EKS-MYL-00339

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00339

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	342.0	2.7E-102	168	587	420

Status

Unreviewed

Ensembl Protein

ENSMLUP00000003480

UniProt Accession

G1P113;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK1

Gene Synonyms/Alias

EIF2AK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000003813	ENSMLUP00000003480	ENSMLUT00000003819

Organism

Myotis lucifugus

Functional Description

Protein Length

635

Protein Sequence
(FASTA)

MLGSSPAAPE REAESDGAGA VPAPPAIDFP KDGSDPKYDE SDVPAELQVL KGPQQQQPTF 60

PFAVANQLLL VSLLEHLSHV HEPNPFRSRQ VFKLLCQTFI KMGLLSSFTC SDEFSSLRLH 120

HNRAITHLMR SARESVRQDP CEDSSHIPKI RSREVAFEAQ TSRYLNEFEE VSILGKGGYG 180

RVYKVRNKLD GQYYAIKKIL IKGATKTDCM KVLREVKVLA GLQHPNIVGY HTAWIEHVHV 240

AQTHADRISV QLPSLKVISA QAGDRDQYDV KNDESNSSSI IFAELTSEKE KLLGESGIEN 300

QNNKLVNYTP NLVTRDASGF ELSIELQENG LAELSSRSMA DNQLPLRLNS DLEGNFTSTE 360

ESSEENLNMV GQTEMQYHLM LHIQMQLCEL SLWDWIVERN RRSRECVDES ACPYVMASVA 420

TKIFQELVEG VFYIHSMGVV HRDLKPRNIF LHGPDQQVKI GDFGLACTDI IQNPNWTGRD 480

GKTFQITGPT HTSRVGTCLY ASPEQLEGSE YDAQSDMYSV GVILLELFQP FGTEMERAQV 540

LTGLRTGQMP ASLSQRCPVQ ARCVQELTRK NASQRPSAMQ LLQSDLFQNP GSVNLTLQMK 600

IVEQEKEIEE LKKQLRLLSQ NKGVKDDMKD GGVPV 635

Nucleotide Sequence
(FASTA)

