EKS-MYL-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.5	5.6E-136	193	479	287

Status

Unreviewed

Ensembl Protein

ENSMLUP00000002211

UniProt Accession

G1NXU6;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000002433	ENSMLUP00000002211	ENSMLUT00000002433

Organism

Myotis lucifugus

Functional Description

Protein Length

490

Protein Sequence
(FASTA)

NIPVKTHTIF LALFLLALRF SGLKCVCLLC DSSNFTCQTE GACWASVMLT NGKEQVIKSC 60

VSLPELNAQV FCHSSNNVTK TECCFTDFCN NITLHLPTAS PNAPKLGPME LTIVITVPVC 120

LLSVAAVLSI WACQGRQCSN RKKKRPNVEE PLSECNLVNA GKTLKDLIYD VTASGSGSGL 180

PLLVQRTIAR TIILQEIVGK GRFGEVWHGR WCGEDVAVKI FSSRDERSWF REAEIYQTVM 240

LRHENVLGFI AADNKDNGTW TQLWLVLEYH EQGSLYDYLN RNVVTVAGMI RLALSIASGL 300

AHLHMEIVGT QGKPAIAHRD IKSKNILVKK CETCAIADFG LAVKHDSILN TIDIPQNPKV 360

GTKRYMAPEM LDDTMNVNIF ESFKRADIYS VGLVYWEIAR RCSVGGIVEE YQLPYYDMVP 420

SDPSIEEMRK VVCDQKFRPS IPNQWQSCEA LRVMGRIMRE CWYANGAARL TALRIKKTIS 480

QLCVKEDCKA 490

Nucleotide Sequence
(FASTA)

AATATACCTG TAAAGACTCA CACTATTTTT TTAGCTCTTT TTTTGCTTGC CTTACGCTTT 60

TCAGGACTGA AGTGTGTATG TCTTTTGTGT GACTCTTCAA ACTTCACCTG CCAGACGGAA 120

GGAGCATGCT GGGCTTCAGT TATGCTAACC AATGGAAAGG AGCAGGTGAT CAAGTCCTGT 180

GTCTCTCTCC CAGAATTAAA TGCTCAAGTC TTCTGTCATA GTTCCAACAA TGTTACCAAA 240

ACCGAGTGCT GCTTCACAGA TTTCTGCAAT AACATAACAC TGCACCTTCC AACAGCCTCA 300

CCAAATGCCC CCAAACTCGG ACCCATGGAG CTGACCATTG TTATTACTGT GCCAGTGTGC 360

CTGCTGTCTG TGGCGGCAGT GCTGAGCATC TGGGCATGCC AAGGTCGACA GTGTAGCAAC 420

AGGAAGAAAA AGAGGCCGAA TGTGGAGGAG CCCCTCTCTG AATGCAACCT GGTAAATGCT 480

GGGAAAACTC TGAAAGATCT GATTTACGAT GTGACCGCCT CTGGATCCGG ATCTGGGTTA 540

CCTCTGTTGG TTCAGAGAAC AATTGCCAGG ACGATTATCC TCCAGGAGAT TGTAGGAAAA 600

GGCCGATTTG GTGAGGTCTG GCATGGAAGA TGGTGTGGGG AAGACGTGGC TGTGAAAATA 660

TTCTCCTCCA GAGATGAAAG ATCCTGGTTT CGCGAGGCAG AAATTTACCA GACGGTGATG 720

CTGAGACACG AGAATGTCCT TGGTTTCATT GCTGCTGACA ACAAAGATAA TGGAACTTGG 780

ACCCAACTTT GGCTTGTCCT GGAATATCAT GAACAGGGCT CCTTGTATGA CTATTTGAAT 840

AGAAACGTAG TGACCGTGGC TGGGATGATC AGGCTGGCAC TTTCCATAGC TAGTGGTCTG 900

GCCCACCTTC ACATGGAGAT TGTTGGTACA CAAGGCAAAC CTGCCATTGC GCATCGAGAC 960

ATAAAATCAA AGAATATCTT AGTGAAAAAA TGTGAAACTT GTGCCATAGC AGACTTTGGA 1020

TTAGCTGTGA AGCACGATTC CATACTGAAC ACTATTGACA TACCTCAGAA CCCTAAAGTG 1080

GGAACCAAAA GGTATATGGC CCCTGAAATG CTTGATGATA CAATGAATGT GAATATCTTT 1140

GAGTCCTTCA AACGCGCTGA CATATATTCT GTTGGTCTGG TTTACTGGGA AATAGCCCGA 1200

AGGTGTTCAG TTGGAGGAAT TGTTGAGGAG TACCAGTTGC CTTATTATGA CATGGTGCCT 1260

TCAGATCCCT CAATAGAGGA AATGAGGAAG GTTGTTTGTG ATCAGAAGTT TCGACCAAGC 1320

ATCCCAAACC AGTGGCAAAG CTGTGAAGCA CTCCGAGTCA TGGGGAGAAT AATGCGCGAG 1380

TGTTGGTATG CCAATGGGGC AGCCCGCCTC ACTGCCCTTC GTATTAAGAA GACTATTTCT 1440

CAACTTTGTG TCAAAGAAGA CTGCAAAGCC 1470

Domain Profile

S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61

          l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhen+l+fiaa

Q: 193   ILQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENVLGFIAA  252

         5899********************************************************

S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121

         d+k+++++t+l+lv+eyhe+gsL+dyL+r++++v  ++rlals+asGlahLH+eivgt+g

Q: 253   DNKDNGTWTQLWLVLEYHEQGSLYDYLNRNVVTVAGMIRLALSIASGLAHLHMEIVGTQG  312

         ************************************************************

S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181

           KpaiaHRD+kskNilvkk +tc+iaD+GLa+k+++  +++d+ +n +vGtkRYmaPE+

Q: 313   --KPAIAHRDIKSKNILVKKCETCAIADFGLAVKHDSILNTIDIPQNPKVGTKRYMAPEM  370

         ..**********************************************************

S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241

         l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  +++veey+lp++++v+sdPs+eem+

Q: 371   LDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV-GGIVEEYQLPYYDMVPSDPSIEEMR  429

         *********************************9.*************************

S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +vv+++k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 430   KVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  479

         ***********************************************986

Domain Sequence
(FASTA)

ILQEIVGKGR FGEVWHGRWC GEDVAVKIFS SRDERSWFRE AEIYQTVMLR HENVLGFIAA 60

DNKDNGTWTQ LWLVLEYHEQ GSLYDYLNRN VVTVAGMIRL ALSIASGLAH LHMEIVGTQG 120

KPAIAHRDIK SKNILVKKCE TCAIADFGLA VKHDSILNTI DIPQNPKVGT KRYMAPEMLD 180

DTMNVNIFES FKRADIYSVG LVYWEIARRC SVGGIVEEYQ LPYYDMVPSD PSIEEMRKVV 240

CDQKFRPSIP NQWQSCEALR VMGRIMRECW YANGAARLTA LRIKKTI 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013