EKS-MYL-00268

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00268

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	461.7	1.3E-138	208	521	314

Status

Unreviewed

Ensembl Protein

ENSMLUP00000001297

UniProt Accession

G1NVJ5;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK3

Gene Synonyms/Alias

DYRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000001418	ENSMLUP00000001297	ENSMLUT00000001414

Organism

Myotis lucifugus

Functional Description

Protein Length

586

Protein Sequence
(FASTA)

MGGSARGPGR KDAGPPGAGL PPQQRRLGDG VYDTFMMIDE TKCPPCSNVL CNPSEPPLPR 60

RLNITTEQLT RENTQRFLNG GEMKVEELFQ EFGNRRSDTF QSDGIHDSEK CSPVSQGKSS 120

DSLNTVKSGS SPKASRGVPL TPEQALKQYK HLLTGYEKVE ILNYPEIYFV GPNAKKRHGV 180

LGGPNNGGYD DAEGAYIHVP RDHLAYRYEV LKIIGKGSFG QVARVYDHKL RQYVALKMVR 240

NEKRFHRQAA EEIRILEHLR KQDKTGSMNV IHMLESFTFR NHVCMAFELL SIDLYELIKK 300

NKFQGFSVQL VRKFAQSILQ SLDALHKNKI IHCDLKPENI LLKHHGRSAT KVIDFGSSCF 360

EYQKLYTYIQ SRFYRAPEII LGGRYSTPID MWSFGCILGE LLTGQPLFPG EDEGDQLACM 420

MELLGMPPPK LLEQSKRAKY FINSKGLPRY CSVTTQADGR VVLGGGRSRR GKKRGPPGSK 480

DWVTALKGCD DYLFIEFLKR CLQWDPTARL TPAQALRHPW ISKSVPKPLT VEKVSGKRVV 540

NSANAFQGLG SKLPPVVGIA NKLKANLMSE TNGGIPLCSV LPKLIS 586

Nucleotide Sequence
(FASTA)

