EKS-MYL-00161

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00161

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	508.7	4.6E-153	702	1007	306

Status

Unreviewed

Ensembl Protein

ENSMLUP00000001883

UniProt Accession

G1NX02;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS1

Gene Synonyms/Alias

LATS1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000002070	ENSMLUP00000001883	ENSMLUT00000002069

Organism

Myotis lucifugus

Functional Description

Protein Length

1126

Protein Sequence
(FASTA)

MKRSEKPEGY RQMRPKTFPA SNYTGSSRQM LQEIRESLRN LSKPSDAAKA EHNMSKMSIE 60

DPRQVRNPPK FGTHHKALLE IRNSLQPFAN ETSRSTLEVN PQMLQDLQAA GFDEDMVIQA 120

LQKTNNRSIE AAIEFISKMS YQDPRREQMV TAAARPINAS LKPGSVQQSV NRRQSWKGSK 180

ESLVPQRHGP PLAESVAYRS ESPNSQTDVG KPLSGSGITA FAQAHPSNGQ RVNPPPPPQV 240

RSVTPPPPPR GQTPPPRGTT PPPPSWEPNS QTKRYSGNME FVISRISPVP PGAWQEGYPP 300

PPLNMSPMNP PNQGQRVISS VPVGRQPIIM QSSNKFNYPP GRPGIQNGSG QTDFMIHQNV 360

PTGAVNRQPP PPYPLTPTNG QSPSALQTGG SAAPSSYTNG NIPQSMMVPN RNSHNMELYN 420

ISVPGLQTTW PQSSSAPAQS SPSIGHEIPT WQPNIPVRSN SFNNPLGNRT SHSANSQPSA 480

TTVTAITPAP IQQPVKSIRV LKPELQTALA PTHPSWIPQP IQTVQPSPFS EGTTSTMTVM 540

SPVAEAPNYQ GPPPPYPKHL LHQNPSVPPY ESVNKSNKED QSTVPKEDEG EKSYENVDSG 600

DKEKKQITTS PITVRKNKKD EERRESRIQS YSPQAFKFFM EQHVENVLKS HQQRLHRKKQ 660

LENEMMRVGL SQEAQDQMRK MLCQKESNYI RLKRAKMDKS MFVKIKTLGI GAFGEVCLAR 720

KVDTKALYAT KTLRKKDVLL RNQVAHVKAE RDILAEADNE WVVRLYYSFQ DKDNLYFVMD 780

YIPGGDMMSL LIRMGIFPEN LARFYIAELT CAVESVHKMG FIHRDIKPDN ILIDRDGHIK 840

LTDFGLCTGF RWTHDSKYYQ SGDHSRQDSM DFSNEWGDPS NCRCGDRLKP LERRAARQHQ 900

RCLAHSLVGT PNYIAPEVLL RTGYTQLCDW WSVGVILFEM LVGQPPFLAQ TPLETQMKVI 960

NWQTSLHIPP QAKLSPEASD LIIKLCRGPE DRLGKNGADE IKAHPFFKTI DFSSDLRQQP 1020

ASYIPKITHP TDTSNFDPVD PDKLWSDDKE EENVNDTLNG WYKNGKHPEH AFYEFTFRRF 1080

FDDNGYPYNY PKPIEYEYIN SQDSGQQSDE DDHTGSEIKN RDLVYV 1126

Nucleotide Sequence
(FASTA)

