EKS-MEG-00319

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00319

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	364.5	3.1E-109	535	789	255

Status

Unreviewed

Ensembl Protein

ENSMGAP00000015541

UniProt Accession

G1NP96;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K15

Gene Synonyms/Alias

MAP3K15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000014668	ENSMGAP00000015541	ENSMGAT00000016498

Organism

Meleagris gallopavo

Functional Description

Protein Length

1213

Protein Sequence
(FASTA)

SDVAVVDMSD ISKQPSLFYH LGVRESFDMA NNVILYHGTD DDTAQSLKDM VSQKNTASSG 60

NYYFIPYIVT PCADYFCCES DAQRRASEYM QPSWDNILGP LCVPLVDRFI SLLKDVHVTS 120

CAYYKETLLN DIRKAREKYQ GDELAKELAR IKLRIDNTEV LTSDIVINLL LSYRDIQDYD 180

AMVKLVETLE MLPTCDLADQ HNIKFHYAFA LNRRNNAGDR EKALQVMLQV LQTCDHPAPD 240

MFCLCGRIYK DMFLDSDCKD VNSRDHAIEW YRKGFELQST LYSGINLAVL LLVEGQQFES 300

SMELRKIGVR LNSLLGRKGS LEKMNNYWDV GQFFSVSMLA NDVSKAVQAA EKLFKLKPPV 360

WYLKSLVQNL MLIQRFKKFT IEHSPKQERL TFWLDIIFEA TKETTNGLRF PVLVIEPTKV 420

YQPAYVSINS EEDERSLSLW HVSPTEMKQI HEWNFAASSI RGISISKFDE RCCFLYVHDN 480

SDDFQIYFST ENQCSRFCGL VKEILSDAVG STLELEGEID GETLEYEYDY DEKGDRVVLG 540

KGTYGIVYAG RDLSNQVRIA IKEIPERDSR YSQPLHEEIA LHKYLKHRNV VQYLGSISED 600

GYIKIFMEQV PGGSLSALLR SKWGPMKEPT IKFYTKQILE GLKYLHENQI VHRDIKGDNV 660

LVNTYSGVVK ISDFGTSKRL AGINPCAETF TGTLQYMAPE IIDKGPRGYG APADIWSLGC 720

TMIEMATGKP PFHELGEPQA AMFKVGMFKI HPEIPESLSA EAKAFILLCF EPDPCKRATA 780

SDLLRDSFLK QVNKGKKSRI AFKPSDYNRN TSLPLSIHGE QAGSSSSEHG SVSPDSDVQH 840

DVFFERPKRS ISEIQTRHPI AHLLSVPDES LALEDRSFSP SSEDKDSGLF LLRKDSERRA 900

ILYKILKEEQ NKVASNLQDC IAQSSEELQL SMAHIKQIIG ILRDFIHSPE HRVMASTISK 960

LKMDLDFDST SINQIHLVLF GFQDAVNKVL RNHLIRPHWM FAMDNIIRRA VQAAVTILIP 1020

ELRAHFEPAS ETEGGDKDCD EVEESFRPSE QNGTEDAAVT SGVSTLSSEV SHEAQQQLCL 1080

ELGRLKQETI RLLEKLVQKE KEYQTLLQQS LEQKTQELHL LQLRFKPRVL LLFSVKDWQW 1140

PSSTLKENAD PELTNWLKQQ GADPDTIRRF AEEDYTLSTV LNDITKDDLR CLQLRGGLLC 1200

RIWNAILTHR QMP 1213

Nucleotide Sequence
(FASTA)

