EKS-MYL-00196

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00196

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	480.1	1.7E-144	321	590	270

Status

Unreviewed

Ensembl Protein

ENSMLUP00000000374

UniProt Accession

G1NT88;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK1

Gene Synonyms/Alias

LIMK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000000411	ENSMLUP00000000374	ENSMLUT00000000410

Organism

Myotis lucifugus

Functional Description

Protein Length

633

Protein Sequence
(FASTA)

GSELPVCASC GQRIYDGQYL QALNTDWHAD CFRCCECSAP LSHQYYEKDG QLFCKKDYWA 60

RYGESCHGCS EHITKGLVMV AGELKYHPEC FICLTCGTFI GDGDTYTLVE HSKLYCGHCY 120

YQTVVTPVIE QILPDSPGSH LPHTVTLVSI PATAHGKRGL SVSIDPPHGP PGCGTEHSHT 180

VRVQGVDPGC MSPDVKNSIH VGDRILEING TPIRNVPLDE IDLLIQETSR LLQLTLEHDP 240

HDTLGHVAGP EPSPLGSPAH TPSGEAGSSA RQKPVLRSYS IDRSPGAGSL GSPASQCRDL 300

GRSESLRVVC RPHRIFRPSD LIHGEVLGKG CFGQAIKVTH RETGEVMVMK ELIRFDEETQ 360

RTFLKEVKVM RCLEHPNVLK FIGVLYKDKR LNFITEYIKG GTLRGIIKSM DSQYPWSQRV 420

SFAKDIASGM AYLHSMNIIH RDLNSHNCLV RENKNVVVAD FGLARLMVDE KTQPEDQPED 480

LRSLKKPDRK KRYTVVGNPY WMAPEMINGR SYDEKVDVFS FGIVLCEIIG RVNADPDYLP 540

RTMDFGLNVR GFLDRYCPPN CPPSFFPITV RCCDLDPEKR PSFVKLEQWL ETLRMHLAGH 600

LPLGSQLEQL DRGFWETYRR GESGLPAHPE VPD 633

Nucleotide Sequence
(FASTA)

