EKS-MYL-00397
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00397
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR601.36.3E-181580915336
StatusUnreviewed
Ensembl ProteinENSMLUP00000002221
UniProt AccessionG1NXV5;
Protein Name
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000002438ENSMLUP00000002221ENSMLUT00000002445
OrganismMyotis lucifugus
Functional Description
Protein Length967
Protein Sequence
(FASTA)
AKGKKKSYST QFPFFLAGSS QPSVSPGELS APSIHPAKSE LIVSVGDEIR LLCTDPGFVK 60
WTFETLGQLS EKTHNEWVTE KAEATNTGNY TCTNEDGLSS SIYVFVRDPA KLFLMGLSLY 120
GKEGNDTLVR CPLTDPDVTN YSLTGCEGKP LPKDLTFVAD PKAGITIRNV KREYHRLCLH 180
CSADRKGKSV LSKKFTLKVR AAIRAVPVVT VSKSSYLLRE GEEFTVTCSI KDVSSSVDSM 240
WIKENSQTKA QVKSNSWHQG DFNFVRQDRL TISSARVNDS GVFMCYANNT FGSANVTTTL 300
EVVDKGFINI IPVANTTIFV NDGENVDLTV EYEAYPKPEH QQWIYMNKTF TDKWENYPKS 360
ENESNIRYVS ELHLTRLKGT EGGTYTFLVS NSDVNSSVTF NVYVNTKPEI LTSERLTNGM 420
LQCVAAGFPE PTIDWYFCPG TEQRCSVPVG PVNVQIQNSS VNPFGKLVVQ SSIDDSAFKL 480
NGTFECRAYN DVGKSSAFFN FAFKEKIHAH TLFTPLLIGF VIAAGMMCII VMILTYKYLQ 540
KPMYEVQWKV VEEINGNNYV YIDPTQLPYD HKWEFPRNRL SFGKTLGAGA FGKVVEATAY 600
GLIKSDAAMT VAVKMLKPSA HLTEREALMS ELKVLSYLGN HMNIVNLLGA CTIGGPTLVI 660
TEYCCYGDLL NFLRRKRDSF ICSKQEDHAE AALYKNLLHS KESSCNDSTN EYMDMKPGVS 720
YVVPTKADKR RPARIGSYIE RDVTPAIMED DELALDLEDL LSFSYQVAKG MAFLASKNCI 780
HRDLAARNIL LTHGRITKIC DFGLARDIKN DSNYVVKGNA RLPVKWMAPE SIFNCVYTFE 840
SDVWSYGIFL WELFSLGSSP YPGMPVDSKF YKMIKEGFRM LSPEHAPAEM YDIMKTCWDA 900
DPLKRPTFKQ IVQLIEKQIS DSSNHIYSNL ANWSPNQENI VVDHSVRINS VGSSTSSTQP 960
LLVHEDA 967
Nucleotide Sequence
(FASTA)
GCCAAGGGAA AAAAAAAATC ATACTCAACA CAATTCCCAT TTTTCTTGGC AGGCTCTTCT 60
CAACCATCTG TGAGTCCAGG GGAACTGTCT GCACCATCCA TCCATCCAGC AAAATCAGAG 120
TTAATAGTCA GTGTTGGCGA CGAGATTAGG CTGCTCTGCA CCGATCCAGG ATTTGTCAAA 180
TGGACTTTTG AGACCCTGGG TCAGCTGAGT GAGAAAACAC ACAATGAATG GGTCACGGAG 240
AAAGCAGAGG CCACCAATAC CGGCAACTAC ACGTGCACCA ACGAGGACGG CTTAAGCAGT 300
TCCATTTATG TGTTTGTTAG AGATCCTGCA AAGCTTTTCC TGATGGGCCT GTCCCTGTAT 360
GGGAAAGAGG GCAATGACAC GCTGGTCCGC TGCCCTCTGA CTGACCCGGA CGTGACCAAT 420
TACTCCCTCA CGGGCTGCGA GGGGAAACCT CTTCCCAAGG ACTTGACGTT CGTCGCTGAT 480
CCCAAGGCTG GCATCACCAT CAGAAACGTG AAGCGCGAGT ACCACCGGCT CTGCTTGCAC 540
TGCTCTGCGG ACAGGAAGGG CAAGTCAGTG CTGTCGAAGA AATTCACCCT GAAAGTGAGG 600
GCAGCCATCA GAGCTGTACC AGTTGTGACA GTGTCCAAAT CAAGCTATCT TCTTAGGGAA 660
GGGGAAGAAT TCACAGTGAC CTGCTCCATA AAGGATGTGT CTAGTTCTGT GGACTCAATG 720
TGGATAAAGG AAAACAGCCA GACTAAAGCA CAGGTAAAGA GCAATAGCTG GCATCAGGGT 780
GACTTCAATT TTGTACGTCA GGATAGGCTG ACTATCAGCT CAGCAAGAGT GAATGATTCT 840
GGAGTGTTCA TGTGTTACGC CAATAATACT TTTGGATCAG CAAATGTCAC AACAACCTTG 900
GAAGTAGTAG ATAAAGGATT CATTAATATC ATCCCTGTGG CAAATACTAC AATATTTGTA 960
AACGACGGAG AAAACGTAGA TCTGACTGTT GAATACGAGG CTTACCCGAA ACCTGAACAC 1020
CAGCAGTGGA TATATATGAA CAAGACCTTC ACTGATAAAT GGGAGAATTA TCCCAAGTCT 1080
GAGAATGAAA GCAATATCAG ATATGTAAGT GAACTTCACC TAACCAGATT GAAAGGGACC 1140
GAAGGCGGCA CTTACACGTT TCTAGTGTCC AATTCTGATG TCAATTCTTC GGTGACATTT 1200
AATGTTTACG TGAACACAAA GCCAGAGATC TTGACTTCTG AGAGGCTCAC GAATGGCATG 1260
CTCCAGTGTG TGGCAGCAGG ATTCCCGGAG CCCACAATAG ATTGGTACTT TTGTCCAGGA 1320
ACGGAGCAGA GATGTTCTGT TCCTGTTGGG CCGGTGAATG TGCAGATACA GAACTCCTCT 1380
