EKS-MEG-00304

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00304

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	429.0	4.3E-129	185	434	250

Status

Unreviewed

Ensembl Protein

ENSMGAP00000015024

UniProt Accession

G1NN27;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000014205	ENSMGAP00000015024	ENSMGAT00000015970

Organism

Meleagris gallopavo

Functional Description

Protein Length

449

Protein Sequence
(FASTA)

ADDIIVIALY DFAASSDRDL ELVKGEKLQI LSNEGDWWLA KSLRSGKKGY IPSNFVALVD 60

SLEQEKWFFK TLSRKDAERL LLSSGNKIGS FLVRESETST GAYSLSVRDS DSAHGDIIKH 120

YRIRSLDGGG YYISPRMTFA TLPELIHHYS QRGDGLCQRL IAPCTSLAPQ RPWAQDEWEI 180

PRESLKLVKK LGSGQFGEVW MGYYKNNFKV AVKTMKEGSM DPNAFLAEAN LMKKLQHNKL 240

VRLYAVVTKQ PIYIVTEYMA NGCLLDYLKS EEGSQLNLPK LIDMSAQVAE GMAYIERMNS 300

IHRDLRAANI LVSETLCCKI ADFGLARIIE DEYLAQEAGA KFPIKWTAPE AINFGVFTIK 360

SDVWSFGILL TEIITYGRIP YPGMTNPEVI RNLEQGYRMP CPDLCPAELY SIILRCWRNK 420

PEERPTFEYL QSVLEDFYTA TEKQYEAEP 449

Nucleotide Sequence
(FASTA)

GCAGATGACA TCATTGTGAT TGCACTGTAT GACTTTGCTG CTTCAAGTGA CCGTGATCTG 60

GAGCTGGTCA AGGGGGAGAA ACTTCAGATC CTCTCCAACG AGGGGGACTG GTGGCTGGCT 120

AAATCCCTCA GAAGTGGGAA GAAAGGCTAT ATCCCCAGCA ACTTCGTTGC ACTAGTAGAC 180

AGCCTGGAAC AAGAAAAGTG GTTTTTTAAA ACTCTGAGCA GAAAAGATGC TGAACGGCTA 240

CTGTTGTCTT CTGGTAACAA AATTGGCTCC TTCCTTGTTC GAGAGAGTGA GACCAGCACA 300

GGTGCCTATT CCTTGTCCGT GAGAGACAGT GATTCTGCTC ATGGGGACAT CATCAAACAC 360

TACAGGATCC GCTCCTTAGA TGGTGGAGGT TATTACATCT CCCCAAGGAT GACTTTTGCC 420

ACCCTGCCAG AGCTAATCCA TCATTACAGC CAGAGGGGAG ATGGTCTGTG CCAGAGGCTC 480

ATAGCTCCCT GCACATCCCT GGCTCCCCAG AGGCCCTGGG CACAGGATGA ATGGGAGATC 540

CCACGGGAGT CTCTGAAACT TGTGAAGAAG CTTGGCAGTG GGCAGTTTGG GGAAGTGTGG 600

ATGGGCTACT ACAAGAACAA CTTCAAGGTG GCTGTGAAGA CCATGAAGGA GGGCAGCATG 660

GATCCCAACG CTTTCTTGGC AGAAGCAAAC TTGATGAAGA AGCTCCAGCA TAATAAGCTG 720

GTCCGGCTCT ATGCTGTAGT CACAAAGCAG CCAATTTACA TCGTGACAGA GTACATGGCC 780

AATGGGTGCT TGCTGGATTA TTTGAAGTCA GAGGAAGGAA GCCAACTGAA TCTCCCCAAA 840

CTCATTGATA TGTCTGCTCA GGTGGCAGAG GGAATGGCAT ACATTGAGAG AATGAACTCC 900

ATCCACCGTG ACTTGAGAGC TGCCAACATC CTTGTCTCAG AGACACTCTG CTGCAAAATT 960

GCTGATTTTG GCTTGGCCAG GATCATCGAG GATGAATACT TGGCACAAGA AGCAGGAGCC 1020

AAATTCCCGA TCAAATGGAC GGCACCAGAA GCCATTAACT TTGGAGTTTT CACCATCAAG 1080

TCTGACGTGT GGTCTTTTGG GATCCTCTTA ACTGAAATCA TAACCTACGG CAGGATCCCT 1140

TATCCAGGGA TGACCAACCC TGAGGTGATT CGCAACCTGG AGCAGGGTTA CCGTATGCCC 1200

TGCCCGGATC TGTGTCCAGC TGAGCTCTAC AGCATCATCC TGAGATGCTG GCGAAACAAA 1260

CCCGAGGAGC GCCCGACTTT TGAGTACCTG CAGTCTGTCC TTGAGGACTT TTACACGGCC 1320

ACAGAGAAGC AGTATGAGGC AGAGCCT 1347

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklvkklG+GqfGevw+g++k++ kvavkt+keg+++p+afl+ea+++kkl+h+klv+ly

Q: 185   LKLVKKLGSGQFGEVWMGYYKNNFKVAVKTMKEGSMDPNAFLAEANLMKKLQHNKLVRLY  244

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ +Piyivte+ma+G+lld+lk+eeg++l+lpkl+d++aqvaeGmay+e++n ihr

Q: 245   AVVTK-QPIYIVTEYMANGCLLDYLKSEEGSQLNLPKLIDMSAQVAEGMAYIERMNSIHR  303

         ****9.9*****************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e+l++k+adfGlar+ied+   ++ gak+PikWtaPeai++g+ftiksdv

Q: 304   DLRAANILVSETLCCKIADFGLARIIEDEYLAQEAGAKFPIKWTAPEAINFGVFTIKSDV  363

         **************************999888999*************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGilltei+t+G++PypGmtn ev++++e+gyr+p+p+ cp+ely+++l+cw+++pee

Q: 364   WSFGILLTEIITYGRIPYPGMTNPEVIRNLEQGYRMPCPDLCPAELYSIILRCWRNKPEE  423

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq+vl

Q: 424   RPTFEYLQSVL  434

         ********986

Domain Sequence
(FASTA)

LKLVKKLGSG QFGEVWMGYY KNNFKVAVKT MKEGSMDPNA FLAEANLMKK LQHNKLVRLY 60

AVVTKQPIYI VTEYMANGCL LDYLKSEEGS QLNLPKLIDM SAQVAEGMAY IERMNSIHRD 120

LRAANILVSE TLCCKIADFG LARIIEDEYL AQEAGAKFPI KWTAPEAINF GVFTIKSDVW 180

SFGILLTEII TYGRIPYPGM TNPEVIRNLE QGYRMPCPDL CPAELYSIIL RCWRNKPEER 240

PTFEYLQSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853	; P:B cell receptor signaling pathway
GO:0032024	; P:positive regulation of insulin secretion

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013