EKS-MYL-00301

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00301

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	453.6	1.8E-136	708	964	257

Status

Unreviewed

Ensembl Protein

ENSMLUP00000000741

UniProt Accession

G1NU59;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB3

Gene Synonyms/Alias

ERBB3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000000801	ENSMLUP00000000741	ENSMLUT00000000810

Organism

Myotis lucifugus

Functional Description

Protein Length

1337

Protein Sequence
(FASTA)

MRAQRALQVL GFLLSLARGS EVGNSQSVCP GTLNGLSVTG DAENQYQTLH KQYERCEVVM 60

GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 120

LNYNTNSSHA LRQLGFTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG 180

RSCEPCHEVC KGRCWGPGPK DCQTLTKTIC APQCNGHCFG PDPNQCCHDE CAGGCSGPQD 240

TDCFACRLFN DSGACVRQCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS 300

CVRACPPDKM EVDKNGLKIC EPCGGLCPKA CEGTGSGSRY QTVDSSNIDG FVNCTKILGN 360

LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420

RSLYNRGFSL LIMKNLNITS LGFRSLKEIS AGRIYISANR QLCYHHSLNW TRLLRGPSEE 480

RLDIKHNRLR RDCVAEGKVC DPLCSGGCWG PGPGQCLSCR NYSRGGVCVT HCNFLNGEPR 540

EFAHEAECFP CHPECQPMEG TATCNGSGSD ACAQCAHFRD GPHCVSSCPS GVLGAKGPIY 600

KFPDAQNECR PCHENCTRGC NGPDLQDCLG QTQAMISKTH LAMALTVVVG LLVIFVILGS 660

TILYLRGRRI QNKRAMRRYL ERGESIEPLD PSEKANKVLA RVFKETELRK LKVLGSGVFG 720

TVHKGVWIPE GESIKIPVCI KVIEDKSGRQ SFQAVTDHML AIGSLDHAHI VRLLGLCPGS 780

SLQLVTQYLP LGSLLDHVRQ HRGSLGPQLL LNWGVQIAKG MYYLEEHGMV HRNLAARNVL 840

LKSTSQVQVA DFGVADLLPP DDKQLLHSEA KTPIKWMALE SIHFGKYTHQ SDVWSYGVTV 900

WELMTFGAEP YAGLRLAEVP DLLEKGERLA QPQICTIDVY MVMVKCWMID ENIRPTFKEL 960

ANEFTRMARD PPRYLVIKRE SGPGIPPGAE PPALTNKELE EVELEPELDL DLDLEAEEDN 1020

LATTLGSALS LPVGTLTWPR GSQSLTSPSS GYMPMNQSNL GEACQEPIVC GGERCPRPAS 1080

LHPMPRGRLV SESSEGHVTG SEAELQEKVS MCRSRSRSPR PRGDSAYHSQ RHSLLTPVTP 1140

LSPPGLEEED VNGYVMPDAH LKGTPSSREG TLSSVGLSSV LGTEEEDEDE EYEYMNRRRR 1200

HSPPRPPRPG SLEELGYEYM DVGSDLSASL GSTQSCPLHP VPIIPTPGTT PDEDYEYMNK 1260

RRGGGGAGGD YAAMGACPAA EQGYEEMKAF QGPGHHAPQV HYTRLKTLRS LEATDSAFDN 1320

PDYWHSRLFP KANAQRT 1337

Nucleotide Sequence
(FASTA)

