EKS-MEG-00130
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00130
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb436.32.9E-131397656260
StatusUnreviewed
Ensembl ProteinENSMGAP00000013792
UniProt AccessionG3UR38;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000013061ENSMGAP00000013792ENSMGAT00000014708
ENSMGAG00000013061ENSMGAP00000018137ENSMGAT00000020542
OrganismMeleagris gallopavo
Functional Description
Protein Length768
Protein Sequence
(FASTA)
LPSANLTGHA EKVGIENFEL LKVLGTGAYG KVFLVRKVSG HDAGKLYAMK VLKKATIVQK 60
AKTTEHTRTE RQVLEHIRQS PFLVTLHYAF QTDTKLHLIL DYINGGELFT HLSQRERFSE 120
NEVQIYIGEI VLALEHLHKL GIIYRDIKLE NILLDSDGHV VLTDFGLSKE FLTDENERAY 180
SFCGTIEYMA PDIVRGGDTG HDKAVDWWSV GVLMYELLTG ASPFTVDGEK NSQAEISRRI 240
LKSEPPYPQE MSALSKDIIQ RLLMKDPKKR LGCGPADADE IKQHPFFQNI NWDDLAAKKV 300
PAPFKPVIRD ELDVSNFAEE FTEMDPTYSP AATPQTSEKI FQGYSFVAPS ILFKRNAATV 360
DPVQFYVGDE RPGTTTIARS AMMKDSPFFQ HYELDLKEKP LGEGSFSICR KCLHKKTSQE 420
YAVKIISKRM EANTQREITA LKLCEGHPNV VKLHEVYHDQ LHTFLVMELL KGGELLERIQ 480
KKQHFSETEA SHIMRRLVSA VSHMHDVGVV HRDLKPENLL FTDETDNSEI KIIDFGFARL 540
KPPDNQPLKT PCFTLHYAAP ELFNHNGYDE SCDLWSLGVI LYTMLSGQVP FQSQDKSLTC 600
TSALEIMKKI KKGEFSFEGE AWKNVSEEAK ELIQGLLTVD PNKRIKMSSL RYNEWLQDGS 660
QLSSNPLMTP DNLGSSGAAV HTYVKATFHA FNKYKREGFC LQNVDKAPLA KRRKMKKTST 720
STETRSSSSE SSHSSSSHSH GKTTPTKTLQ PTNPTDSNNP ETIFQFSD 768
Nucleotide Sequence
(FASTA)
CTTCCTTCAG CAAATTTGAC AGGCCATGCA GAGAAAGTTG GCATTGAGAA CTTTGAACTC 60
TTGAAAGTCC TTGGAACTGG GGCATATGGA AAAGTGTTCC TAGTAAGGAA AGTAAGTGGC 120
CACGATGCTG GAAAGTTGTA TGCCATGAAA GTACTGAAGA AAGCAACAAT AGTTCAAAAA 180
GCCAAAACAA CTGAGCACAC AAGGACAGAA CGACAAGTAT TGGAACACAT TAGGCAATCA 240
CCATTTTTGG TCACGTTGCA TTATGCCTTC CAGACAGATA CAAAGCTTCA TCTCATTTTA 300
GACTATATAA ATGGAGGAGA ACTTTTCACT CATCTTTCAC AAAGAGAGAG ATTCTCAGAA 360
AATGAGGTGC AAATTTACAT TGGGGAAATC GTTTTGGCAC TTGAACATCT ACACAAGTTG 420
GGAATTATAT ATCGCGATAT AAAACTTGAG AATATTCTCC TGGATTCTGA TGGCCACGTG 480
GTGCTGACAG ACTTTGGTCT GAGTAAGGAG TTTCTTACTG ATGAGAATGA GAGAGCATAT 540
TCTTTCTGTG GAACAATAGA ATACATGGCT CCAGATATTG TAAGAGGAGG AGATACAGGA 600
CATGATAAGG CTGTCGATTG GTGGAGTGTT GGTGTTCTTA TGTATGAATT GCTAACTGGA 660
GCATCACCGT TTACGGTTGA TGGAGAGAAG AATTCTCAAG CTGAGATTTC TAGGAGAATA 720
TTAAAAAGTG AGCCACCTTA CCCACAAGAA ATGAGTGCAC TGTCAAAGGA TATAATTCAG 780
CGCCTTTTGA TGAAAGACCC CAAGAAGAGA CTTGGTTGTG GTCCAGCTGA TGCTGATGAA 840
ATCAAACAGC ATCCCTTTTT CCAGAATATA AATTGGGATG ATTTAGCTGC CAAAAAAGTG 900
CCAGCTCCAT TTAAACCAGT AATTAGAGAT GAGTTGGATG TCAGTAACTT TGCAGAAGAG 960
TTTACAGAAA TGGACCCAAC ATATTCTCCT GCAGCAACCC CTCAGACTTC AGAAAAAATA 1020
TTTCAGGGAT ATTCTTTCGT TGCACCTTCT ATTTTGTTTA AACGCAATGC AGCTACAGTA 1080
GATCCTGTTC AGTTTTATGT GGGGGATGAG CGACCCGGAA CTACAACTAT TGCCAGAAGT 1140
GCTATGATGA AGGACTCTCC ATTTTTTCAA CATTATGAAC TGGATCTGAA AGAGAAACCA 1200
TTGGGAGAAG GAAGTTTTTC CATTTGTCGA AAGTGCTTAC ACAAGAAAAC TAGCCAGGAG 1260
TATGCAGTAA AAATAATTAG CAAAAGGATG GAAGCGAACA CCCAGAGAGA AATAACAGCT 1320
CTGAAACTCT GCGAAGGACA CCCCAACGTA GTGAAGTTGC ATGAAGTTTA TCATGACCAG 1380
