EKS-MYL-00157

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00157

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	547.5	4.5E-165	476	755	280

Status

Unreviewed

Ensembl Protein

ENSMLUP00000001615

UniProt Accession

G1NWC0;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000001759	ENSMLUP00000001615	ENSMLUT00000001764

Organism

Myotis lucifugus

Functional Description

Protein Length

823

Protein Sequence
(FASTA)

MWSWKCLLFW AVLVTATLCT ARPAPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD 60

VQSINWLRDG VQLVESNRTR ITGEEVEVRD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD 120

ALPSSEDDDD DDDSSSEEKE TDNTKPNPVA PYWTSPEKME KKLHAVPAAK TVKFKCPSSG 180

TPNPTLRWLK NGKEFKPDHR IGGYKVRYAT WSIIMDSVVP SDKGNYTCIV ENEYGSINHT 240

YQLDVVERSP HRPILQAGLP ANKTVALGSN VEFMCKVYSD PQPHIQWLKH IEVNGSKIGP 300

DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL 360

EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIIYKMKSG TKKSDFHSQM AVHKLAKSIP 420

LRRQVTVSAD SSASMNSGVL LVRPSRLSSS GTPMLAGVSE YELPEDPRWE LPRDRLVLGK 480

PLGEGCFGQV VLAEAIGLDK DKPNRVTKVA VKMLKLCKAD ATEKDLSDLI SEMEMMKMIG 540

KHKNIINLLG ACTQDGPLYV IVEYASKGNL REYLQARRPP GLEYCYNPSH NPEEQLSSKD 600

LVSCAYQVAR GMEYLASKKC IHRDLAARNV LVTEDNVMKI ADFGLARDIH HIDYYKKTTN 660

GRLPVKWMAP EALFDRIYTH QSDVWSFGVL LWEIFTLGGS PYPGVPVEEL FKLLKEGHRM 720

DKPSNCTNEL YMMMRDCWHA VPSQRPTFKQ LVEDLDRIVA LTSNQEYLDL SMPLDQYSPS 780

FPDTRSSTCS SGEDSVFSHE PLPEEPCLPR HPAQLANGGL KRR 823

Nucleotide Sequence
(FASTA)

ATGTGGAGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC ACTCTGCACT 60

GCCAGGCCAG CCCCGACCTT GCCTGAACAA GCCCAGCCCT GGGGAGCCCC TGTGGAAGTG 120

GAGTCCTTCC TGGTCCACCC TGGTGACCTG CTGCAGCTCC GCTGTCGGCT GCGGGACGAT 180

GTCCAGAGCA TCAACTGGCT GCGGGACGGG GTACAGCTGG TGGAAAGCAA CCGTACCCGC 240

ATCACAGGGG AGGAGGTGGA GGTGCGGGAT TCTGTGCCCG CTGACTCCGG CCTCTACGCT 300

TGCGTGACCA GCAGCCCCTC GGGCAGCGAC ACCACCTACT TCTCCGTCAA TGTCTCAGAT 360

GCTCTCCCCT CCTCGGAGGA CGACGATGAC GATGATGACT CCTCTTCAGA GGAGAAAGAG 420

ACAGATAACA CCAAACCAAA CCCCGTGGCT CCGTACTGGA CGTCTCCAGA AAAAATGGAA 480

AAGAAACTGC ACGCAGTACC AGCTGCCAAA ACAGTCAAGT TCAAATGCCC TTCCAGTGGG 540

ACTCCTAACC CCACACTGCG CTGGTTGAAA AATGGCAAAG AATTCAAACC TGACCACAGG 600

ATTGGAGGCT ACAAGGTCCG TTATGCCACC TGGAGCATCA TCATGGACTC CGTGGTGCCT 660

TCTGATAAGG GCAACTACAC CTGCATTGTG GAGAACGAGT ACGGCAGCAT TAACCACACC 720

TACCAGCTTG ACGTTGTGGA GCGGTCCCCT CACCGGCCCA TCCTGCAGGC AGGGTTGCCT 780

GCCAACAAGA CCGTGGCCCT GGGCAGCAAT GTGGAGTTCA TGTGTAAGGT GTACAGTGAC 840

CCACAGCCCC ACATCCAGTG GCTAAAGCAC ATCGAGGTGA ATGGGAGTAA GATTGGTCCG 900

GACAACCTGC CTTATGTCCA GATCTTGAAG ACTGCCGGAG TTAATACCAC CGACAAAGAG 960

ATGGAAGTGC TTCACTTAAG GAATGTCTCC TTTGAGGACG CGGGGGAGTA TACGTGCTTG 1020

GCGGGTAACT CTATCGGACT CTCCCATCAC TCTGCATGGT TGACCGTTCT GGAAGCCCTG 1080

GAAGAGAGAC CCGCAGTGAT GACCTCGCCC CTGTACTTGG AGATCATCAT CTACTGCACA 1140

GGGGCCTTCC TCATCTCCTG CATGGTGGGG TCTGTCATCA TCTACAAGAT GAAGAGTGGC 1200

ACCAAGAAGA GCGACTTCCA TAGCCAGATG GCCGTGCATA AGCTGGCCAA GAGCATTCCT 1260

CTGCGCAGAC AGGTAACAGT GTCGGCTGAC TCCAGCGCAT CCATGAACTC GGGGGTTCTG 1320

CTCGTGCGGC CCTCACGCCT CTCCTCCAGC GGAACCCCCA TGCTGGCTGG GGTCTCTGAG 1380

TATGAGCTTC CCGAAGACCC TCGCTGGGAG CTGCCTCGAG ACAGACTGGT TCTAGGCAAA 1440

CCCCTGGGAG AGGGCTGCTT TGGGCAGGTG GTGTTGGCAG AGGCCATTGG CCTGGACAAG 1500

GACAAACCCA ACCGTGTGAC CAAAGTGGCT GTGAAGATGT TGAAGTTGTG CAAAGCGGAT 1560

GCAACAGAGA AAGACCTGTC TGACCTGATC TCAGAAATGG AGATGATGAA GATGATCGGG 1620

AAGCACAAGA ACATCATCAA CCTGCTGGGG GCCTGCACAC AGGATGGTCC TTTGTACGTC 1680

ATCGTGGAGT ATGCCTCCAA GGGCAACCTC CGCGAGTACC TGCAGGCCCG GAGGCCTCCT 1740

GGGCTGGAAT ACTGTTACAA CCCCAGCCAC AACCCCGAGG AGCAGCTCTC CTCCAAGGAC 1800

CTGGTATCCT GCGCCTACCA GGTGGCCCGA GGCATGGAGT ATCTCGCCTC CAAGAAGTGC 1860

ATACACCGAG ACCTGGCTGC CAGGAATGTC CTGGTGACGG AGGACAACGT GATGAAGATC 1920

GCGGACTTTG GCCTCGCTCG GGACATTCAC CACATCGACT ACTATAAAAA GACAACCAAT 1980

GGCCGACTGC CTGTGAAGTG GATGGCACCC GAGGCATTGT TCGACCGGAT CTACACCCAC 2040

CAGAGTGATG TGTGGTCTTT TGGGGTGCTC CTGTGGGAAA TCTTCACTCT GGGAGGCTCC 2100

CCGTATCCTG GCGTGCCTGT GGAGGAGCTG TTCAAGCTGC TGAAGGAGGG TCATCGTATG 2160

GACAAGCCCA GCAACTGCAC CAACGAGCTG TACATGATGA TGCGGGATTG TTGGCACGCA 2220

GTACCCTCTC AGAGGCCTAC CTTCAAGCAG CTGGTAGAAG ACCTGGACCG CATTGTGGCT 2280

TTGACCTCCA ACCAGGAGTA TCTGGACCTG TCAATGCCCC TGGACCAATA CTCTCCCAGC 2340

TTTCCCGACA CCCGAAGCTC TACCTGCTCC TCGGGGGAAG ATTCTGTCTT CTCTCATGAG 2400

CCGTTGCCTG AGGAGCCCTG TCTGCCCCGA CACCCAGCCC AGCTTGCCAA TGGCGGACTC 2460

AAACGACGCT GA 2472

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlk...edatdkdladlvsemev  57

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk    dat+kdl+dl+seme+

Q: 476   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKlckADATEKDLSDLISEMEM  535

         79************************************9643389***************

S: 58    lkliGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeq  117

         +k+iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeq

Q: 536   MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ  595

         ************************************************************

S: 118   ltekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyy  177

         l++kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyy

Q: 596   LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY  655

         ************************************************************

S: 178   kkttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllk  237

         kkttnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllk

Q: 656   KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK  715

         ************************************************************

S: 238   eGhrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         eGhrm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 716   EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  755

         **************************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK LCKADATEKD LSDLISEMEM 60

MKMIGKHKNI INLLGACTQD GPLYVIVEYA SKGNLREYLQ ARRPPGLEYC YNPSHNPEEQ 120

LSSKDLVSCA YQVARGMEYL ASKKCIHRDL AARNVLVTED NVMKIADFGL ARDIHHIDYY 180

KKTTNGRLPV KWMAPEALFD RIYTHQSDVW SFGVLLWEIF TLGGSPYPGV PVEELFKLLK 240

EGHRMDKPSN CTNELYMMMR DCWHAVPSQR PTFKQLVEDL 280

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013