EKS-MEG-00337
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00337
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR526.72.4E-158619950332
StatusUnreviewed
Ensembl ProteinENSMGAP00000016011
UniProt AccessionG1NQC8;
Protein Name
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000015097ENSMGAP00000016011ENSMGAT00000016978
OrganismMeleagris gallopavo
Functional Description
Protein Length1001
Protein Sequence
(FASTA)
ALIAEQGGRF PVFLVMTAMA FTSAMNQSTS EITCVFIRQR DGASRTEETS VSSKISNILE 60
DLECHLNSQG AENIYEPIKK VEANVFEDIE LRVIMNISEI ISCHWFFKEI QACEPSLDSD 120
NRYVTSLPFS QIRETQAGKY TLSVISKNSN YTIIVPVLIR STFLGKPGKP YFRISEKLDI 180
IKCISQSYPQ PSVKWTFCKT HEKSCLNKMH GENGEIDGIQ KVQYELHQSE LFETYILCCA 240
ANDLGRECTS LFTIDLSERR ATPSAELLLK VGEPLLIRCR AVYRNYKFRI NLSFENKEVQ 300
QNRRFEGLEY QTDHSAIRIQ YMFTSAARKG DSGRYTCSST AHPNQTALVT VLEKGFINIT 360
DSREDFEIGD EEFCFEVNFT AYPPVECMWL FSQKTFPCKQ SYSEDGHSIS SKFCNHQHRS 420
GIYVFYAEND DTVMTKKFTL YVRRKPEVTM QLLFKQISCI ADSYPASSWV WRNCPDLNSS 480
NCTEEIKEGI QNFLPERRSL GSWISSSILD VKETATTFSV ECCASNLVGS NCRKSFINIV 540
AGTVSSLPDN AALYVFAGFI FLLIIFLCVL ICHKYKKQFR YESQLQMIQV IGPLDNEYIY 600
IDFREYEYDL KWEFPRENLE FGQVLGSGAF GKVLNATAYG ISKAGDSVQV AVKMLKEKSD 660
TSEKDALMSE LKMMIHIGSH ENIVNLLGAC TVSGPIYLIF EYCCYGDLLN YLRSKREKFH 720
WTLTDIFKQH NFSFYHNICL DQNSRENELK VTQTSQNINM TSGPNGIALC SEEDEIKCAS 780
RQMDEDEDFN VLTFEDLLCF SYQIAKGMEF LESKSCIHRD LAARNILVTH GKVMKICDFG 840
LARDVMNDSN YIVQGNVRLP VKWMAPESLF EGMYTMKSDV WSYGILLWEI FSLGVNPYPG 900
IQVDVNFYKL IKSGFKMDRP YYATKHVYYV MQSCWALDSR RRPSFSQLVS SLACQLVEAE 960
GAVYQNMKKT VSPPKSNNKT NPGVSKDEES LLSPALLQHE D 1001
Nucleotide Sequence
(FASTA)
GCTCTTATTG CCGAGCAGGG CGGGCGCTTC CCTGTGTTTC TAGTTATGAC AGCCATGGCT 60
TTCACTTCTG CAATGAATCA AAGCACATCT GAGATTACGT GTGTGTTTAT CAGACAAAGA 120
GATGGAGCTT CAAGGACAGA AGAGACATCA GTATCTTCCA AGATCTCCAA CATTTTGGAA 180
GATCTCGAGT GCCATCTGAA TTCTCAGGGA GCAGAGAACA TCTATGAGCC GATTAAAAAA 240
GTAGAAGCGA ATGTGTTTGA AGATATTGAA TTAAGAGTAA TAATGAACAT TTCAGAGATC 300
ATTTCATGCC ATTGGTTTTT TAAAGAAATC CAAGCTTGTG AACCTTCATT GGATTCAGAT 360
AACCGGTATG TTACTTCTTT GCCTTTTTCT CAAATACGAG AAACACAAGC TGGAAAATAC 420
ACTCTCTCAG TCATCAGTAA AAACAGCAAT TACACCATCA TTGTTCCTGT TCTCATCCGA 480
AGCACCTTCC TAGGTAAACC GGGCAAACCC TATTTCAGGA TATCTGAGAA ACTGGATATA 540
ATAAAGTGCA TATCACAGAG CTACCCCCAG CCCTCTGTGA AGTGGACATT TTGCAAAACA 600
