EKS-MYL-00087

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00087

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Musk	608.7	1.6E-183	585	865	281

Status

Unreviewed

Ensembl Protein

ENSMLUP00000003579

UniProt Accession

G1P198;

Protein Name

Protein Synonyms/Alias

Gene Name

MUSK

Gene Synonyms/Alias

MUSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000003928	ENSMLUP00000003579	ENSMLUT00000003931

Organism

Myotis lucifugus

Functional Description

Protein Length

879

Protein Sequence
(FASTA)

MRELVNIPLV HILTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 60

WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCI ADNGVGGAAE SCGALQVKMK 120

PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDSA LRENSRIAVL ESGSLRIHNV 180

QKEDAGHYRC VAKNSLGTAY SKLVKLEVEE ETEPEQDNKV FARILRTPES HNVTFGSFVT 240

LRCTATGIPV PTITWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE 300

KFTTSKAAAT VSIGEWSKPQ KDNKGYCAQY RGEVCNTVLA NGALVFFNNS YADPEEAQEL 360

LVHTAWSELR AVSPFCRPAA EALLCNHIFQ ECNPGVLPTP IPICREYCLG VKELFCAKEW 420

LALEEKTHRG LYRPGLHLLS VLDCSKLPSM HWDPRACTRL PYLDFKKENL TTFPSMTSSK 480

PSVDIPNLPS SSSSSFSVSP AYSMTVIISI MSSFAVFALL TITTLYCCRR RKQWKNKKRE 540

SAAVTLTTLP SELLLDRLHP NPMYQRMPLL LNPKLLSLEY PRNNIEYVRD IGEGAFGRVF 600

QARAPGLLPH EPSTMVAVKM LKEEASADMQ ADFQREAALM AEFDNPNIVK LLGVCAVGKP 660

MCLLFEYMAY GDLNEFLRSM SPHTARSLSH SDLSPRAHIS SPGPPPLSCA EQLCIARQVA 720

AGMAYLSERK FVHRDLATRN CLVGENMVVK IADFGLSRNI YSADYYKANE NDAIPIRWMP 780

PESIFFNRYT TESDVWAYGV VLWEIFSYGL QPYYGMAHEE VIYYVRDGNI LSCPENCPLE 840

LYNLMRLCWS KLPADRPSFA SIHRILERMC ERADGTVSV 879

Nucleotide Sequence
(FASTA)

