EKS-MEG-00043
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00043
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Sev483.11.7E-145113384272
StatusUnreviewed
Ensembl ProteinENSMGAP00000018079
UniProt AccessionG1NKX7;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameROS1
Gene Synonyms/Alias ROS1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000013356ENSMGAP00000014122ENSMGAT00000015045
ENSMGAG00000013356ENSMGAP00000018079ENSMGAT00000020671
OrganismMeleagris gallopavo
Functional Description
Protein Length398
Protein Sequence
(FASTA)
MLGLGEYSDT SKDIVLAKDT VTSPDITAIV AVIGAVVLGL TMIILFGFVW HQRWKSRKPT 60
LTGQIVLVKE DKELAQLRGM AETVGLANAC YAVSTLPSQA EIESLPAFPR DKLNLHKLLG 120
SGAFGEVYEG TALDILADGR GESKVAVKTL KRGATDQEKS EFLKEAHLMS KFDHPHILKL 180
LGVCLLNEPQ YLILELMEGG DLLSYLRGAR KQKFQSPLLT LTDLLDICLD ICKGCVYLEK 240
MRFIHRDLAA RNCLVSEKQY GSCSRVVKIG DFGLARDIYK NDYYRKRGEG LLPVRWMAPE 300
SLIDGVFTNR SDVWAFGVLV WETLTLGQQP YPGLSNIEVL HHVRSGGRLE SPNNCPDDIR 360
DLMTRCWAQD PHNRPTFFYI QHKLQEIRHS PLCFSYFL 398
Nucleotide Sequence
(FASTA)
ATGCTGGGGC TTGGTGAATA CAGTGACACA AGCAAAGATA TTGTGTTGGC TAAAGATACT 60
GTGACCTCTC CAGATATCAC TGCTATTGTT GCTGTGATTG GAGCAGTTGT ACTGGGCTTG 120
ACTATGATCA TACTGTTTGG TTTTGTATGG CATCAAAGAT GGAAATCAAG AAAACCAACC 180
TTAACTGGGC AGATAGTGCT TGTCAAGGAA GATAAAGAAT TAGCTCAACT CAGGGGGATG 240
GCTGAGACTG TGGGATTAGC CAATGCTTGT TATGCTGTCA GCACTCTTCC TTCTCAAGCA 300
GAGATCGAGT CATTGCCAGC TTTTCCTCGG GACAAATTGA ACCTACATAA GTTGTTAGGA 360
AGTGGAGCAT TTGGAGAGGT GTATGAAGGG ACTGCATTAG ATATCCTGGC AGATGGAAGA 420
GGGGAATCCA AAGTAGCAGT CAAGACTTTG AAGAGGGGTG CAACAGACCA AGAGAAGAGT 480
GAATTCTTGA AGGAGGCACA CTTAATGAGT AAATTTGATC ATCCCCACAT TCTGAAGCTA 540
CTTGGAGTGT GCCTGTTAAA TGAACCTCAG TACCTTATAC TGGAACTGAT GGAAGGAGGA 600
GATCTGCTTA GCTATTTACG AGGAGCCAGA AAGCAAAAGT TCCAGAGTCC CTTACTGACA 660
TTGACTGACC TCTTGGATAT ATGCTTGGAT ATTTGCAAAG GTTGTGTCTA TTTAGAGAAA 720
ATGCGTTTCA TACACAGGGA CCTGGCTGCT CGCAACTGCC TTGTGTCTGA GAAGCAATAC 780
GGGAGCTGCT CCCGAGTGGT AAAGATTGGT GATTTTGGAC TTGCCAGAGA TATCTATAAA 840
AATGATTACT ACAGGAAAAG AGGAGAAGGC CTGCTCCCTG TCAGATGGAT GGCTCCTGAA 900
AGCCTCATTG ATGGCGTGTT TACAAATCGC TCTGATGTTT GGGCTTTTGG AGTCTTAGTG 960
TGGGAAACAT TAACTTTGGG TCAACAGCCG TATCCGGGTC TCTCCAATAT AGAAGTTTTA 1020
CACCATGTAC GATCAGGAGG AAGGCTGGAA TCACCGAACA ACTGTCCTGA TGACATACGT 1080
GATTTAATGA CACGATGCTG GGCCCAAGAT CCTCACAACA GACCAACTTT CTTTTATATT 1140
CAGCACAAAC TTCAGGAGAT AAGGCACTCT CCACTGTGCT TCAGCTACTT CCTTGA 1196
Domain Profile
S: 1     lklrlllgsgafgevyegtavdilkvesgeikvavktlkkgstdqekiellkeaqlmskf  60
         l+l++llgsgafgevyegta+dil  + ge kvavktlk+g+tdqek e+lkea+lmskf
Q: 113   LNLHKLLGSGAFGEVYEGTALDILADGRGESKVAVKTLKRGATDQEKSEFLKEAHLMSKF  172