TCAGATGTTG CAGTTGTGGA TATGAGTGAT ATTTCCAAGC AACCATCACT GTTCTACCAC 60

CTTGGTGTGC GTGAAAGCTT TGACATGGCA AATAATGTTA TACTCTACCA TGGCACTGAT 120

GATGACACTG CTCAGTCTCT CAAAGATATG GTATCTCAGA AAAATACAGC TTCCAGTGGA 180

AATTATTACT TCATTCCATA CATTGTTACC CCTTGTGCAG ACTACTTCTG CTGCGAAAGC 240

GATGCCCAGA GAAGAGCTTC TGAGTATATG CAGCCCAGCT GGGACAATAT CCTGGGGCCA 300

CTCTGCGTGC CTCTGGTGGA CAGGTTTATC AGCCTTCTCA AGGATGTTCA TGTTACATCG 360

TGTGCCTATT ATAAAGAAAC GCTGCTAAAT GATATTAGGA AGGCTAGAGA GAAGTACCAA 420

GGAGATGAAC TGGCTAAGGA GCTGGCTAGA ATTAAGCTTC GTATAGATAA TACTGAAGTG 480

CTGACTTCTG ACATTGTCAT AAACCTGCTT CTTTCTTACC GAGATATACA GGACTATGAT 540

GCTATGGTGA AGCTGGTAGA AACACTAGAA ATGCTTCCTA CATGTGACTT GGCTGATCAA 600

CACAACATTA AGTTTCATTA TGCTTTTGCT TTGAACAGAA GAAATAATGC AGGTGACAGG 660

GAGAAGGCAC TGCAAGTCAT GCTTCAGGTC CTGCAGACGT GTGATCACCC TGCTCCAGAT 720

ATGTTTTGCT TGTGTGGAAG AATATACAAG GATATGTTTC TTGACTCTGA CTGTAAAGAT 780

GTCAACAGTC GAGATCATGC CATTGAATGG TACCGCAAAG GATTTGAACT CCAGTCAACA 840

CTGTATTCAG GAATTAACCT TGCGGTTTTA CTACTTGTTG AAGGACAGCA GTTTGAAAGC 900

TCAATGGAAC TGAGAAAGAT AGGTGTACGG TTAAACAGTT TATTGGGAAG AAAGGGGAGC 960

CTAGAAAAAA TGAACAATTA CTGGGACGTG GGACAGTTCT TCAGTGTGAG CATGTTGGCT 1020

AATGATGTTA GTAAAGCAGT TCAAGCAGCA GAGAAGCTAT TTAAGCTGAA ACCTCCAGTA 1080

TGGTACTTGA AATCATTAGT TCAGAATCTG ATGTTAATTC AGCGTTTCAA GAAATTCACC 1140

ATAGAACATT CTCCTAAACA AGAAAGATTG ACTTTCTGGC TAGATATAAT TTTTGAGGCA 1200

ACGAAAGAAA CAACTAATGG ACTGAGATTT CCAGTTTTGG TGATAGAACC AACTAAAGTC 1260

TACCAGCCTG CATATGTTTC AATCAACAGT GAAGAAGATG AGAGATCTCT TTCTTTGTGG 1320

CATGTCTCTC CTACTGAAAT GAAACAGATT CATGAATGGA ACTTTGCAGC TTCTTCCATA 1380

AGGGGAATAA GTATTTCCAA GTTTGATGAA CGATGTTGTT TTCTTTATGT GCATGATAAC 1440

TCTGATGATT TTCAAATCTA CTTTTCTACA GAAAACCAGT GTAGTAGATT CTGTGGGTTG 1500

GTGAAAGAAA TTTTGTCTGA TGCAGTTGGC AGTACTTTGG AGCTAGAAGG AGAAATAGAT 1560

GGAGAAACAT TGGAGTACGA ATATGATTAT GATGAGAAGG GTGACAGAGT AGTTCTAGGA 1620

AAAGGTACTT ATGGGATAGT GTATGCTGGA AGAGACCTTA GCAACCAGGT GCGAATAGCC 1680

ATCAAAGAAA TACCTGAGAG AGACAGCAGA TATTCTCAGC CTCTTCATGA AGAGATAGCA 1740

CTGCATAAAT ATTTAAAGCA TCGGAATGTT GTCCAATATC TTGGATCCAT TTCAGAGGAT 1800

GGATACATTA AGATTTTTAT GGAGCAGGTG CCAGGAGGCA GCCTCTCAGC TCTCCTGAGG 1860

TCTAAGTGGG GTCCAATGAA AGAACCCACA ATTAAATTTT ACACCAAGCA GATTCTGGAA 1920

GGCCTTAAGT ATCTCCATGA GAACCAGATT GTACACAGAG ATATAAAGGG GGATAATGTG 1980

TTGGTGAACA CCTATAGTGG CGTCGTGAAG ATATCTGATT TTGGTACTTC CAAAAGGCTG 2040

GCAGGAATCA ATCCGTGTGC TGAAACGTTT ACGGGCACGT TGCAGTACAT GGCTCCAGAA 2100

ATCATTGACA AGGGACCACG AGGATATGGT GCACCAGCTG ATATCTGGTC GCTAGGCTGT 2160

ACCATGATTG AAATGGCAAC AGGCAAGCCT CCATTTCATG AGCTAGGAGA GCCTCAAGCA 2220

GCAATGTTTA AAGTTGGGAT GTTTAAGATT CATCCTGAAA TTCCAGAATC GCTGTCTGCT 2280

GAAGCAAAAG CCTTTATTTT GCTCTGTTTT GAACCTGATC CTTGTAAGCG TGCTACAGCA 2340

TCTGATTTGC TCAGAGATTC TTTCCTGAAA CAAGTCAACA AGGGCAAGAA AAGCAGAATC 2400

GCATTCAAGC CTTCAGATTA CAATCGGAAC ACATCCCTCC CACTGTCAAT CCACGGAGAA 2460

