EKS-MEG-00264

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00264

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	315.7	1.9E-94	5	236	232

Status

Unreviewed

Ensembl Protein

ENSMGAP00000015692

UniProt Accession

G1NPM5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP4K4

Gene Synonyms/Alias

MAP4K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000014806	ENSMGAP00000015692	ENSMGAT00000016651

Organism

Meleagris gallopavo

Functional Description

Protein Length

1227

Protein Sequence
(FASTA)

RVLDEDQDEE EEIKLEINML KKYSHHRNIA TYYGAFIKKS PPGHDDQLWL VMEFCGAGSI 60

TDLVKNTKGN TLKEDWIAYI SREILRGLAH LHAHHVIHRD IKGQNVLLTE NAEVKLVDFG 120

VSAQLDRTVG RRNTFIGTPY WMAPEVIACD ENPDATYDYR SDLWSCGITA IEMAEGAPPL 180

CDMHPMRALF LIPRNPPPRL KSKKWSKKFF SFIEGCLVKN YMQRPSTEQL LKHPFIRDQP 240

NERQVRIQLK DHIDRTRKKR GEKDETEYEY SGSEEEEEEV PEQEGEPSSI VNVPGESTLR 300

RDFLRLQQEN KERSEALRRQ QLLQEQQLRE QEEYKRQLLA ERQKRIEQQK EQRRRLEEQQ 360

RREREARRQQ EREQRRREQE EKRRLEEMER RRKEEEERRR AEEEKRRVER EQEYIRRQLE 420

EEQRHLEILQ QQLLQEQAML LLHFNNEINK KKTKQQQPKM NTDGERRNKQ SYHTPEPKSH 480

YEPAERAREV EERFRKTNQG SPEAQSKQMG KVLEPPVPSR SESFSNGNSE PAQPALQRPM 540

EPQVQWSHLA SLKNNVSPVS RSHSFSDPSP KFAHHHLRSQ DPYPPSRSEV LNQSSDSKSE 600

VPDPTQKAWA RSDSDEVPPR VPVRTTSRSP VLSRRDSPLQ GSGQQNNQAG QRNSTSNIEP 660

RLLWERVEKL VPRPGSGSSS GSSGSGERFR MRSSSKSEGS PSQRHESAPK KPEEKKEVFR 720

PIKPAGEVDL TALAKELRAV EDVRPPHKVT DYSSSSEESG TTDEEDDDME QEGADESTSG 780

PDDVRAVSTL NLSNGETESV KTMIVHDDVE SEPALTPSKE GTLIVRQTQS ASNTLQKHKS 840

SSSFTPFIDP RLLQISPSSG TTVTSVVGFS SEAMRSEAIR QDPTRKGSVV NVNPTNTRPQ 900

SDTPEIRKYK KRFNSEILCA ALWGVNLLVG TESGLMLLDR SGQGKVYPLI NRRRFQQMDV 960

LEGLNVLVTI SGKKNKLRVY YLSWLRNKIL HNDPEVEKKQ GWTTVGDLEG CVHYKVVKYE 1020

RIKFLVIALK SSVEVYAWAP KPYHKFMAFK SFGELVHKPL LVDLTVEEGQ RLKVIYGSCA 1080

GFHAVDVDSG SVYDIYLPTH IQSSIQPHAI IILPNTDGME LLVCYEDEGV YVNTYGRITK 1140

DVVLQWGEMP TSVAYIRSNQ IMGWGEKAIE IRSVETGHLD GVFMHKRAQR LKFLCERNDK 1200

VFFASVRSGG SSQVYFMTLG RTSLLSW 1227

Nucleotide Sequence
(FASTA)

