EKS-MEG-00354

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00354

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	342.7	1.0E-102	207	479	273

Status

Unreviewed

Ensembl Protein

ENSMGAP00000013994

UniProt Accession

G1NKM8;

Protein Name

Protein Synonyms/Alias

Gene Name

WEE2

Gene Synonyms/Alias

WEE2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000013242	ENSMGAP00000013994	ENSMGAT00000014914

Organism

Meleagris gallopavo

Functional Description

Protein Length

556

Protein Sequence
(FASTA)

IQRLDFSSCG EEGEDRSINE EDTLSSSPIK SCDFQKWNSP LPTTPHRKFS EIFLSRTKSW 60

MSPTLKSSPG VSRTHGNAET PLHITWKKLQ LCDTPHTPKT LLSKTAFPSP GAKVPPKGFR 120

HLRFTPGADL DDSTQASLVN INPFTPESYR QMLFLPNGKR KAREIRNPDL RGQVKQELPT 180

KESQQQFLWK RCPLKDSNMV SRYQKEFLEL ERIGVGEFGS VYKCIKRLDG CVYAIKRSKR 240

PLAGSSDEQL ALREVYAHAV LGHHPHVVRY YSAWAEDDHM IIQNEHCNGG SLQDVLLENA 300

KHGQYFPETK LKEILLQVSM GLKYIHNSGL VHLDIKPSNI FICHKLAVEG QAGQEESDSD 360

DEFSSGVMYK IGDLGHVTSI ANPQVEEGDR RFLANEILQE QYFHLPKADI FALALTTALA 420

AGAGPLPHNG AMWHHIRKGN IPSIPQKLPN GFIELLKLMI HPDPMERPSA TALTKHPILR 480

PSLGKAVQLQ KQLNVEKCKT AMLERELKAA RLAQTLMKDQ PLGNANLQES ETSPKKNNKR 540

LVGGKSCRSF SFTVGY 556

Nucleotide Sequence
(FASTA)

