EKS-MEG-00367

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00367

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	461.1	9.0E-139	45	307	263

Status

Unreviewed

Ensembl Protein

ENSMGAP00000014827

UniProt Accession

G1NML1;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK2

Gene Synonyms/Alias

ROCK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000014017	ENSMGAP00000018712	ENSMGAT00000019871
ENSMGAG00000014017	ENSMGAP00000014827	ENSMGAT00000015767

Organism

Meleagris gallopavo

Functional Description

Protein Length

1401

Protein Sequence
(FASTA)

DGLNSLVLDL DYPALRKNKN IDNFLNRYEK IVEKIRALQM KAEDYDVVKV IGRGAFGEVQ 60

LVRHKMTQKV YAMKLLSKFE MIKRSDSAFF WEERDIMAFA NSPWVVQLFC AFQDDKYLYM 120

VMEYMPGGDL VNLMSNYDVP EKWAKFYTAE VVLALDAIHS MGLIHRDVKP DNMLLDKHGH 180

LKLADFGTCM KMDETGMVRC DTAVGTPDYI SPEVLKSQGG DGYYGRECDW WSVGVFLFEM 240

LVGDTPFYAD SLVGTYSKIM DHKNSLHFPD DVEISKHAKN LICAFLTDRD VRLGRNGVEE 300

IKHHPFFKSD QWNWDNIRET AAPVVPELSS DIDSSNFDDI EDDKGDVETF PIPKAFVGNQ 360

LPFIGFTYYR DNLLLSDSSQ SCRENESVQS SKNEEDSKEF QKKLSKLEEQ LSNELQAKDE 420

LEQKYRSANT RLEKIVKELD EEITSRKNVE SAVRQLEREK ALLQHKNTEY QRKAEHEADK 480

KRNLENEVNS LKDQLEDLKK RNQNSQISNE KINQLQRQLD EANSLLRSES ETASRLRKNQ 540

TESTKQIQQL EANNRELQDK NCLLENAKLK LEKDFLNLQS ALESERRDRS HGSEIISDLQ 600

GRISSLEEEV KNGKSALAKL EMEKRQLQEK LTDLEKEKSN MEIDMTYKFK VMQQNLEQEE 660

AEHKATKARL ADKNKIYESI EEAKSEAMKE MEKKLLEERA LKQKVENRLL EAEKQRSMLD 720

CDLKQSQQKI NELLRQKDKL NEDVKNLTLK IEQETQKRCL TQNDLKMQTQ QVNTLKMSEK 780

QLKQENNHLQ EIKLSLEKQN NELRKERQDA DGQMKELQDQ LEAEQYFSTL YKTQVRELKE 840

ECEEKTKLSK EMQQKIQELQ DERDSLAAQL EITLTKADSE QLARSIAEEQ YSDLEKEKIM 900

KELEIKEMMA RHKQELTEKD ATIASLEEAN RTLTSDVANL ANEKEELNNK LKEEQEQIAK 960

LKEEEANIGN IKAQFEKQLL NERTLKTQAV NKLAEIMNRK GPVKRGADTD VRRKEKENRK 1020

LHMELKSERE KLTQMMIKYQ KEINEMQAQI AEESQIRIEL QMTLDSKDSD IEQLRSQLQS 1080

LHIGLDNSSI GSGPGDAEAD DGFPVHITQS HTMESMSFTY KHSSTSVSIA TKPSSSRMLL 1140

DSDSDSEEEP MSCSHSPTEV DSTESRLEGW LSLPVRNNTK KFGWVKKYVI VSSKKILFYD 1200

SEQDKEQSNP YMVLDIDKLF HVRPVTQTDV YRADAKEIPR IFQILYANEG ESKKEQEFPV 1260

EPMGEKSNYI CHKGHEFIPT LYHFPTNCEA CMKPLWHMFK PPPALECRRC HIKCHKDHMD 1320

KKEEIIAPCK VYYDISTAKN LLLLANSTEE QQKWVSRLVK KIPKKPPAPD PFARSSPRTS 1380

MKVQPNQSIR RPSRQLPPNK P 1401

Nucleotide Sequence
(FASTA)

