EPS-MEG-00015

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MEG-00015

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	150.0	3.2E-44	135	279	145

Status

Unreviewed

Ensembl Protein

ENSMGAP00000015278

UniProt Accession

G1NNP2;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000014435	ENSMGAP00000015278	ENSMGAT00000016227

Organism

Meleagris gallopavo

Functional Description

Protein Length

1161

Protein Sequence
(FASTA)

MASGGDSDSE QVVPDEEKDG SDVKAVQAHY LRSPSPSRYS MISDTDTESI FMEPIHLSSA 60

VAAKQIINEE LKTKHIKVDA VCPKMLESAQ QLMVEDLYNR VKEKIDDTSL FNTPCVMDLQ 120

RALVKDRLET PRDAVDEVWP NVFIAEKSVA VNKSRLKRLG ITHVLNAAHG TGVYTGPDFY 180

NGLNIQYMGI EVDDFPDMDI SKHFHPAAEF MDEALLTYRG KILVSSEMGI SRSAVLVAAY 240

LMIYHHMTIL EALMTLRKKR AIYPNDGFLK QLRELNEQLL EERELEHTGD EDVTPSQSPV 300

THPGTSSRLS GAEDSESIIG PKAHSITVEE EDNISMLSSF MSSSSVGKTS WVSKRSTLIS 360

EEEEEQLYEE WRKKQGLPAK ESATEHGKRM SPRLLAQEGE QYDENVDRRI HDWQRRNEKY 420

QMKGPPGEED ENSNMGGRPY RSDEFSDDES VSSFEIRTLK RQLEASSFSR MRRSRSDSMS 480

SESTWDMWNQ RLMEIEKEAV QRYRSKNKNG GERQSPETGR KERDVDEESV LSDCSSFYNF 540

CQKNKDKLTP LERWKIKRIQ FGFHKKDLES SSSSAPSPAE DGSQTGEEGT EEKNFSDVNL 600

SAYQAWKMKR QKKVGSESKE EFVEFAKSED SASAKKKQRR VELLERSKKI LEESQSMCSW 660

ETDSTMSGSI PLSAFWASAP SANGAEDAAS TLSMKTNHSS LSQARSSTGT AQPNIPLPNL 720

PVGPGDTISM ASIQNWIANV VSETIAQKQN EIMMLSRPSS AMASSVMSGD LGRRVDDDKI 780

SLLSSQCGSS FSASHLGQQD VHRAESQSVL SCNTSVNGRA EGTSSNMKTM QTSKPLYSLF 840

ADDVDLKKLS RKEKEMQMEM REKMSDYQIE KVISDNKRST LFKKKVTKGE QSEVEGDVES 900

ITNNYRHPLQ ADLDRNDTIF TLSSLSANTG ALKSEVETDV TKWLSSLKAE KQSSYHDQSE 960

NFREKYSRSS KVREMDSETS SYRFSRSQRE ELDSSSYESK GDSLRTMSRF SSASAKEDKK 1020

MYKFTRSRVT ETASSGEKSP ELHVFSQTPE SSFDSESPES STQSRVRSHH VEACEEEAMS 1080

DMSEFGAKRK FTQSFSKSEE NGKKEAKVEQ SEERFASRQF SQYKRSVRKE EEEELDDDAI 1140

IAAWRSRLEE TTAKLRRRKE E 1161

Nucleotide Sequence
(FASTA)