GTGAACCCGT TTGGCAAGCT GGTGGTTCAG AGTTCCATCG ATGACAGTGC CTTCAAGCTC 1440
AACGGCACGT TCGAGTGCAG GGCTTACAAC GATGTGGGCA AGAGTTCTGC CTTTTTTAAC 1500
TTTGCATTTA AAGAGAAAAT TCATGCCCAC ACCCTGTTCA CGCCTTTGCT GATCGGTTTT 1560
GTGATTGCGG CCGGCATGAT GTGCATTATT GTAATGATTC TTACCTACAA ATACTTACAG 1620
AAGCCCATGT ATGAAGTGCA GTGGAAGGTT GTTGAGGAGA TCAATGGAAA CAATTACGTG 1680
TACATAGACC CAACGCAACT TCCTTATGAT CACAAGTGGG AGTTTCCCAG AAACAGGCTG 1740
AGTTTTGGGA AAACCTTGGG GGCCGGCGCC TTCGGCAAAG TTGTGGAGGC CACAGCGTAC 1800
GGCTTGATCA AGTCGGATGC AGCCATGACT GTTGCTGTGA AGATGCTCAA GCCGAGTGCC 1860
CATTTAACAG AACGAGAAGC CCTCATGTCT GAACTCAAGG TCTTGAGCTA CCTCGGCAAT 1920
CATATGAATA TCGTGAATCT TCTGGGAGCG TGCACCATCG GAGGGCCCAC GCTGGTCATT 1980
ACAGAATATT GTTGCTATGG TGATCTTTTG AATTTTTTGA GGAGAAAACG TGATTCATTT 2040
ATTTGCTCGA AGCAGGAAGA TCATGCAGAA GCGGCACTTT ATAAGAACCT TCTGCATTCA 2100
AAGGAGTCTT CCTGTAATGA CAGTACTAAT GAGTACATGG ACATGAAACC CGGAGTTTCT 2160
TATGTTGTAC CAACCAAGGC AGACAAAAGG CGACCGGCAA GAATAGGCTC ATACATAGAA 2220
AGAGATGTGA CACCTGCCAT CATGGAAGAT GACGAGTTGG CCCTGGACCT GGAAGACCTG 2280
TTGAGCTTTT CTTACCAGGT GGCGAAGGGC ATGGCCTTCC TGGCCTCGAA GAACTGTATT 2340
CACAGAGACT TGGCAGCCAG AAATATTCTT CTTACCCATG GTCGAATCAC AAAGATTTGC 2400
GATTTTGGTC TAGCCAGAGA CATCAAGAAT GACTCTAATT ATGTGGTCAA AGGAAATGCT 2460
CGGCTGCCTG TGAAGTGGAT GGCGCCTGAA AGCATTTTCA ACTGTGTGTA CACATTCGAA 2520
AGCGATGTCT GGTCCTATGG GATTTTTCTG TGGGAGCTGT TCTCTTTAGG AAGCAGCCCC 2580
TACCCTGGAA TGCCGGTCGA TTCCAAGTTC TACAAGATGA TCAAGGAGGG TTTCCGGATG 2640
CTGAGCCCGG AGCACGCACC TGCTGAAATG TATGACATAA TGAAGACTTG CTGGGATGCC 2700
GATCCCCTGA AAAGGCCGAC ATTCAAGCAG ATCGTTCAGC TGATTGAGAA GCAGATTTCA 2760
GACAGCAGCA ACCATATTTA TTCCAACTTA GCCAACTGGA GCCCCAACCA GGAGAACATC 2820
GTGGTGGACC ACTCTGTGCG GATCAACTCC GTGGGCAGCA GCACCTCGTC CACCCAGCCC 2880
CTGCTTGTTC ACGAAGACGC CTGA 2904
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 580   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  639
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact gGp++viteyccyGdlln+lrrkr+sf+   ++k+++++e++ +k+
Q: 640   NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEAALYKN  696
         ******************************************...99999*********9
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk+s++ +s++ey+d+k++vs+v ++kadk++ +++ s++er+v++a++e+d
Q: 697   L-----LHSKESSCNDSTNEYMDMKPGVSYVVPTKADKRRPARIGSYIERDVTPAIMEDD  751
         9.....9*****************************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 752   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  811
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy
Q: 812   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  871
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p++a++e+y+im++cw+a+p krp+fkq+v+l+
Q: 872   KMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI  915
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDHA EAALYKNLLH 120
SKESSCNDST NEYMDMKPGV SYVVPTKADK RRPARIGSYI ERDVTPAIME DDELALDLED 180
LLSFSYQVAK GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN 240
ARLPVKWMAP ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR 300
MLSPEHAPAE MYDIMKTCWD ADPLKRPTFK QIVQLI 336
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013