EKS-MEG-00300
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00300
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src449.91.8E-135273521249
StatusUnreviewed
Ensembl ProteinENSMGAP00000014175
UniProt AccessionG1NL23;
Protein Name
Protein Synonyms/Alias
Gene NameFYN
Gene Synonyms/Alias FYN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000013415ENSMGAP00000017439ENSMGAT00000018840
ENSMGAG00000013415ENSMGAP00000014175ENSMGAT00000015099
OrganismMeleagris gallopavo
Functional Description
Protein Length539
Protein Sequence
(FASTA)
IMGCVQCKDK EATKLTDERD GSLTQSSGYR YGTDPTPQHY PSFGVTSIPN YNNFHATGGQ 60
GLTVFGGVNS SSHTGTLRTR GGTGVTLFVA LYDYEARTED DLSFHKGEKF QILNSSEGDW 120
WEARSLTTGE TGYIPSNYVA PVDSIQAEEW YFGKLGRKDA ERQLLSFGNP RGTFLIRESE 180
TTKAGAYSLS IRDWDDMKGD HVKHYKIRKL DNGGYYITTR AQFETLQQLV QHYSERAAGL 240
CCRLVVPCHK GMPRLTDLSV KTKDVWEIPR ESLQLIKRLG NGQFGEVWMG TWNGNTKVAI 300
KTLKPGTMSP ESFLEEAQIM KKLKHDKLVQ LYAVVSEEPI YIVTEYMSKG SLLDFLKDGE 360
GRALKLPNLV DMAAQVAAGM AYIERMNYIH RDLRSANILV GNGLICKIAD FGLARLIEDN 420
EYTARQGAKF PIKWTAPEAA LYGRFTIKSD VWSFGILLTE LVTKGRVPYP GMNNREVLEQ 480
VERGYRMPCP QDCPISLHEL MIHCWKKDPE ERPTFEYLQG FLEDYFTATE PQYQPGDNL 539
Nucleotide Sequence
(FASTA)
ATAATGGGCT GTGTGCAATG TAAGGACAAA GAGGCAACAA AACTGACTGA CGAGAGGGAT 60
GGGAGTTTAA CACAAAGCTC AGGCTACCGC TATGGCACAG ATCCCACGCC ACAGCACTAT 120
CCAAGCTTTG GTGTGACTTC AATTCCAAAC TACAACAACT TCCATGCCAC GGGAGGCCAA 180
GGACTGACAG TGTTTGGTGG AGTCAATTCC TCCTCTCATA CAGGGACACT ACGTACAAGA 240
GGAGGAACGG GTGTAACTCT TTTTGTGGCG CTTTATGACT ATGAAGCAAG AACAGAAGAT 300
GACTTAAGTT TTCACAAAGG AGAAAAATTT CAAATTCTTA ACAGCTCGGA AGGAGACTGG 360
TGGGAGGCTC GGTCCCTGAC AACAGGCGAA ACTGGTTACA TTCCCAGTAA TTATGTGGCT 420
CCGGTCGATT CCATCCAAGC AGAGGAGTGG TACTTTGGCA AACTTGGCCG AAAAGATGCT 480
GAGAGGCAGC TGTTGTCATT TGGAAACCCA AGAGGTACCT TCCTGATCCG GGAAAGTGAA 540
ACTACCAAAG CAGGTGCCTA TTCCCTGTCT ATTCGTGACT GGGACGATAT GAAAGGAGAT 600
CATGTCAAAC ATTATAAGAT TCGTAAACTT GACAATGGTG GATATTATAT CACAACTCGG 660
GCACAATTTG AAACTCTTCA ACAGCTGGTT CAGCATTATT CAGAGAGAGC TGCAGGTCTT 720
TGCTGCCGCT TAGTAGTCCC CTGTCATAAA GGAATGCCAA GGCTTACTGA TCTGTCTGTC 780
AAAACCAAAG ATGTCTGGGA AATTCCACGA GAATCCCTAC AGTTGATCAA GAGACTGGGA 840
AATGGGCAGT TTGGGGAAGT ATGGATGGGT ACATGGAATG GAAATACTAA AGTGGCTATC 900
AAGACTCTGA AGCCTGGCAC TATGTCTCCA GAATCATTCT TGGAGGAAGC CCAAATCATG 960
AAGAAGCTAA AACATGACAA ACTGGTCCAG CTTTATGCTG TGGTGTCTGA AGAACCCATC 1020
TATATTGTCA CAGAGTACAT GAGCAAAGGG AGCTTACTAG ATTTCTTAAA AGATGGAGAA 1080
GGAAGAGCTC TGAAGCTACC AAACTTAGTG GACATGGCAG CTCAGGTAGC TGCAGGAATG 1140
GCATATATTG AACGAATGAA TTACATACAC AGAGATCTGC GATCTGCAAA CATTCTGGTG 1200
