EKS-MEG-00072

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00072

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	391.9	2.0E-117	1060	1388	329

Status

Unreviewed

Ensembl Protein

ENSMGAP00000016065

UniProt Accession

G1NQH3;

Protein Name

Protein Synonyms/Alias

Gene Name

ATM

Gene Synonyms/Alias

ATM;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000015148	ENSMGAP00000016065	ENSMGAT00000017036
ENSMGAG00000015148	ENSMGAP00000016064	ENSMGAT00000017035

Organism

Meleagris gallopavo

Functional Description

Protein Length

1430

Protein Sequence
(FASTA)

YKDQMKDLLK IFREKPEDSV MVKLVVSLLQ LSKMAVNHAG EKAVLEAVGS CLGEIGPMDF 60

STIALQHAEN ALDSKAVDLL EDRKLQWVFI MLTQINTALT DNCIDVRSAA VSCLKNILAT 120

NSGSEFWEVY KNKGDPMLIY LQPFRMSKKK VLAMPANDSE ASSETLDDTN LWIPLGESHE 180

TWIKNLTRSI LDSGGVQNEV LQLMKPLCEV KTDLSQTLLP YLIHDILLHD SNESWRNILS 240

VHVRKFFTAC CRFASSSRSA TPPNSDSEQE THVLRSLDKV SRRTMLAVVD YLRRQKRSVS 300

GTVFDDSFWL DLNYLEVAVA AQSCAAHFTA LLYAEIYADK INIDKQQESL TFEEESEKSA 360

IAILNEKSKE TGISLQDLLM DIYKSIGEPD SLYGCGGGRM LQPLARIRTY EHEAVWDKAL 420

LTYDLEATLS PSTRQAGIIE ALQNFGLCHT LSMYLKGLEH ENTEWCAELQ EIRYQAAWRN 480

MQWDSISSVK NETGGSGYHE SLYDALQSLR DKEFSTFYDT LKVARVNEVE ELCKGSLESV 540

YTLYPSLCRL QLVGELENIG LLFSRPATTQ QLNDVYSKWQ RQSQLLEDSD FRFQEPVMAL 600

RAVILEILLE KENESAKREC IKDVLTKHLV ELSKLARTAN NTQLPERAMF QIKQHNPTQY 660

GVSEWQLEEA QVFWAKKEES LALNILKELI KKLDANWFQN DPHLKLMYTE CLRLCGTWLA 720

ETCLENPTII MQKYLEKAVE IAASHRGDNR DELKKGKTKA FLSLARFSDN QYQRIENYMK 780

SSEFENKQAL LKKAKEEVGL LRERRVQTNR YTVKVQRELE LDECAIHALT EDRQRFLCKA 840

VENYISCLLS GEEHDMWIFR LCSLWLENSG VDRINEMMKK NAEKIPSYKF LPLMYQLAAR 900

MGTKMMGGLG FHEVLNNLMS RISLDHPHHT LFIILALANA NKDELLTKTD AKRINKLIKN 960

APKEISQLDV DRMEAARNII NIIRKRRAYM VRDVEALCDA YITLANVDAT PWKAQRGGIS 1020

IPADQPIIKL KNLEDVVVPT MEIKVDPTGR YENLVTVRSF KPEFHLAGGL NLPKIINCVG 1080

SDGKERRQLV KGRDDLRQDA VMQQVFQMCN TLLQQNTETR KRKLTIRRYK VVPLSQRSGV 1140

LEWCTGTTPI GEFLVNADKG AHKRYRPHDY SGFQCQKIMM DAQKKHSEEK YNIFMKVCDN 1200

FQPVFRYFCM EKFRDPAVWF EKRLAYTRSV ATSSIVGYIL GLGDRHVQNI LIDEQTAELV 1260

HIDLGVAFEQ GKILPTPETV PFRLTRDIVD GMGITGVEGV FRRCCEKTMA VMRNSQEALL 1320

TIVEVLLYDP LFDWTMNPLK ALYLQQRPED EADMSSTLGA DPRACKGKAS SDDQSFNKVA 1380

ERVLMRLQEK LKGVEEGTVL SVGGLVNLLI QQAMDPKNLS RLFPGWKPWV 1430

Nucleotide Sequence
(FASTA)