CATGAAAAGA GCTGCCTTAA TAAAATGCAT GGAGAAAATG GAGAAATAGA TGGCATACAG 660
AAGGTACAAT ATGAATTACA CCAGAGTGAA TTGTTTGAAA CTTACATATT GTGCTGTGCA 720
GCTAATGACC TGGGCAGAGA ATGCACCAGC CTCTTTACTA TAGATTTAAG TGAAAGACGA 780
GCAACACCTT CAGCTGAGTT ACTTCTCAAA GTTGGGGAAC CACTGCTGAT CAGATGCAGA 840
GCTGTTTATC GTAATTACAA ATTCAGAATA AATTTATCTT TTGAAAACAA AGAAGTGCAG 900
CAGAATCGCC GATTTGAGGG GTTGGAGTAC CAAACAGACC ACTCAGCCAT TCGGATCCAG 960
TACATGTTTA CTTCAGCAGC AAGAAAAGGT GACAGCGGAC GTTATACCTG CTCTTCTACA 1020
GCTCATCCAA ATCAAACTGC TCTGGTTACT GTTTTAGAAA AGGGATTTAT AAATATAACT 1080
GACTCTAGAG AAGATTTTGA AATTGGTGAT GAAGAGTTTT GCTTTGAAGT TAACTTTACA 1140
GCGTATCCAC CAGTTGAATG CATGTGGCTA TTTTCCCAGA AAACATTTCC ATGTAAGCAA 1200
AGTTACAGTG AGGATGGACA CAGCATTTCA TCAAAATTCT GCAATCATCA GCACCGTTCT 1260
GGGATATATG TATTTTATGC TGAAAATGAT GATACGGTCA TGACAAAAAA ATTCACTTTG 1320
TATGTGAGAA GAAAACCTGA AGTAACAATG CAGTTATTGT TCAAGCAGAT CTCCTGCATC 1380
GCTGACAGCT ATCCAGCCTC ATCCTGGGTT TGGAGGAACT GTCCTGACCT GAACTCATCC 1440
AACTGTACTG AAGAAATCAA GGAAGGGATC CAGAACTTCT TGCCAGAAAG GAGATCTCTG 1500
GGGTCATGGA TTTCAAGCAG TATTTTAGAT GTAAAGGAGA CAGCAACAAC GTTCTCTGTT 1560
GAATGCTGTG CAAGCAATTT GGTCGGCTCC AACTGCAGGA AGAGCTTCAT TAACATAGTT 1620
GCAGGAACTG TTTCTTCTCT GCCAGACAAT GCTGCACTCT ATGTTTTTGC TGGATTTATC 1680
TTCCTGTTGA TCATTTTTTT GTGTGTTCTC ATTTGTCATA AATACAAAAA GCAATTTAGA 1740
TATGAAAGCC AGCTGCAAAT GATTCAGGTG ATTGGACCAT TGGATAATGA GTACATCTAC 1800
ATTGACTTCC GTGAATATGA ATATGATCTC AAATGGGAAT TTCCCAGGGA AAATCTGGAA 1860
TTTGGACAGG TTCTCGGTTC TGGGGCTTTT GGGAAAGTGC TGAATGCTAC AGCTTATGGA 1920
ATTAGCAAGG CAGGAGACTC AGTGCAGGTT GCAGTCAAAA TGCTAAAAGA AAAGTCTGAC 1980
ACTTCAGAAA AAGATGCTCT GATGTCTGAA CTGAAAATGA TGATTCACAT TGGAAGCCAT 2040
GAAAATATTG TGAACCTGCT AGGAGCCTGC ACTGTGTCAG GACCAATCTA CTTGATTTTT 2100
GAATACTGTT GCTATGGTGA CCTTCTGAAC TACTTAAGGA GCAAGAGAGA AAAATTTCAC 2160
TGGACTCTGA CTGATATTTT TAAACAGCAC AACTTCAGTT TCTATCACAA TATCTGTTTG 2220
GACCAAAATT CCAGAGAGAA CGAACTTAAA GTCACACAGA CAAGCCAAAA CATAAATATG 2280
ACCTCTGGAC CAAATGGGAT TGCACTCTGC TCTGAGGAAG ATGAAATTAA GTGTGCAAGC 2340
AGACAGATGG ATGAAGATGA GGATTTTAAT GTGCTCACTT TTGAAGACCT TTTATGCTTC 2400
TCTTATCAAA TTGCCAAAGG AATGGAGTTT CTTGAGTCCA AATCGTGCAT TCACAGAGAC 2460
CTCGCTGCCC GTAATATACT GGTGACCCAT GGGAAAGTCA TGAAAATATG TGACTTTGGC 2520
CTTGCCAGAG ATGTCATGAA TGACTCCAAC TACATCGTCC AGGGCAATGT TCGTTTACCC 2580
