EKS-MEG-00002
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00002
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph517.73.1E-156572829258
StatusUnreviewed
Ensembl ProteinENSMGAP00000015250
UniProt AccessionG1NNL7;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA3
Gene Synonyms/Alias EPHA3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000014410ENSMGAP00000015250ENSMGAT00000016199
OrganismMeleagris gallopavo
Functional Description
Protein Length934
Protein Sequence
(FASTA)
WEEISGVDEH YTPIRTYQVC NVMDHSQNNW LRTNWIPRNS AQKIYVELKF TLRDCNSIPL 60
VLGTCKETFN LYYMESDDDH LAKFREHQFT KIDTIAADES FTQMDLGDRI LKLNTEVREV 120
GPVSKKGFYL AFQDVGACVA LVSVRVYFKK CPFTVKNLAM FPDTVPMDSQ SLVEVRGSCV 180
NHSKEEEPPK MYCSTEGEWL VPIGKCLCNA GYEERGFACQ ACRPGFYKAS AGNVKCAKCP 240
PHSSTYEDAS LNCRCEKNYF RSEKDPPSMA CTRPPSAPRN VISNINETSV ILDWSWPLDT 300
GGRKDVTFNI ICKKCGGSSK ICEPCSDNVR FLPRQTGLTN TTVTVVDLLA HTNYTFEIDA 360
VNGVSDLSTL SRQFAAVSIT TNQAAPSPIT VIRKDRTSRN SVSLSWQEPE HPNGIILDYE 420
VKYYEKKQEQ ETSYTILRAK STNVTISGLK PDTTYVFQIR ARTAAGYGTS SRKFEFETSP 480
DSFSISSENS QVVMIAISAA VAIILLTVVV YVLIGRFCGY KKSKHGTDEK RLHFGNGHLK 540
LPGLRTYVDP HTYEDPNQAV HEFAKELDAS NISIDKVVGA GEFGEVCSGR LKLPSKKEIS 600
VAIKTLKAGY TEKQRRDFLG EASIMGQFDH PNIIRLEGVV TKSKPVMIVT EYMENGSLDS 660
FLRKHDAQFT VIQLVGMLRG IASGMKYLSD MGYVHRDLAA RNILINSNLV CKVSDFGLSR 720
VLEDDPEAAY TTRGGKIPIR WTSPEAIAYR KFTSASDAWS YGIVLWEVMS YGERPYWEMS 780
NQDVIKAVDE GYRLPPPMDC PAALYQLMLD CWQKDRNNRP KFEQIVSILD KLIRNPSSLK 840
IITNAAARPS NLLLDQSNID ISAFRTTGDW LNGFRTGQCK GIFTGVEYSS CDTIAKISTD 900
DMKKIGVTVV GPQKKIVSSI KTLETHTKNS PVPV 934
Nucleotide Sequence
(FASTA)
TGGGAAGAGA TTAGTGGTGT TGATGAGCAT TATACTCCAA TCAGAACTTA CCAGGTGTGC 60
AATGTTATGG ATCACAGTCA GAACAATTGG CTGCGAACAA ACTGGATTCC ACGCAATTCA 120
GCGCAGAAGA TATATGTGGA GCTCAAATTT ACCTTGAGGG ACTGCAATAG TATCCCTCTA 180
GTTCTGGGCA CTTGCAAAGA GACTTTCAAT CTGTATTACA TGGAATCCGA TGATGACCAT 240
TTGGCAAAGT TCAGAGAGCA CCAGTTTACA AAGATTGACA CCATTGCAGC TGATGAGAGC 300
TTCACCCAGA TGGATCTTGG GGACCGGATT CTCAAGCTGA ATACAGAAGT CCGCGAGGTG 360
GGACCTGTTA GCAAGAAGGG CTTTTACTTG GCTTTCCAAG ATGTAGGTGC ATGTGTTGCC 420
TTAGTCTCGG TGCGAGTGTA CTTCAAGAAG TGCCCTTTCA CTGTCAAGAA CCTCGCCATG 480
TTTCCAGATA CAGTTCCTAT GGACTCCCAA TCCCTGGTGG AGGTGCGGGG CTCTTGTGTC 540
AATCATTCCA AGGAGGAAGA GCCACCCAAG ATGTACTGCA GCACGGAAGG AGAATGGCTA 600
GTGCCCATAG GGAAGTGCTT GTGTAATGCT GGCTATGAAG AAAGAGGCTT TGCGTGCCAA 660