TATAAGGACC AGATGAAGGA CCTCCTGAAG ATTTTCAGGG AAAAACCAGA AGATTCTGTA 60

ATGGTGAAGC TCGTGGTGAG CTTACTGCAG CTGTCAAAGA TGGCAGTTAA TCATGCAGGT 120

GAAAAAGCAG TGCTGGAGGC TGTTGGAAGT TGCTTGGGAG AAATAGGCCC CATGGATTTC 180

TCCACCATCG CTCTTCAGCA TGCTGAAAAT GCACTGGATT CTAAAGCAGT GGACTTGCTT 240

GAAGATAGAA AGCTTCAGTG GGTCTTCATA ATGTTAACAC AAATAAATAC TGCTTTAACA 300

GATAATTGTA TTGATGTTAG ATCTGCTGCT GTTTCCTGTT TGAAAAACAT ATTAGCCACC 360

AATTCTGGCA GTGAATTTTG GGAAGTTTAT AAAAATAAAG GTGATCCCAT GTTAATCTAT 420

CTACAGCCTT TCAGAATGTC CAAGAAGAAG GTTTTGGCAA TGCCAGCTAA TGATTCAGAG 480

GCTTCTTCAG AAACTTTGGA TGACACAAAC CTGTGGATTC CTCTGGGAGA AAGTCATGAA 540

ACCTGGATCA AGAACTTAAC CCGTTCAATA CTGGACAGTG GAGGTGTACA AAATGAAGTT 600

CTCCAGTTAA TGAAGCCACT GTGTGAGGTG AAAACGGACT TGAGTCAAAC TTTGCTTCCG 660

TACCTGATTC ATGATATCCT TCTTCATGAT TCAAACGAAT CTTGGCGAAA TATTTTGTCG 720

GTTCACGTAC GGAAGTTTTT TACTGCCTGT TGCAGATTTG CCTCATCTAG TAGATCTGCT 780

ACACCACCAA ATTCTGACTC AGAGCAAGAA ACCCATGTGC TTAGAAGTTT GGATAAAGTA 840

TCTCGACGAA CCATGCTTGC TGTTGTTGAT TACTTAAGGA GGCAAAAAAG GTCTGTTTCA 900

GGTACAGTTT TTGATGACAG CTTCTGGCTA GATCTGAATT ATCTTGAGGT TGCTGTAGCA 960

GCACAGTCTT GTGCTGCCCA CTTCACAGCC CTGCTCTATG CAGAAATCTA CGCAGACAAG 1020

ATAAATATAG ACAAACAGCA AGAAAGTTTG ACATTTGAAG AAGAAAGTGA AAAATCAGCT 1080

ATTGCTATTT TGAATGAAAA AAGTAAAGAA ACTGGCATAA GTTTACAGGA CCTTCTCATG 1140

GACATATATA AAAGTATTGG AGAGCCTGAC AGTCTCTATG GTTGTGGTGG AGGAAGAATG 1200

TTACAGCCAT TAGCACGGAT AAGAACATAT GAGCATGAAG CAGTATGGGA TAAAGCTCTT 1260

CTAACATACG ACCTTGAGGC AACCCTCTCT CCATCTACTC GCCAAGCAGG GATAATTGAG 1320

GCTTTGCAGA ATTTTGGGCT TTGCCACACT CTTTCCATGT ATTTAAAAGG ACTGGAACAT 1380

GAAAACACTG AGTGGTGTGC AGAACTACAG GAAATACGCT ACCAGGCAGC ATGGAGGAAT 1440

ATGCAGTGGG ACAGCATCTC ATCTGTCAAG AATGAGACTG GTGGATCAGG GTACCACGAA 1500

TCATTGTATG ATGCTCTTCA GTCTTTACGA GATAAAGAAT TTTCTACCTT TTATGACACT 1560

CTTAAGGTTG CCAGGGTGAA TGAAGTGGAA GAGCTGTGCA AAGGCAGTCT CGAGTCTGTG 1620

TATACATTAT ATCCAAGTCT TTGCAGATTA CAGCTCGTTG GAGAGCTGGA AAATATAGGT 1680

CTGCTATTTT CCAGACCTGC TACAACTCAA CAACTGAATG ATGTTTATTC GAAATGGCAG 1740

AGACAGTCCC AGCTTCTTGA GGACAGTGAC TTCCGTTTCC AGGAACCTGT CATGGCTCTG 1800

CGCGCTGTAA TTCTGGAGAT CTTGCTTGAA AAGGAGAATG AAAGTGCCAA AAGAGAATGT 1860

ATTAAAGACG TTCTCACCAA ACATCTTGTG GAGCTCTCTA AATTGGCAAG AACTGCTAAT 1920

AATACGCAGC TTCCAGAAAG AGCTATGTTT CAGATCAAAC AACACAACCC CACACAATAT 1980

GGAGTTTCTG AATGGCAGCT AGAAGAAGCT CAGGTTTTCT GGGCTAAAAA GGAAGAGAGC 2040

CTTGCACTGA ATATTCTGAA AGAATTGATA AAAAAATTAG ATGCAAATTG GTTTCAGAAT 2100

GATCCTCACC TGAAATTGAT GTATACAGAG TGTCTGAGGC TATGTGGAAC CTGGTTAGCA 2160

GAAACATGTT TGGAAAACCC TACAATCATC ATGCAGAAAT ACTTAGAAAA GGCTGTGGAA 2220

ATTGCTGCAA GCCACCGTGG AGACAACAGA GATGAACTGA AGAAAGGAAA GACAAAGGCT 2280

TTCCTGTCTT TGGCTCGTTT CTCTGATAAT CAGTACCAGC GAATTGAGAA TTACATGAAA 2340

TCCTCGGAGT TTGAAAATAA GCAGGCATTA CTGAAGAAGG CCAAGGAGGA GGTTGGCCTC 2400

