EKS-MEG-00114
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00114
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR561.02.9E-169431707277
StatusUnreviewed
Ensembl ProteinENSMGAP00000013789
UniProt AccessionG1MT16;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR3
Gene Synonyms/Alias FGFR3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000013059ENSMGAP00000001513ENSMGAT00000002175
ENSMGAG00000013059ENSMGAP00000013789ENSMGAT00000014705
ENSMGAG00000013059ENSMGAP00000017732ENSMGAT00000019467
OrganismMeleagris gallopavo
Functional Description
Protein Length771
Protein Sequence
(FASTA)
AEYLRSETAF LEELVFGSGD TIELSCNTQS SSVSVFWFKD GIGIAPSNRT HIGQKLLKII 60
NVSYDDSGLY SCKPRHSNEV LGNFTVRVTD SPSSGDDEDD DDESEDTGVP FWTRPDKMEK 120
KLLAVPAANT VRFRCPAGGN PTPTIYWLKN GKEFKGEHRI GGIKLRHQQW SLVMESVVPS 180
DRGNYTCVVE NKYGNIRHTY QLDVLERSPH RPILQAGLPA NQTVVVGSNV EFHCKVYSDA 240
QPHIQWLKHV EVNGSKYGPD GTPYVTVLKT AGVNTTDKEL EILYLRNVTF EDAGEYTCLA 300
GNSIGFSHHS AWLTVLPAEE LMEMDDSGSV YAGILSYGTG LVLFILVLVI VIICRMKMPN 360
KKAMNTTTVQ KVSKFPLKRQ QVSLESNSSM NSNTPLVRIT RLSSSDGPML ANVSELELPP 420
DPKWELARTR LTLGKPLGEG CFGQVVMAEA IGIDKDKPNK AITVAVKMLK DDATDKDLSD 480
LVSEMEMMKM IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT 540
CKLPEEQLTF KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD 600
VHNIDYYKKT TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE 660
ELFKLLKEGH RMDKPANCTH DLYMIMRECW HAIPSQRPTF KQLVEDLERV LTMTSTDEYL 720
DLSVPFEQYS PAGQDTHSTC SSGDDSVFAH DLLPDEPCLP KHAPCNGVIR T 771
Nucleotide Sequence
(FASTA)
GCAGAATACT TGAGAAGCGA GACCGCCTTT CTGGAAGAGT TGGTGTTTGG AAGTGGAGAT 60
ACCATTGAAC TTTCCTGTAA CACCCAAAGC TCTTCTGTGT CAGTTTTCTG GTTTAAAGAT 120
GGTATTGGGA TTGCACCTTC CAACAGAACT CATATTGGAC AAAAACTGTT GAAGATAATC 180
AATGTGTCAT ATGATGATTC AGGGCTGTAC AGTTGCAAGC CAAGGCATTC CAACGAGGTC 240
CTGGGAAACT TTACAGTCAG AGTGACAGAT TCCCCTTCGT CAGGTGATGA TGAAGATGAT 300
GATGATGAGT CAGAAGATAC AGGTGTCCCC TTCTGGACCC GGCCAGATAA GATGGAGAAG 360
AAGCTGCTGG CAGTTCCTGC CGCCAACACC GTTCGTTTCC GATGTCCAGC AGGTGGAAAC 420
CCAACTCCCA CCATCTACTG GCTGAAGAAT GGCAAAGAGT TCAAGGGGGA GCACAGGATT 480
GGGGGCATCA AGTTGCGACA CCAGCAGTGG AGCTTGGTGA TGGAGAGTGT TGTGCCATCA 540
GATCGAGGAA ACTACACCTG TGTTGTGGAG AACAAATATG GCAATATTAG GCACACGTAC 600
CAGCTTGATG TTTTAGAACG ATCACCCCAC CGACCAATCC TGCAAGCAGG ACTCCCTGCC 660
AATCAGACCG TGGTGGTTGG GAGCAATGTG GAATTTCACT GCAAGGTCTA TAGTGATGCC 720
CAGCCTCATA TCCAGTGGCT GAAACACGTG GAAGTCAACG GCAGCAAGTA TGGACCTGAT 780
GGGACACCCT ACGTCACAGT GCTGAAGACA GCAGGTGTTA ACACAACGGA TAAGGAGCTA 840
GAGATTCTGT ACTTGCGAAA TGTTACTTTT GAGGATGCTG GGGAATATAC TTGTCTCGCA 900
GGGAATTCTA TTGGGTTCTC ACATCACTCT GCTTGGCTGA CGGTGCTACC AGCAGAGGAG 960
CTGATGGAAA TGGATGATTC AGGCTCAGTG TATGCTGGCA TTCTCAGCTA TGGCACTGGC 1020
TTAGTCCTCT TCATCCTGGT GCTGGTCATT GTGATTATCT GCAGGATGAA AATGCCAAAC 1080
AAAAAAGCCA TGAACACCAC CACTGTACAG AAAGTCTCCA AATTTCCACT CAAGAGACAG 1140
CAGGTGTCGT TGGAGTCCAA CTCTTCCATG AATTCCAACA CACCCCTGGT CCGGATCACT 1200
CGTCTCTCCT CCAGCGATGG GCCGATGCTG GCCAACGTCT CTGAGCTGGA ACTTCCTCCA 1260
GATCCCAAGT GGGAATTGGC ACGCACTCGC CTGACCCTGG GGAAGCCACT TGGTGAGGGC 1320
TGTTTTGGCC AAGTGGTGAT GGCAGAAGCA ATTGGGATTG ATAAAGACAA GCCAAACAAG 1380
GCCATCACGG TGGCTGTCAA GATGCTAAAA GATGATGCCA CAGACAAGGA TCTTTCAGAC 1440
CTGGTCTCTG AGATGGAAAT GATGAAAATG ATTGGGAAAC ACAAAAACAT CATTAACCTC 1500
CTCGGTGCCT GTACACAGGA CGGACCACTC TACGTGTTGG TTGAATACGC ATCGAAGGGG 1560