ATGAAGAGAA GTGAAAAGCC AGAAGGATAT AGACAAATGA GGCCTAAGAC CTTTCCTGCC 60

AGTAACTATA CTGGCAGTAG TCGGCAAATG TTGCAAGAAA TTCGGGAATC CCTTAGGAAT 120

TTATCTAAAC CATCCGATGC TGCAAAGGCT GAACATAACA TGAGTAAAAT GTCAATTGAA 180

GATCCTCGAC AAGTCAGAAA TCCACCCAAA TTTGGGACTC ATCATAAAGC CTTGCTGGAA 240

ATTCGAAACT CTCTGCAACC ATTCGCAAAT GAAACAAGTC GGAGTACTTT AGAGGTTAAT 300

CCACAAATGC TTCAAGACTT ACAAGCCGCT GGATTCGATG AGGATATGGT TATACAAGCT 360

CTTCAGAAAA CTAATAACAG AAGTATAGAA GCTGCAATTG AATTCATTAG TAAAATGAGT 420

TACCAAGATC CTCGACGGGA ACAGATGGTT ACAGCAGCTG CCAGACCTAT TAATGCCAGT 480

TTGAAACCAG GGAGTGTGCA ACAATCGGTT AACCGCAGAC AAAGCTGGAA AGGTTCTAAA 540

GAATCCTTAG TTCCTCAGAG ACATGGCCCA CCATTAGCAG AAAGTGTGGC TTATCGTTCC 600

GAAAGTCCCA ACTCACAAAC AGATGTAGGA AAACCTTTGT CAGGATCTGG TATCACAGCA 660

TTTGCTCAAG CTCACCCTAG CAACGGACAG AGAGTGAACC CCCCACCACC TCCTCAAGTA 720

AGGAGTGTCA CTCCTCCACC ACCCCCAAGA GGCCAGACTC CTCCTCCAAG AGGTACAACT 780

CCACCTCCCC CCTCATGGGA ACCAAACTCT CAAACAAAGC GCTATTCTGG GAATATGGAA 840

TTTGTAATCT CTCGAATCTC TCCTGTTCCA CCTGGAGCCT GGCAGGAGGG CTATCCTCCA 900

CCACCTCTGA ACATGTCCCC AATGAATCCT CCTAATCAGG GACAGAGAGT CATTAGTTCT 960

GTTCCTGTTG GCAGACAACC AATCATCATG CAGAGTTCTA ACAAATTTAA CTACCCACCA 1020

GGGAGACCCG GAATTCAGAA TGGTAGTGGT CAAACTGATT TTATGATACA CCAAAATGTC 1080

CCTACTGGTG CAGTGAATCG GCAACCACCC CCTCCATATC CTCTGACCCC AACTAATGGA 1140

CAAAGCCCTT CTGCTTTACA AACAGGGGGA TCTGCTGCTC CTTCATCATA TACAAATGGA 1200

AATATTCCTC AGTCTATGAT GGTGCCAAAT AGGAATAGTC ATAATATGGA ACTTTATAAC 1260

ATTAGTGTTC CTGGACTTCA AACAACTTGG CCTCAGTCAT CTTCAGCTCC AGCCCAGTCA 1320

TCCCCAAGCA TTGGGCATGA AATCCCTACA TGGCAACCTA ACATACCAGT GAGGTCAAAT 1380

TCTTTTAATA ATCCACTAGG AAATAGAACA AGTCATTCTG CTAATTCTCA GCCTTCAGCC 1440

ACAACAGTCA CTGCAATTAC ACCAGCCCCA ATACAACAAC CCGTGAAAAG CATACGCGTG 1500

TTAAAACCAG AGCTACAGAC TGCTTTAGCA CCTACTCATC CTTCTTGGAT ACCACAGCCA 1560

ATTCAAACTG TTCAACCTAG TCCTTTTTCT GAGGGTACCA CTTCAACTAT GACTGTTATG 1620

TCACCTGTTG CTGAAGCTCC AAACTATCAA GGTCCACCAC CACCTTATCC AAAACATCTG 1680

CTACACCAAA ACCCATCTGT TCCTCCATAT GAATCAGTCA ATAAATCTAA CAAAGAGGAT 1740

CAGTCAACTG TGCCCAAGGA AGATGAGGGT GAAAAAAGTT ATGAAAATGT TGATAGTGGG 1800

GATAAAGAAA AGAAACAGAT TACAACTTCA CCTATCACCG TTAGGAAAAA CAAGAAAGAT 1860

GAAGAGCGAA GGGAATCTCG TATTCAAAGT TACTCTCCTC AGGCATTTAA ATTCTTTATG 1920

GAGCAACATG TAGAAAATGT TCTCAAATCT CATCAGCAAC GTCTACATCG TAAAAAACAA 1980

TTAGAGAATG AAATGATGCG GGTTGGATTA TCTCAAGAAG CCCAGGATCA AATGAGAAAG 2040

ATGCTTTGCC AAAAAGAGTC TAATTACATC CGTCTTAAGA GGGCTAAAAT GGACAAGTCT 2100

ATGTTTGTGA AGATAAAGAC ACTAGGAATA GGAGCATTTG GTGAAGTCTG TCTAGCAAGA 2160

AAAGTAGATA CTAAGGCATT ATATGCAACA AAAACTCTTC GAAAGAAAGA TGTTCTACTT 2220

CGAAATCAGG TTGCTCATGT TAAAGCTGAG AGAGATATCC TGGCTGAAGC TGACAATGAA 2280

TGGGTAGTTC GTCTATATTA TTCATTCCAA GATAAGGACA ATTTATACTT TGTAATGGAC 2340

TACATTCCTG GGGGTGATAT GATGAGCCTA CTAATTAGAA TGGGCATCTT TCCAGAAAAT 2400

CTGGCACGAT TCTACATAGC AGAACTTACC TGTGCAGTTG AAAGTGTTCA TAAAATGGGT 2460