CTGAGGGAGC GTAGAGTTCA GACCAATAGA TATACAGTGA AGGTTCAGCG AGAGCTTGAG 2460

CTGGATGAAT GTGCCATCCA TGCCCTAACT GAGGATCGTC AGCGTTTCTT GTGTAAAGCA 2520

GTGGAGAACT ACATCAGCTG TTTGCTCAGT GGAGAGGAAC ATGATATGTG GATCTTCCGA 2580

CTATGTTCCC TATGGCTTGA AAATTCTGGA GTTGACAGAA TCAATGAAAT GATGAAGAAA 2640

AATGCAGAGA AAATCCCTTC TTACAAGTTT TTGCCTCTGA TGTACCAGCT GGCTGCTCGA 2700

ATGGGAACCA AGATGATGGG TGGTCTAGGA TTCCATGAAG TTCTGAATAA TCTAATGTCT 2760

AGGATTTCAC TGGATCACCC ACACCACACT TTGTTCATAA TACTGGCCTT GGCAAATGCT 2820

AACAAAGATG AACTCCTGAC AAAAACAGAT GCAAAAAGAA TAAATAAGCT AATTAAAAAT 2880

GCACCAAAAG AAATTTCACA GCTTGATGTG GACAGAATGG AGGCTGCTAG AAATATAATC 2940

AACATCATAA GAAAAAGGAG AGCTTACATG GTTAGAGATG TAGAAGCGCT TTGTGATGCT 3000

TACATCACAT TAGCAAATGT AGACGCTACT CCATGGAAAG CCCAAAGAGG AGGAATAAGT 3060

ATCCCAGCTG ACCAGCCAAT TATTAAACTG AAGAACCTGG AGGATGTTGT TGTTCCTACC 3120

ATGGAAATTA AGGTGGATCC CACAGGAAGA TACGAAAATT TGGTGACAGT AAGGTCTTTT 3180

AAGCCAGAAT TTCACTTAGC AGGAGGTCTG AATCTGCCAA AAATAATAAA TTGTGTAGGA 3240

TCAGATGGTA AAGAAAGGAG GCAGCTGGTG AAGGGCCGTG ATGATCTGAG ACAAGATGCT 3300

GTTATGCAGC AGGTTTTCCA GATGTGTAAC ACATTGCTCC AGCAGAACAC TGAAACACGG 3360

AAGAGAAAAT TAACCATCCG AAGATACAAG GTAGTTCCCC TTTCTCAGAG GAGTGGTGTG 3420

CTCGAGTGGT GCACGGGAAC AACCCCCATT GGGGAGTTCC TTGTGAATGC TGACAAGGGA 3480

GCCCACAAGA GATACAGGCC TCACGATTAC TCCGGTTTCC AGTGCCAGAA GATAATGATG 3540

GATGCACAAA AGAAACATTC TGAAGAGAAA TACAACATCT TCATGAAGGT CTGTGACAAT 3600

TTTCAACCTG TGTTTCGTTA TTTCTGCATG GAAAAATTCC GGGACCCAGC TGTGTGGTTT 3660

GAGAAGCGGT TGGCGTACAC TCGCAGTGTG GCTACGTCTT CTATAGTTGG CTACATCCTT 3720

GGACTTGGAG ACAGACATGT TCAAAATATC CTGATAGATG AACAAACTGC AGAACTGGTG 3780

CATATAGATT TGGGAGTTGC TTTTGAGCAA GGTAAAATCC TTCCCACACC AGAGACTGTT 3840

CCATTTAGAT TAACCAGGGA CATTGTGGAT GGAATGGGCA TTACTGGAGT AGAAGGAGTC 3900

TTCAGGAGAT GCTGTGAGAA AACAATGGCT GTCATGAGAA ATTCTCAGGA AGCTTTGCTG 3960

ACTATTGTAG AGGTGCTGCT CTATGATCCC CTTTTTGACT GGACCATGAA CCCCTTGAAA 4020

GCTTTATATC TGCAGCAGAG ACCAGAGGAC GAGGCTGACA TGAGCTCTAC TCTTGGTGCT 4080

GATCCACGAG CATGTAAAGG AAAGGCCAGC AGTGATGACC AGAGCTTTAA CAAGGTGGCT 4140

GAGCGCGTTC TCATGAGACT TCAGGAGAAG CTGAAGGGCG TTGAGGAGGG AACGGTGCTC 4200

AGCGTGGGAG GGCTAGTGAA CCTGCTCATA CAGCAGGCCA TGGACCCTAA AAACCTGAGC 4260

CGCCTCTTTC CTGGCTGGAA ACCCTGGGTG 4290

Domain Profile

S: 4     fderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdket  63

         f+++ ++   ++ pk +   Gsdgke+++Lvkg++Dlrqd++++q+f+++NtlL++++et

Q: 1060  FKPEFHLAGGLNLPKIINCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQQNTET  1119

         5666666666778999********************************************

S: 64    srrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdlstv  123

         ++rkL+ir+ykVvpls+rsg++ew+++t++++e+l   v+  +++++   +yr++d s +

Q: 1120  RKRKLTIRRYKVVPLSQRSGVLEWCTGTTPIGEFL---VNADKGAHK---RYRPHDYSGF  1173

