EKS-MIM-00017

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MIM-00017

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	423.6	2.3E-127	53	305	253

Status

Unreviewed

Ensembl Protein

ENSMICP00000007127

Gene Name

PLK1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMICG00000007827	ENSMICP00000007127	ENSMICT00000007831

Organism

Microcebus murinus

Protein Length

604

Protein Sequence
(FASTA)

MSAAATAGKL ARAQTDPAKA GVPGVAAPGA PAAAPPAKEI PEVLVDPRSR RRYVRGRFLG 60

KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQKEKMSM EISIHRSLAH QHVVGFHGFF 120

EDNDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG 180

NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI 240

MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTINELL 300

NDEIFTSGYI PARLPITCLT MPPRFSIAPS TLDPSNRKPL TVLNKGMENP LPERPREKEE 360

PVVRETGEVV DCHLGDLLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK 420

YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLSVSSHPN SLLKKITLLK 480

YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGSV QINFFQDHTK 540

LILCPLMAAV TYIDEKRDFR TYRLSLLEEY GCCKELASRL RYARTMVDKL LSSRSATNRL 600

KASS 604

Nucleotide Sequence
(FASTA)

ATGAGTGCAG CGGCGACTGC AGGGAAGCTG GCACGGGCGC AGACCGACCC AGCCAAAGCT 60

GGGGTCCCTG GAGTTGCAGC TCCTGGGGCC CCGGCGGCCG CTCCACCGGC GAAAGAGATC 120

CCAGAGGTCC TAGTGGACCC ACGCAGCCGG CGGCGCTATG TGCGGGGGCG CTTTTTGGGC 180

AAGGGCGGCT TCGCCAAGTG CTTCGAGATC TCGGACGCAG ACACCAAGGA GGTGTTCGCA 240

GGCAAGATCG TGCCTAAGTC TCTGCTGCTC AAGCCGCACC AGAAGGAAAA GATGTCCATG 300

GAGATTTCCA TTCACCGCAG CCTTGCCCAC CAGCACGTCG TAGGCTTCCA TGGCTTTTTC 360

GAGGACAACG ACTTTGTGTT CGTGGTGTTG GAGCTCTGCC GCCGGCGGTC TCTCCTGGAG 420

CTGCACAAGA GGAGGAAAGC CCTGACCGAG CCTGAGGCCC GATACTACCT GAGGCAAATC 480

GTGCTTGGTT GCCAGTACCT GCACCGAAAC CGAGTTATTC ATCGGGACCT CAAGCTGGGC 540

AACCTCTTCC TGAATGAGGA CCTGGAGGTG AAAATAGGGG ATTTTGGACT GGCAACCAAA 600

GTCGAATATG ATGGGGAGCG GAAGAAGACT CTGTGTGGGA CTCCTAATTA CATAGCTCCT 660

GAGGTGCTGA GCAAGAAAGG GCACAGTTTC GAGGTGGATG TGTGGTCCAT TGGGTGCATC 720

ATGTATACCT TGTTAGTGGG CAAACCACCT TTTGAGACCT CTTGCCTAAA AGAGACCTAC 780

CTCCGGATCA AAAAGAATGA ATACAGTATT CCCAAGCACA TCAACCCTGT GGCAGCCTCC 840

CTCATCCAGA AGATGCTTCA GACAGATCCC ACTGCCCGCC CAACCATTAA TGAGCTGCTC 900

AATGACGAGA TCTTTACTTC TGGCTACATC CCTGCCCGGC TCCCCATCAC CTGCCTCACC 960

ATGCCACCGA GGTTTTCAAT CGCTCCCAGC ACCCTGGACC CCAGCAACCG GAAACCCCTC 1020

ACAGTCCTCA ATAAAGGCAT GGAGAACCCC CTGCCTGAGC GTCCCCGGGA GAAAGAGGAA 1080

CCAGTGGTTC GAGAGACGGG TGAGGTTGTC GACTGCCACC TTGGTGACTT GCTGCAGCAG 1140

CTACACAGTG TCAATGCTTC CAAGCCCTCA GAGAGAGGGC TGGTGAGGCA AGAGGAGGCT 1200

GAGGATCCCG CCTGCATCCC CATCTTCTGG GTCAGCAAGT GGGTGGACTA TTCGGATAAG 1260

TACGGCCTCG GGTACCAGCT GTGTGACAAC AGCGTGGGGG TTCTCTTCAA TGACTCAACA 1320

CGGCTTATCC TCTACAACGA CGGTGACAGC CTGCAGTACA TCGAGCGTGA CGGCACTGAG 1380

TCCTACCTCA GTGTGAGTTC CCATCCCAAC TCCTTATTGA AGAAGATCAC CCTCCTTAAG 1440

TATTTCCGAA ATTACATGAG CGAACACTTG TTGAAAGCGG GTGCCAACAT CACACCACGG 1500

GAAGGCGACG AGCTAGCCCG GCTTCCCTAC CTGCGTACCT GGTTCCGCAC CCGCAGCGCT 1560

ATCATCCTGC ACCTCAGCAA TGGCAGTGTG CAGATCAACT TCTTCCAGGA CCATACCAAA 1620

CTCATCTTGT GCCCGCTGAT GGCAGCTGTG ACCTACATTG ATGAGAAGCG TGACTTCCGC 1680

ACGTACCGTC TGAGCCTCCT GGAGGAGTAC GGCTGTTGCA AGGAGCTGGC CAGCCGGCTG 1740

CGCTACGCCC GCACCATGGT GGACAAGCTG CTGAGCTCGC GCTCGGCCAC CAACCGCCTC 1800

AAGGCCTCCT CA 1812

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakc+e++d++tkevfa k+vpksll k++q+ek+++ei+ihrsl+h++

Q: 53    YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQH  112

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ ffed+++v++vlelc+rrsl el+krrkaltepe+ryylrqiv g++ylh++r+

Q: 113   VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV  172

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlflne+levkigdfGlat++e+++erkktlcGtPnyiaPevlskkghs+ev

Q: 173   IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEV  232

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+Ws+Gci+ytllvGkPPfet++lkety +ikk+eys+P+++++ a+sli+k+l+++P++

Q: 233   DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTA  292

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++e+l+de +

Q: 293   RPTINELLNDEIF  305

         ********99865

Domain Sequence
(FASTA)

YVRGRFLGKG GFAKCFEISD ADTKEVFAGK IVPKSLLLKP HQKEKMSMEI SIHRSLAHQH 60

VVGFHGFFED NDFVFVVLEL CRRRSLLELH KRRKALTEPE ARYYLRQIVL GCQYLHRNRV 120

IHRDLKLGNL FLNEDLEVKI GDFGLATKVE YDGERKKTLC GTPNYIAPEV LSKKGHSFEV 180

DVWSIGCIMY TLLVGKPPFE TSCLKETYLR IKKNEYSIPK HINPVAASLI QKMLQTDPTA 240

RPTINELLND EIF 253

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>