GATGGCTTGA ATTCTTTGGT CCTTGATCTG GATTATCCGG CGCTGAGGAA GAACAAGAAC 60

ATTGATAATT TCCTAAATAG ATATGAGAAG ATTGTGGAAA AAATACGAGC TTTACAAATG 120

AAAGCTGAAG ACTATGATGT TGTTAAGGTG ATTGGAAGAG GGGCTTTTGG AGAAGTGCAG 180

CTGGTTCGCC ATAAAATGAC ACAGAAGGTT TATGCAATGA AGCTCCTTAG TAAATTTGAA 240

ATGATCAAGA GATCAGATTC AGCCTTTTTC TGGGAAGAAA GAGATATCAT GGCCTTTGCT 300

AATAGTCCAT GGGTGGTTCA GCTTTTTTGT GCCTTTCAAG ATGACAAATA CTTGTATATG 360

GTAATGGAAT ACATGCCAGG AGGAGATCTT GTAAACCTTA TGAGCAATTA TGATGTGCCT 420

GAGAAATGGG CCAAGTTCTA TACAGCTGAA GTTGTTCTTG CTCTTGATGC GATTCACTCC 480

ATGGGCTTGA TACACAGAGA TGTGAAGCCT GACAATATGC TATTAGACAA ACATGGGCAC 540

CTGAAGCTGG CAGATTTTGG CACTTGCATG AAAATGGATG AAACAGGTAT GGTGCGCTGT 600

GACACGGCTG TGGGAACCCC CGACTACATA TCCCCCGAAG TTCTGAAATC ACAAGGGGGT 660

GATGGTTATT ATGGACGGGA GTGTGACTGG TGGTCTGTGG GAGTTTTCCT TTTTGAGATG 720

CTAGTTGGTG ATACTCCTTT TTATGCAGAC TCCTTAGTAG GGACATACAG TAAAATTATG 780

GATCACAAGA ACTCATTACA TTTCCCAGAT GATGTAGAAA TCTCTAAGCA TGCAAAGAAC 840

CTCATCTGTG CCTTCTTAAC TGACAGGGAC GTGCGACTTG GGAGAAATGG GGTAGAAGAA 900

ATAAAGCATC ACCCTTTCTT TAAGAGTGAT CAGTGGAATT GGGACAACAT CCGAGAGACT 960

GCTGCTCCTG TTGTTCCTGA GCTTAGCAGT GATATAGACA GTAGTAATTT TGATGACATT 1020

GAGGATGACA AAGGAGACGT GGAAACCTTT CCAATTCCCA AAGCCTTTGT GGGAAACCAG 1080

CTGCCTTTTA TAGGATTTAC CTACTATAGA GATAATTTGT TGCTAAGTGA CTCCTCTCAG 1140

TCTTGCAGAG AAAATGAATC GGTGCAATCT AGTAAAAATG AGGAAGACAG CAAGGAGTTT 1200

CAGAAAAAAC TAAGCAAGTT AGAAGAGCAA CTCAGTAATG AATTGCAAGC CAAAGATGAA 1260

CTAGAACAGA AATACAGATC TGCTAATACT CGTTTAGAGA AGATAGTGAA AGAGCTAGAT 1320

GAAGAGATAA CTTCAAGGAA AAATGTAGAG TCTGCAGTCA GACAACTAGA AAGGGAGAAG 1380

GCTCTTCTTC AGCATAAGAA TACAGAATAC CAGAGAAAAG CAGAACATGA AGCAGATAAG 1440

AAACGCAATT TGGAAAATGA GGTTAACAGT TTGAAAGATC AGCTTGAAGA TTTAAAAAAG 1500

AGGAATCAGA ACTCTCAAAT ATCCAATGAG AAAATCAATC AACTACAAAG ACAGTTGGAT 1560

GAGGCCAATT CTTTGCTGCG ATCGGAGTCT GAAACTGCAT CCAGGCTAAG GAAGAACCAG 1620

ACTGAAAGTA CAAAGCAAAT CCAGCAGTTG GAAGCTAATA ATCGAGAGCT ACAGGATAAG 1680

AACTGCCTGC TAGAGAATGC TAAGCTCAAA CTGGAGAAGG ACTTTCTCAA TCTTCAGTCA 1740

GCTCTAGAAT CAGAAAGGAG AGATCGAAGT CATGGATCAG AGATTATCAG TGATTTACAA 1800

GGTCGAATAT CAAGCCTGGA AGAAGAAGTG AAAAATGGAA AGAGTGCATT AGCCAAACTA 1860

GAAATGGAGA AAAGGCAATT GCAGGAAAAA CTTACAGATT TGGAAAAGGA AAAGAGCAAC 1920