         ***********************************...677888888...9*********

S: 124   qarkpklkhlkls....levfkevlenlvpkdllkklllekfpspeewfelrkaytrslA  179

         q++k +++++k++    +++f++v+ n++p  +++++++ekf +p++wfe+r aytrs+A

Q: 1174  QCQKIMMDAQKKHseekYNIFMKVCDNFQP--VFRYFCMEKFRDPAVWFEKRLAYTRSVA  1231

         **********9999999*************..9***************************

S: 180   vislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivn  239

         ++s+vgyiLgLgdrh++n+lid++t+e+vhid+gvafe++k+ l++pe+vPFRLTr+iv+

Q: 1232  TSSIVGYILGLGDRHVQNILIDEQTAELVHIDLGVAFEQGKI-LPTPETVPFRLTRDIVD  1290

         ******************************************.*****************

S: 240   algvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk......kkktsket  293

         ++g+tgveGvfr++ce+++ v+r+s+e llti+ev+lydpl+dw++      + ++++e+

Q: 1291  GMGITGVEGVFRRCCEKTMAVMRNSQEALLTIVEVLLYDPLFDWTMnplkalYLQQRPED  1350

         ****************************************************9*******

S: 294   eeelaekakaealkikkllskvekaenavatrdlllle  331

         e +++++  a+   +k + s  ++++n+va+r+l++l+

Q: 1351  EADMSSTLGADPRACKGKASSDDQSFNKVAERVLMRLQ  1388

         ********************************999987

Domain Sequence
(FASTA)

FKPEFHLAGG LNLPKIINCV GSDGKERRQL VKGRDDLRQD AVMQQVFQMC NTLLQQNTET 60

RKRKLTIRRY KVVPLSQRSG VLEWCTGTTP IGEFLVNADK GAHKRYRPHD YSGFQCQKIM 120

MDAQKKHSEE KYNIFMKVCD NFQPVFRYFC MEKFRDPAVW FEKRLAYTRS VATSSIVGYI 180

LGLGDRHVQN ILIDEQTAEL VHIDLGVAFE QGKILPTPET VPFRLTRDIV DGMGITGVEG 240

VFRRCCEKTM AVMRNSQEAL LTIVEVLLYD PLFDWTMNPL KALYLQQRPE DEADMSSTLG 300

ADPRACKGKA SSDDQSFNKV AERVLMRLQ 329

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000781	; C:chromosome, telomeric region
GO:0005819	; C:spindle
GO:0016303	; F:1-phosphatidylinositol-3-kinase activity
GO:0005524	; F:ATP binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0007050	; P:cell cycle arrest
GO:0071480	; P:cellular response to gamma radiation
GO:0006975	; P:DNA damage induced protein phosphorylation
GO:0006281	; P:DNA repair
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0071044	; P:histone mRNA catabolic process
GO:0016572	; P:histone phosphorylation
GO:0008630	; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0042159	; P:lipoprotein catabolic process
GO:0007094	; P:mitotic cell cycle spindle assembly checkpoint
GO:0043066	; P:negative regulation of apoptotic process
GO:0030889	; P:negative regulation of B cell proliferation
GO:0051402	; P:neuron apoptotic process
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525	; P:positive regulation of neuron apoptotic process
GO:0090399	; P:replicative senescence
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR021668	; TAN.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF11640	; TAN; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013