ATGAGAGAGC TCGTCAACAT TCCACTGGTA CATATTCTTA CCCTGGTTGC CTTCAGCGGG 60

ACTGAGAAAC TTCCAAAAGC TCCTGTCATC ACCACTCCTC TTGAAACAGT GGATGCCTTA 120

GTTGAAGAAG TGGCTACTTT CATGTGTGCA GTGGAATCTT ATCCCCAGCC TGAAATTTCC 180

TGGACTAGGA ATAAAATTCT CATCAAGCTC TTCGACACCC GGTACAGCAT TCGGGAGAAC 240

GGGCAGCTCC TCACCATCCT GAGTGTGGAA GATAGTGACG ACGGCATTTA CTGCTGCATC 300

GCTGACAATG GCGTGGGAGG AGCTGCGGAG AGCTGCGGGG CTCTGCAAGT GAAGATGAAG 360

CCGAAAATAA CTCGTCCTCC CATAAATGTA AAAATAATAG AAGGATTAAA GGCAGTTCTA 420

CCATGTACTA CAATGGGCAA TCCCAAACCA TCGGTGTCAT GGATTAAAGG AGATAGTGCT 480

CTCAGGGAAA ATTCCCGCAT TGCAGTTCTT GAATCTGGGA GTTTAAGGAT TCATAATGTG 540

CAAAAGGAAG ATGCAGGACA TTATCGATGT GTGGCAAAAA ACAGCCTCGG GACAGCATAT 600

TCCAAATTGG TGAAGCTGGA AGTTGAGGAA GAAACTGAAC CTGAGCAAGA TAATAAAGTT 660

TTTGCCAGAA TCCTGCGGAC TCCTGAATCC CACAATGTCA CCTTTGGCTC CTTTGTGACC 720

CTGCGTTGTA CGGCAACAGG CATCCCTGTC CCCACCATCA CCTGGATTGA GAACGGAAAT 780

GCTGTTTCTT CTGGGTCCAT TCAAGAAAGT GTGAAAGACC GAGTGATTGA CTCAAGACTG 840

CAGCTGTTTA TCACCAAGCC TGGACTCTAC ACATGCATAG CTACTAATAA GCATGGAGAG 900

AAATTCACTA CTTCAAAGGC TGCAGCCACT GTCAGTATAG GAGAATGGAG TAAACCACAG 960

AAAGATAACA AAGGCTACTG CGCCCAGTAC AGAGGGGAGG TGTGTAACAC TGTCCTGGCA 1020

AACGGTGCTC TTGTTTTCTT CAACAACTCC TACGCGGACC CTGAGGAGGC CCAAGAACTA 1080

CTCGTGCACA CCGCCTGGAG TGAACTGAGA GCAGTGAGCC CGTTCTGCCG GCCAGCTGCG 1140

GAGGCTTTGC TGTGTAACCA CATTTTCCAA GAATGCAACC CTGGGGTTCT ACCTACTCCT 1200

ATACCCATTT GCAGAGAATA CTGCCTGGGG GTGAAGGAGC TCTTCTGTGC AAAAGAATGG 1260

CTGGCTCTGG AAGAGAAGAC CCACAGGGGA CTCTACAGAC CTGGGCTGCA TCTGCTCTCG 1320

GTGCTCGACT GCAGCAAGCT CCCCAGCATG CACTGGGACC CGCGGGCCTG CACCAGACTG 1380

CCATATTTAG ATTTTAAAAA AGAAAACCTA ACAACATTCC CATCAATGAC ATCCTCAAAG 1440

CCGAGTGTGG ACATTCCAAA TTTGCCTTCC TCCTCCTCCT CCTCCTTTTC TGTCTCACCT 1500

GCATATTCCA TGACTGTAAT CATCTCTATC ATGTCCAGCT TTGCAGTATT TGCGCTTCTT 1560

ACCATAACCA CTCTTTATTG CTGCCGAAGG CGAAAACAAT GGAAAAATAA GAAAAGAGAA 1620

TCAGCAGCAG TGACCCTCAC TACTCTTCCG TCTGAGCTCC TGCTGGACAG ACTGCATCCT 1680

AACCCCATGT ACCAGAGGAT GCCACTCCTT CTGAATCCCA AATTGCTCAG CCTGGAGTAT 1740

CCAAGGAATA ATATTGAATA TGTGAGGGAT ATTGGAGAAG GAGCATTTGG AAGGGTCTTT 1800

CAAGCAAGGG CTCCAGGCTT ACTCCCCCAT GAACCGTCCA CCATGGTGGC AGTGAAGATG 1860

CTCAAAGAAG AGGCTTCAGC TGACATGCAA GCCGACTTTC AACGGGAGGC GGCCCTCATG 1920

GCGGAATTTG ACAATCCTAA CATTGTGAAA CTCTTAGGTG TGTGTGCCGT GGGGAAACCC 1980

ATGTGCCTGC TCTTTGAATA CATGGCCTAT GGCGACCTCA ATGAGTTCCT CCGCAGCATG 2040

TCGCCTCACA CAGCGCGCAG CCTCAGTCAC AGCGACCTGT CCCCGAGGGC ACACATCTCC 2100

AGCCCTGGGC CCCCGCCCCT CTCCTGCGCT GAGCAGCTTT GCATAGCCAG GCAGGTAGCA 2160

GCTGGCATGG CTTACCTCTC AGAGCGCAAG TTTGTCCACC GGGATTTAGC CACCAGGAAC 2220

TGCCTGGTGG GTGAGAACAT GGTGGTGAAA ATTGCCGATT TTGGCCTCTC CAGGAACATC 2280

TATTCAGCAG ACTACTACAA AGCTAATGAG AACGATGCGA TCCCTATCCG GTGGATGCCA 2340

CCTGAGTCCA TTTTCTTCAA CCGTTACACC ACCGAGTCTG ACGTGTGGGC CTACGGTGTG 2400

GTCCTGTGGG AGATCTTCTC CTATGGCTTG CAGCCCTACT ATGGGATGGC CCATGAGGAG 2460

GTCATTTACT ACGTGCGAGA TGGCAACATC CTCTCCTGCC CTGAGAATTG CCCCTTGGAG 2520

CTGTACAATC TAATGCGTCT GTGTTGGAGC AAGCTGCCTG CCGACAGACC CAGCTTCGCC 2580

AGTATTCACC GAATTCTGGA ACGCATGTGT GAGAGGGCAG ATGGAACTGT GAGTGTCTAA 2640

Domain Profile

S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60

         ieyvrd+gegafgrvfqarapgllp+e+ ++vavkmlkeeasadmqadf+reaal+aefd

Q: 585   IEYVRDIGEGAFGRVFQARAPGLLPHEPSTMVAVKMLKEEASADMQADFQREAALMAEFD  644

         89**********************************************************

S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120

         npnivkllgvcavgkpmcllfeymaygdlneflrs+sp+t+ slshsdls ra++ssp++

Q: 645   NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTARSLSHSDLSPRAHISSPGP  704

         ************************************************************

S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180

         +pls+ae+lciarqvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr+iysad

Q: 705   PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD  764

         ************************************************************

S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240

         yyka+endaipirwmp+esi++nryt+esdvwaygvvlweifsy+lqpyyg+aheevi+y

Q: 765   YYKANENDAIPIRWMPPESIFFNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYY  824

         ************************************************************

S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281

         vrdgnil+cpen+plely+lmrlcwsklpadrpsfasihri

Q: 825   VRDGNILSCPENCPLELYNLMRLCWSKLPADRPSFASIHRI  865

         ***************************************98

Domain Sequence
(FASTA)

IEYVRDIGEG AFGRVFQARA PGLLPHEPST MVAVKMLKEE ASADMQADFQ REAALMAEFD 60

NPNIVKLLGV CAVGKPMCLL FEYMAYGDLN EFLRSMSPHT ARSLSHSDLS PRAHISSPGP 120

PPLSCAEQLC IARQVAAGMA YLSERKFVHR DLATRNCLVG ENMVVKIADF GLSRNIYSAD 180

YYKANENDAI PIRWMPPESI FFNRYTTESD VWAYGVVLWE IFSYGLQPYY GMAHEEVIYY 240

VRDGNILSCP ENCPLELYNL MRLCWSKLPA DRPSFASIHR I 281

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR020067	; Frizzled_dom.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF01392	; Fz; 1.
PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50038	; FZ; 1.
PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013