EKS-MYL-00005

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00005

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	515.4	2.0E-155	608	867	260

Status

Unreviewed

Ensembl Protein

ENSMLUP00000002891

UniProt Accession

G1NZJ5;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000003167	ENSMLUP00000002891	ENSMLUT00000003178

Organism

Myotis lucifugus

Functional Description

Protein Length

975

Protein Sequence
(FASTA)

LLTLPTETLM DSTTATAELG WIVHPPSGWE EVSGYDENMN TIRTYQVCNV FESSQNNWLR 60

TKFIRRRGAH RIHVEMKFSV RDCSSIPSVP GSCKETFNLY YYEADFDSAT KTFPNWMENP 120

WVKVDTIAAD ESFSQVDLGG RVMKINTEVR SFGPVSRSGF YLAFQDYGGC MSLIAVRVFY 180

RKCPRIIQNG AIFQETLSGA ESTSLVAARG SCIANAEEVD VPIKLYCNGD GEWLVPIGRC 240

MCKAGFEAVE NGTVCRGCPS GTFKANQGDE ACTHCPINSR TTSEGATNCV CRNGYYRADL 300

DPLDMPCTTI PSAPQAVISS VNETSLMLEW TPPRDSGGRE DLVYNIICKS CGSGRGACTR 360

CGDNVQYAPR QLGLTEPRIY ISDLLAHTQY TFEIQAVNGV TDQSPFSPQF ASVNITTNQA 420

APSAVSIMHQ VSRTVDSITL SWSQPDQPNG VILDYELQYY EKELSEYNAT AIKSPTNTVT 480

VQGLKAGAIY VFQVRARTVA GYGRYSGKMY FQTMTEAEYQ TSIQEKLPLI VGSSAAALVF 540

LIAVVVIAIV CNRRRGFERA DSEYTDKLQH YTSGHMTPGM KIYIDPFTYE DPNEAVREFA 600

KEIDISCVKI EQVIGAGEFG EVCSGHLKLP GKREIFVAIK TLKSGYTEKQ RRDFLSEASI 660

MGQFDHPNVI HLEGVVTKST PVMIITEFME NGSLDSFLRQ NDGQFTVIQL VGMLRGIAAG 720

MKYLADMNYV HRDLAARNIL VNSNLVCKVS DFGLSRFLED DTSDPTYTSA LGGKIPIRWT 780

APEAIQYRKF TSASDVWSYG IVMWEVMSYG ERPYWDMTNQ DVINAIEQDY RLPPPMDCPS 840

ALHQLMLDCW QKDRNHRPKF GQIVNTLDKM IRNPNSLKAM APLSSGYGPA PSLWLRPSWP 900

LPSPNTLPPW LPCLKQILCL NWDGEDGFTH HSLLSLSFLW DILRVGVTLA GHQKKILNSI 960

QVMRAQMNQI QSVEV 975

Nucleotide Sequence
(FASTA)