GGAAGCGAGT TGCCCGTGTG TGCAAGCTGC GGCCAGAGGA TCTATGATGG CCAGTACCTC 60

CAGGCCCTGA ACACTGACTG GCACGCAGAT TGCTTCAGGT GTTGTGAATG CAGCGCGCCC 120

CTCTCACACC AGTACTATGA GAAGGATGGG CAGCTCTTCT GCAAGAAAGA CTATTGGGCC 180

CGCTATGGCG AATCTTGCCA CGGATGCTCG GAACACATCA CCAAGGGGCT GGTCATGGTG 240

GCGGGGGAGC TGAAGTACCA CCCCGAGTGC TTCATCTGCC TCACGTGTGG GACCTTCATT 300

GGTGACGGGG ACACCTACAC GCTGGTGGAA CACTCCAAGC TGTACTGCGG GCACTGCTAC 360

TACCAGACTG TGGTGACCCC CGTCATCGAG CAGATCCTGC CCGACTCCCC CGGCTCTCAC 420

CTGCCCCACA CCGTCACCCT CGTCTCCATC CCAGCCACAG CTCATGGCAA ACGTGGCCTT 480

TCAGTCTCCA TCGACCCACC TCATGGCCCG CCAGGTTGTG GCACGGAGCA CTCCCACACC 540

GTCCGTGTCC AAGGCGTGGA CCCAGGCTGC ATGAGCCCAG ATGTGAAGAA CTCCATCCAT 600

GTTGGAGACC GGATCCTGGA GATCAATGGC ACACCCATTC GGAACGTGCC CCTGGATGAG 660

ATTGATCTGC TGATCCAGGA AACCAGCCGC CTGCTCCAGC TGACTCTTGA GCACGACCCC 720

CACGACACGC TGGGCCATGT GGCAGGCCCT GAGCCCAGCC CCCTGGGCTC CCCAGCTCAC 780

ACTCCCAGTG GAGAGGCCGG CAGCTCTGCC CGGCAGAAAC CTGTCCTGAG GAGCTACAGC 840

ATCGACAGAT CTCCGGGTGC CGGCTCACTG GGCTCCCCTG CCTCCCAGTG CAGGGACCTG 900

GGACGCTCCG AGTCCCTTCG CGTGGTTTGC CGGCCACACC GCATCTTCCG GCCGTCGGAC 960

CTCATCCACG GGGAGGTGTT GGGCAAGGGC TGCTTCGGCC AGGCCATCAA GGTGACACAC 1020

CGGGAGACGG GTGAGGTGAT GGTGATGAAG GAGCTGATCC GGTTCGACGA GGAGACGCAG 1080

AGGACATTTC TCAAGGAGGT GAAGGTCATG CGATGCCTGG AGCATCCCAA TGTGCTCAAG 1140

TTCATCGGGG TGCTCTACAA GGACAAGAGG CTCAACTTCA TCACCGAGTA CATCAAGGGG 1200

GGCACACTGC GGGGCATCAT CAAGAGCATG GACAGCCAGT ACCCGTGGAG TCAGAGGGTG 1260

AGCTTTGCCA AGGACATTGC TTCGGGGATG GCCTACCTCC ACTCCATGAA CATCATCCAC 1320

CGGGACCTCA ACTCCCACAA CTGCCTGGTC CGTGAGAACA AGAACGTGGT GGTGGCTGAC 1380

TTTGGGTTGG CGCGGCTCAT GGTGGATGAG AAGACTCAGC CTGAAGACCA GCCTGAAGAC 1440

CTGCGGAGCC TCAAGAAGCC AGACCGGAAA AAGCGCTACA CAGTGGTAGG CAACCCCTAC 1500

TGGATGGCGC CCGAGATGAT CAATGGCCGA AGCTATGATG AGAAGGTGGA TGTATTTTCC 1560

TTTGGAATCG TCCTGTGCGA GATCATCGGG CGGGTGAACG CTGACCCCGA CTACCTGCCT 1620

CGCACCATGG ACTTTGGCCT CAATGTGCGA GGCTTCCTGG ACCGCTATTG CCCCCCAAAC 1680

TGCCCCCCGA GCTTCTTCCC CATTACCGTG CGCTGCTGTG ATCTGGACCC TGAGAAGAGG 1740

CCCTCTTTCG TGAAGCTGGA GCAATGGTTG GAGACCCTCC GCATGCACTT GGCCGGCCAC 1800

CTGCCACTAG GCTCACAGCT GGAGCAGCTG GACAGGGGCT TCTGGGAGAC CTACAGGCGT 1860

GGCGAAAGTG GACTGCCTGC CCACCCCGAG GTCCCTGACT GA 1902

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkG+f++++kvthr++Gevmv+kelir+dee+++++lkevk++r+lehpnvlk

Q: 321   LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLK  380

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiih  119

         fiGvl+kdk+l+++teyi+gGtl+ ++ks++s +pw+qrv++akdiasG++ylhs++iih

Q: 381   FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSqYPWSQRVSFAKDIASGMAYLHSMNIIH  440

         ******************************999***************************

S: 120   rdlnsknclvredksvvvadfGlarlvveerkks....eklrslkkkdrkkrltvvGsPy  175

         rdlns+nclvre+k+vvvadfGlarl+v+e++++    e+lrslkk drkkr+tvvG+Py

Q: 441   RDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPedqpEDLRSLKKPDRKKRYTVVGNPY  500

         *******************************9987777999*******************

S: 176   wmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaed  235

         wmaPe+++g+sydekvdvfsfGivlceii+rv+adPdylPrt+dfgl+v+ f +++++ +

Q: 501   WMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPN  560

         ************************************************************

S: 236   cPeaflklavvccdldpesrpsfeelekkl  265

         cP++f++++v+ccdldpe+rpsf++le++l

Q: 561   CPPSFFPITVRCCDLDPEKRPSFVKLEQWL  590

         ****************************97

Domain Sequence
(FASTA)

LIHGEVLGKG CFGQAIKVTH RETGEVMVMK ELIRFDEETQ RTFLKEVKVM RCLEHPNVLK 60

FIGVLYKDKR LNFITEYIKG GTLRGIIKSM DSQYPWSQRV SFAKDIASGM AYLHSMNIIH 120

RDLNSHNCLV RENKNVVVAD FGLARLMVDE KTQPEDQPED LRSLKKPDRK KRYTVVGNPY 180

WMAPEMINGR SYDEKVDVFS FGIVLCEIIG RVNADPDYLP RTMDFGLNVR GFLDRYCPPN 240

CPPSFFPITV RCCDLDPEKR PSFVKLEQWL 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 2.
PS50023	; LIM_DOMAIN_2; 2.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013