATATG ACTTCCAGAA ACTCTAGCAC TCAGCTGTGG 840

TTAATTACTC ACTACCACGA GATGGGATCT TTGTATGACT ATCTGCAGCT CACCACCCTG 900

GACACTGTCA GCTGCCTGCG GATAGTGCTG TCCATAGCCA GTGGCCTTGC ACATTTGCAC 960

ATAGAGATAT TTGGAACGCA GGGGAAGCCT GCCATTTCTC ATCGGGACTT GAAGAGCAAA 1020

AATATCCTCG TTAAGAAAAA TGGACAGTGC TGCATAGCAG ACTTGGGCCT TGCAGTCATG 1080

CACTCCCAAA GCACGAACCA GTTGGATGTG GGGAACAACC CCGTGGGCAC CAAACGCTAC 1140

ATGGCGCCGG AGGTGCTGGA CGAAACCATC CAGGCAGACT GCTTCGACTC CTACAAGAGG 1200

GTCGACATCT GGGCCTTCGG GCTGGTCCTG TGGGAGGTGG CTCGGCGCAT GGTTAGCAAT 1260

GGTATTGTAG AAGACTATAA ACCACCATTT TATGACCTGG TTCCAAACGA TCCCAGTTTT 1320

GAAGACATGA GGAAGGTGGT CTGTGTAGAT CAGCAAAGGC CAAACATTCC CAACAGGTGG 1380

TTCTCAGACC CTACATTAAC ATCTCTTGCC AAGTTGATGA AAGAATGCTG GTATCAGAAT 1440

CCATCAGCAA GACTAACAGC CCTGCGAATC AAAAAGACTT TGACCAAAAT TGACAATTCC 1500

TTAGATAAAC TGAAAGCTGA CTGTTGA 1527

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l+e++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tvllrhenil+fia

Q: 208   ITLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIA  267

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 268   SDMTSRNSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  327

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kpai+HRDlkskNilvkk+++cciaDlGLa+++++++++ld+  n+ vGtkRYmaPE

Q: 328   G--KPAISHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDV-GNNPVGTKRYMAPE  384

         *..*****************************************7.5678**********

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+++ ++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++ v++dPs+e+m

Q: 385   VLDETIQADCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDLVPNDPSFEDM  443

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 444   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  494

         *************************************************97

Domain Sequence
(FASTA)

ITLVECVGKG RYGEVWRGQW QGENVAVKIF SSRDEKSWFR ETELYNTVLL RHENILGFIA 60

SDMTSRNSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAISHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPVGT KRYMAPEVLD 180

ETIQADCFDS YKRVDIWAFG LVLWEVARRM VSNGIVEDYK PPFYDLVPND PSFEDMRKVV 240

CVDQQRPNIP NRWFSDPTLT SLAKLMKECW YQNPSARLTA LRIKKTL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0045177	; C:apical part of cell
GO:0005887	; C:integral to plasma membrane
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0002526	; P:acute inflammatory response
GO:0030509	; P:BMP signaling pathway
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0032926	; P:negative regulation of activin receptor signaling pathway
GO:0043066	; P:negative regulation of apoptotic process
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0030501	; P:positive regulation of bone mineralization
GO:2000017	; P:positive regulation of determination of dorsal identity
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013