EKS-MEG-00313
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00313
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK309.21.8E-922243242
StatusUnreviewed
Ensembl ProteinENSMGAP00000014401
UniProt AccessionG1NLK0;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K7
Gene Synonyms/Alias MAP3K7;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000013620ENSMGAP00000014401ENSMGAT00000015335
OrganismMeleagris gallopavo
Functional Description
Protein Length577
Protein Sequence
(FASTA)
VVGRGAFGVV CKAKWRAKDV AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV 60
CLVMEYAEGG SLYNVLHGAE PLPHYTAAHA MSWCLQCSQG VAYLHSMKPK ALIHRDLKPP 120
NLLLVAGGTV LKICDFGTAC DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW 180
EVITRRKPFD EIGGPAFRIM WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI 240
VKIMTHLMRY FPGADEPLQY PCQYSDEGQS NSATSTGSFM DITSTNTSNK SDANMEPNDF 300
QGASTNDTIK RLESKLAQQM KNTAKQPGDP GRLSLPPSRG SSVESLSDVR EAKRMSADMS 360
EMEARIPSTT AYSKPKRGHR KTASFGNILD VPEIIIPAGN GQQRRRSIQD LTVAGTESSQ 420
ESRNSSRSSS PSVRMITTSG PTSEKPTRNP WTPDDAVTET NGSDNSIPMA YLTLDHQLQP 480
LAPCPNSKES MAVFEQHCKM AQEYMKVQTE IALLLQRKQE LIAELDQDEK DQQNTSRLVQ 540
EHKKLLDENK SLSTYYQQCK KQLEVIRNQQ QKRPGTS 577
Nucleotide Sequence
(FASTA)
GTTGTTGGAA GAGGAGCCTT TGGTGTGGTC TGCAAGGCAA AATGGCGAGC TAAGGATGTA 60
GCCATTAAAC AAATAGAAAG TGAATCTGAA AGAAAAGCCT TCATTGTAGA GCTTCGTCAA 120
CTGTCACGAG TAAACCATCC CAATATTGTC AAGTTATATG GAGCCTGTCT AAACCCAGTG 180
TGTCTTGTTA TGGAGTATGC TGAAGGAGGT TCTCTATACA ATGTGCTGCA TGGTGCTGAA 240
CCTCTGCCTC ATTATACTGC TGCACACGCG ATGAGTTGGT GTTTACAGTG TTCCCAAGGA 300
GTGGCATATC TTCACAGTAT GAAACCAAAG GCCCTAATTC ACAGAGACCT GAAACCACCA 360
AATTTGCTGT TGGTAGCTGG GGGGACAGTT CTAAAAATCT GTGATTTTGG TACAGCCTGT 420
GATATTCAAA CACACATGAC CAACAATAAG GGAAGTGCTG CTTGGATGGC ACCTGAAGTT 480
TTTGAAGGTA GCAATTACAG TGAAAAATGT GATGTTTTCA GTTGGGGTAT TATTCTCTGG 540
GAGGTAATCA CCCGTAGGAA ACCTTTTGAT GAGATTGGTG GTCCAGCTTT CCGCATAATG 600
TGGGCAGTTC ACAATGGTAC TCGACCACCA CTGATCAAAA ACTTACCTAA ACCAATTGAG 660
AGTTTAATGA CCCGTTGTTG GTCCAAGGAT CCCTCACAAC GACCTTCCAT GGAAGAAATT 720
GTTAAGATAA TGACACACTT GATGCGGTAC TTTCCAGGAG CTGATGAACC TCTGCAGTAT 780
CCTTGCCAGT ATTCAGATGA AGGGCAAAGC AACTCTGCCA CTAGTACAGG TTCATTTATG 840
GACATCACTT CTACAAATAC AAGTAACAAA AGCGATGCAA ACATGGAACC GAATGACTTC 900
CAAGGAGCTT CTACCAATGA CACTATTAAA CGTTTAGAAT CAAAATTGGC ACAGCAAATG 960
AAAAATACAG CCAAGCAGCC GGGTGATCCT GGCCGTTTGA GTTTACCACC ATCTCGTGGG 1020
AGCAGTGTGG AGAGCTTGTC AGATGTTCGA GAAGCCAAAA GGATGAGTGC TGACATGTCC 1080
GAAATGGAAG CAAGAATACC TTCTACAACA GCCTATTCCA AGCCTAAACG AGGCCATCGT 1140
AAAACTGCTT CATTTGGCAA CATTCTGGAT GTCCCTGAGA TCATCATACC AGCAGGAAAC 1200
GGACAGCAGA GGCGCAGATC CATTCAAGAT CTTACTGTTG CTGGAACAGA GTCCAGTCAG 1260
GAGAGTAGAA ACAGCAGTAG ATCATCTAGT CCTAGTGTGA GAATGATCAC TACCTCGGGA 1320
CCAACCTCTG AAAAGCCAAC TCGTAATCCA TGGACACCTG ATGATGCAGT TACAGAGACC 1380
AATGGGTCAG ATAACTCCAT CCCAATGGCG TATCTTACAT TAGATCATCA GTTACAGCCT 1440
CTAGCACCAT GCCCGAACTC CAAAGAATCT ATGGCTGTGT TTGAACAGCA CTGCAAAATG 1500
GCACAAGAAT ATATGAAAGT TCAGACAGAA ATTGCATTGC TGTTGCAGAG GAAGCAAGAA 1560
TTAATAGCAG AACTGGACCA GGATGAAAAA GACCAGCAAA ATACATCCCG TCTGGTACAA 1620
GAACATAAAA AGCTGTTAGA TGAAAATAAA AGTCTCTCAA CTTATTATCA GCAATGCAAA 1680