TTTATTCATA GAGATATTAA ACCTGATAAC ATTTTGATTG ATCGTGATGG TCATATTAAA 2520

TTGACTGACT TCGGCCTCTG CACTGGCTTC AGATGGACAC ATGATTCTAA GTACTACCAG 2580

AGTGGTGACC ATTCACGGCA AGATAGCATG GATTTCAGTA ATGAATGGGG TGACCCTTCT 2640

AACTGTCGAT GTGGAGATAG ATTGAAGCCA CTAGAACGGA GAGCTGCACG CCAGCACCAG 2700

CGATGTCTAG CACATTCTTT GGTTGGGACT CCCAATTATA TTGCACCTGA AGTGTTGTTA 2760

CGAACAGGCT ATACACAGTT ATGTGATTGG TGGAGTGTTG GTGTAATTCT TTTTGAAATG 2820

TTGGTGGGAC AACCTCCTTT TTTGGCACAA ACACCATTAG AAACACAAAT GAAGGTTATC 2880

AACTGGCAAA CATCTCTTCA CATTCCTCCT CAAGCTAAAT TGAGTCCTGA AGCCTCTGAT 2940

CTTATAATCA AACTTTGCCG AGGACCAGAA GATCGCTTAG GCAAGAATGG TGCTGATGAA 3000

ATAAAAGCTC ATCCATTTTT TAAAACAATT GATTTCTCCA GTGACCTGAG ACAACAACCT 3060

GCTTCATATA TTCCTAAAAT CACACATCCA ACAGATACAT CAAATTTTGA TCCTGTTGAT 3120

CCTGACAAAT TATGGAGTGA TGATAAAGAG GAAGAAAATG TGAATGACAC TCTCAACGGA 3180

TGGTATAAAA ATGGAAAGCA CCCTGAACAT GCTTTCTATG AATTTACCTT TAGGAGGTTT 3240

TTTGATGACA ATGGCTACCC ATATAATTAT CCAAAGCCTA TTGAATATGA ATATATTAAT 3300

TCGCAAGACT CAGGGCAACA GTCAGATGAA GATGATCACA CAGGCTCAGA GATCAAAAAT 3360

CGTGATCTAG TGTATGTTTA A 3381

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f k+k++g+GafGev+l+rk dtk++ya+k+lrkkd+l +nqvahvkaerdilaead+ew

Q: 702   FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW  761

         889*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vv+lyysfqdk+nly+vm+y+PGGd+m+lli+++i++e+larfyiael++avesvhk+Gf

Q: 762   VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGF  821

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ +++++d++++s+

Q: 822   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHSRQDSMDFSNewgdpsn  881

         ***************************************************999******

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk+lerr++++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvil+eml

Q: 882   crcgdRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML  941

         ************************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPfla+tp et++kvinw+++l++p++++ls+ea+dli +l+  +e+rlgk+G+dei

Q: 942   VGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEI  1001

         ************************************************************

S: 289   kkhpff  294

         k+hpff

Q: 1002  KAHPFF  1007

         *****9

Domain Sequence
(FASTA)

FVKIKTLGIG AFGEVCLARK VDTKALYATK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60

VVRLYYSFQD KDNLYFVMDY IPGGDMMSLL IRMGIFPENL ARFYIAELTC AVESVHKMGF 120

IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHSRQDSMD FSNEWGDPSN 180

CRCGDRLKPL ERRAARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILFEML 240

VGQPPFLAQT PLETQMKVIN WQTSLHIPPQ AKLSPEASDL IIKLCRGPED RLGKNGADEI 300

KAHPFF 306

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR009060	; UBA-like.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.
PF00627	; UBA; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013