EKS-MEG-00320
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00320
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11362.21.5E-108537793257
StatusUnreviewed
Ensembl ProteinENSMGAP00000013731
UniProt AccessionG1NK21;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K5
Gene Synonyms/Alias MAP3K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000013015ENSMGAP00000013731ENSMGAT00000014646
OrganismMeleagris gallopavo
Functional Description
Protein Length1229
Protein Sequence
(FASTA)
FLSTDIAVVE MSDAFRQPSL FYHLGVRESF SMANNIILYC DTNSESLQSL KEIICQKNNM 60
CTGNYIFVPY MITPHNKVYC CDSSFMKGLT ELMQPSFESL LGPICLPLVD RFIQLLKVAQ 120
ASSGQYFRES ILNDIRKART LYTGKELAAE LARIRQRVDN IEVLSADIVI NLLLSYRDIQ 180
DYDSIVKLVK TLEKLPTFDL ASHHHVRLHY AFALNRRNLP GDRQKALEIM IPLVEQEDQV 240
ASDMYCLVGR IYKDMFLESG FIDTESRDKG TFWFKKAFES EPTLQSGINY AVLLLAAGHC 300
FDTSFELRKV GVKISSLLGK KGSLEKLQSY WEVGSFLAAS MLANDHIRVI QASEKLFKLK 360
APAWYLKSIV ETILIYQHFK KLNPEQHTAK QELVDFWMDF LVEATKTDVS VVRFPVLILE 420
PTKIYQPSYL SINSEAEEKT VSIWHVLPDD KKGIHEWNFS AASIRGVSIS KFEERCCFLY 480
VLHNSDDFQI YFCTEVHCRR FFDMVNSITE EIGKSTEEGE CDGDSLEYDY EYDENGERVV 540
LGKGTYGIVY AGRDLSNQVR IAIKEIPERD SRYSQPLHEE IALHKHLKHK NIVQYLGSLS 600
ENGFIKIFME QVPGGSLSAL LRSKWGPLKN NEQTIGFYTK QILEGLKYLH DNQIVHRDIK 660
GDNVLINTYS GVLKISDFGT SKRLAGINPC TETFTGTLQY MAPEIIDKGP RGYGKAADIW 720
SLGCTIIEMA TGKPPFYELG EPQAAMFKVG MFKIHPEIPE SMSAEAKSFI LRCFEPDPDK 780
RAFAHELLVD EFLKVSSKKR KSPSKLSVLS ANTNEYLRSI SLPVPVLVED TSSSSEYGSV 840
SPDTELKIDP FSFKTRAKSC GEKDGKGIRS LFLSIPDENF EDHSAPPSPE EKDSGFFMLK 900
KDSERRATLH RILTEDQEKV VRNLMEALAQ GAEEPKLKWE HITTLVSSLR EFVRSTDRKI 960
IATTLSKLKL ELDFDSHGIS QVQLVLFGFQ DAVNKVLRNH NIKPHWMFAL DNIIRKAVQT 1020
AITILVPELR PHFSLASESD AADQDDIEVE EDQDEQPQNQ TIQQPCIVME DAVATSGVST 1080
LSSTVSHDSQ AAQRTLSVQL GRLKLETNRL LEELVQKERE FQVLLHQAIE EKDQEIKNLR 1140
LRSQPIDIPG LSVCHRHSTG TGSEDPDLIN WLSVQGADEA TINKFLAEDY TLMDVLCYVT 1200
RDDLKCLRLR GGMLCTLWKA ITDFRQKHA 1229
Nucleotide Sequence
(FASTA)
TTTCTTTCTA CAGATATTGC TGTTGTAGAG ATGAGTGATG CCTTTCGTCA GCCTTCCCTC 60
TTCTACCACC TGGGAGTCAG AGAGAGCTTC AGTATGGCTA ACAACATTAT CCTCTACTGT 120
GATACGAATT CTGAGTCTCT GCAGTCGCTG AAGGAAATTA TTTGCCAGAA GAATAATATG 180
TGCACTGGTA ACTACATCTT TGTTCCTTAC ATGATAACTC CGCATAACAA GGTGTACTGC 240
TGCGATAGTA GTTTTATGAA GGGACTAACA GAACTGATGC AGCCAAGTTT TGAATCACTG 300
CTTGGGCCTA TTTGCTTACC TCTGGTGGAT CGATTTATCC AACTCTTGAA GGTGGCACAG 360
GCCAGCTCGG GCCAGTATTT CCGGGAATCC ATCCTTAATG ACATTAGGAA GGCCCGTACC 420
CTCTACACTG GCAAAGAGCT TGCAGCAGAG CTGGCGAGGA TTCGGCAGCG AGTGGATAAT 480
ATTGAAGTCT TGTCTGCTGA CATTGTAATC AACTTGCTGC TGTCCTACAG AGACATCCAG 540
GATTATGATT CCATTGTGAA ACTGGTGAAG ACTTTAGAAA AACTGCCTAC TTTCGACTTG 600
GCTTCCCACC ACCATGTGAG GTTACATTAT GCGTTTGCAC TGAACAGACG AAATCTACCT 660
GGGGACAGAC AGAAAGCTCT AGAAATTATG ATTCCTTTAG TAGAACAAGA AGATCAAGTA 720
