EKS-MEG-00160

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00160

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	416.3	3.8E-125	2	265	264

Status

Unreviewed

Ensembl Protein

ENSMGAP00000015547

UniProt Accession

G1NPA2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000014674	ENSMGAP00000015547	ENSMGAT00000016504

Organism

Meleagris gallopavo

Functional Description

Protein Length

981

Protein Sequence
(FASTA)

QETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI VELKEAFRRR GKLYLVFEYV 60

EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV HRDIKPENLL ISHNDVLKLC 120

DFGFARNLSE GSNANYTEYV ATRWYRSPEL LLGAPYGKAV DMWSVGCILG ELSDGQPLFP 180

GESEIDQLFT IQKVLGPLPA EQMKLFYSNP RFHGLRFPAV NHPQSLERRY LGILSGVLLD 240

LMKNLLKLDP ADRYLTEQCL NHPSFQTQRL LDRCGSSPSR SAKRKPYHVD SNTLSNRNQA 300

SKSSALQSHH RSNSKDIQTL GVGGSREEGL PANESFLNGN LSAAAHSPMH AKKSSNQPGS 360

GNKDLANNNM PHLLSPKETK AKTEFDFNVD PKSSDGPGTK YLKSNTRSQQ NRHSFMETSQ 420

SKTGTLQPGD KHSRHSYIDT IPQSSKSPSY RTKSKSHGVL TDSKSVGNLS EARAQAAEPN 480

SSRYFPSSCM DLNSPTSPTA PRHSDNRTLL SPSGRNNRSE GTLDTRRPST RHSKTMEELK 540

LPDHMDGSHS HSLSAPHESF SYGLGYTSPF SSQQRPHRHS MYVSRDRVRS KGSEGGLSVG 600

QGMAARANSL QLLSPQVQHK SLTRSVGSSR EDCTEDTNRQ SDQIPSETNL TRPPVKDSSR 660

DVTAAFHSRR KSEGGAYHDP HTEDGASTKE NRILYNEAVP RRVGSFYRVP SPRPDSTYIE 720

NNVSNRASVL PADSSTVANH SKRQTTFDTW FRKSPENLNS HSEQLKEKEK QGFFRAIKKK 780

KKKSQTVNTS SSNLDQILLQ HTPFRLGGRE HFKSLANMSR QRKKEIGRDR GFTQKAIHSS 840

NHQSNRQKDW HPEKMTEIQP HSQPLKSLRK LLHLSSEPRF QPLPSQPAKP AFSEVRIHPM 900

SQSSSSSSSN ARQEPQPKSR PTLQIPSQLE PTWHVSPVNR SASDGPPYSE QPSKSGQNGH 960

TYNRTNRSRM PNLNDLKETA L 981

Nucleotide Sequence
(FASTA)

