EKS-MEG-00270

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00270

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	299.0	2.4E-89	3	222	220

Status

Unreviewed

Ensembl Protein

ENSMGAP00000014528

UniProt Accession

G1NLW0;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K5

Gene Synonyms/Alias

MAP4K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000013740	ENSMGAP00000014528	ENSMGAT00000015464

Organism

Meleagris gallopavo

Functional Description

Protein Length

853

Protein Sequence
(FASTA)

GDDFSLIQQE IYMVKECKHC NIVAYFGSYL SREKLWICME YCGGGSLQDI YHVTGPLSEL 60

QIAYVCRETL QGLAYLHMKG KMHRDIKGAN ILLTDHGDIK LADFGVAAKI TATIAKRKSF 120

IGTPYWMAPE VAAVEKNGGY NQLCDIWAVG ITAIELAELQ PPMFDLHPMR ALFLMSKSNF 180

QPPKLKEKAK WSSTFHNFVK IALTKNPKKR PTADRLLAHS FVGQPGLSRS LAVELLDKVN 240

NPDNHTHCSE VDDDDFEPHS VIRHTIRSTN RNVRAERTAS EINFDKLQFE PPLRKETEAR 300

DEMMESKDLE FVSSSMEVEI TARQTERISK LCLELSSTQY ISLAFLKGCH HSLLGDMEGY 360

LSPRGLLTKF GDGSEDVEDN SMSTLKRAGP PPLPPKPRIN SYPEENLPDD EKSQTIKHFP 420

DSQNRAPPAH RRQSIPVCGP QKEISLGSAL FSVDRNGDGM LKLIEENAEG SGQIPQLPRK 480

KEKRDFPKPA INGLPPTPKV LMGACFSKVF DGCPLKINCA TSWIHPDTKD QYIIFGTEEG 540

IYTLNLNELH EATMEQLFPR KCTWLYVINN TLMSLSGKTF QLYSHNLIAL FEQAKKTGLA 600

AHIQTHRFPD KILPRKFALT TKIPDTKGCH KCCIVRNPYT GHKYLCGALQ SGIVLLQWYE 660

PMQKFMLIKH FDFPLPSPLN VFEMLVIPEQ EYPMVCVAIS KGAEPNQVVH FETINLNSAS 720

SWFTEIGAGN QQLDAIHVTQ LERDTVLVCL DKFVKIVNLQ GKLKSSKKLA SELSFDFCIE 780

SVVCLQDSVL AFWKHGMQGK SFKSDEVTQE ISDETRVFRL LGSDRVVVLE SRPTENPTAH 840

SNLYILAGHE NSY 853

Nucleotide Sequence
(FASTA)