CGGGTTTTGG ATGAAGACCA GGACGAAGAA GAAGAAATCA AACTGGAGAT TAATATGCTA 60

AAGAAATATT CTCATCACAG AAATATTGCA ACTTATTATG GTGCTTTCAT TAAGAAAAGT 120

CCTCCAGGAC ATGATGACCA ACTGTGGCTT GTTATGGAGT TTTGTGGAGC AGGCTCTATC 180

ACAGACCTTG TGAAGAACAC GAAAGGGAAT ACTCTGAAAG AAGACTGGAT AGCATACATC 240

TCCAGAGAGA TTCTCAGGGG GCTGGCACAT CTTCATGCCC ACCATGTGAT TCACAGGGAT 300

ATCAAAGGGC AAAATGTGTT GTTAACAGAG AATGCAGAAG TGAAACTCGT GGATTTTGGT 360

GTGAGCGCTC AGCTGGACAG GACAGTTGGC AGGAGAAACA CTTTCATTGG AACTCCATAC 420

TGGATGGCTC CAGAAGTTAT TGCCTGTGAT GAAAATCCAG ATGCTACGTA TGATTACAGA 480

AGTGACCTCT GGTCCTGCGG CATTACAGCC ATAGAAATGG CAGAAGGAGC TCCCCCACTT 540

TGTGACATGC ATCCCATGAG GGCACTCTTT CTGATACCCA GAAACCCTCC CCCACGGTTA 600

AAATCCAAGA AATGGTCAAA AAAGTTTTTC AGCTTTATAG AAGGTTGTCT AGTGAAGAAT 660

TACATGCAGC GACCTTCTAC AGAGCAACTA CTGAAACATC CATTTATACG TGACCAACCA 720

AATGAAAGGC AAGTCCGAAT CCAGCTTAAG GACCATATAG ACAGGACCAG GAAGAAGAGA 780

GGAGAGAAAG ATGAGACGGA GTATGAATAT AGTGGAAGTG AGGAAGAAGA GGAGGAAGTG 840

CCTGAACAAG AAGGAGAGCC AAGTTCCATT GTCAATGTGC CTGGAGAATC AACCCTCCGA 900

CGTGATTTCC TGAGGCTGCA GCAGGAAAAC AAGGAACGAT CCGAAGCCCT TCGGAGACAG 960

CAGCTGCTGC AGGAGCAGCA GCTCCGTGAG CAGGAGGAGT ACAAGAGGCA GCTACTGGCA 1020

GAGAGACAGA AGCGCATTGA GCAGCAGAAG GAGCAAAGGA GACGGCTGGA AGAGCAACAA 1080

AGAAGAGAAC GGGAAGCTCG CAGGCAACAA GAGCGTGAGC AAAGGCGGAG GGAACAGGAA 1140

GAAAAAAGAC GTCTGGAAGA AATGGAGAGG AGACGTAAGG AAGAGGAAGA GAGAAGAAGA 1200

GCAGAGGAGG AAAAGAGGAG GGTAGAAAGG GAGCAGGAGT ATATCAGGCG ACAGCTAGAA 1260

GAGGAGCAGC GGCACTTGGA AATTCTACAG CAGCAGCTGC TCCAGGAGCA GGCCATGTTA 1320

CTGTTACACT TTAACAATGA AATAAATAAA AAAAAAACAA AGCAACAGCA ACCAAAAATG 1380

AATACAGATG GCGAGAGAAG AAATAAACAA AGCTATCATA CCCCTGAGCC AAAATCCCAC 1440

TATGAGCCTG CTGAAAGAGC GCGTGAGGTG GAGGAGAGAT TTAGAAAAAC TAATCAAGGC 1500

TCCCCTGAAG CACAGTCTAA GCAGATGGGC AAAGTGTTGG AGCCACCAGT GCCTTCAAGA 1560

TCAGAGTCCT TTTCCAATGG AAACTCAGAA CCTGCTCAGC CTGCCCTGCA GAGGCCAATG 1620

GAGCCCCAAG TACAGTGGTC CCATCTGGCA TCTCTCAAGA ACAATGTTTC CCCTGTCTCG 1680

CGATCCCATT CCTTCAGTGA CCCTTCTCCC AAATTTGCTC ATCACCATCT TCGTTCCCAG 1740

GACCCATATC CACCTTCACG CAGTGAAGTG CTAAATCAGA GTTCTGACTC TAAGTCGGAG 1800

GTACCCGACC CCACCCAAAA GGCTTGGGCT AGATCAGACA GTGACGAGGT GCCTCCAAGG 1860

GTACCTGTGA GAACAACATC CCGATCACCA GTTCTGTCCC GTCGTGATTC TCCACTGCAG 1920

GGCAGTGGGC AGCAAAATAA CCAAGCAGGT CAAAGAAACT CCACGAGCAA TATAGAGCCT 1980

CGCCTGCTGT GGGAAAGGGT GGAAAAGCTC GTACCAAGAC CAGGCAGTGG CAGTTCTTCA 2040

GGTTCGAGTG GGTCTGGCGA GCGGTTCCGG ATGAGATCAT CATCCAAATC AGAGGGTTCA 2100

CCATCACAGC GTCATGAAAG TGCACCTAAA AAGCCTGAAG AGAAGAAGGA GGTCTTCAGA 2160

CCTATCAAGC CTGCTGGAGA AGTGGATTTA ACTGCATTGG CAAAGGAGCT GCGAGCAGTA 2220

GAAGATGTGC GACCTCCGCA TAAAGTGACA GATTATTCGT CCTCAAGTGA GGAGTCAGGG 2280

ACGACAGATG AAGAAGATGA TGATATGGAA CAAGAAGGAG CAGATGAATC TACTTCTGGA 2340

CCAGATGATG TCCGAGCAGT GTCAACACTG AACTTGAGCA ATGGTGAAAC AGAGTCTGTA 2400

AAAACTATGA TTGTCCATGA TGATGTGGAG AGTGAACCTG CCTTGACTCC TTCTAAGGAG 2460

GGCACCTTAA TTGTCCGACA GACTCAGTCC GCTAGTAACA CACTCCAGAA ACACAAATCT 2520

TCCTCCTCCT TTACACCTTT TATAGACCCC AGATTACTAC AGATTTCTCC ATCTAGTGGG 2580