CAGGAGACAC ATGAAATTGT GGCTATCAAG AAATTCAAAG ACAGTGAAGA AAATGAAGAA 60

GTCAAAGAAA CCACTTTACG AGAGCTTAAA ATGCTTCGCA CTTTAAAACA GGAGAACATA 120

GTGGAGCTGA AGGAAGCCTT CAGAAGAAGA GGAAAATTAT ACTTAGTTTT TGAATATGTG 180

GAAAAAAATA TGCTTGAATT GCTAGAAGAA ATGCCAAATG GAGTTCCACC AGAAAAAGTG 240

AAAAGTTATA TCTACCAGCT AATTAAAGCA ATTCATTGGT GTCATAAGAA TGATATCGTT 300

CACAGAGATA TCAAACCAGA GAATCTCTTA ATAAGCCACA ATGATGTTCT CAAATTGTGT 360

GACTTTGGCT TTGCCCGTAA CCTTTCTGAA GGAAGCAATG CTAACTATAC AGAATATGTG 420

GCTACCAGGT GGTACCGCTC ACCTGAACTC TTGCTTGGAG CCCCATATGG GAAGGCTGTG 480

GATATGTGGT CTGTGGGCTG TATTCTGGGT GAGCTGAGTG ACGGACAGCC CTTGTTCCCA 540

GGGGAGAGCG AGATTGACCA GCTCTTTACC ATTCAGAAGG TGCTAGGCCC ACTGCCAGCT 600

GAGCAGATGA AGCTCTTCTA CAGCAACCCA CGCTTCCATG GACTGAGGTT TCCTGCAGTC 660

AATCATCCAC AATCTTTAGA GAGAAGATAC TTGGGAATTT TAAGTGGTGT TTTGCTTGAT 720

CTTATGAAGA ACTTGCTGAA GTTAGATCCA GCAGACAGAT ACTTGACAGA GCAATGTTTG 780

AACCATCCTT CATTTCAAAC ACAAAGACTC TTGGATCGCT GTGGAAGCTC ACCCTCACGG 840

TCAGCTAAAA GAAAGCCTTA CCACGTTGAC AGCAACACAT TATCTAACAG AAATCAAGCC 900

AGCAAAAGTT CTGCTTTGCA GTCACACCAC AGATCAAACA GCAAGGATAT ACAGACACTA 960

GGGGTTGGCG GGTCAAGAGA AGAAGGTCTT CCAGCAAATG AAAGCTTTTT AAATGGAAAC 1020

CTTTCTGCAG CTGCACATAG CCCAATGCAT GCGAAGAAAT CAAGCAACCA GCCTGGATCT 1080

GGCAATAAAG ACCTAGCCAA CAATAACATG CCACATCTTC TTAGTCCAAA GGAGACAAAG 1140

GCAAAAACAG AGTTTGATTT TAATGTGGAC CCAAAAAGTT CCGATGGTCC AGGCACAAAG 1200

TACCTGAAGT CTAACACCAG ATCTCAGCAG AACCGGCACT CATTTATGGA AACGTCTCAG 1260

AGCAAAACTG GGACGCTGCA GCCCGGCGAT AAGCATAGTC GCCACAGCTA CATTGATACC 1320

ATTCCACAGT CTTCTAAGAG TCCCTCGTAT CGGACAAAGT CAAAGAGCCA TGGGGTTCTG 1380

ACAGACTCGA AATCCGTGGG CAACCTATCT GAGGCTAGGG CTCAAGCTGC AGAACCAAAC 1440

AGCAGTCGCT ATTTTCCATC CAGCTGCATG GACTTGAATT CTCCTACCAG TCCGACCGCT 1500

CCCCGCCATA GCGATAACAG AACTTTGCTC AGCCCTTCTG GGAGGAATAA CCGCAGCGAG 1560

GGTACCCTGG ACACCCGAAG ACCTTCAACC AGACACTCCA AAACAATGGA GGAGTTAAAA 1620

CTGCCAGATC ACATGGATGG AAGCCATTCC CACTCGCTCT CTGCTCCGCA CGAATCTTTT 1680

TCCTATGGCC TAGGTTATAC CAGTCCTTTC TCTTCACAAC AGCGCCCTCA TAGACACTCT 1740

ATGTATGTGA GCCGGGACAG AGTGAGGTCA AAGGGCTCAG AGGGTGGCTT AAGCGTAGGG 1800

CAAGGGATGG CAGCCAGAGC AAACAGCCTG CAACTGTTAT CTCCACAGGT GCAGCATAAG 1860

TCACTCACAA GGTCTGTTGG CTCTTCACGA GAAGACTGTA CAGAAGATAC TAATAGGCAG 1920

AGTGACCAGA TTCCATCAGA AACAAATTTA ACAAGACCTC CAGTAAAAGA TTCCTCCAGA 1980

GATGTTACAG CTGCATTTCA TTCACGGCGA AAATCTGAGG GTGGAGCATA TCATGATCCA 2040

CACACAGAAG ATGGAGCATC TACTAAGGAA AATAGAATTC TGTATAATGA AGCTGTTCCC 2100

AGAAGAGTTG GCAGTTTTTA CAGAGTTCCA TCTCCACGTC CAGACAGCAC GTACATAGAA 2160

AACAATGTGT CAAACAGAGC TTCTGTACTG CCAGCAGACA GCAGCACGGT GGCAAACCAC 2220