GGGAATGGAT TAATATGCAA GATTGCTGAC TTTGGATTAG CAAGGCTGAT CGAAGACAAT 1260
GAATATACAG CAAGACAAGG TGCAAAGTTT CCCATTAAAT GGACTGCACC AGAAGCGGCA 1320
TTGTATGGAA GGTTCACAAT CAAGTCGGAT GTGTGGTCTT TTGGGATCCT ACTGACAGAG 1380
CTGGTAACAA AAGGGAGAGT GCCATACCCA GGCATGAATA ACCGTGAAGT CTTGGAGCAA 1440
GTAGAACGCG GTTATCGGAT GCCGTGTCCT CAGGACTGTC CCATTTCCTT GCACGAGCTT 1500
ATGATCCACT GCTGGAAAAA AGACCCAGAG GAGCGTCCAA CTTTTGAATA TTTGCAGGGT 1560
TTTCTCGAAG ACTACTTTAC TGCAACAGAA CCCCAGTACC AGCCCGGTGA CAACCTGTAA 1620
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+k+lG+GqfGevw+g+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+ly
Q: 273   LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY  332
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihr
Q: 333   AVVSE-EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR  391
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 392   DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  451
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp +l+el+++cwkkdpee
Q: 452   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE  511
         ************************************************************
S: 241   rPtfetlqev  250
         rPtfe+lq +
Q: 512   RPTFEYLQGF  521
         *******976
Domain Sequence
(FASTA)
LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LKHDKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD 120
LRSANILVGN GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI HCWKKDPEER 240
PTFEYLQGF 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00339
EKS-ANC-00354
EKS-BOT-00365
EKS-CAJ-00369
EKS-CAF-00366
EKS-CAP-00398
EKS-CHH-00039
EKS-DAR-00743
EKS-DAN-00035
EKS-EQC-00367
EKS-FEC-00353
EKS-GAM-00219
EKS-GAG-00309
EKS-GAA-00446
EKS-GOG-00358
EKS-HOS-00371
EKS-ICT-00346
EKS-LAC-00380
EKS-LOA-00374
EKS-MAM-00365
EKS-MOD-00354
EKS-MUM-00397
EKS-MUP-00359
EKS-MYL-00364
EKS-NOL-00335
EKS-ORN-00471
EKS-ORA-00320
EKS-ORC-00343
EKS-ORL-00432
EKS-OTG-00370
EKS-PAT-00345
EKS-PES-00325
EKS-POA-00355
EKS-PRC-00071
EKS-PTV-00093
EKS-RAN-00379
EKS-SAH-00336
EKS-SUS-00322
EKS-TAG-00440
EKS-TAR-00466
EKS-TEN-00462
EKS-TUB-00053
EKS-TUT-00097
EKS-VIP-00051
EKS-XET-00483
EKS-XIM-00460
Gene Ontology
GO:0005768; C:endosome
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050798; P:activated T cell proliferation
GO:0010629; P:negative regulation of gene expression
GO:0042177; P:negative regulation of protein catabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045471; P:response to ethanol
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013