CAGGCTGGCA GCAGCAGCAG TGAGCATGGC TCTGTTTCTC CAGACTCCGA TGTACAGCAT 2520

GACGTGTTTT TCGAAAGGCC GAAGAGATCC ATTTCAGAGA TTCAGACAAG GCATCCCATT 2580

GCCCATTTAT TGAGCGTGCC TGATGAGAGT CTGGCCCTGG AAGACAGAAG TTTCTCTCCT 2640

TCCAGTGAGG ATAAGGATTC TGGTTTGTTC CTGCTACGGA AGGACAGCGA ACGCCGGGCA 2700

ATTCTATATA AAATTCTCAA GGAAGAACAG AATAAAGTTG CTTCAAATTT GCAGGACTGT 2760

ATTGCACAGA GCTCTGAAGA ACTGCAGCTT TCAATGGCCC ACATCAAGCA AATTATTGGG 2820

ATTTTAAGGG ACTTCATACA CTCTCCTGAG CACAGAGTGA TGGCTTCTAC CATATCCAAA 2880

TTGAAAATGG ATCTGGACTT TGACAGCACT TCTATCAATC AGATTCATCT GGTGCTGTTT 2940

GGATTTCAGG ATGCGGTTAA CAAAGTGTTA AGAAATCATT TAATAAGGCC CCACTGGATG 3000

TTTGCAATGG ACAATATAAT TCGCCGTGCA GTCCAAGCAG CAGTCACCAT TCTTATTCCA 3060

GAACTTCGAG CTCACTTTGA GCCAGCATCA GAAACTGAAG GTGGCGACAA AGATTGTGAT 3120

GAAGTGGAAG AGAGTTTCCG TCCCTCTGAA CAAAATGGGA CAGAGGATGC TGCTGTCACG 3180

TCAGGAGTTA GCACCCTCAG CTCCGAGGTG TCACACGAGG CTCAGCAGCA GCTTTGCCTG 3240

GAATTGGGCA GACTCAAACA AGAGACCATA AGGCTTTTGG AAAAACTCGT TCAGAAGGAG 3300

AAGGAGTATC AGACACTCTT ACAACAATCT TTGGAGCAAA AAACGCAGGA ATTGCACTTG 3360

CTTCAATTAA GATTTAAACC CAGAGTATTA TTATTATTTT CTGTTAAAGA CTGGCAGTGG 3420

CCTTCATCAA CTTTAAAAGA GAATGCAGAC CCAGAGCTCA CAAACTGGCT GAAACAACAA 3480

GGGGCAGACC CAGATACCAT TAGAAGGTTT GCTGAAGAGG ATTATACACT GAGTACTGTC 3540

CTTAATGACA TCACTAAGGA TGATTTGCGA TGCCTTCAAC TGCGTGGCGG ACTTCTCTGC 3600

AGAATTTGGA ATGCGATATT AACCCACCGA CAAATGCCT 3639

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k lkH+n

Q: 535   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKYLKHRN  589

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121

         +v+y+G+ +e++++kif+E+v+gGsls+ll+ k+g+++e +ik+ytkqilegl+yLHe++

Q: 590   VVQYLGSISEDGYIKIFMEQVPGGSLSALLRsKWGPMKEPTIKFYTKQILEGLKYLHENQ  649

         *******************************9****************************

S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ivHRDiKg+N+l+++ sgvvk+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k+

Q: 650   IVHRDIKGDNVLVNTySGVVKISDFGTSKRLAGINPC---AETFTGTLQYMAPEIIDKGP  706

         *************************************...89******************

S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240

         +gyg+ aDiWslgc++iem+tgk+Pf+el+e++a+mfkvg+ k++Peipe+ls+e+k+f+

Q: 707   RGYGAPADIWSLGCTMIEMATGKPPFHELGEPQAAMFKVGMFKIHPEIPESLSAEAKAFI  766

         ************************************************************

S: 241   ekcleldpkkrpsaeeLLkhefl  263

           c+e dp kr++a++LL+++fl

Q: 767   LLCFEPDPCKRATASDLLRDSFL  789

         ********************996

Domain Sequence
(FASTA)

DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKY LKHRNVVQYL 60

GSISEDGYIK IFMEQVPGGS LSALLRSKWG PMKEPTIKFY TKQILEGLKY LHENQIVHRD 120

IKGDNVLVNT YSGVVKISDF GTSKRLAGIN PCAETFTGTL QYMAPEIIDK GPRGYGAPAD 180

IWSLGCTMIE MATGKPPFHE LGEPQAAMFK VGMFKIHPEI PESLSAEAKA FILLCFEPDP 240

CKRATASDLL RDSFL 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR011990	; TPR-like_helical.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013