GGGGATGACT TTTCGTTGAT CCAGCAGGAA ATATATATGG TAAAAGAATG CAAACATTGC 60

AACATAGTCG CCTATTTTGG GAGCTATCTC AGCCGTGAAA AGCTGTGGAT ATGCATGGAG 120

TACTGCGGCG GGGGATCCCT CCAAGATATC TACCATGTCA CGGGACCTCT GTCAGAGTTA 180

CAAATTGCAT ATGTTTGCAG AGAGACTTTG CAGGGTCTCG CTTATTTGCA TATGAAGGGG 240

AAAATGCACA GAGATATAAA GGGTGCAAAT ATTCTACTAA CAGACCATGG AGACATCAAG 300

TTAGCTGACT TCGGTGTAGC AGCAAAAATA ACAGCCACCA TTGCAAAGAG GAAATCATTT 360

ATCGGTACCC CTTACTGGAT GGCCCCAGAG GTGGCGGCGG TGGAGAAGAA CGGCGGCTAC 420

AACCAGCTCT GTGACATCTG GGCAGTCGGC ATCACAGCCA TCGAGCTGGC GGAGCTTCAG 480

CCCCCCATGT TCGACCTGCA CCCCATGAGG GCTTTGTTCT TAATGTCAAA AAGTAATTTT 540

CAACCACCAA AGCTAAAGGA AAAAGCAAAA TGGTCATCAA CATTCCATAA TTTTGTCAAA 600

ATAGCACTTA CAAAAAATCC AAAGAAGAGA CCAACAGCAG ACAGACTCCT TGCTCATAGC 660

TTTGTAGGTC AGCCTGGTCT TTCACGATCT TTAGCAGTTG AGCTGTTGGA CAAAGTTAAT 720

AATCCTGACA ACCACACACA CTGCAGTGAA GTGGATGATG ATGATTTTGA GCCTCATTCT 780

GTTATTCGCC ATACGATTCG TTCTACAAAC AGGAATGTTA GGGCAGAAAG AACAGCATCA 840

GAGATAAACT TTGATAAGCT CCAGTTTGAG CCCCCTCTGC GGAAAGAAAC AGAAGCTCGG 900

GATGAAATGA TGGAAAGCAA AGATTTGGAA TTTGTGAGCA GTAGTATGGA AGTTGAAATA 960

ACGGCCAGGC AAACAGAGCG CATTTCCAAG CTTTGTTTGG AGCTGAGCAG CACACAATAC 1020

ATTTCTTTGG CTTTTTTGAA GGGCTGTCAC CATTCCTTGC TAGGTGACAT GGAAGGATAC 1080

CTCTCACCTA GGGGACTGCT TACAAAGTTT GGCGATGGGA GCGAAGATGT TGAAGACAAT 1140

TCTATGTCAA CCCTTAAGCG AGCAGGGCCA CCTCCACTGC CCCCTAAGCC AAGAATAAAC 1200

AGCTACCCTG AGGAAAACCT CCCGGATGAT GAGAAATCTC AGACGATAAA ACACTTCCCT 1260

GACTCACAGA ACAGAGCCCC ACCAGCTCAT AGGAGGCAGA GTATTCCTGT CTGTGGGCCT 1320

CAGAAGGAAA TCAGTTTGGG ATCAGCTTTG TTTTCAGTAG ACAGAAATGG GGACGGCATG 1380

TTGAAACTCA TTGAGGAAAA TGCAGAAGGA TCCGGACAGA TCCCTCAGCT GCCACGTAAA 1440

AAAGAGAAAA GAGATTTTCC TAAGCCAGCA ATCAATGGTT TGCCACCAAC GCCAAAGGTG 1500

CTGATGGGAG CATGTTTCTC CAAAGTTTTC GATGGTTGCC CTTTGAAGAT TAACTGTGCA 1560

ACATCGTGGA TTCATCCAGA TACTAAAGAT CAGTACATCA TCTTTGGAAC AGAAGAAGGT 1620

ATCTATACTC TGAATTTGAA TGAACTTCAT GAAGCAACAA TGGAACAGTT GTTTCCCCGA 1680

AAGTGCACCT GGCTGTATGT TATCAATAAC ACCTTAATGT CCTTGTCAGG GAAGACGTTC 1740

CAGCTCTACT CCCATAATCT GATAGCTTTG TTTGAACAAG CCAAAAAAAC AGGACTAGCT 1800

GCTCACATCC AAACCCATAG GTTTCCTGAC AAAATATTAC CAAGGAAGTT TGCCTTGACG 1860

ACAAAGATTC CTGACACAAA AGGGTGTCAC AAATGCTGTA TAGTAAGAAA TCCATACACA 1920

GGACACAAGT ACCTCTGCGG TGCGTTGCAG TCTGGAATTG TTCTGTTACA GTGGTATGAG 1980

CCAATGCAGA AATTCATGTT AATAAAGCAC TTTGATTTTC CTTTGCCGAG CCCTCTGAAT 2040

GTCTTTGAGA TGCTGGTGAT CCCAGAGCAG GAGTACCCCA TGGTCTGCGT CGCTATCAGT 2100

AAAGGCGCTG AGCCAAACCA GGTCGTTCAC TTTGAGACAA TCAACTTGAA CTCTGCTTCT 2160

TCGTGGTTTA CAGAAATCGG TGCAGGCAAT CAGCAGCTGG ATGCCATTCA TGTGACACAG 2220

CTGGAAAGAG ACACCGTGCT GGTCTGCCTG GACAAATTTG TGAAAATAGT GAATTTACAA 2280

GGGAAACTGA AGTCAAGCAA GAAGTTGGCC TCGGAGCTGA GCTTTGATTT CTGCATTGAG 2340

TCAGTGGTGT GCCTTCAGGA CAGCGTGCTG GCCTTCTGGA AACACGGCAT GCAGGGCAAG 2400

AGCTTCAAGT CAGATGAAGT TACCCAGGAG ATATCAGATG AAACCAGGGT TTTTCGCTTA 2460

CTGGGCTCTG ACAGAGTGGT GGTGCTGGAG AGCAGGCCGA CGGAGAACCC AACTGCACAC 2520

AGCAACCTCT ACATCTTGGC TGGCCATGAA AACAGTTACT GA 2562

Domain Profile

S: 39    kleelqkeisvlkklkhpniveylesflkeeelwlvmeylagGslsdlvkeelkselkEe  98

         + +++q+ei ++k++kh niv+y++s+l +e+lw++mey+ gGsl+d+++  ++ +l+E

Q: 3     DFSLIQQEIYMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYH--VTGPLSEL  60

         6789**********************************************..********

S: 99    qiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktv  158

         qiay++re+l++L+ylH k+++Hrdik++niLlt++g++kL+dfgvaa++++t +krk++

Q: 61    QIAYVCRETLQGLAYLHMKGKMHRDIKGANILLTDHGDIKLADFGVAAKITATIAKRKSF  120

         ************************************************************

S: 159   vgtpywmAPEviaqe.ekgYdekaDiwslGItaielaegepPfkdleplkallkilkne.  216

         +gtpywmAPEv a+e + gY++ +Diw++GItaielae +pP++dl+p++al++++k++

Q: 121   IGTPYWMAPEVAAVEkNGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNf  180

         **************98889***********************************999998

S: 217   .ppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257

          ppklk+k k+s++f++fv+ +l+knp+kRp+a++ll h+F+

Q: 181   qPPKLKEKAKWSSTFHNFVKIALTKNPKKRPTADRLLAHSFV  222

         8****************************************7

Domain Sequence
(FASTA)

DFSLIQQEIY MVKECKHCNI VAYFGSYLSR EKLWICMEYC GGGSLQDIYH VTGPLSELQI 60

AYVCRETLQG LAYLHMKGKM HRDIKGANIL LTDHGDIKLA DFGVAAKITA TIAKRKSFIG 120

TPYWMAPEVA AVEKNGGYNQ LCDIWAVGIT AIELAELQPP MFDLHPMRAL FLMSKSNFQP 180

PKLKEKAKWS STFHNFVKIA LTKNPKKRPT ADRLLAHSFV 220

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036

; CNH; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013