ATGGCCAGCG GCGGGGATTC AGACAGCGAG CAAGTGGTGC CTGATGAAGA GAAGGATGGC 60

TCAGACGTGA AAGCAGTGCA GGCCCACTAC CTGCGCAGTC CTTCGCCCAG TCGGTACTCA 120

ATGATATCGG ACACTGATAC AGAAAGCATA TTCATGGAGC CTATCCATCT GTCATCTGCT 180

GTGGCTGCCA AACAAATAAT CAATGAAGAA CTGAAGACGA AGCACATCAA GGTAGATGCA 240

GTGTGTCCCA AGATGTTAGA GTCTGCACAA CAGTTGATGG TGGAAGACCT GTACAACCGA 300

GTTAAGGAAA AGATTGATGA CACCAGCTTG TTTAACACTC CATGTGTCAT GGACTTGCAG 360

AGGGCACTTG TAAAGGACAG GCTGGAGACT CCCAGAGATG CCGTGGATGA AGTCTGGCCT 420

AATGTATTCA TAGCAGAAAA GAGTGTTGCA GTGAACAAAA GTCGTTTGAA GAGGTTGGGC 480

ATTACACATG TCTTGAACGC AGCTCATGGT ACAGGTGTAT ACACAGGACC AGATTTCTAC 540

AATGGTCTAA ATATCCAATA TATGGGCATT GAAGTGGATG ATTTTCCAGA TATGGATATC 600

TCCAAACACT TCCATCCAGC TGCAGAGTTC ATGGATGAAG CCCTGCTGAC TTACAGAGGA 660

AAAATCCTTG TCAGCAGTGA AATGGGAATC AGTCGCTCAG CTGTGCTGGT GGCTGCTTAC 720

TTGATGATCT ATCACCATAT GACCATTCTG GAGGCTCTGA TGACTCTGAG AAAGAAGCGT 780

GCCATTTACC CCAATGATGG CTTCCTCAAG CAGCTAAGGG AGCTTAACGA GCAATTATTG 840

GAGGAACGAG AGCTGGAGCA TACTGGAGAT GAAGATGTTA CTCCTAGTCA AAGTCCTGTC 900

ACCCACCCTG GGACATCTTC CCGGCTGTCT GGAGCTGAGG ACTCCGAAAG TATCATAGGA 960

CCCAAAGCAC ACTCCATCAC AGTAGAAGAA GAAGACAACA TCAGCATGCT AAGTAGTTTT 1020

ATGAGCTCTT CATCAGTGGG AAAAACTAGC TGGGTTTCAA AACGCTCCAC CCTCATCAGT 1080

GAGGAGGAAG AGGAACAGTT ATATGAGGAA TGGAGGAAGA AACAAGGTCT ACCTGCAAAG 1140

GAATCAGCAA CTGAGCATGG AAAAAGAATG TCACCAAGGC TTCTGGCTCA GGAAGGGGAG 1200

CAATATGACG AGAATGTGGA TCGGAGGATC CATGACTGGC AGCGCAGAAA TGAGAAATAC 1260

CAAATGAAGG GTCCACCCGG AGAGGAGGAT GAAAATTCTA ACATGGGAGG AAGACCTTAC 1320

CGATCAGATG AATTCAGTGA TGATGAGAGT GTAAGCAGTT TTGAGATCCG AACCTTAAAG 1380

CGACAGTTGG AAGCCAGCAG CTTTAGCAGG ATGAGGAGGA GCCGCTCAGA CTCCATGTCT 1440

TCAGAGAGCA CTTGGGACAT GTGGAACCAG AGGCTGATGG AGATTGAGAA GGAAGCTGTT 1500

CAGAGGTATC GTTCTAAGAA TAAGAATGGT GGGGAGAGAC AATCCCCAGA AACAGGAAGA 1560

AAGGAGAGGG ATGTGGATGA GGAAAGTGTG TTGTCAGACT GTAGCTCCTT CTATAATTTC 1620

TGCCAAAAGA ACAAAGACAA GTTGACTCCT CTAGAAAGAT GGAAGATCAA GAGGATCCAG 1680

TTTGGCTTTC ACAAGAAGGA TTTAGAATCA TCATCGTCTT CTGCACCATC TCCAGCAGAA 1740

GATGGCAGCC AGACTGGTGA GGAGGGGACT GAAGAGAAAA ATTTCTCAGA TGTTAACCTG 1800

AGTGCTTACC AGGCTTGGAA AATGAAGCGG CAGAAGAAGG TGGGCTCTGA AAGCAAGGAG 1860

GAATTTGTAG AGTTTGCCAA AAGTGAAGAT TCTGCTTCAG CTAAAAAGAA GCAGAGACGT 1920

GTAGAGCTCC TTGAACGTTC AAAGAAAATT TTAGAAGAAA GCCAGTCCAT GTGCAGCTGG 1980

GAGACAGACA GTACAATGAG TGGGAGTATC CCGCTGTCTG CTTTCTGGGC CTCAGCGCCT 2040

TCTGCGAATG GTGCTGAGGA TGCAGCTTCT ACACTGAGCA TGAAGACAAA TCATTCATCT 2100

TTATCACAGG CCAGGAGCAG CACTGGGACA GCACAGCCAA ATATTCCCCT TCCCAATCTC 2160

CCAGTTGGCC CAGGTGACAC GATATCTATG GCAAGCATTC AGAACTGGAT TGCTAATGTG 2220