ATGGAAATAG ATATGACATA CAAATTCAAA GTTATGCAGC AAAATCTTGA GCAAGAGGAA 1980

GCTGAACACA AAGCCACAAA AGCGCGATTG GCAGACAAAA ATAAGATTTA TGAATCTATA 2040

GAGGAGGCAA AATCTGAAGC CATGAAAGAA ATGGAGAAGA AACTTTTGGA AGAGAGAGCT 2100

TTGAAGCAAA AAGTGGAAAA TCGGTTGTTA GAAGCTGAAA AGCAGCGCTC CATGTTGGAT 2160

TGTGATCTCA AACAATCACA GCAGAAAATA AATGAACTCC TTAGGCAAAA GGATAAACTA 2220

AATGAAGATG TTAAAAACCT GACTTTAAAA ATAGAGCAAG AAACACAAAA GCGTTGTCTC 2280

ACTCAAAATG ACCTCAAGAT GCAAACACAA CAGGTCAACA CCTTAAAAAT GTCAGAGAAG 2340

CAGCTAAAAC AGGAGAATAA CCATCTTCAG GAAATCAAAT TAAGTCTGGA GAAACAAAAT 2400

AATGAACTCC GCAAAGAACG TCAGGATGCA GATGGACAAA TGAAAGAGCT TCAAGACCAA 2460

CTTGAAGCTG AACAGTATTT CTCGACTCTG TATAAGACAC AAGTTCGAGA ACTTAAAGAA 2520

GAATGTGAGG AAAAGACCAA ACTTAGCAAA GAGATGCAGC AAAAGATACA AGAGTTACAG 2580

GATGAGAGAG ATTCCTTGGC AGCACAGCTA GAAATCACTT TGACAAAAGC AGATTCAGAA 2640

CAACTTGCAC GTTCCATTGC TGAAGAACAG TACTCTGATT TGGAAAAAGA GAAGATCATG 2700

AAAGAACTGG AGATTAAAGA AATGATGGCT CGGCATAAAC AGGAGCTTAC TGAGAAGGAT 2760

GCCACCATAG CCTCTTTGGA GGAAGCAAAT AGAACACTAA CAAGCGACGT GGCTAATCTT 2820

GCTAATGAGA AAGAAGAACT AAACAATAAA CTGAAGGAGG AACAAGAACA AATTGCGAAG 2880

TTAAAAGAAG AAGAAGCAAA TATAGGAAAT ATTAAAGCAC AGTTTGAAAA ACAACTGTTG 2940

AATGAAAGAA CACTGAAAAC CCAGGCTGTG AATAAATTGG CTGAGATCAT GAATCGGAAG 3000

GGTCCAGTCA AACGTGGAGC TGACACCGAC GTACGGCGGA AGGAAAAGGA AAATAGGAAA 3060

CTGCATATGG AACTGAAATC TGAACGAGAG AAGTTAACAC AAATGATGAT CAAATATCAG 3120

AAAGAAATCA ATGAAATGCA GGCACAAATA GCAGAAGAGA GTCAGATACG AATTGAACTC 3180

CAGATGACTC TGGACAGCAA AGACAGTGAC ATTGAACAGC TTCGGTCACA GCTACAGTCA 3240

TTACACATTG GTCTAGACAA CAGTAGCATA GGCAGCGGAC CTGGAGATGC TGAGGCAGAT 3300

GATGGATTCC CTGTCCATAT CACTCAATCC CACACTATGG AATCCATGTC TTTTACCTAC 3360

AAGCACTCTT CCACCTCTGT CAGTATTGCC ACTAAGCCTT CCAGTTCTCG CATGCTTCTC 3420

GATTCTGATT CTGACTCAGA AGAAGAACCT ATGTCTTGTT CTCACAGCCC TACAGAAGTT 3480

GATAGCACAG AATCAAGATT GGAAGGCTGG TTATCGCTAC CTGTTCGAAA TAACACTAAA 3540

AAATTTGGTT GGGTTAAAAA GTATGTAATT GTAAGCAGTA AGAAGATCCT GTTCTATGAC 3600

AGCGAACAAG ATAAAGAACA ATCCAATCCC TATATGGTAT TAGACATAGA CAAACTATTC 3660

CATGTCCGAC CAGTCACCCA GACTGATGTG TACAGAGCAG ATGCCAAGGA AATTCCAAGG 3720

ATATTCCAGA TTCTATATGC TAATGAAGGA GAGAGCAAAA AGGAGCAGGA ATTTCCAGTG 3780

GAGCCTATGG GAGAGAAGTC AAATTATATT TGTCACAAAG GACATGAGTT TATACCTACT 3840