GTTAAATGGA TGGCTCCTGA AAGTTTATTT GAGGGGATGT ACACCATGAA GAGCGATGTT 2640
TGGTCTTATG GAATACTGCT GTGGGAAATA TTCTCTTTGG GTGTAAATCC CTACCCTGGC 2700
ATTCAAGTTG ATGTGAACTT CTACAAATTA ATTAAAAGTG GATTTAAAAT GGACCGACCT 2760
TATTATGCTA CAAAACATGT CTATTATGTG ATGCAGTCCT GCTGGGCACT GGACTCCAGA 2820
AGAAGACCCT CATTTTCCCA GCTGGTTTCC TCTCTTGCCT GTCAGCTGGT GGAGGCAGAG 2880
GGAGCAGTCT ACCAGAACAT GAAGAAAACT GTTTCTCCAC CCAAATCCAA CAACAAAACT 2940
AACCCGGGTG TAAGTAAGGA TGAGGAATCT CTTCTGTCCC CAGCTCTGCT CCAACATGAG 3000
GAC 3003
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+G+vlGsGafGkv++atayG+sk++ +++vavkmlk+++++sek+almselk++ h+G
Q: 619   LEFGQVLGSGAFGKVLNATAYGISKAGDSVQVAVKMLKEKSDTSEKDALMSELKMMIHIG  678
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact++Gpiy+i+eyccyGdllnylr+kre+f+ + ++++k+++++++++ 
Q: 679   SHENIVNLLGACTVSGPIYLIFEYCCYGDLLNYLRSKREKFHWTLTDIFKQHNFSFYHN-  737
         *******************************************************9987.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         +  d++ r ++   +++s++ +++  + + +   +++        +      +++ e+ed
Q: 738   ICLDQNSRENELKVTQTSQN-INMTSGPNGIALCSEEDEI-----KC---ASRQMDEDED  788
         65555555554444455544.7888866666554443332.....23...3344568899
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+fsyq+akGmefl+sk+c+hrdlaarn+l+t+Gkv+kicdfGlard+m+d
Q: 789   FNVLTFEDLLCFSYQIAKGMEFLESKSCIHRDLAARNILVTHGKVMKICDFGLARDVMND  848
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         sny+v+Gn rlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg+ vd +fy
Q: 849   SNYIVQGNVRLPVKWMAPESLFEGMYTMKSDVWSYGILLWEIFSLGVNPYPGIQVDVNFY  908
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         klik+G++m++p yat+++y +mq+cw+ ++++rpsf+qlv+
Q: 909   KLIKSGFKMDRPYYATKHVYYVMQSCWALDSRRRPSFSQLVS  950
         ***************************************996
Domain Sequence
(FASTA)
LEFGQVLGSG AFGKVLNATA YGISKAGDSV QVAVKMLKEK SDTSEKDALM SELKMMIHIG 60
SHENIVNLLG ACTVSGPIYL IFEYCCYGDL LNYLRSKREK FHWTLTDIFK QHNFSFYHNI 120
CLDQNSRENE LKVTQTSQNI NMTSGPNGIA LCSEEDEIKC ASRQMDEDED FNVLTFEDLL 180
CFSYQIAKGM EFLESKSCIH RDLAARNILV THGKVMKICD FGLARDVMND SNYIVQGNVR 240
LPVKWMAPES LFEGMYTMKS DVWSYGILLW EIFSLGVNPY PGIQVDVNFY KLIKSGFKMD 300
RPYYATKHVY YVMQSCWALD SRRRPSFSQL VS 332
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TAR-00506
EKS-TEN-00504
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013