ATGAGGGCGC AGCGGGCTCT GCAGGTGCTG GGCTTCCTCC TCAGCCTGGC CCGGGGCTCC 60

GAGGTGGGCA ACTCGCAGTC AGTGTGTCCC GGGACTTTGA ATGGTCTGAG TGTGACCGGC 120

GATGCTGAGA ACCAATACCA GACGCTGCAC AAGCAGTACG AGAGGTGTGA GGTGGTGATG 180

GGGAACCTGG AGATTGTGCT CACAGGACAC AACGCTGACC TCTCCTTCCT GCAGTGGATT 240

CGAGAAGTGA CCGGCTATGT CCTTGTGGCC ATGAACGAGT TCTCCACGCT GCCCCTGCCC 300

AACCTCCGCG TGGTGCGGGG CACCCAGGTG TACGACGGGA AGTTTGCCAT CTTCGTCATG 360

TTGAACTACA ACACCAACTC CAGCCACGCT CTGCGCCAGC TCGGCTTCAC CCAGCTCACA 420

GAGATTCTGT CAGGGGGCGT GTATATTGAG AAGAATGATA AGCTCTGTCA CATGGACACC 480

ATTGACTGGA GGGACATCGT GAGGGACCGA GACGCCGAGA TCGTGGTGAA GGACAATGGC 540

AGGAGCTGTG AGCCGTGTCA TGAGGTCTGC AAGGGGCGAT GCTGGGGTCC CGGACCAAAA 600

GACTGCCAGA CATTGACCAA GACCATCTGT GCGCCTCAGT GTAATGGTCA CTGCTTCGGG 660

CCCGACCCCA ACCAGTGCTG CCATGATGAG TGTGCAGGGG GCTGCTCAGG CCCTCAGGAC 720

ACCGACTGCT TTGCCTGCCG GCTCTTCAAT GACAGTGGAG CCTGTGTACG CCAGTGTCCA 780

CAGCCTCTTG TCTACAACAA GCTGACTTTC CAGCTGGAAC CCAATCCTCA CACCAAGTAT 840

CAGTATGGAG GAGTTTGTGT AGCCAGCTGT CCCCACAACT TCGTGGTGGA TCAGACGTCG 900

TGTGTCAGGG CCTGTCCTCC TGACAAGATG GAAGTGGATA AAAACGGACT CAAGATATGT 960

GAACCTTGTG GGGGGCTGTG CCCCAAAGCT TGTGAGGGGA CCGGCTCGGG GAGCCGATAC 1020

CAGACTGTGG ACTCGAGCAA CATTGATGGA TTTGTGAACT GCACCAAGAT CCTGGGCAAC 1080

CTGGACTTTC TCATCACTGG CCTCAATGGA GACCCTTGGC ACAAGATCCC TGCCTTGGAC 1140

CCTGAGAAGC TCAATGTCTT CCGGACAGTA CGGGAGATCA CTGGCTACCT GAACATTCAG 1200

TCCTGGCCTC CCCACATGCA CAACTTTAGT GTCTTTTCCA ACCTGACGAC CATCGGGGGC 1260

AGAAGCCTCT ACAACCGGGG CTTCTCATTG TTGATCATGA AGAACTTGAA CATAACATCT 1320

CTGGGCTTCC GATCCTTGAA AGAAATAAGT GCTGGGCGTA TCTACATAAG TGCCAATCGG 1380

CAGCTCTGCT ACCACCATTC TCTTAACTGG ACCAGGCTGC TTCGAGGGCC TTCTGAAGAG 1440

AGACTAGACA TCAAGCATAA CCGGCTCCGC AGAGACTGCG TGGCAGAGGG CAAGGTGTGT 1500

GACCCACTCT GCTCTGGGGG ATGCTGGGGC CCAGGCCCTG GGCAGTGCCT ATCCTGTCGA 1560

AACTACAGCC GAGGAGGTGT CTGTGTGACC CACTGCAACT TTCTAAATGG GGAGCCTCGT 1620

GAGTTTGCCC ACGAGGCTGA ATGCTTCCCC TGCCACCCGG AATGCCAGCC CATGGAGGGC 1680

ACTGCCACAT GCAATGGCTC GGGCTCTGAT GCTTGTGCCC AGTGTGCCCA TTTTCGAGAT 1740

GGGCCCCACT GTGTGAGCAG CTGCCCCTCT GGAGTGCTGG GTGCCAAGGG CCCCATCTAC 1800

AAGTTCCCAG ATGCTCAGAA TGAATGTCGG CCCTGCCATG AGAACTGCAC CCGGGGGTGT 1860

AATGGGCCTG ACCTGCAGGA CTGTTTAGGC CAAACACAGG CGATGATCAG CAAAACGCAC 1920

TTGGCGATGG CTTTGACAGT GGTAGTAGGA TTGCTAGTGA TTTTCGTCAT CCTGGGCAGC 1980

ACTATCCTCT ATTTGCGTGG GCGTCGGATT CAGAATAAGA GGGCTATGAG GCGCTACTTG 2040

GAACGGGGTG AGAGCATAGA GCCTCTGGAT CCCAGTGAGA AGGCTAACAA AGTCTTGGCG 2100

AGAGTCTTCA AGGAGACAGA GCTGAGGAAG CTTAAAGTAC TTGGCTCAGG CGTCTTTGGA 2160

ACCGTGCACA AGGGCGTGTG GATTCCTGAG GGCGAATCAA TAAAGATCCC AGTCTGCATT 2220

AAAGTCATTG AGGATAAGAG TGGACGGCAA AGTTTTCAAG CTGTGACGGA TCATATGCTG 2280

GCCATTGGCA GCCTAGACCA CGCTCACATT GTACGGCTGC TGGGACTGTG CCCAGGGTCA 2340

TCTCTGCAGC TTGTCACTCA ATACTTGCCT CTGGGATCCC TGCTGGATCA TGTGAGACAG 2400

CACCGGGGGT CCCTGGGGCC ACAGTTGCTG CTCAATTGGG GAGTACAAAT TGCCAAGGGT 2460

ATGTACTACC TTGAGGAGCA TGGTATGGTT CATAGGAACT TGGCTGCCCG AAATGTGCTA 2520

CTCAAGTCAA CCAGTCAGGT CCAGGTGGCA GATTTTGGGG TGGCTGACCT GCTGCCCCCT 2580