TCAAAGAGAC AAACCACCTT TGATACCTGG TTTAGGAAGA GTCCTGAAAA TCTTAACAGT 2280

CACTCTGAAC AGCTTAAGGA GAAAGAAAAG CAAGGTTTTT TCAGGGCCAT AAAAAAGAAA 2340

AAGAAGAAAT CTCAAACCGT AAATACTTCA TCATCCAATT TAGATCAAAT CCTTTTGCAG 2400

CATACGCCAT TCAGACTTGG TGGTAGGGAG CACTTTAAAA GCCTAGCTAA TATGTCAAGA 2460

CAAAGAAAGA AAGAGATAGG AAGAGATAGA GGATTTACCC AGAAAGCCAT TCATTCTTCT 2520

AATCACCAGA GCAACAGGCA GAAGGATTGG CATCCTGAGA AGATGACAGA AATCCAGCCC 2580

CATAGCCAGC CATTAAAATC CCTGCGAAAG CTGTTACACC TCTCTTCNGA GCCTCGCTTC 2640

CAGCCCTTAC CAAGTCAGCC GGCCAAACCT GCTTTTTCTG AAGTGCGAAT TCACCCCATG 2700

AGTCAAAGCT CCAGCAGCAG CAGCAGCAAC GCACGGCAAG AGCCGCAGCC AAAGAGCCGG 2760

CCAACGCTGC AGATCCCGAG CCAGCTGGAG CCCACCTGGC ACGTCTCCCC CGTCAACAGG 2820

AGCGCCAGCG ACGGGCCCCC CTACTCTGAG CAGCCTTCCA AGAGTGGACA GAACGGGCAC 2880

ACGTATAACC GAACAAACCG GTCGCGAATG CCAAATCTGA ATGATCTGAA AGAGACAGCC 2940

TTGTAA 2946

Domain Profile

S: 22    dtgqivaikkfleseddkevkkialreikllkqlkhenlvnllevfrrkkklylvfeyvd  81

         +t++ivaikkf++se+++evk+++lre+k+l++lk+en+v+l+e+frr+ klylvfeyv+

Q: 2     ETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVE  61

         89**********************************************************

S: 82    ktvldelerypnGveeelvkkilyqilkaiefchknniihrdikpenilisksgvvklcd  141

         k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+hrdikpen+lis+++v+klcd

Q: 62    KNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCD  121

         ************************************************************

S: 142   fGfarlla.apgdvytdyvatrwyrapellvgdtkyGksvdvwaiGcllaelltGeplfp  200

         fGfar+l+ +++++yt+yvatrwyr+pell+g + yGk+vd+w++Gc+l el++G+plfp

Q: 122   FGFARNLSeGSNANYTEYVATRWYRSPELLLG-APYGKAVDMWSVGCILGELSDGQPLFP  180

         *******98999********************.9**************************

S: 201   gksdvdqlykirktlGeliprhqkifsknevfaGvklpevedleslekkyp.klnevlld  259

         g+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+v++++sle++y   l+ vlld

Q: 181   GESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLgILSGVLLD  240

         **************************************************98899*****

S: 260   llkkclkldpaerlsceellkheyf  284

         l+k++lkldpa+r+++e++l+h+ f

Q: 241   LMKNLLKLDPADRYLTEQCLNHPSF  265

         **********************987

Domain Sequence
(FASTA)

ETHEIVAIKK FKDSEENEEV KETTLRELKM LRTLKQENIV ELKEAFRRRG KLYLVFEYVE 60

KNMLELLEEM PNGVPPEKVK SYIYQLIKAI HWCHKNDIVH RDIKPENLLI SHNDVLKLCD 120

FGFARNLSEG SNANYTEYVA TRWYRSPELL LGAPYGKAVD MWSVGCILGE LSDGQPLFPG 180

ESEIDQLFTI QKVLGPLPAE QMKLFYSNPR FHGLRFPAVN HPQSLERRYL GILSGVLLDL 240

MKNLLKLDPA DRYLTEQCLN HPSF 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013