EKS-MEG-00305

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00305

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	410.9	1.4E-123	248	499	252

Status

Unreviewed

Ensembl Protein

ENSMGAP00000014145

UniProt Accession

G1NKZ9;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000013388	ENSMGAP00000014145	ENSMGAT00000015068

Organism

Meleagris gallopavo

Functional Description

Protein Length

518

Protein Sequence
(FASTA)

MGNFCQKYCS CLEPYVPCLF SGKEDEREED VGQVFANPAV VRIGSQAGEK DKHLVSTCNF 60

VALFNYEART EDDLSFQAGD KLEVLDASHE GWWYAKLLLP EGSVCPGRKL QGYIPANYIA 120

AVQSIEAEPW FFGPIKRADA ERQLLYPGNQ AGAFLIRESE SLKGEYSLSV FDGESVKHYR 180

IRRLDGEGFF LSKLKTFKTL NEFVDYYSKN SNGLCVMLGK PCPKVQIPTT FDLSYKTVDQ 240

WEIDRKSLKF LKKLGSGQFG EVWEGLWNNT TPVAIKTLKP GSMDPKDFLR EAQIMKNLRH 300

PKLIQLYAVC TLEDPIYIVT ELMKYGSLIE YLQNDAGSHI SLPHQIDMAA QVASGMAYLE 360

SQNYIHRDLA ARNVLVGEHN VYKVADFGLA RVFKVENENI YEARPETKLP VKWTAPEAIR 420

YSKFSVKSDV WSFGVLVFEI MTYGKMPYAG MPGHQVIQML DKGYRLPQPE TCPKALYELM 480

LKCWSTEPSE RPTFEALYCQ LEDYFDNDSY MDKHATIK 518

Nucleotide Sequence
(FASTA)

ATGGGAAACT TCTGTCAGAA GTACTGCAGC TGTTTGGAGC CCTATGTTCC TTGCTTATTC 60

TCAGGGAAAG AAGATGAGCG GGAAGAGGAT GTTGGACAGG TTTTTGCCAA CCCTGCTGTG 120

GTAAGGATTG GCTCACAGGC AGGAGAGAAG GACAAACATT TGGTGAGCAC TTGCAATTTT 180

GTGGCGCTCT TCAACTATGA GGCTCGCACG GAGGATGATT TGAGCTTCCA AGCTGGGGAT 240

AAGCTTGAAG TGCTGGACGC ATCCCACGAG GGCTGGTGGT ACGCTAAGCT CCTCCTGCCA 300

GAAGGGTCAG TCTGTCCTGG CCGCAAGCTC CAGGGCTACA TCCCTGCCAA CTACATAGCC 360

GCTGTACAGA GCATTGAAGC TGAGCCATGG TTTTTTGGAC CAATCAAGCG AGCAGACGCT 420

GAGAGACAAC TGTTGTATCC TGGAAACCAG GCAGGAGCCT TCCTAATCCG AGAAAGCGAA 480

AGTCTAAAAG GCGAATACTC ACTTTCAGTG TTCGATGGTG AATCAGTGAA GCACTACAGG 540

ATCAGAAGAC TGGATGGAGA AGGTTTTTTC TTAAGTAAAT TGAAAACTTT TAAAACTCTG 600

AATGAGTTTG TTGACTATTA CAGTAAGAAC AGTAATGGCC TCTGTGTGAT GCTTGGAAAG 660

CCGTGTCCGA AGGTACAAAT TCCTACTACT TTTGATTTGT CATATAAAAC TGTTGATCAG 720

TGGGAGATAG ACAGAAAATC TCTGAAATTC TTGAAAAAGT TAGGATCCGG TCAGTTTGGT 780

GAGGTATGGG AAGGACTGTG GAATAATACC ACCCCAGTGG CAATCAAAAC ATTAAAACCA 840

GGTTCAATGG ATCCAAAGGA CTTTCTGAGG GAAGCACAAA TAATGAAGAA CTTGAGGCAT 900

CCAAAGCTTA TACAACTTTA TGCTGTTTGC ACTTTGGAGG ATCCAATTTA TATTGTTACA 960

GAGCTGATGA AATATGGAAG TCTTATAGAA TACCTTCAAA ATGATGCAGG CTCCCACATC 1020

TCCCTGCCAC ATCAAATAGA CATGGCTGCT CAGGTGGCTT CTGGCATGGC TTATCTTGAA 1080

TCTCAAAACT ATATCCATCG AGATTTGGCA GCCAGGAATG TTCTCGTTGG TGAACACAAT 1140

GTTTACAAAG TGGCAGATTT TGGACTTGCA AGAGTTTTTA AGGTAGAAAA TGAAAACATA 1200

TATGAAGCTA GGCCTGAAAC AAAACTCCCA GTGAAGTGGA CAGCCCCTGA GGCAATCCGC 1260

TATAGCAAAT TCAGTGTTAA GTCAGATGTA TGGTCGTTTG GAGTACTTGT CTTTGAAATA 1320

ATGACGTATG GGAAGATGCC ATATGCTGGC ATGCCAGGAC ACCAGGTGAT CCAGATGCTG 1380

GACAAGGGAT ACAGACTCCC TCAGCCCGAG ACCTGCCCGA AGGCGCTCTA TGAACTGATG 1440

CTGAAGTGCT GGAGTACAGA GCCCAGTGAG AGGCCCACTT TTGAGGCCTT ATACTGTCAG 1500

CTGGAGGACT ACTTTGACAA TGACTCCTAT ATGGACAAGC ATGCCACCAT TAAGTGA 1557

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lk++kklG+GqfGevw+g+w+++++va+ktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 248   LKFLKKLGSGQFGEVWEGLWNNTTPVAIKTLKPGSMDPKDFLREAQIMKNLRHPKLIQLY  307

         5789********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyivtelm+ Gsl+++l+++ g++++lp+++d+aaqva+Gmayle++n+ihr

Q: 308   AVCTLEDPIYIVTELMKYGSLIEYLQNDAGSHISLPHQIDMAAQVASGMAYLESQNYIHR  367

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++v+kvadfGlar+++   +++y+a+ ++klP+kWtaPeai+++kf++k

Q: 368   DLAARNVLVGEHNVYKVADFGLARVFKvenENIYEARPETKLPVKWTAPEAIRYSKFSVK  427

         ************************99887899****************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfG+l++ei+t+Gk+Py Gm  ++v++++++gyrlp+pe+cp+ lyel+l+cw+++

Q: 428   SDVWSFGVLVFEIMTYGKMPYAGMPGHQVIQMLDKGYRLPQPETCPKALYELMLKCWSTE  487

         ************************************************************

S: 238   peerPtfetlqe  249

         p+erPtfe+l+

Q: 488   PSERPTFEALYC  499

         ********9975

Domain Sequence
(FASTA)

LKFLKKLGSG QFGEVWEGLW NNTTPVAIKT LKPGSMDPKD FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IVTELMKYGS LIEYLQNDAG SHISLPHQID MAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNVYKVADF GLARVFKVEN ENIYEARPET KLPVKWTAPE AIRYSKFSVK 180

SDVWSFGVLV FEIMTYGKMP YAGMPGHQVI QMLDKGYRLP QPETCPKALY ELMLKCWSTE 240

PSERPTFEAL YC 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013