AACTTGCGGG AATACCTCAG GGCACGTCGC CCACCTGGCA TGGACTATTC CTTCGACACC 1620
TGCAAGCTGC CCGAGGAGCA GTTGACATTT AAAGACTTGG TTTCCTGTGC CTACCAGGTG 1680
GCCCGGGGCA TGGAGTACTT GGCATCACAG AAATGCATTC ATCGTGACTT GGCAGCCAGG 1740
AATGTGTTAG TCACTGAGGA CAATGTGATG AAAATAGCTG ATTTTGGCCT TGCTAGAGAC 1800
GTTCACAACA TCGACTATTA CAAGAAAACC ACCAATGGTC GGCTGCCTGT GAAATGGATG 1860
GCTCCAGAAG CATTGTTTGA CCGGGTCTAT ACTCACCAGA GCGATGTCTG GTCTTTTGGA 1920
GTGCTACTAT GGGAGATCTT CACTTTGGGA GGATCTCCAT ACCCGGGAAT TCCTGTTGAA 1980
GAACTTTTCA AACTCTTGAA AGAGGGCCAT CGGATGGATA AACCCGCCAA CTGCACCCAC 2040
GACCTGTACA TGATCATGCG GGAGTGCTGG CATGCCATCC CCTCGCAGCG ACCCACCTTC 2100
AAGCAGCTGG TGGAAGACCT GGAAAGAGTC CTCACCATGA CATCCACTGA TGAGTACCTG 2160
GACCTCTCGG TGCCCTTTGA GCAATACTCG CCCGCTGGCC AGGATACCCA CAGCACCTGC 2220
TCCTCAGGGG ACGACTCGGT TTTTGCACAT GACCTGCTGC CTGATGAGCC CTGCCTGCCC 2280
AAGCATGCAC CCTGTAACGG TGTCATCCGC ACA 2313
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aeaig+dkdk++k++tvavkmlk+datdkdl+dlvseme++k+
Q: 431   LTLGKPLGEGCFGQVVMAEAIGIDKDKPNKAITVAVKMLKDDATDKDLSDLVSEMEMMKM  490
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+++s d++k +eeqlt+
Q: 491   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKLPEEQLTF  550
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh+idyykkt
Q: 551   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKT  610
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh
Q: 611   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  670
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct++ly++mrecwha +s+rptfkqlvedl
Q: 671   RMDKPANCTHDLYMIMRECWHAIPSQRPTFKQLVEDL  707
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA IGIDKDKPNK AITVAVKMLK DDATDKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKLPEEQLTF 120
KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTH DLYMIMRECW HAIPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00142
EKS-ANC-00140
EKS-BOT-00148
EKS-CAE-00120
EKS-CAJ-00152
EKS-CAF-00155
EKS-CAP-00149
EKS-CII-00090
EKS-DAR-00435
EKS-DRM-00072
EKS-EQC-00146
EKS-FEC-00138
EKS-GAM-00077
EKS-GAG-00124
EKS-GAA-00177
EKS-GOG-00150
EKS-HOS-00154
EKS-ICT-00141
EKS-LAC-00156
EKS-LOA-00146
EKS-MAM-00145
EKS-MOD-00146
EKS-MUM-00152
EKS-MUP-00153
EKS-MYL-00157
EKS-NOL-00142
EKS-ORN-00181
EKS-ORA-00127
EKS-ORC-00139
EKS-ORL-00169
EKS-OTG-00154
EKS-PAT-00138
EKS-PES-00131
EKS-PEM-00079
EKS-POA-00144
EKS-PTV-00139
EKS-RAN-00146
EKS-SAH-00141
EKS-SUS-00129
EKS-TAG-00175
EKS-TAR-00190
EKS-TEN-00186
EKS-XET-00135
EKS-XIM-00175
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0009898; C:internal side of plasma membrane
GO:0005764; C:lysosome
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0030154; P:cell differentiation
GO:0000165; P:MAPK cascade
GO:0043066; P:negative regulation of apoptotic process
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0045879; P:negative regulation of smoothened signaling pathway
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0045597; P:positive regulation of cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010518; P:positive regulation of phospholipase activity
GO:0031398; P:positive regulation of protein ubiquitination
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777; P:protein autophosphorylation
GO:0048678; P:response to axon injury
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013