CTCCTCACTC TCCCCACAGA AACGCTGATG GATTCAACCA CAGCGACGGC GGAGCTCGGC 60

TGGATCGTGC ATCCTCCATC AGGGTGGGAA GAGGTGAGTG GCTACGATGA GAACATGAAC 120

ACGATCCGCA CCTACCAGGT TTGCAATGTA TTTGAATCGA GCCAGAACAA CTGGCTACGG 180

ACCAAGTTCA TCCGGCGCCG CGGTGCCCAC CGCATCCACG TGGAGATGAA GTTCTCGGTG 240

CGGGACTGCA GCAGCATCCC CAGTGTGCCC GGCTCCTGCA AGGAGACCTT CAACCTCTAT 300

TACTATGAGG CCGACTTTGA CTCGGCCACC AAGACCTTCC CCAACTGGAT GGAGAATCCG 360

TGGGTGAAGG TGGACACCAT CGCGGCCGAC GAGAGCTTCT CCCAGGTGGA CCTGGGTGGC 420

CGCGTCATGA AGATCAACAC CGAGGTGAGG AGCTTCGGGC CCGTGTCCCG CAGCGGCTTC 480

TACCTGGCCT TCCAGGACTA TGGCGGCTGC ATGTCCCTCA TCGCTGTGCG CGTCTTCTAC 540

CGCAAGTGCC CCCGCATCAT CCAGAACGGC GCCATCTTCC AGGAGACGCT GTCAGGGGCC 600

GAGAGCACTT CGCTGGTGGC CGCCCGGGGC AGCTGCATCG CCAATGCTGA GGAGGTGGAC 660

GTGCCCATCA AACTCTACTG TAACGGGGAC GGCGAGTGGC TGGTGCCCAT CGGGCGCTGC 720

ATGTGCAAAG CGGGCTTCGA GGCCGTGGAG AATGGCACCG TCTGCCGAGG TTGCCCATCT 780

GGAACCTTCA AGGCCAACCA AGGGGACGAG GCCTGCACCC ACTGCCCCAT CAACAGCCGG 840

ACCACTTCGG AAGGGGCCAC CAACTGTGTC TGCCGCAACG GCTACTACCG AGCAGACCTG 900

GACCCGCTGG ACATGCCCTG CACAACCATC CCCTCTGCAC CCCAGGCCGT GATCTCCAGC 960

GTCAACGAGA CCTCACTCAT GTTAGAGTGG ACCCCGCCCC GCGACTCCGG AGGCCGGGAG 1020

GATCTCGTCT ATAACATCAT CTGCAAGAGC TGTGGCTCCG GCCGGGGCGC CTGCACCCGC 1080

TGTGGGGACA ACGTGCAGTA TGCACCCCGC CAGCTGGGCC TGACGGAGCC CCGCATCTAC 1140

ATCAGCGACC TGCTGGCCCA CACCCAGTAC ACCTTCGAGA TCCAGGCCGT GAACGGCGTC 1200

ACCGACCAGA GCCCCTTCTC CCCTCAGTTC GCCTCCGTGA ACATCACCAC CAACCAAGCA 1260

GCTCCGTCGG CTGTGTCCAT CATGCACCAG GTGAGCCGCA CCGTGGACAG CATCACCCTG 1320

TCGTGGTCCC AGCCTGACCA GCCCAACGGC GTCATCCTGG ACTATGAGCT GCAGTACTAC 1380

GAGAAGGAGC TCAGTGAGTA CAACGCCACG GCCATAAAGA GCCCCACCAA CACAGTCACT 1440

GTGCAGGGCC TCAAAGCCGG CGCCATCTAT GTCTTCCAGG TGCGGGCACG CACCGTGGCG 1500

GGCTATGGGC GCTACAGTGG CAAGATGTAC TTCCAGACCA TGACAGAAGC CGAGTACCAG 1560

ACCAGCATCC AGGAGAAGCT GCCACTCATC GTCGGCTCCT CGGCGGCTGC CCTGGTCTTC 1620

CTCATCGCCG TGGTTGTCAT CGCCATCGTG TGTAACAGAA GACGGGGGTT TGAGCGTGCT 1680

GACTCGGAAT ACACGGACAA GCTGCAGCAC TACACCAGTG GCCACATGAC CCCAGGCATG 1740

AAGATCTACA TCGACCCGTT CACCTACGAG GACCCCAATG AGGCAGTGCG GGAGTTTGCC 1800

AAGGAAATCG ACATCTCCTG TGTCAAAATT GAGCAGGTGA TCGGAGCAGG GGAGTTTGGT 1860

GAGGTGTGCA GTGGCCACCT GAAACTGCCA GGCAAGAGAG AGATCTTTGT AGCCATCAAG 1920

ACGCTCAAGT CGGGCTATAC TGAGAAGCAG CGCCGGGACT TCCTGAGCGA GGCCTCCATC 1980

ATGGGCCAGT TCGACCACCC CAACGTCATT CACCTGGAGG GTGTTGTCAC CAAGAGCACG 2040

CCCGTGATGA TCATCACTGA GTTCATGGAG AATGGCTCCC TGGACTCCTT CCTCCGGCAA 2100

AACGACGGGC AGTTCACAGT CATCCAGCTG GTGGGCATGC TGCGGGGCAT CGCGGCCGGC 2160

ATGAAGTACC TGGCGGACAT GAACTACGTC CACCGCGACC TGGCCGCCCG CAACATCCTC 2220

GTCAACAGCA ACCTGGTCTG CAAGGTGTCC GACTTCGGCC TCTCACGCTT TCTGGAGGAT 2280

GATACCTCAG ACCCCACCTA CACCAGCGCC CTGGGTGGGA AGATCCCCAT CCGCTGGACA 2340

GCCCCAGAAG CCATCCAGTA CCGGAAGTTC ACCTCAGCCA GCGACGTGTG GAGCTATGGC 2400

ATCGTCATGT GGGAGGTGAT GTCGTACGGG GAGCGGCCCT ACTGGGACAT GACCAACCAG 2460

GACGTAATCA ATGCCATAGA GCAGGACTAC CGGCTGCCAC CGCCCATGGA CTGCCCAAGC 2520

GCCCTGCACC AGCTCATGCT GGACTGCTGG CAGAAGGACC GCAACCACCG GCCCAAGTTT 2580

GGTCAGATCG TCAACACGCT GGACAAGATG ATCCGCAACC CCAACAGCCT CAAAGCCATG 2640

GCGCCCCTCT CTTCTGGGTA TGGCCCTGCC CCTTCTCTGT GGCTCCGCCC CAGCTGGCCC 2700

TTACCCTCTC CAAATACCCT CCCACCCTGG CTACCCTGCC TCAAGCAGAT ACTCTGCCTG 2760

AACTGGGATG GAGAAGATGG ATTTACTCAT CATTCCTTGC TCTCTCTCTC TTTTCTTTGG 2820

GACATTCTCC GGGTTGGGGT CACCTTGGCC GGCCACCAGA AAAAAATCCT GAACAGTATC 2880

CAGGTGATGC GGGCACAGAT GAACCAGATC CAGTCTGTGG AGGTTTGA 2928

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viGaGefGevcsG+lklpgkrei vaiktlk+g+tekqrrdflseasi+Gqfdhp

Q: 608   VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP  667

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         n+i+leGvvtks+pvmi+te+meng+ldsflr++dgqftviqlvgmlrGia+gmkyl+dm

Q: 668   NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM  727

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178

         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt++ ggkipirwtapeai+y

Q: 728   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsDPTYTSAlGGKIPIRWTAPEAIQY  787

         **********************************99*****999****************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkftsasdvwsyGiv+wev+syGerpywdm+nqdvi+aie++yrlpppmdcp+al+qlml

Q: 788   RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML  847

         ************************************************************

S: 239   dcwqkdraerpkfeqivsil  258

         dcwqkdr++rpkf qiv++l

Q: 848   DCWQKDRNHRPKFGQIVNTL  867

         *****************975

Domain Sequence
(FASTA)

VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT EKQRRDFLSE ASIMGQFDHP 60

NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLADM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY 180

RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD CPSALHQLML 240

DCWQKDRNHR PKFGQIVNTL 260

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013