CTTTATCACT TTCCAACCAA TTGTGAAGCT TGTATGAAGC CTCTTTGGCA TATGTTTAAA 3900

CCTCCTCCTG CTCTAGAATG TCGCCGTTGC CATATCAAAT GTCACAAAGA TCATATGGAT 3960

AAAAAAGAAG AGATTATAGC ACCTTGCAAA GTGTATTACG ATATTTCAAC GGCGAAGAAT 4020

CTACTACTGT TAGCTAATTC TACAGAAGAA CAGCAAAAAT GGGTGAGCCG ACTGGTAAAA 4080

AAAATACCCA AGAAACCTCC AGCACCAGAC CCCTTTGCTA GATCTTCTCC CAGAACTTCT 4140

ATGAAGGTAC AGCCAAACCA GTCCATCAGA CGACCAAGTC GACAGCTTCC TCCAAACAAA 4200

CCA 4203

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         ++++kviGrGafgev++vr+k t+kvyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 45    YDVVKVIGRGAFGEVQLVRHKMTQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  104

         799*********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql++afqd+kyly+vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlald++h++g

Q: 105   VVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMG  162

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldk+Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++ g+

Q: 163   LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVRCDTAVGTPDYISPEVLKSQG-GD  221

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+l+e+lvg+tpfya+slv tyski++hk+sl+fp+d+++s++ak+l

Q: 222   GYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLHFPDDVEISKHAKNL  281

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+r+ rlgr+g+e++k+hpff

Q: 282   ICAFLTDRDVRLGRNGVEEIKHHPFF  307

         *************************9

Domain Sequence
(FASTA)

YDVVKVIGRG AFGEVQLVRH KMTQKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLFCAFQD DKYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LDAIHSMGLI 120

HRDVKPDNML LDKHGHLKLA DFGTCMKMDE TGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLFEMLVGD TPFYADSLVG TYSKIMDHKN SLHFPDDVEI SKHAKNLICA 240

FLTDRDVRLG RNGVEEIKHH PFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031616	; C:spindle pole centrosome
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030036	; P:actin cytoskeleton organization
GO:0051298	; P:centrosome duplication
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction
GO:0016525	; P:negative regulation of angiogenesis
GO:0010825	; P:positive regulation of centrosome duplication
GO:0045616	; P:regulation of keratinocyte differentiation

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013