CTTCACACTT TTCTAGTAAT GGAATTACTG AAAGGAGGAG AATTGCTTGA ACGTATTCAG 1440
AAGAAGCAGC ATTTCAGTGA GACAGAAGCC AGTCATATTA TGCGCAGACT TGTTTCAGCA 1500
GTGAGCCACA TGCATGATGT AGGAGTAGTC CATAGAGATC TGAAACCTGA GAATTTGTTG 1560
TTTACAGATG AAACTGATAA TTCAGAAATA AAAATAATTG ATTTTGGCTT TGCTCGTTTA 1620
AAACCACCTG ACAATCAGCC TCTTAAGACT CCATGTTTTA CTCTGCATTA TGCTGCCCCA 1680
GAGCTCTTTA ATCACAATGG TTATGATGAA TCTTGTGATC TCTGGAGTTT GGGAGTCATT 1740
CTGTATACGA TGTTATCAGG ACAGGTACCA TTTCAGTCTC AAGACAAAAG TTTAACATGT 1800
ACTAGTGCAT TGGAAATAAT GAAAAAAATA AAAAAGGGAG AATTTTCCTT TGAAGGGGAA 1860
GCTTGGAAAA ATGTTTCTGA AGAGGCCAAA GAGTTAATTC AAGGACTTCT GACAGTGGAT 1920
CCGAACAAAA GAATTAAGAT GTCCAGTCTG AGATACAACG AATGGCTTCA GGATGGCAGC 1980
CAGCTGTCAT CTAACCCTCT AATGACTCCT GATAACTTGG GTTCTTCAGG CGCTGCAGTG 2040
CATACATATG TCAAAGCCAC TTTTCATGCC TTTAACAAGT ACAAAAGAGA AGGATTTTGT 2100
CTCCAGAATG TTGACAAGGC ACCTCTTGCA AAGAGAAGGA AAATGAAAAA AACGAGTACA 2160
AGCACAGAGA CACGTAGCAG CTCCAGTGAA AGTTCACATT CTTCTTCCTC TCATTCTCAT 2220
GGTAAAACTA CACCTACAAA GACACTGCAG CCAACAAACC CTACAGACAG CAATAACCCA 2280
GAAACTATCT TCCAGTTCTC TGACTGA 2307
Domain Profile
S: 3     vkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdv  61
         ++++lG+Gs+s+c++c+hk+t qe+avkii+k+ +++t++ei++l+++e+hpn+v+l++v
Q: 397   KEKPLGEGSFSICRKCLHKKTSQEYAVKIISKRmEANTQREITALKLCEGHPNVVKLHEV  456
         6899*****************************9**************************
S: 62    yddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkp  121
         y+d+++++lv+ellkGGell+ri+kk++fse+eas+i+r lv+av+++h++Gvvhrdlkp
Q: 457   YHDQLHTFLVMELLKGGELLERIQKKQHFSETEASHIMRRLVSAVSHMHDVGVVHRDLKP  516
         ************************************************************
S: 122   enilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdlw  181
         en+l++de+dn+e ikiidfGfa+lk+++n++lktpc+tl+++ape+++++Gyde+cdlw
Q: 517   ENLLFTDETDNSE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELFNHNGYDESCDLW  575
         *************.**********************************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+lytml+G+vpf    +++++++a ei++kik+G+fs++Geaw++vseeak+l+++
Q: 576   SLGVILYTMLSGQVPFqsqdKSLTCTSALEIMKKIKKGEFSFEGEAWKNVSEEAKELIQG  635
         ****************98888899************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdp+kr+k+++l++++wl
Q: 636   LLTVDPNKRIKMSSLRYNEWL  656
         ********************7
Domain Sequence
(FASTA)
KEKPLGEGSF SICRKCLHKK TSQEYAVKII SKRMEANTQR EITALKLCEG HPNVVKLHEV 60
YHDQLHTFLV MELLKGGELL ERIQKKQHFS ETEASHIMRR LVSAVSHMHD VGVVHRDLKP 120
ENLLFTDETD NSEIKIIDFG FARLKPPDNQ PLKTPCFTLH YAAPELFNHN GYDESCDLWS 180
LGVILYTMLS GQVPFQSQDK SLTCTSALEI MKKIKKGEFS FEGEAWKNVS EEAKELIQGL 240
LTVDPNKRIK MSSLRYNEWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00163
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MAM-00160
EKS-MAE-00060
EKS-MOD-00162
EKS-MUM-00169
EKS-MUP-00167
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PES-00145
EKS-PEM-00087
EKS-POA-00160
EKS-RAN-00161
EKS-SAH-00157
EKS-SUS-00141
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013