GCTTGTCGAC CTGGGTTCTA TAAAGCTTCT GCTGGCAATG TGAAGTGTGC CAAATGCCCA 720
CCTCACAGCT CCACCTATGA AGATGCATCT CTGAACTGCA GGTGTGAAAA GAATTACTTT 780
CGCTCTGAGA AAGACCCTCC ATCCATGGCT TGCACCAGAC CACCATCTGC TCCAAGAAAC 840
GTTATTTCTA ATATCAATGA GACATCTGTT ATCCTGGACT GGAGCTGGCC TCTTGACACA 900
GGAGGTCGAA AGGATGTCAC TTTCAACATC ATTTGCAAAA AATGTGGAGG AAGCAGCAAG 960
ATATGCGAGC CTTGTAGTGA CAACGTACGA TTCTTACCCC GTCAGACTGG CCTCACCAAC 1020
ACCACGGTGA CAGTAGTGGA CCTTTTGGCA CATACCAATT ACACTTTTGA GATTGATGCA 1080
GTCAATGGGG TATCTGACTT GAGTACACTT TCCAGACAAT TTGCTGCTGT CAGCATCACG 1140
ACTAATCAGG CTGCACCATC CCCCATCACA GTGATAAGGA AAGACCGGAC ATCCAGGAAC 1200
AGCGTGTCTC TGTCTTGGCA GGAACCTGAG CACCCAAATG GAATCATCTT GGACTACGAG 1260
GTCAAATACT ATGAAAAGAA GCAGGAACAA GAGACAAGCT ATACTATTCT GAGAGCCAAA 1320
AGCACTAATG TTACTATCAG CGGCCTCAAA CCTGATACCA CCTACGTCTT CCAAATTCGA 1380
GCCCGAACTG CAGCTGGATA TGGGACAAGC AGCCGCAAGT TTGAATTTGA AACCAGTCCA 1440
GATTCATTCT CCATTTCCAG TGAAAATAGC CAGGTCGTTA TGATTGCCAT TTCAGCTGCG 1500
GTTGCCATCA TTCTCCTCAC GGTTGTTGTG TACGTCTTGA TTGGGAGATT CTGTGGATAC 1560
AAGAAGTCTA AACATGGTAC TGATGAGAAA AGACTACATT TTGGGAATGG CCATTTAAAA 1620
CTCCCAGGCC TGAGAACTTA TGTAGATCCA CATACATACG AAGATCCTAA TCAAGCTGTA 1680
CATGAATTTG CCAAGGAACT AGATGCTTCC AATATATCAA TTGATAAAGT TGTTGGAGCA 1740
GGGGAATTTG GAGAAGTGTG CAGTGGGCGC CTGAAGCTGC CTTCTAAAAA GGAAATTTCA 1800
GTGGCCATCA AAACTCTGAA AGCTGGCTAC ACAGAAAAGC AGAGAAGGGA TTTCCTGGGA 1860
GAAGCAAGCA TCATGGGGCA GTTTGACCAT CCCAACATCA TCCGACTGGA GGGCGTTGTG 1920
ACTAAAAGTA AACCAGTTAT GATTGTTACT GAATATATGG AAAATGGTTC ATTGGACAGC 1980
TTCCTACGGA AACACGATGC CCAGTTCACA GTCATTCAGC TAGTAGGCAT GCTTCGTGGG 2040
ATCGCATCTG GCATGAAATA TTTGTCAGAT ATGGGTTATG TCCACCGTGA TCTAGCTGCT 2100
CGTAATATAC TCATCAATAG TAACTTGGTG TGCAAAGTCT CAGATTTTGG TCTTTCCCGT 2160
GTATTGGAAG ATGATCCAGA AGCTGCTTAC ACAACAAGGG GGGGCAAGAT TCCCATCCGA 2220
TGGACATCAC CAGAAGCCAT TGCATACCGG AAGTTCACCT CAGCCAGTGA TGCGTGGAGC 2280
TACGGGATTG TCCTCTGGGA GGTGATGTCT TATGGAGAGA GGCCGTACTG GGAGATGTCC 2340
AACCAGGATG TAATTAAGGC TGTTGATGAA GGGTATCGTT TGCCACCTCC TATGGACTGC 2400
CCAGCTGCCT TGTATCAGCT GATGCTGGAC TGCTGGCAGA AAGACAGAAA CAACAGACCC 2460
AAGTTTGAGC AGATTGTCAG CATCCTGGAT AAGCTGATCC GTAATCCCAG CAGTCTGAAA 2520
ATAATCACCA ATGCAGCAGC AAGGCCATCG AATCTTCTCC TGGACCAAAG TAACATTGAC 2580
ATTTCAGCTT TCCGCACGAC AGGTGATTGG CTCAATGGTT TTCGAACAGG ACAGTGCAAA 2640
