EKS-MIM-00032

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MIM-00032

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	320.6	6.7E-96	6	290	285

Status

Unreviewed

Ensembl Protein

ENSMICP00000003449

Gene Name

CDK4

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMICG00000003789	ENSMICP00000003449	ENSMICT00000003783

Organism

Microcebus murinus

Protein Length

298

Protein Sequence
(FASTA)

MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGAGGGLP ISTVREVALL 60

RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHIDQDL RTYLDKAPPP GLPAETIKDL 120

MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY 180

RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR 240

DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLNPHKRIS AFRALQHSYL RKDEGNPE 298

Nucleotide Sequence
(FASTA)

ATGGCTACCT CTCGATATGA GCCAGTGGCT GAAATTGGCG TCGGTGCCTA TGGGACGGTG 60

TACAAGGCCC GTGATCCCCA CAGTGGCCAC TTTGTGGCCC TCAAGAGTGT AAGAGTGCCT 120

AATGGAGGAG GAGCTGGAGG GGGCCTTCCC ATCAGCACAG TTCGAGAGGT GGCCTTACTA 180

AGGCGGCTGG AGGCTTTTGA GCACCCCAAT GTTGTTCGGC TGATGGACGT CTGTGCCACA 240

TCCCGAACTG ACCGAGAGAT CAAGGTAACC TTGGTGTTTG AGCATATAGA CCAAGACCTA 300

AGAACTTATC TGGACAAGGC ACCCCCTCCA GGTTTGCCAG CGGAGACCAT CAAGGATCTG 360

ATGCGCCAGT TTCTAAGAGG CCTTGATTTT CTGCATGCTA ATTGCATCGT TCACCGAGAT 420

CTGAAGCCAG AAAACATTCT AGTGACAAGT GGTGGGACAG TGAAGCTGGC TGACTTTGGC 480

CTGGCCAGAA TCTACAGCTA CCAGATGGCA CTTACACCCG TGGTTGTTAC ACTCTGGTAC 540

CGTGCTCCAG AAGTTCTTCT GCAGTCTACA TATGCAACAC CTGTGGACAT GTGGAGCGTT 600

GGCTGTATCT TTGCAGAGAT GTTTCGTCGA AAGCCTCTCT TCTGTGGAAA CTCTGAAGCT 660

GACCAGTTGG GCAAAATCTT TGACCTGATT GGGCTGCCTC CAGAGGACGA CTGGCCCAGA 720

GATGTCTCTC TACCCCGAGG TGCCTTTCCC CCAAGAGGTC CCCGCCCAGT GCAGTCGGTG 780

GTGCCCGAGA TGGAGGAGTC TGGAGCACAG CTGCTGCTGA ACCCACACAA GCGAATTTCT 840

GCCTTCCGAG CTCTGCAGCA CTCTTATCTA CGTAAGGATG AAGGTAATCC GGAGTGA 897

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkel..  55

         ye +++ig G+yg+vyka+d ++g++vAlK++r+ +      g+pi+++rE++ll++l

Q: 6     YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGaggGLPISTVREVALLRRLea  65

         88899*****************************99874444***************988

S: 56    .khknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqll  110

          +h+n+v+L++v+a     ++ k++Lvfe+++qdL ++l+k +  +l+ e++k l++q+l

Q: 66    fEHPNVVRLMDVCAtsrtDREIKVTLVFEHIDQDLRTYLDKAPPPGLPAETIKDLMRQFL  125

         89************887444589*************************************

S: 111   eglaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPe  170

         +gl++lH+n i+HRDlKp+N+L+++ g++klaDfGlar +s ++  +t++vvTlwYraPe

Q: 126   RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYRAPE  184

         ******************************************999.**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         +Ll+++ Y t vD+Wsvgci+ae+++rkplf g+se dql +if+l+g p e++wp+  +

Q: 185   VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS  243

         ***985.*****************************************************

S: 231   lpeykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp+    fp++ ++ ++++v++++e++ +ll     l+p+kRisa +alqh+y+

Q: 244   LPRGA--FPPRGPRPVQSVVPEMEESGAQLL-----LNPHKRISAFRALQHSYL  290

         ***65..******************999987.....79**************96

Domain Sequence
(FASTA)

YEPVAEIGVG AYGTVYKARD PHSGHFVALK SVRVPNGGGA GGGLPISTVR EVALLRRLEA 60

FEHPNVVRLM DVCATSRTDR EIKVTLVFEH IDQDLRTYLD KAPPPGLPAE TIKDLMRQFL 120

RGLDFLHANC IVHRDLKPEN ILVTSGGTVK LADFGLARIY SYQMALTPVV VTLWYRAPEV 180

LLQSTYATPV DMWSVGCIFA EMFRRKPLFC GNSEADQLGK IFDLIGLPPE DDWPRDVSLP 240

RGAFPPRGPR PVQSVVPEME ESGAQLLLNP HKRISAFRAL QHSYL 285

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>