EKS-MEG-00060
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00060
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/GSK409.74.9E-12337285249
StatusUnreviewed
Ensembl ProteinENSMGAP00000015113
UniProt AccessionG1NNA1;
Protein Name
Protein Synonyms/Alias
Gene NameGSK3B
Gene Synonyms/Alias GSK3B;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000014288ENSMGAP00000015113ENSMGAT00000016062
OrganismMeleagris gallopavo
Functional Description
Protein Length285
Protein Sequence
(FASTA)
LQTLCRAAQT RDKDGSKVTT VVATPGQGPD RPQEVSYTDT KVIGNGSFGV VYQAKLCDSG 60
ELVAIKKVLQ DKRFKNRELQ IMRKLDHCNI VRLRYFFYSS GEKKDEVYLN LVLDYVPETV 120
YRVARHYSRA KQTLPMIYVK LYMYQLFRSL AYIHSFGICH RDIKPQNLLL DPDTAVLKLC 180
DFGSAKQLVR GEPNVSYICS RYYRAPELIF GATDYTSSID VWSAGCVLAE LLLGQPIFPG 240
DSGVDQLVEI IKVLGTPTRE QIREMNPNYT EFKFPQIKAH PWTKV 285
Nucleotide Sequence
(FASTA)
CTGCAAACGC TGTGCCGGGC TGCACAAACA AGAGACAAAG ATGGCAGCAA AGTGACTACA 60
GTAGTGGCAA CTCCTGGACA AGGTCCAGAC CGACCGCAAG AAGTTAGCTA CACGGACACC 120
AAGGTGATTG GAAATGGATC TTTTGGTGTT GTGTATCAAG CCAAACTCTG TGATTCAGGA 180
GAGCTTGTGG CCATTAAGAA AGTCCTGCAG GATAAAAGAT TTAAGAACCG AGAGCTCCAG 240
ATTATGAGAA AGCTGGATCA TTGTAACATT GTCCGATTGC GTTATTTCTT CTACTCCAGT 300
GGAGAGAAGA AAGATGAAGT GTACCTCAAC TTGGTGCTGG ACTATGTTCC TGAAACAGTA 360
TACAGAGTTG CCAGACATTA TAGTCGGGCC AAACAGACAC TCCCTATGAT TTATGTCAAG 420
TTGTACATGT ATCAGCTGTT CCGGAGTTTA GCCTATATCC ATTCCTTTGG GATCTGCCAC 480
CGGGATATAA AACCACAAAA CCTCTTGCTG GACCCTGATA CAGCTGTCCT TAAACTCTGC 540
GACTTCGGAA GTGCAAAACA GCTGGTTCGT GGAGAACCTA ACGTTTCATA CATCTGCTCT 600
CGGTACTACA GGGCACCAGA GTTGATCTTT GGAGCCACCG ATTATACCTC CAGTATAGAT 660
GTGTGGTCAG CGGGCTGTGT ATTGGCTGAA CTGTTACTAG GACAACCAAT CTTCCCAGGT 720
GACAGTGGTG TGGATCAGTT GGTGGAAATA ATCAAGGTTC TGGGAACGCC TACAAGGGAG 780
CAAATTAGAG AAATGAATCC AAACTATACT GAATTTAAAT TCCCTCAGAT TAAGGCACAT 840
CCGTGGACTA AGGTA 855
Domain Profile
S: 1     leelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLly  60
         ++++k+ig+GsFg+Vyqa+l+++ e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+y
Q: 37    YTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY  95
         5789**********************.*********************************
S: 61    ffsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhs  120
         ff++s ekkd+vylnlvl+y+Pet+++v+r+++++k++l++++vkly+yQlfr+lay+hs
Q: 96    FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMIYVKLYMYQLFRSLAYIHS  155
         ************************************************************
S: 121   leivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakey  180
         ++i+HrDiKPqNll+d++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++y
Q: 156   FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY  215
         ************************************************************
S: 181   ttkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfk  240
         t++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf+
Q: 216   TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP  275
         ************************************************************
S: 241   kikkvslakv  250
         +ik+++++kv
Q: 276   QIKAHPWTKV  285
         *******986
Domain Sequence
(FASTA)
YTDTKVIGNG SFGVVYQAKL CDSGELVAIK KVLQDKRFKN RELQIMRKLD HCNIVRLRYF 60
FYSSGEKKDE VYLNLVLDYV PETVYRVARH YSRAKQTLPM IYVKLYMYQL FRSLAYIHSF 120
GICHRDIKPQ NLLLDPDTAV LKLCDFGSAK QLVRGEPNVS YICSRYYRAP ELIFGATDYT 180
SSIDVWSAGC VLAELLLGQP IFPGDSGVDQ LVEIIKVLGT PTREQIREMN PNYTEFKFPQ 240
IKAHPWTKV 249
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00075
EKS-ANC-00072
EKS-BOT-00080
EKS-CAE-00055
EKS-CAJ-00081
EKS-CAF-00080
EKS-CAP-00080
EKS-CII-00034
EKS-CIS-00077
EKS-DAR-00329
EKS-DRM-00034
EKS-EQC-00078
EKS-FEC-00078
EKS-GAM-00043
EKS-GAG-00064
EKS-GAA-00098
EKS-GOG-00080
EKS-HOS-00082
EKS-ICT-00073
EKS-LAC-00085
EKS-LOA-00077
EKS-MAM-00079
EKS-MAE-00033
EKS-MOD-00078
EKS-MUM-00080
EKS-MUP-00080
EKS-MYL-00089
EKS-NOL-00076
EKS-OCP-00051
EKS-ORN-00107
EKS-ORA-00064
EKS-ORC-00075
EKS-ORL-00099
EKS-OTG-00084
EKS-PAT-00073
EKS-PES-00070
EKS-POA-00075
EKS-PRC-00044
EKS-PTV-00066
EKS-RAN-00076
EKS-SAH-00076
EKS-SUS-00071
EKS-TAG-00115
EKS-TAR-00111
EKS-TEN-00105
EKS-TUT-00071
EKS-VIP-00034
EKS-XET-00075
EKS-XIM-00102
EKS-SAC-00071
EKS-SCP-00065
Gene Ontology
GO:0030877; C:beta-catenin destruction complex
GO:0005813; C:centrosome
GO:0005829; C:cytosol
GO:0043198; C:dendritic shaft
GO:0030426; C:growth cone
GO:0043025; C:neuronal cell body
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0030529; C:ribonucleoprotein complex
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0050321; F:tau-protein kinase activity
GO:0044337; P:canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process
GO:0016477; P:cell migration
GO:0006983; P:ER overload response
GO:0045444; P:fat cell differentiation
GO:0005977; P:glycogen metabolic process
GO:0044027; P:hypermethylation of CpG island
GO:0035556; P:intracellular signal transduction
GO:0043066; P:negative regulation of apoptotic process
GO:0051534; P:negative regulation of NFAT protein import into nucleus
GO:0032091; P:negative regulation of protein binding
GO:0031333; P:negative regulation of protein complex assembly
GO:0018105; P:peptidyl-serine phosphorylation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation
GO:0032092; P:positive regulation of protein binding
GO:0031334; P:positive regulation of protein complex assembly
GO:0046827; P:positive regulation of protein export from nucleus
GO:0032855; P:positive regulation of Rac GTPase activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006611; P:protein export from nucleus
GO:0035372; P:protein localization to microtubule
GO:0000320; P:re-entry into mitotic cell cycle
GO:0006349; P:regulation of gene expression by genetic imprinting
GO:0032886; P:regulation of microtubule-based process
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013