GGCATTTTCA CAGGTGTGGA GTACAGTTCC TGTGATACAA TAGCCAAGAT TTCCACCGAT 2700
GATATGAAGA AAATTGGTGT TACAGTTGTG GGGCCTCAAA AGAAGATCGT TAGCAGTATC 2760
AAAACTCTAG AAACTCATAC GAAGAACAGC CCTGTTCCTG TGTAA 2805
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++i+kv+GaGefGevcsGrlklp+k+ei+vaiktlkag+tekqrrdfl easi+Gqfdhp
Q: 572   ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKAGYTEKQRRDFLGEASIMGQFDHP  631
         689*********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtkskpvmivteymeng+ldsflrk+d qftviqlvgmlrGiasgmkylsdm
Q: 632   NIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM  691
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwt+peaiayrk
Q: 692   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK  751
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasd+wsyGivlwev+syGerpyw+msnqdvika++egyrlpppmdcpaalyqlmldc
Q: 752   FTSASDAWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDC  811
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rpkfeqivsil
Q: 812   WQKDRNNRPKFEQIVSIL  829
         ***************986
Domain Sequence
(FASTA)
ISIDKVVGAG EFGEVCSGRL KLPSKKEISV AIKTLKAGYT EKQRRDFLGE ASIMGQFDHP 60
NIIRLEGVVT KSKPVMIVTE YMENGSLDSF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TSPEAIAYRK 180
FTSASDAWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP AALYQLMLDC 240
WQKDRNNRPK FEQIVSIL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00002
EKS-ANC-00002
EKS-BOT-00003
EKS-CAE-00001
EKS-CAJ-00002
EKS-CAF-00003
EKS-CAP-00002
EKS-DAR-00003
EKS-EQC-00003
EKS-FEC-00004
EKS-GAM-00003
EKS-GAG-00003
EKS-GAA-00003
EKS-GOG-00002
EKS-HOS-00003
EKS-ICT-00002
EKS-LOA-00002
EKS-MAM-00002
EKS-MOD-00002
EKS-MUM-00002
EKS-MUP-00002
EKS-MYL-00003
EKS-NOL-00002
EKS-ORN-00002
EKS-ORA-00003
EKS-ORC-00002
EKS-ORL-00003
EKS-OTG-00001
EKS-PAT-00002
EKS-PES-00003
EKS-POA-00002
EKS-PRC-00002
EKS-PTV-00002
EKS-RAN-00003
EKS-SAH-00003
EKS-SOA-00001
EKS-SUS-00002
EKS-TAG-00004
EKS-TAR-00003
EKS-TAS-00002
EKS-TEN-00001
EKS-TUT-00001
EKS-XET-00001
EKS-XIM-00009
Gene Ontology
GO:0005769; C:early endosome
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0071300; P:cellular response to retinoic acid
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0051893; P:regulation of focal adhesion assembly
GO:0070507; P:regulation of microtubule cytoskeleton organization
GO:0032319; P:regulation of Rho GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013