GCTTCAGATA TGTACTGCCT GGTTGGTCGC ATTTACAAGG ACATGTTTTT GGAATCTGGG 780
TTCATAGATA CGGAAAGCAG AGACAAAGGG ACCTTCTGGT TCAAGAAGGC GTTTGAGTCA 840
GAGCCAACAC TGCAGTCGGG AATCAATTAT GCAGTGCTTC TTCTGGCAGC TGGACATTGC 900
TTTGATACTT CTTTTGAGCT TCGGAAAGTT GGGGTAAAGA TCAGCAGCCT GCTTGGTAAA 960
AAGGGGAGCT TGGAGAAGCT GCAGAGCTAT TGGGAAGTGG GATCTTTCTT GGCAGCCAGT 1020
ATGTTGGCTA ATGACCACAT AAGAGTGATC CAGGCTTCAG AAAAGCTATT TAAGCTAAAG 1080
GCACCAGCAT GGTACCTGAA GTCTATTGTA GAGACTATTT TGATATATCA GCATTTTAAA 1140
AAACTGAATC CTGAACAACA TACAGCCAAA CAGGAACTCG TGGACTTCTG GATGGACTTC 1200
CTTGTTGAAG CCACAAAGAC AGATGTGTCT GTAGTTAGAT TTCCAGTTTT AATATTGGAA 1260
CCAACCAAAA TCTATCAGCC CTCATATCTC TCCATCAACA GCGAAGCTGA GGAGAAGACT 1320
GTATCTATCT GGCATGTGCT GCCTGATGAC AAGAAAGGTA TCCATGAGTG GAACTTCAGC 1380
GCTGCGTCCA TCAGGGGAGT AAGCATTTCG AAGTTTGAAG AACGGTGCTG TTTTCTGTAT 1440
GTGCTGCACA ATTCTGATGA CTTTCAAATC TATTTCTGCA CGGAAGTTCA TTGTAGAAGG 1500
TTTTTTGATA TGGTGAACAG CATCACTGAA GAAATAGGGA AGTCTACAGA GGAAGGAGAA 1560
TGTGATGGAG ACTCCCTGGA GTATGACTAT GAATATGATG AAAATGGCGA GCGAGTCGTT 1620
CTGGGGAAAG GAACTTATGG CATTGTGTAT GCAGGACGAG ATTTGAGCAA TCAAGTCAGA 1680
ATTGCTATTA AAGAAATCCC AGAGAGAGAT AGCAGATACT CCCAACCTCT GCATGAAGAA 1740
ATAGCCTTGC ATAAGCATCT CAAACACAAG AACATTGTCC AGTATTTGGG GTCTCTTAGT 1800
GAGAATGGTT TCATTAAGAT ATTCATGGAG CAGGTGCCTG GTGGCAGTCT TTCTGCTCTT 1860
CTACGATCAA AATGGGGACC ATTAAAAAAT AATGAGCAGA CAATTGGCTT TTACACTAAG 1920
CAGATTCTCG AAGGATTAAA ATACCTCCAT GATAATCAAA TAGTGCATCG AGACATAAAG 1980
GGTGATAATG TGCTTATCAA CACTTACAGT GGAGTGTTAA AAATTTCAGA CTTTGGAACT 2040
TCAAAGAGAC TTGCGGGAAT CAACCCTTGT ACTGAAACTT TCACTGGTAC CCTTCAGTAT 2100
ATGGCACCAG AAATAATTGA CAAAGGGCCA CGTGGTTATG GGAAGGCTGC AGACATCTGG 2160
TCTTTGGGAT GTACTATAAT TGAGATGGCT ACAGGGAAAC CCCCATTTTA TGAACTGGGA 2220
GAACCGCAAG CAGCTATGTT TAAGGTGGGA ATGTTTAAAA TCCACCCAGA GATTCCTGAA 2280
TCCATGTCTG CAGAAGCCAA GTCGTTCATA CTGCGTTGCT TTGAACCAGA TCCTGATAAA 2340
CGAGCTTTTG CTCATGAGCT CCTTGTAGAT GAATTCTTGA AGGTGTCAAG CAAAAAAAGA 2400
AAATCCCCAT CAAAACTCTC GGTTCTTTCA GCTAACACAA ATGAGTATCT TCGGAGCATA 2460
TCCTTACCTG TTCCTGTTCT GGTGGAAGAT ACAAGTAGTA GCAGTGAATA TGGCTCTGTC 2520
TCACCTGATA CAGAGTTAAA AATTGATCCA TTCTCTTTCA AAACAAGAGC AAAATCCTGT 2580
GGAGAAAAAG ATGGGAAGGG AATCCGGTCC CTTTTTCTGA GCATCCCAGA TGAAAATTTT 2640
GAGGATCACA GTGCACCTCC TTCACCTGAA GAGAAAGATT CTGGATTTTT CATGCTGAAG 2700
AAGGATAGTG AGAGGAGAGC TACCCTTCAC AGAATATTGA CTGAGGACCA AGAGAAGGTG 2760
GTGAGGAACT TGATGGAGGC TTTGGCTCAG GGAGCCGAAG AGCCCAAGCT AAAATGGGAA 2820
CATATTACAA CGCTTGTTTC CAGCCTCAGA GAGTTTGTAC GGTCCACTGA TCGTAAAATC 2880
ATTGCAACCA CTCTTTCAAA ACTGAAACTG GAGTTAGACT TTGACAGCCA CGGTATCAGT 2940
CAAGTGCAGC TTGTGCTGTT TGGTTTTCAA GATGCTGTCA ATAAAGTTCT CCGAAATCAT 3000
AACATCAAGC CACACTGGAT GTTTGCATTG GACAACATAA TTAGAAAAGC TGTGCAGACA 3060
GCTATTACTA TTCTGGTCCC AGAATTGAGG CCACATTTTA GTCTTGCATC TGAAAGTGAT 3120