ATGGGAGGCT CGGCTCGCGG GCCCGGGCGG AAGGATGCGG GGCCGCCTGG AGCCGGACTC 60

CCGCCCCAGC AGCGGAGATT GGGGGATGGT GTCTATGATA CCTTCATGAT GATAGATGAA 120

ACCAAATGCC CACCCTGTTC AAATGTTCTC TGCAATCCTT CTGAGCCACC TCTACCCAGA 180

AGACTAAATA TCACCACTGA GCAGTTAACA AGAGAGAATA CCCAGCGCTT TCTGAATGGA 240

GGTGAAATGA AGGTAGAAGA GCTGTTTCAA GAATTTGGCA ACCGAAGATC TGACACTTTC 300

CAGTCGGATG GCATTCACGA CTCGGAAAAG TGCTCTCCTG TTTCTCAGGG GAAAAGTTCA 360

GACAGCCTGA ATACGGTCAA ATCCGGCAGT TCACCCAAAG CTTCCCGAGG GGTGCCCCTG 420

ACCCCGGAGC AGGCACTGAA GCAATACAAG CACCTGCTCA CCGGTTACGA GAAGGTGGAA 480

ATCCTCAATT ATCCAGAAAT TTACTTTGTG GGTCCAAATG CCAAAAAAAG ACACGGAGTC 540

CTTGGTGGTC CCAATAATGG GGGGTACGAT GATGCAGAAG GGGCCTATAT TCATGTACCT 600

CGAGACCACC TCGCGTATCG ATACGAGGTG CTGAAAATTA TTGGCAAGGG GAGTTTTGGA 660

CAGGTAGCCC GGGTCTATGA TCACAAACTC CGACAGTACG TGGCCCTGAA GATGGTGCGC 720

AATGAAAAGC GTTTCCATCG GCAAGCCGCC GAGGAGATCC GGATTCTGGA GCATCTTAGG 780

AAGCAGGATA AAACCGGCAG CATGAATGTT ATCCACATGC TGGAGAGCTT CACGTTCCGG 840

AACCACGTGT GCATGGCCTT CGAATTGCTG AGCATAGACC TGTATGAGCT CATTAAAAAA 900

AACAAGTTCC AGGGCTTCAG CGTCCAGCTA GTGCGAAAGT TTGCCCAATC CATTTTGCAA 960

TCCTTGGATG CGCTCCACAA AAATAAGATC ATTCACTGTG ACCTGAAGCC CGAAAACATT 1020

CTCCTGAAAC ACCATGGGCG CAGCGCGACC AAGGTCATTG ACTTCGGGTC CAGCTGCTTC 1080

GAGTACCAGA AGCTCTACAC GTACATCCAG TCCCGCTTCT ATAGAGCTCC AGAGATCATC 1140

CTAGGAGGCC GCTACAGCAC GCCTATCGAC ATGTGGAGCT TTGGCTGCAT CCTTGGAGAA 1200

CTTCTCACAG GACAGCCCCT CTTCCCCGGG GAGGACGAAG GGGACCAGCT GGCTTGTATG 1260

ATGGAGCTGC TAGGGATGCC GCCCCCCAAA CTTCTGGAGC AGTCCAAACG GGCCAAGTAC 1320

TTTATCAACT CCAAGGGCCT CCCTCGCTAC TGCTCTGTGA CGACGCAGGC AGATGGGAGG 1380

GTGGTGCTTG GGGGGGGTCG CTCACGCAGG GGTAAAAAGC GGGGTCCCCC AGGCAGCAAA 1440

GACTGGGTGA CAGCACTGAA AGGCTGTGAT GACTACTTGT TTATAGAGTT TTTGAAAAGG 1500

TGTCTTCAGT GGGACCCCAC TGCCCGCCTG ACCCCCGCTC AAGCGTTAAG ACACCCTTGG 1560

ATTAGCAAGT CTGTACCCAA ACCTCTCACC GTGGAGAAGG TGTCAGGGAA ACGGGTAGTA 1620

AATTCTGCAA ATGCTTTCCA GGGCCTGGGT TCCAAGCTGC CTCCGGTGGT TGGCATAGCC 1680

AATAAGCTTA AAGCTAACTT GATGTCAGAA ACCAATGGTG GTATACCTCT GTGCAGTGTG 1740

TTGCCAAAAC TGATTAGCTA A 1761

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl++igkGsfgqV++++d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+ +

Q: 208   YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLRKQDKTGS  267

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le+f+frnh+c+ fells++Lyel+kknkf+g+s++lvrk+aq+il++L++L++

Q: 268   MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK  327

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill++++rs+ kviDFGss+++ qk +ytyiqsrfYraPEiilg +y+

Q: 328   NKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQK-LYTYIQSRFYRAPEIILGGRYS  386

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWS+Gc+l El+tG+pLfpGe+e dqla+++e+lg+pp+klle++k+ak+f+++k+

Q: 387   TPIDMWSFGCILGELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKG  446

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

          p+y+ +t+++d +++l  ++++++kkr +p+sk++++alk ++d+lf+++lkr+l++dp

Q: 447   LPRYCSVTTQADGRVVLGGGRSRRGKKRGPPGSKDWVTALKGCDDYLFIEFLKRCLQWDP  506

         ************************************************************

S: 301   akRitpkealkhpfv  315

         ++R+tp++al+hp++

Q: 507   TARLTPAQALRHPWI  521

         **************7

Domain Sequence
(FASTA)

YEVLKIIGKG SFGQVARVYD HKLRQYVALK MVRNEKRFHR QAAEEIRILE HLRKQDKTGS 60

MNVIHMLESF TFRNHVCMAF ELLSIDLYEL IKKNKFQGFS VQLVRKFAQS ILQSLDALHK 120

NKIIHCDLKP ENILLKHHGR SATKVIDFGS SCFEYQKLYT YIQSRFYRAP EIILGGRYST 180

PIDMWSFGCI LGELLTGQPL FPGEDEGDQL ACMMELLGMP PPKLLEQSKR AKYFINSKGL 240

PRYCSVTTQA DGRVVLGGGR SRRGKKRGPP GSKDWVTALK GCDDYLFIEF LKRCLQWDPT 300

ARLTPAQALR HPWI 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013