         6899********************************************************
S: 61    khenilkllgvclltesqylilelmeagdllsylrkarattfqepsltlvdlvelcvdis  120
         +h+ ilkllgvcll+e+qylilelme+gdllsylr ar   fq p ltl+dl+++c+di+
Q: 173   DHPHILKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLDIC  232
         ************************************************************
S: 121   kgcvyledmhfihrdlaarnclvsvkdyts.rrvvkigdfglardiykndyyrkrgegll  179
         kgcvyle+m fihrdlaarnclvs k+y s  rvvkigdfglardiykndyyrkrgegll
Q: 233   KGCVYLEKMRFIHRDLAARNCLVSEKQYGScSRVVKIGDFGLARDIYKNDYYRKRGEGLL  292
         ****************************8647****************************
S: 180   pvrwmapeslvdglfttqsdvwsfgilvweiltlgqqpyaarsnldvlayvkeggrleqp  239
         pvrwmapesl+dg+ft +sdvw+fg+lvwe ltlgqqpy+  sn++vl +v++ggrle p
Q: 293   PVRWMAPESLIDGVFTNRSDVWAFGVLVWETLTLGQQPYPGLSNIEVLHHVRSGGRLESP  352
         ************************************************************
S: 240   rnctddlynllllcwaqepderptfrriqnql  271
         +nc+dd+ +l+++cwaq+p++rptf  iq++l
Q: 353   NNCPDDIRDLMTRCWAQDPHNRPTFFYIQHKL  384
         **************************999876
Domain Sequence
(FASTA)
LNLHKLLGSG AFGEVYEGTA LDILADGRGE SKVAVKTLKR GATDQEKSEF LKEAHLMSKF 60
DHPHILKLLG VCLLNEPQYL ILELMEGGDL LSYLRGARKQ KFQSPLLTLT DLLDICLDIC 120
KGCVYLEKMR FIHRDLAARN CLVSEKQYGS CSRVVKIGDF GLARDIYKND YYRKRGEGLL 180
PVRWMAPESL IDGVFTNRSD VWAFGVLVWE TLTLGQQPYP GLSNIEVLHH VRSGGRLESP 240
NNCPDDIRDL MTRCWAQDPH NRPTFFYIQH KL 272
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00050
EKS-BOT-00055
EKS-CAJ-00077
EKS-CAF-00056
EKS-CAP-00075
EKS-DRM-00021
EKS-EQC-00054
EKS-FEC-00073
EKS-GAG-00060
EKS-GOG-00074
EKS-HOS-00077
EKS-ICT-00051
EKS-LAC-00058
EKS-LOA-00054
EKS-MAM-00054
EKS-MUM-00076
EKS-MUP-00057
EKS-MYL-00084
EKS-NOL-00072
EKS-ORA-00062
EKS-ORC-00052
EKS-OTG-00079
EKS-PAT-00050
EKS-PES-00049
EKS-POA-00072
EKS-PTV-00062
EKS-SUS-00048
EKS-TAG-00065
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0030154; P:cell differentiation
GO:0016049; P:cell growth
GO:0008283; P:cell proliferation
GO:0010629; P:negative regulation of gene expression
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0010966; P:regulation of phosphate transport
GO:0032006; P:regulation of TOR signaling cascade
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR011042; 6-blade_b-propeller_TolB-like.
IPR003961; Fibronectin_type3.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000033; LDLR_classB_rpt.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 9.
SM00135; LY; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 9.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013