ATTCAGAGGC TGGATTTTTC CAGCTGTGGA GAAGAGGGTG AAGACAGAAG CATTAATGAG 60

GAGGACACAC TAAGTTCCAG CCCAATCAAG AGCTGTGACT TCCAGAAATG GAACAGTCCT 120

CTCCCTACAA CTCCTCACAG GAAGTTCAGT GAGATTTTCC TGAGCAGGAC TAAATCCTGG 180

ATGAGCCCTA CCCTGAAGTC CTCCCCAGGT GTGAGCAGGA CCCATGGCAA CGCAGAGACA 240

CCGCTGCACA TCACCTGGAA GAAGCTGCAG CTCTGTGACA CCCCACACAC TCCCAAGACC 300

CTGCTATCAA AGACAGCTTT TCCTTCACCT GGGGCAAAGG TCCCACCCAA AGGCTTCAGA 360

CATCTGAGAT TTACTCCTGG TGCTGACTTG GATGACTCTA CTCAAGCTTC TCTTGTCAAC 420

ATTAATCCCT TTACACCAGA ATCATACCGA CAAATGCTCT TTCTTCCTAA TGGCAAGCGG 480

AAAGCCAGAG AGATAAGGAA TCCTGATCTA AGAGGCCAGG TAAAACAGGA GCTACCTACC 540

AAGGAATCAC AGCAGCAGTT TTTGTGGAAA AGGTGTCCTC TGAAAGACAG CAATATGGTT 600

TCCCGCTACC AGAAGGAATT CCTGGAACTG GAGAGGATTG GTGTAGGGGA ATTTGGTTCT 660

GTCTACAAAT GCATCAAGCG CCTTGACGGA TGTGTTTATG CCATCAAACG CTCCAAGAGG 720

CCTCTGGCAG GATCCTCGGA TGAGCAGCTG GCATTGCGTG AGGTTTATGC TCATGCGGTC 780

CTTGGACACC ACCCCCATGT TGTGCGCTAC TACTCAGCAT GGGCAGAAGA TGATCACATG 840

ATTATACAAA ATGAACACTG TAATGGTGGG AGTCTCCAAG ATGTGCTTCT AGAAAATGCA 900

AAGCATGGCC AGTATTTCCC TGAAACAAAG CTGAAAGAAA TCTTGTTACA AGTCTCCATG 960

GGACTGAAAT ACATCCACAA CTCTGGCCTT GTGCACTTGG ATATCAAACC TAGTAATATC 1020

TTTATCTGTC ACAAGCTGGC AGTTGAGGGC CAAGCTGGGC AGGAAGAGAG TGACAGTGAT 1080

GATGAGTTCT CTTCTGGTGT GATGTATAAG ATTGGTGATC TTGGCCATGT GACATCAATA 1140

GCAAACCCTC AAGTGGAGGA AGGAGACAGA CGGTTCTTAG CCAATGAAAT TTTGCAGGAG 1200

CAATACTTCC ATTTGCCAAA GGCAGACATC TTTGCCCTGG CGCTCACAAC AGCTCTGGCA 1260

GCAGGTGCAG GACCACTGCC TCACAATGGG GCCATGTGGC ACCACATCCG CAAGGGCAAT 1320

ATCCCATCAA TCCCTCAGAA GCTTCCCAAT GGCTTCATTG AACTCCTCAA GCTCATGATC 1380

CATCCTGACC CAATGGAAAG ACCCTCTGCC ACAGCTCTTA CTAAGCACCC AATTCTCCGT 1440

CCTTCACTTG GAAAAGCTGT GCAGCTCCAG AAGCAGCTAA ATGTGGAGAA GTGTAAGACT 1500

GCCATGCTGG AAAGGGAACT AAAAGCAGCT CGCCTTGCCC AGACCCTCAT GAAGGACCAG 1560

CCCTTAGGAA ATGCCAACTT ACAGGAGTCT GAGACCTCTC CAAAGAAGAA CAACAAGCGC 1620

CTGGTGGGAG GGAAGAGTTG TCGCTCATTT AGCTTTACTG TGGGTTACTG A 1671

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F e+e+iG+Gefg+v+k++kr+dg++yAik+sk+pl+g+s+e+ alrEv+ahavlg+h++

Q: 207   FLELERIGVGEFGSVYKCIKRLDGCVYAIKRSKRPLAGSSDEQLALREVYAHAVLGHHPH  266

         7899********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E C+ggsL+++l e+ ++ ++++e++lk+ill+++ gl+y+H

Q: 267   VVRYYSAWAEDDHMIIQNEHCNGGSLQDVLLENAKHGQYFPETKLKEILLQVSMGLKYIH  326

         ************************************************************

S: 121   ssslvHlDikpenifi.....................tkevtlklgDlGlvtelnsedks  159

         +s lvHlDikp+nifi                     ++ v++k+gDlG+vt++    ++

Q: 327   NSGLVHLDIKPSNIFIchklavegqagqeesdsddefSSGVMYKIGDLGHVTSI---ANP  383

         ***********************************99999**************...99*

S: 160   kveEGDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpd  218

         +veEGD+r+la+Eilqe+y +l kaDiF+l+lt + +a++ +lP+nG +Wh++Rkg++p

Q: 384   QVEEGDRRFLANEILQEQYFHLpKADIFALALTTALAAGAGPLPHNGAMWHHIRKGNIP-  442

         ***********************************************************.

S: 219   eilkelsedlrellklmlepdperRptaeellkhevl  255

          i ++l + + ellklm++pdp +Rp+a++l kh++l

Q: 443   SIPQKLPNGFIELLKLMIHPDPMERPSATALTKHPIL  479

         **********************************986

Domain Sequence
(FASTA)

FLELERIGVG EFGSVYKCIK RLDGCVYAIK RSKRPLAGSS DEQLALREVY AHAVLGHHPH 60

VVRYYSAWAE DDHMIIQNEH CNGGSLQDVL LENAKHGQYF PETKLKEILL QVSMGLKYIH 120

NSGLVHLDIK PSNIFICHKL AVEGQAGQEE SDSDDEFSSG VMYKIGDLGH VTSIANPQVE 180

EGDRRFLANE ILQEQYFHLP KADIFALALT TALAAGAGPL PHNGAMWHHI RKGNIPSIPQ 240

KLPNGFIELL KLMIHPDPME RPSATALTKH PIL 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007343	; P:egg activation
GO:0007143	; P:female meiosis
GO:0035038	; P:female pronucleus assembly
GO:0007137	; P:meiotic metaphase II
GO:0007128	; P:meiotic prophase I
GO:0007067	; P:mitosis
GO:0060283	; P:negative regulation of oocyte development
GO:0060631	; P:regulation of meiosis I

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013