ATGCTGGGGA GCAGCCCCGC GGCACCGGAG CGCGAGGCCG AGAGCGACGG GGCGGGGGCT 60

GTTCCTGCAC CGCCTGCCAT CGACTTCCCG AAGGACGGCT CGGACCCCAA GTATGACGAA 120

TCTGATGTTC CAGCAGAACT CCAGGTGTTA AAAGGACCGC AGCAGCAGCA GCCGACCTTC 180

CCTTTTGCAG TTGCCAACCA ACTATTGCTT GTCTCTCTGC TGGAACACTT GAGCCATGTG 240

CATGAACCAA ACCCATTTCG TTCAAGACAG GTGTTTAAAT TACTTTGTCA GACCTTTATC 300

AAAATGGGGC TGCTGTCTTC TTTCACCTGC AGTGATGAGT TCAGCTCATT GAGACTACAT 360

CACAACAGAG CCATCACTCA TTTAATGAGG TCAGCGAGAG AGAGCGTTCG ACAGGATCCT 420

TGTGAGGATA GTTCTCATAT TCCGAAGATC AGATCAAGGG AAGTAGCCTT TGAAGCACAG 480

ACTTCACGTT ACTTAAATGA GTTTGAAGAG GTTTCCATCT TAGGAAAAGG TGGATATGGA 540

AGAGTATACA AGGTCAGGAA TAAATTAGAT GGTCAGTATT ATGCGATTAA GAAAATCCTG 600

ATTAAGGGTG CAACTAAGAC AGATTGCATG AAGGTTCTAC GGGAAGTGAA GGTGCTGGCG 660

GGTCTTCAGC ACCCTAACAT TGTGGGCTAT CACACTGCTT GGATTGAGCA TGTTCACGTG 720

GCCCAAACGC ACGCAGATAG AATTTCTGTT CAGTTGCCAT CTCTGAAAGT GATCTCCGCC 780

CAGGCGGGCG ACAGAGATCA ATATGATGTT AAAAATGATG AAAGTAACAG CTCATCCATT 840

ATCTTCGCCG AGTTGACCTC AGAAAAAGAA AAACTCTTAG GAGAGTCTGG CATTGAAAAT 900

CAGAATAACA AATTGGTGAA CTATACCCCC AATCTAGTCA CAAGAGATGC CAGTGGATTT 960

GAATTATCCA TTGAGCTCCA AGAAAATGGC CTGGCTGAGT TGTCTTCCAG ATCGATGGCT 1020

GACAATCAGC TGCCACTTAG GCTTAATTCA GACTTGGAGG GGAATTTCAC ATCCACTGAG 1080

GAATCGTCTG AAGAAAACTT AAACATGGTG GGACAGACAG AGATGCAATA CCACCTGATG 1140

CTGCACATCC AGATGCAGCT GTGTGAGCTC TCCCTGTGGG ACTGGATCGT GGAGAGGAAC 1200

AGGCGGAGCC GGGAGTGTGT GGATGAGTCT GCCTGTCCTT ACGTTATGGC CAGTGTTGCA 1260

ACAAAAATTT TTCAAGAATT GGTGGAAGGT GTATTTTACA TCCATAGCAT GGGGGTTGTG 1320

CACAGAGACC TGAAGCCCAG AAATATTTTT CTTCATGGCC CTGATCAGCA AGTGAAAATA 1380

GGAGACTTCG GTCTGGCCTG CACAGACATC ATACAGAACC CAAACTGGAC CGGCAGGGAT 1440

GGGAAGACTT TTCAAATTAC AGGACCAACA CATACTTCCA GAGTGGGCAC CTGCCTGTAC 1500

GCATCACCCG AACAGCTGGA AGGATCTGAA TATGATGCCC AGTCGGACAT GTACAGCGTG 1560

GGCGTGATCC TGCTGGAGCT CTTCCAGCCG TTTGGGACAG AAATGGAGCG AGCGCAGGTT 1620

CTGACGGGTC TGAGAACTGG TCAGATGCCC GCGTCCCTCA GCCAGAGGTG TCCCGTCCAA 1680

GCCAGGTGCG TCCAGGAGCT GACCAGAAAG AACGCGTCCC AGAGGCCGTC GGCTATGCAG 1740

CTGCTGCAGA GCGACCTTTT CCAGAATCCC GGAAGCGTCA ATCTCACCCT GCAGATGAAG 1800

ATAGTAGAGC AAGAAAAAGA AATAGAAGAA CTAAAGAAGC AGTTACGCCT CCTTTCTCAA 1860

AACAAAGGGG TGAAGGATGA CATGAAAGAT GGGGGTGTTC CTGTCTAG 1908

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59

         fee+ +lGkGg+g+V+k++nkld+++yaik+i ++ a+k+ ++kv+revk+La l+hpni

Q: 168   FEEVSILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTdCMKVLREVKVLAGLQHPNI  227

         899*********************************************************

S: 60    vrYfaawleekeesl.............................................  74

         v Y++aw+e+ +  +

Q: 228   VGYHTAWIEHVHVAQthadrisvqlpslkvisaqagdrdqydvkndesnsssiifaelts  287

         ************999788888888888877777777777777777775444444444444

S: 75    ..........tdsseveaeaeleesesseesdtk..........................  98

Q: 288   ekekllgesgI----------------------Enqnnklvnytpnlvtrdasgfelsie  325

         44444444440......................366666666666666666666666666

S: 99    ......................................................llyiqm  104

                                                               +l+iqm

Q: 326   lqenglaelssrsmadnqlplrlnsdlegnftsteesseenlnmvgqtemqyhlMLHIQM  385

         666666666666666666667777777777777777777777777777777777******

S: 105   elceketLkdwiderk......llesrselvm.....rlfkqllegleylHskgliHrdL  153

         +lce  +L+dwi er+      ++es++ +vm     ++f++l+eg+ y+Hs+g++HrdL

Q: 386   QLCE-LSLWDWIVERNrrsrecVDESACPYVMasvatKIFQELVEGVFYIHSMGVVHRDL  444

         ****.*******99998889989999999999****************************

S: 154   kpsniFld.sddqvKigDFgLatalaealkedvkqdaqske....akhtgqvgtklymsP  208

         kp+niFl+  d+qvKigDFgLa++++ + + +++ ++ ++     ++ht++vgt+ly+sP

Q: 445   KPRNIFLHgPDQQVKIGDFGLACTDIIQ-NPNWTGRDGKTFqitgPTHTSRVGTCLYASP  503

         ********99**************7766.55799988888767778**************

S: 209   eqleksqYnkkvDifsLGlilfeLlypfstemervetltelrdgkipedfddkvpkekkl  268

         eqle+s+Y++++D++s+G+il+eL++pf temer+++lt lr+g++p+++++++p+++++

Q: 504   EQLEGSEYDAQSDMYSVGVILLELFQPFGTEMERAQVLTGLRTGQMPASLSQRCPVQARC  563

         ************************************************************

S: 269   lqkllsrdpkeRpsasellksell  292

         +q+l+++++++Rpsa++ll+s+l+

Q: 564   VQELTRKNASQRPSAMQLLQSDLF  587

         ********************9876

Domain Sequence
(FASTA)

FEEVSILGKG GYGRVYKVRN KLDGQYYAIK KILIKGATKT DCMKVLREVK VLAGLQHPNI 60

VGYHTAWIEH VHVAQTHADR ISVQLPSLKV ISAQAGDRDQ YDVKNDESNS SSIIFAELTS 120

EKEKLLGESG IENQNNKLVN YTPNLVTRDA SGFELSIELQ ENGLAELSSR SMADNQLPLR 180

LNSDLEGNFT STEESSEENL NMVGQTEMQY HLMLHIQMQL CELSLWDWIV ERNRRSRECV 240

DESACPYVMA SVATKIFQEL VEGVFYIHSM GVVHRDLKPR NIFLHGPDQQ VKIGDFGLAC 300

TDIIQNPNWT GRDGKTFQIT GPTHTSRVGT CLYASPEQLE GSEYDAQSDM YSVGVILLEL 360

FQPFGTEMER AQVLTGLRTG QMPASLSQRC PVQARCVQEL TRKNASQRPS AMQLLQSDLF 420

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006950	; P:response to stress

KEGG

InterPros

IPR015516	; Haem-reg_EIF2A_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013