AAACAATTAG AGGTCATCAG AAATCAGCAA CAGAAACGGC CAGGCACGTC ATGA 1734
Domain Profile
S: 7     igsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellGvcl  66
         +g+gafg v+kakwr+k+va+K++++e+e+    +++  e+++ls+++hpni++l+G+cl
Q: 2     VGRGAFGVVCKAKWRAKDVAIKQIESESER----KAFIVELRQLSRVNHPNIVKLYGACL  57
         8*************************9888....**************************
S: 67    eepnlllvmeyveggsLsnvlhe.kskreidlevlvswalqiArGmaYLhseapkkiihr  125
         ++  ++lvmey+eggsL+nvlh+ +  ++++ ++++sw+lq+++G+aYLhs++pk++ihr
Q: 58    NP--VCLVMEYAEGGSLYNVLHGaEPLPHYTAAHAMSWCLQCSQGVAYLHSMKPKALIHR  115
         *9..89*****************77899********************************
S: 126   dLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvseksDvwS  185
         dLk++n+Ll +  ++lkicdFGta++++ +++++++g++awmaPEv++ +++sek+Dv+S
Q: 116   DLKPPNLLLVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMAPEVFEGSNYSEKCDVFS  174
         **************************99.9******************************
S: 186   ygvvLWelltrevPykdlse..laiaykvalkglrlpipsscpeklkkLmkecwnedpek  243
         +g++LWe++tr++P++++    ++i+++v ++g+r+p+++++p+++++Lm++cw++dp++
Q: 175   WGIILWEVITRRKPFDEIGGpaFRIMWAV-HNGTRPPLIKNLPKPIESLMTRCWSKDPSQ  233
         ****************9987447889999.99****************************
S: 244   Rpsfseivks  253
         Rps++eivk+
Q: 234   RPSMEEIVKI  243
         *******986
Domain Sequence
(FASTA)
VGRGAFGVVC KAKWRAKDVA IKQIESESER KAFIVELRQL SRVNHPNIVK LYGACLNPVC 60
LVMEYAEGGS LYNVLHGAEP LPHYTAAHAM SWCLQCSQGV AYLHSMKPKA LIHRDLKPPN 120
LLLVAGGTVL KICDFGTACD IQTHMTNNKG SAAWMAPEVF EGSNYSEKCD VFSWGIILWE 180
VITRRKPFDE IGGPAFRIMW AVHNGTRPPL IKNLPKPIES LMTRCWSKDP SQRPSMEEIV 240
KI 242
KeywordComplete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00356
EKS-ANC-00370
EKS-BOT-00382
EKS-CAE-00306
EKS-CAJ-00387
EKS-CAF-00382
EKS-CAP-00414
EKS-CII-00215
EKS-CIS-00135
EKS-DAR-00762
EKS-DRM-00178
EKS-ECT-00079
EKS-EQC-00371
EKS-FEC-00369
EKS-GAM-00229
EKS-GAG-00321
EKS-GAA-00466
EKS-GOG-00372
EKS-HOS-00389
EKS-ICT-00360
EKS-LAC-00396
EKS-LOA-00390
EKS-MAM-00381
EKS-MOD-00371
EKS-MUM-00415
EKS-MUP-00374
EKS-MYL-00379
EKS-NOL-00347
EKS-ORN-00491
EKS-ORA-00331
EKS-ORC-00359
EKS-ORL-00453
EKS-OTG-00384
EKS-PAT-00362
EKS-PES-00338
EKS-PEM-00202
EKS-POA-00372
EKS-RAN-00397
EKS-SAH-00349
EKS-SUS-00336
EKS-TAG-00451
EKS-TAR-00491
EKS-TEN-00484
EKS-TUT-00105
EKS-VIP-00054
EKS-XET-00495
EKS-XIM-00481
Gene Ontology
GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0008385; C:IkappaB kinase complex
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004708; F:MAP kinase kinase activity
GO:0004709; F:MAP kinase kinase kinase activity
GO:0007250; P:activation of NF-kappaB-inducing kinase activity
GO:0043966; P:histone H3 acetylation
GO:0007252; P:I-kappaB phosphorylation
GO:0007254; P:JNK cascade
GO:0043066; P:negative regulation of apoptotic process
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032743; P:positive regulation of interleukin-2 production
GO:0046330; P:positive regulation of JNK cascade
GO:0043507; P:positive regulation of JUN kinase activity
GO:0002726; P:positive regulation of T cell cytokine production
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR017421; MAPKKK7.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013