EKS-MYL-00399
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00399
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR577.98.5E-174612944333
StatusUnreviewed
Ensembl ProteinENSMLUP00000002354
UniProt AccessionG1NY78;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000002582ENSMLUP00000002354ENSMLUT00000002589
OrganismMyotis lucifugus
Functional Description
Protein Length995
Protein Sequence
(FASTA)
MKMVYLLEYR DLDFTVVFSA MIFETITNQD LPVIKCVLIH HKSNDSSVGI PSSYPTASES 60
PEDLGCALRP ESAEAVYEAA RVEVDASASI TLQVLLTTPG NISCLWVFKH SSLNCQPHFD 120
LQNRGVVSMF ILKMTETQAG EYLLFIQSEA TNYTILFTVS IRNTLLYTLR RPYFRKMENE 180
DALVCISESI PEPTVEWVFR DSQSESYKGE SPPIVTKEQS VLHELFGTDI RCCARNELGR 240
ECTKLFTIDL NQTPRNTLPQ LFLKVGEPLW LRCKAVHVNH GFGLTWELEN QALEEGNYFE 300
MSTYSTNRTM IRILFAFVSS VGRNDTGYYT CSSSKHPSQS ALVTIVEKGF IHASKTNEEY 360
EIDQYEEFCF SVRFKAYPQI RCTWSFSRKS FPCEQSGLDD GYSISKFCNH KHQPGEYTFH 420
AENDDAQFTK MFTLNIRRKP QVLAKASASQ ASCSSDGYPL PSWTWKKCSD KSPNCTEEIT 480
EGIWNRKANR KVFGQWISSS TLNMSEAIKG SLVKCCAYNS LGTSCETIHL GSPAGPFPFF 540
QDNISFYATI GLCVPFIAVL TMLICHKYKK QYRYESQLQM VQVTGSLDNE YFYIDFREYE 600
YDLKWEFPRE NLEFGKVLGS GAFGKVMNAT AYGISKTEVS IQVAVKMLKE KADSSEREAL 660
MSELKMMTQL GNHENIVNLL GACTQSGPVY LIFEYCCYGD LLNYLRSKRE KFHRTWTEIF 720
KEHNFSFYPT FQSHPNSSMP GSQEVHIHQD TDHISGFNGN SFQPKDEVEY ENQKRLEEEE 780
DLNVLTFEDL LCFAYQVAKG MEFLEFKSCV HRDLAARNVL VTRGKVVKIC DFGLARDIMS 840
DSNYVIRGNA RLPVKWMAPE SLFEGIYTIK SDVWSYGILL WEIFSLGVNP YPGIPVDANF 900
YKLIQSGFKM DQPFYATEEI YFIMQSCWAF DSRKRPSFSN LTSCLGCQLA DAEEAMYQNM 960
DDHVSKHPSG YQNRQPYSRE TGTGLPSPQD HAEDS 995
Nucleotide Sequence
(FASTA)
ATGAAAATGG TTTATTTGTT AGAATATAGG GATTTAGATT TTACAGTTGT TTTTTCAGCA 60
ATGATATTTG AGACTATTAC AAATCAAGAT CTGCCTGTGA TCAAGTGTGT TTTAATCCAT 120
CATAAGAGCA ATGATTCATC AGTGGGGATA CCTTCATCAT ATCCCACGGC ATCAGAATCC 180
CCGGAAGACC TTGGCTGTGC CTTGAGGCCT GAGAGTGCAG AGGCAGTCTA CGAGGCGGCC 240
AGGGTAGAAG TAGACGCATC TGCATCCATC ACACTGCAAG TGCTACTCAC AACCCCGGGG 300
AACATTTCCT GTCTCTGGGT CTTTAAACAC AGCTCCCTGA ATTGCCAGCC ACACTTTGAT 360
TTACAAAACA GAGGAGTTGT TTCCATGTTC ATTTTGAAAA TGACAGAAAC CCAAGCTGGA 420
GAATACCTGC TTTTTATTCA GAGTGAAGCG ACCAATTACA CGATATTGTT CACAGTGAGT 480
ATAAGAAATA CACTGCTTTA CACATTGAGG AGACCATACT TTAGAAAAAT GGAAAATGAG 540