GATGATAAAC AGCTACTACA CAGTGAGGCC AAGACTCCAA TTAAGTGGAT GGCCCTCGAG 2640

AGTATCCACT TTGGGAAATA CACACACCAG AGTGACGTCT GGAGCTACGG TGTGACGGTT 2700

TGGGAGCTGA TGACTTTTGG GGCAGAGCCC TATGCAGGGC TGCGGTTGGC TGAAGTACCA 2760

GACCTGCTGG AGAAGGGGGA GCGGTTGGCA CAGCCCCAGA TCTGTACCAT TGATGTCTAC 2820

ATGGTCATGG TCAAGTGTTG GATGATTGAT GAGAACATTC GCCCAACCTT TAAAGAACTA 2880

GCCAATGAGT TCACCAGGAT GGCCCGAGAC CCACCGCGGT ATCTGGTCAT AAAGAGAGAG 2940

AGTGGACCTG GAATTCCCCC TGGGGCGGAG CCACCTGCTC TGACAAACAA GGAACTGGAG 3000

GAAGTAGAGC TGGAGCCAGA ACTAGACCTA GACCTGGACT TGGAGGCAGA GGAGGACAAC 3060

CTGGCGACAA CCCTAGGCTC TGCCCTCAGC CTGCCAGTTG GAACGCTTAC TTGGCCACGT 3120

GGGAGCCAGA GCCTTACAAG TCCATCATCT GGATATATGC CTATGAACCA GAGTAATCTT 3180

GGGGAAGCTT GCCAGGAGCC TATAGTTTGT GGGGGTGAAC GGTGCCCCCG TCCAGCCTCT 3240

CTGCACCCAA TGCCACGGGG ACGCCTGGTA TCAGAGTCAT CTGAGGGCCA CGTGACAGGC 3300

TCTGAAGCTG AGCTCCAGGA GAAGGTGTCC ATGTGTAGAA GCCGGAGCCG GAGCCCGCGG 3360

CCACGTGGAG ACAGTGCCTA CCATTCCCAG CGCCATAGCC TGCTTACTCC TGTCACCCCA 3420

CTCTCCCCAC CAGGGTTAGA GGAAGAGGAT GTGAATGGTT ATGTCATGCC AGATGCACAC 3480

CTCAAAGGTA CTCCATCCTC TCGGGAAGGC ACCCTTTCTT CTGTGGGTCT CAGTTCTGTC 3540

CTGGGCACCG AAGAAGAAGA TGAAGATGAG GAGTATGAAT ACATGAACCG GAGGAGAAGG 3600

CACAGTCCAC CTCGTCCCCC AAGGCCAGGT TCCCTCGAGG AGCTGGGTTA TGAGTACATG 3660

GATGTGGGAT CAGACCTCAG TGCTTCCCTG GGCAGCACAC AGAGTTGCCC ACTCCACCCT 3720

GTGCCCATCA TACCTACTCC TGGCACAACT CCTGACGAGG ACTATGAATA TATGAATAAG 3780

CGACGTGGAG GAGGAGGTGC TGGGGGGGAT TATGCAGCCA TGGGGGCCTG CCCAGCAGCT 3840

GAACAAGGGT ATGAAGAGAT GAAAGCCTTC CAGGGGCCTG GACACCATGC TCCCCAAGTC 3900

CATTATACCC GCCTCAAAAC TCTACGCAGC TTAGAAGCCA CCGACTCTGC CTTTGACAAC 3960

CCGGATTACT GGCATAGCAG GCTTTTCCCC AAGGCTAATG CCCAGAGAAC ATAA 4014

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+klkvlGsG+fGtv+kG+wipege++kipv+ikv+e+k+g++++++++d++l+++sldh

Q: 708   LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDH  767

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         a++vrllglc  s+lqlvtq+lplG+lld+vr+h+++lG+q llnw+vqiakGm+ylee+

Q: 768   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGSLGPQLLLNWGVQIAKGMYYLEEH  827

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

          +vhr+laarnvl+ks ++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky

Q: 828   GMVHRNLAARNVLLKSTSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  887

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGa+py+g++++e+pdllekGerlaqp+ictidvymv+vkcw

Q: 888   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW  947

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+++rp+fkela+ef

Q: 948   MIDENIRPTFKELANEF  964

         ****************9

Domain Sequence
(FASTA)

LRKLKVLGSG VFGTVHKGVW IPEGESIKIP VCIKVIEDKS GRQSFQAVTD HMLAIGSLDH 60

AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VRQHRGSLGP QLLLNWGVQI AKGMYYLEEH 120

GMVHRNLAAR NVLLKSTSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180

THQSDVWSYG VTVWELMTFG AEPYAGLRLA EVPDLLEKGE RLAQPQICTI DVYMVMVKCW 240

MIDENIRPTF KELANEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013