GTCAGTGAAA CCATTGCTCA AAAGCAAAAT GAGATCATGA TGCTGTCCCG TCCATCGTCT 2280

GCAATGGCCT CCAGTGTAAT GTCAGGAGAC CTTGGCAGGC GTGTAGATGA CGATAAGATT 2340

TCCCTTCTCA GTTCTCAATG TGGCTCATCT TTTTCTGCCT CTCATCTCGG TCAGCAGGAT 2400

GTGCACAGGG CTGAGTCTCA GTCTGTCCTG TCTTGCAATA CCTCTGTAAA TGGGAGGGCA 2460

GAAGGGACTA GTTCGAACAT GAAGACTATG CAAACAAGCA AACCACTGTA TAGCCTCTTT 2520

GCCGATGATG TTGACCTAAA GAAACTCAGC AGGAAGGAGA AGGAGATGCA AATGGAAATG 2580

AGAGAGAAAA TGTCAGATTA CCAAATTGAA AAGGTGATAA GTGACAATAA ACGCAGCACT 2640

CTATTTAAAA AAAAGGTGAC CAAAGGTGAG CAAAGTGAAG TAGAAGGTGA TGTGGAGAGT 2700

ATAACGAACA ACTACAGGCA CCCATTGCAA GCAGATCTTG ACAGAAATGA TACAATCTTT 2760

ACTCTATCCA GTCTATCTGC AAACACAGGT GCACTGAAGT CAGAAGTAGA GACTGATGTT 2820

ACCAAGTGGC TCAGTAGTCT GAAAGCAGAA AAACAGTCAT CATATCATGA TCAAAGTGAG 2880

AATTTCAGAG AGAAATACAG CAGGTCATCC AAAGTAAGAG AGATGGATTC TGAAACATCC 2940

AGTTACAGAT TCTCCAGATC CCAGAGAGAA GAGCTGGACA GTTCTTCCTA TGAGTCAAAA 3000

GGAGATTCAC TGAGAACCAT GTCAAGATTT TCCTCTGCTT CGGCAAAAGA GGACAAAAAG 3060

ATGTATAAGT TCACAAGGTC GAGGGTCACT GAGACAGCAA GTTCTGGTGA AAAAAGCCCG 3120

GAACTGCATG TTTTCAGCCA AACACCGGAA TCATCCTTTG ACTCCGAATC CCCTGAATCA 3180

TCTACACAGA GTCGAGTCAG ATCTCATCAC GTGGAGGCGT GTGAAGAGGA GGCCATGTCA 3240

GACATGTCAG AATTTGGAGC TAAGAGAAAG TTCACTCAGA GCTTTTCAAA GTCTGAAGAG 3300

AATGGAAAGA AAGAGGCAAA AGTGGAACAA AGTGAAGAGA GATTTGCATC TAGACAGTTC 3360

TCCCAGTACA AGCGAAGTGT GCGTAAAGAG GAGGAAGAAG AATTGGATGA TGATGCTATT 3420

ATTGCTGCAT GGAGAAGCCG ACTAGAAGAA ACTACAGCAA AACTCCGTCG GAGAAAGGAA 3480

GAGTGA 3486

Domain Profile

S: 2     vteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvd  61

         v+e++p+++++++ +a+++  L++lgit+v+na++++    ++P+++   +i+y++i+vd

Q: 135   VDEVWPNVFIAEKSVAVNKSRLKRLGITHVLNAAHGTGV-YTGPDFYNGLNIQYMGIEVD  193

         89*********************************8765.79******************

S: 62    Dsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAi  120

         D +++d++++f++aaef+dea  + +gk+lv +++G+sRSa+lv aYLm+++++++ +A+

Q: 194   DFPDMDISKHFHPAAEFMDEAlLTYRGKILVSSEMGISRSAVLVAAYLMIYHHMTILEAL  253

         *********************8999***********************************

S: 121   eavkrkrpsiepnegfleQLlelekkl  147

         +++++kr +i+pn+gfl+QL+el+++l

Q: 254   MTLRKKR-AIYPNDGFLKQLRELNEQL  279

         *******.***************9987

Domain Sequence
(FASTA)

VDEVWPNVFI AEKSVAVNKS RLKRLGITHV LNAAHGTGVY TGPDFYNGLN IQYMGIEVDD 60

FPDMDISKHF HPAAEFMDEA LLTYRGKILV SSEMGISRSA VLVAAYLMIY HHMTILEALM 120

TLRKKRAIYP NDGFLKQLRE LNEQL 145

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

mgp:100543131

;

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013