GACGCCCTGG TCTGCATATC TGAGAGCATT CCAGAACCAA CTGTGGAATG GGTGTTTCGT 600
GATTCACAGA GTGAAAGCTA TAAAGGAGAA AGTCCACCCA TTGTTACAAA GGAGCAAAGT 660
GTACTTCATG AGTTATTTGG AACAGACATA AGGTGCTGTG CAAGAAATGA GCTGGGCAGG 720
GAATGTACCA AGCTGTTCAC TATAGATCTA AACCAGACTC CTCGGAACAC ACTGCCACAA 780
TTATTTCTTA AAGTGGGGGA ACCCTTGTGG CTCAGGTGCA AAGCTGTTCA TGTAAACCAT 840
GGATTTGGGC TCACCTGGGA GTTAGAAAAT CAAGCACTGG AGGAGGGCAA CTACTTTGAG 900
ATGAGTACCT ATTCCACAAA CAGAACTATG ATACGGATTC TGTTTGCTTT TGTATCATCA 960
GTGGGAAGAA ACGACACTGG ATATTACACT TGTTCCTCTT CCAAGCATCC CAGTCAGTCA 1020
GCTTTGGTTA CCATCGTAGA AAAGGGATTT ATACATGCTT CCAAAACAAA TGAAGAGTAT 1080
GAAATTGACC AGTATGAAGA GTTCTGTTTT TCTGTCAGGT TTAAAGCATA CCCACAAATC 1140
AGATGTACGT GGAGCTTCTC TAGAAAATCA TTTCCTTGTG AACAAAGTGG CCTTGATGAT 1200
GGGTACAGCA TATCTAAGTT TTGCAACCAC AAACACCAGC CAGGAGAATA CACCTTCCAT 1260
GCAGAAAATG ACGATGCCCA GTTCACAAAA ATGTTCACGC TAAATATAAG AAGGAAACCT 1320
CAAGTGCTGG CCAAGGCATC AGCAAGTCAG GCCTCTTGTT CCTCAGATGG ATATCCATTA 1380
CCATCTTGGA CCTGGAAGAA GTGTTCAGAC AAGTCTCCCA ACTGCACAGA AGAAATCACG 1440
GAAGGAATTT GGAATAGAAA GGCTAACAGA AAAGTATTTG GACAGTGGAT ATCGAGCAGT 1500
ACACTGAACA TGAGTGAGGC CATCAAAGGG TCCCTGGTGA AGTGCTGTGC GTACAATTCC 1560
CTGGGCACAT CTTGTGAAAC AATCCATTTA GGCTCACCAG CAGGACCCTT CCCTTTCTTC 1620
CAGGACAACA TCTCATTCTA TGCCACCATT GGGCTCTGTG TCCCCTTCAT TGCCGTTTTA 1680
ACCATGCTCA TTTGTCACAA GTACAAAAAG CAATATAGGT ATGAAAGCCA ACTGCAGATG 1740
GTACAGGTGA CTGGTTCTTT GGATAATGAG TACTTCTACA TTGATTTCAG AGAATATGAA 1800
TATGATCTCA AATGGGAGTT TCCAAGAGAA AATTTAGAAT TTGGGAAGGT GCTAGGATCA 1860
GGTGCTTTTG GAAAAGTGAT GAACGCAACA GCTTATGGAA TTAGTAAAAC AGAAGTCTCC 1920
ATCCAGGTTG CTGTCAAAAT GCTGAAAGAG AAAGCAGACA GCTCTGAAAG GGAAGCTCTC 1980
ATGTCTGAAC TCAAAATGAT GACTCAGCTG GGGAACCACG AAAATATTGT GAATCTGCTG 2040
GGGGCGTGCA CACAGTCAGG GCCAGTTTAC TTGATTTTTG AATATTGTTG CTATGGTGAT 2100
CTTCTCAACT ATCTAAGAAG TAAAAGAGAA AAATTTCACA GAACATGGAC GGAAATTTTC 2160
AAGGAACACA ATTTCAGTTT TTACCCCACT TTCCAGTCAC ATCCAAATTC CAGTATGCCT 2220
GGTTCACAAG AAGTTCACAT ACACCAGGAC ACAGACCATA TCTCAGGGTT CAATGGGAAT 2280
TCCTTTCAAC CCAAAGATGA AGTTGAATAT GAAAACCAAA AAAGGTTGGA GGAAGAAGAG 2340
GACCTGAATG TACTTACATT TGAAGATCTT CTTTGTTTTG CTTATCAAGT TGCCAAAGGA 2400
ATGGAATTTC TGGAATTTAA GTCGTGTGTC CACAGAGATC TGGCAGCCAG GAATGTGCTG 2460