GCAGCAGATC AAGATGATAT AGAAGTTGAA GAAGATCAAG ATGAGCAGCC TCAGAATCAA 3180
ACTATCCAAC AGCCTTGCAT TGTCATGGAA GATGCAGTAG CTACCTCAGG TGTGAGCACA 3240
CTCAGCTCTA CAGTATCCCA TGACTCACAG GCTGCTCAGA GAACACTGAG TGTCCAGCTG 3300
GGCAGGCTAA AATTAGAGAC TAATAGGTTA CTGGAGGAGC TGGTTCAAAA GGAGAGAGAA 3360
TTTCAAGTCC TTTTACATCA AGCTATAGAA GAAAAAGATC AGGAGATCAA AAACCTCCGG 3420
CTTAGGTCAC AGCCAATAGA TATTCCTGGA TTATCTGTCT GTCATCGTCA TTCCACTGGC 3480
ACAGGGAGTG AGGACCCTGA TCTCATAAAC TGGCTGAGCG TTCAAGGAGC TGATGAGGCC 3540
ACAATAAACA AGTTCTTGGC TGAAGACTAT ACCTTAATGG ATGTTCTCTG CTATGTTACA 3600
CGAGATGACC TGAAGTGTTT GAGACTGAGG GGAGGAATGC TATGCACACT CTGGAAGGCC 3660
ATTACTGACT TTCGACAGAA ACATGCCTGA 3690
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n
Q: 537   ERVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  591
         6899**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+
Q: 592   IVQYLGSLSENGFIKIFMEQVPGGSLSALLRsKWGPLKnnEQTIGFYTKQILEGLKYLHD  651
         *******************************9*****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k
Q: 652   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  708
         ***************************************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+
Q: 709   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKIHPEIPESMSAEAKS  768
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         f+ +c+e dp+kr+ a+eLL +efl
Q: 769   FILRCFEPDPDKRAFAHELLVDEFL  793
         **********************996
Domain Sequence
(FASTA)
ERVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60
GSLSENGFIK IFMEQVPGGS LSALLRSKWG PLKNNEQTIG FYTKQILEGL KYLHDNQIVH 120
RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180
ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKIHP EIPESMSAEA KSFILRCFEP 240
DPDKRAFAHE LLVDEFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00361
EKS-ANC-00378
EKS-BOT-00387
EKS-CAF-00390
EKS-CAP-00418
EKS-DAR-00769
EKS-EQC-00380
EKS-FEC-00376
EKS-GAG-00327
EKS-GAA-00475
EKS-GOG-00384
EKS-HOS-00395
EKS-LAC-00401
EKS-LOA-00395
EKS-MAM-00386
EKS-MAE-00046
EKS-MIM-00057
EKS-MOD-00376
EKS-MUM-00421
EKS-MUP-00382
EKS-MYL-00386
EKS-NOL-00355
EKS-ORN-00500
EKS-ORA-00336
EKS-ORC-00364
EKS-ORL-00460
EKS-OTG-00390
EKS-PAT-00368
EKS-PES-00346
EKS-POA-00379
EKS-RAN-00402
EKS-SAH-00359
EKS-TAG-00460
EKS-TAR-00496
EKS-TEN-00496
EKS-TUT-00109
EKS-XET-00502
EKS-XIM-00493
Gene Ontology
GO:0005524; F:ATP binding
GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0000186; P:activation of MAPKK activity
GO:0070301; P:cellular response to hydrogen peroxide
GO:0010421; P:hydrogen peroxide-mediated programmed cell death
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254; P:JNK cascade
GO:0043065; P:positive regulation of apoptotic process
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013