ACAACTGTGA CTTCTGTGGT AGGATTTTCT AGTGAAGCAA TGAGATCAGA GGCAATAAGA 2640

CAAGACCCAA CGCGGAAAGG ATCAGTTGTC AACGTGAATC CTACAAATAC ACGACCACAA 2700

AGTGATACCC CAGAGATCCG CAAATACAAG AAAAGATTCA ATTCTGAGAT ACTGTGTGCT 2760

GCCTTATGGG GAGTGAACTT GTTAGTGGGC ACGGAAAGTG GTCTGATGCT GCTAGACAGA 2820

AGTGGTCAGG GGAAGGTTTA TCCACTCATC AATCGAAGAA GATTCCAGCA AATGGATGTA 2880

CTTGAAGGGC TAAATGTCTT GGTGACAATT TCTGGTAAGA AGAACAAATT GCGAGTTTAC 2940

TATTTGTCCT GGTTGAGAAA TAAAATCCTT CACAATGATC CCGAAGTAGA AAAGAAACAG 3000

GGTTGGACAA CGGTGGGTGA CTTGGAAGGC TGTGTGCACT ATAAAGTTGT AAAATATGAA 3060

AGAATCAAAT TCTTGGTAAT TGCATTGAAG AGTTCTGTGG AAGTCTATGC ATGGGCGCCA 3120

AAGCCATACC ACAAATTTAT GGCCTTTAAG TCATTTGGTG AATTGGTACA TAAGCCATTA 3180

CTGGTGGATC TAACTGTAGA AGAGGGTCAG AGACTAAAAG TCATTTATGG TTCCTGTGCT 3240

GGCTTCCATG CTGTTGATGT GGATTCAGGA TCAGTCTACG ATATTTATCT ACCAACACAT 3300

ATCCAGAGCA GTATCCAACC TCATGCAATC ATAATTCTCC CAAATACGGA TGGAATGGAG 3360

CTACTGGTCT GTTATGAGGA TGAAGGAGTT TATGTAAACA CATATGGAAG GATCACCAAG 3420

GATGTGGTTC TGCAGTGGGG AGAAATGCCA ACTTCAGTTG CATACATTCG ATCCAATCAG 3480

ATTATGGGCT GGGGAGAAAA AGCGATCGAA ATACGCTCGG TAGAAACTGG ACACTTGGAC 3540

GGTGTGTTCA TGCACAAAAG GGCACAAAGA CTCAAGTTCT TATGTGAACG TAATGACAAG 3600

GTTTTCTTTG CCTCTGTACG GTCAGGTGGA AGCAGTCAAG TTTATTTCAT GACCCTTGGC 3660

AGGACTTCTC TTCTGAGCTG GTAG 3684

Domain Profile

S: 35    ekqekleelqkeisvlkklkh.pniveylesflk......eeelwlvmeylagGslsdlv  87

         e+q+++ee++ ei++lkk++h +ni +y+++f+k      +++lwlvme++ +Gs++dlv

Q: 5     EDQDEEEEIKLEINMLKKYSHhRNIATYYGAFIKksppghDDQLWLVMEFCGAGSITDLV  64

         56799**************998*****************9********************

S: 88    keelkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaq  147

         k+++ ++lkE++iayi re+l++L++lH+++viHrdik++n+Llte++eVkL+dfgv+aq

Q: 65    KNTKGNTLKEDWIAYISREILRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQ  124

         ************************************************************

S: 148   lektrkkrktvvgtpywmAPEviaqe...ekgYdekaDiwslGItaielaegepPfkdle  204

         l++t+ +r+t++gtpywmAPEvia++   + +Yd+++D+ws+GItaie+aeg+pP++d++

Q: 125   LDRTVGRRNTFIGTPYWMAPEVIACDenpDATYDYRSDLWSCGITAIEMAEGAPPLCDMH  184

         **************************999999****************************

S: 205   plkallkilkneppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257

         p++al++i++n+pp+lksk k+sk+f +f+e cl kn+ +Rps+++llkh+F+

Q: 185   PMRALFLIPRNPPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI  236

         ****************888.********************************7

Domain Sequence
(FASTA)

EDQDEEEEIK LEINMLKKYS HHRNIATYYG AFIKKSPPGH DDQLWLVMEF CGAGSITDLV 60

KNTKGNTLKE DWIAYISREI LRGLAHLHAH HVIHRDIKGQ NVLLTENAEV KLVDFGVSAQ 120

LDRTVGRRNT FIGTPYWMAP EVIACDENPD ATYDYRSDLW SCGITAIEMA EGAPPLCDMH 180

PMRALFLIPR NPPPRLKSKK WSKKFFSFIE GCLVKNYMQR PSTEQLLKHP FI 232

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0046328	; P:regulation of JNK cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036

; CNH; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013