GTGACCCGTG GGAAAGTGGT GAAGATATGC GATTTCGGAT TGGCTCGAGA TATTATGAGT 2520
GATTCCAACT ATGTTATCAG GGGCAACGCC CGCCTGCCTG TGAAGTGGAT GGCTCCTGAA 2580
AGCTTGTTTG AAGGGATCTA CACAATTAAG AGTGATGTCT GGTCATACGG AATATTACTC 2640
TGGGAGATAT TCTCGCTTGG TGTCAACCCT TACCCTGGCA TTCCAGTTGA TGCGAACTTC 2700
TATAAACTCA TTCAGAGTGG ATTTAAAATG GACCAGCCAT TTTATGCTAC AGAAGAAATA 2760
TACTTTATAA TGCAATCCTG CTGGGCTTTC GACTCCAGGA AACGGCCATC CTTCTCTAAC 2820
CTGACTTCAT GTTTGGGATG TCAGCTGGCA GACGCGGAGG AAGCGATGTA TCAGAACATG 2880
GACGACCATG TTTCTAAACA TCCTTCCGGC TACCAAAACA GGCAACCTTA CAGCAGAGAG 2940
ACGGGCACAG GGCTGCCCTC TCCGCAGGAT CACGCTGAAG ACTCGTAG 2988
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+sse+ealmselk++++lG
Q: 612   LEFGKVLGSGAFGKVMNATAYGISKTEVSIQVAVKMLKEKADSSEREALMSELKMMTQLG  671
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact++Gp+y+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 672   NHENIVNLLGACTQSGPVYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  730
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+ ++s+++s+e v++++d++++s ++ ++++ +++ +++++++   +eeed
Q: 731   ------FQSHPNSSMPGSQE-VHIHQDTDHISGFNGNSFQPKDEVEYENQKRL--EEEED  781
         ......9*************.**********************9999999876..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+GkvvkicdfGlardim+d
Q: 782   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTRGKVVKICDFGLARDIMSD  841
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyv++Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy
Q: 842   SNYVIRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  901
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         kli++G++m+qp+yateeiy imq+cw+++++krpsf++l++ 
Q: 902   KLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFSNLTSC  944
         ***************************************9975
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTEVSI QVAVKMLKEK ADSSEREALM SELKMMTQLG 60
NHENIVNLLG ACTQSGPVYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120
QSHPNSSMPG SQEVHIHQDT DHISGFNGNS FQPKDEVEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFKSCVH RDLAARNVLV TRGKVVKICD FGLARDIMSD SNYVIRGNAR 240
LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY KLIQSGFKMD 300
QPFYATEEIY FIMQSCWAFD SRKRPSFSNL TSC 333
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013