EKS-MYL-00310

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00310

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	353.1	9.3E-106	304	555	252

Status

Unreviewed

Ensembl Protein

ENSMLUP00000003581

UniProt Accession

G1P1A0;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK3

Gene Synonyms/Alias

PAK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000003929	ENSMLUP00000003581	ENSMLUT00000003933

Organism

Myotis lucifugus

Functional Description

Protein Length

580

Protein Sequence
(FASTA)

MSDNLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN 60

KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTNSPFQTSR PVTVASSQSE GKMPDLYGSQ 120

MCPGKLPEGI PEQWARLLQT SNITKLEQKK NPQAVLDVLK FYDSKETVNN QKYMSFTSGD 180

KSAHGYIAAH SSSTKTASEP PLAPPVSEEE DEEEEEEEDD NEPPPVIAPR PEHTKSIYTR 240

SVVESIASPA APSKEVTPPS AENANSSTLY RNTDRQRKKS KMTDEEILEK LRSIVSVGDP 300

KKKYTRFEKI GQGASGTVYT ALDIATGQEV AIKQMNLQQQ PKKELIINEI LVMRENKNPN 360

IVNYLDSYLV GDELWVVMEY LAGGSLTDVV TETCMDEGQI AAVCRECLQA LDFLHSNQVI 420

HRDIKSDNIL LGMDGSVKLT DFGFCAQITP EQSKRSTMVG TPYWMAPEVV TRKAYGPKVD 480

IWSLGIMAIE MVEGEPPYLN ENPLRALYLI ATNGTPELQN PERLSAVFRD FLNRCLEMDV 540

DRRGSAKELL QHPFLKLAKP LSSLTPLIIA AKEAIKNSSR 580

Nucleotide Sequence
(FASTA)

ATGTCTGACA ATCTGGATAA TGAAGAGAAA CCCCCAGCTC CCCCACTGAG GATGAATAGT 60

AACAATCGGG ATTCTTCAGC ACTCAACCAC AGCTCCAAAC CGCTTCCCAT GGCCCCTGAA 120

GAGAAGAATA AGAAAGCCAG GCTTCGCTCT ATCTTCCCAG GAGGAGGGGA TAAAACCAAT 180

AAGAAGAAAG AGAAAGAACG CCCAGAGATC TCTCTTCCTT CAGACTTTGA ACATACGATT 240

CATGTGGGGT TTGATGCAGT CACTGGGGAA TTCACTAACT CCCCCTTCCA GACCTCTAGA 300

CCTGTGACGG TCGCTTCAAG TCAATCAGAG GGAAAAATGC CAGATCTCTA TGGCTCACAG 360

ATGTGCCCAG GGAAGCTCCC AGAGGGAATT CCTGAGCAAT GGGCACGATT ACTCCAAACC 420

TCCAACATAA CAAAACTGGA ACAGAAGAAG AACCCACAAG CAGTTCTAGA TGTTCTCAAA 480

TTCTATGATT CCAAAGAAAC AGTCAACAAC CAGAAATACA TGAGCTTTAC ATCAGGAGAT 540

AAAAGTGCAC ATGGATACAT AGCAGCCCAT TCTTCGAGTA CAAAAACAGC ATCAGAGCCT 600

CCTTTGGCCC CTCCTGTGTC TGAAGAAGAA GATGAAGAAG AGGAAGAAGA AGAAGATGAC 660

AATGAACCCC CACCAGTTAT TGCACCAAGA CCTGAGCATA CAAAATCAAT CTATACTCGT 720

TCTGTGGTTG AATCCATTGC TTCACCAGCA GCACCAAGTA AAGAGGTCAC ACCACCTTCT 780

GCTGAGAATG CCAATTCCAG TACTTTGTAT AGAAATACAG ATCGACAAAG GAAAAAATCC 840

AAGATGACAG ATGAGGAGAT TCTAGAGAAG CTGAGAAGCA TTGTGAGTGT TGGTGATCCA 900

AAGAAAAAAT ACACAAGATT TGAAAAAATT GGCCAAGGGG CATCGGGTAC TGTCTATACA 960

GCACTTGATA TTGCAACAGG ACAAGAGGTG GCCATAAAGC AGATGAACCT TCAACAGCAG 1020

CCCAAAAAGG AACTAATTAT TAATGAAATT CTGGTCATGA GGGAAAATAA GAACCCCAAT 1080

ATTGTTAATT ATTTAGATAG CTACTTAGTG GGTGATGAAC TATGGGTAGT CATGGAATAC 1140

TTGGCTGGTG GCTCTTTGAC TGATGTGGTC ACAGAGACCT GTATGGATGA AGGGCAGATA 1200

GCAGCTGTCT GCAGAGAGTG CCTCCAAGCT TTGGATTTCT TACACTCAAA CCAAGTGATC 1260

CATAGAGACA TAAAGAGTGA CAATATTCTC CTTGGGATGG ATGGCTCTGT TAAATTGACT 1320

GATTTTGGGT TCTGTGCCCA GATCACCCCT GAGCAAAGTA AACGAAGCAC TATGGTGGGA 1380

ACTCCCTATT GGATGGCACC TGAGGTGGTG ACTCGAAAAG CTTATGGTCC GAAAGTTGAT 1440

ATCTGGTCTC TGGGGATTAT GGCAATTGAA ATGGTGGAAG GTGAACCTCC ATACCTTAAT 1500

GAAAATCCAC TCAGGGCATT ATATCTGATA GCTACTAATG GAACCCCAGA GCTCCAGAAT 1560

CCAGAAAGAC TGTCGGCTGT ATTCCGTGAC TTTTTAAATC GCTGTCTTGA GATGGATGTG 1620

GATAGGCGAG GATCTGCCAA GGAGCTTTTG CAGCATCCAT TTTTAAAATT AGCCAAGCCT 1680

CTCTCCAGTC TGACTCCTCT GATTATCGCT GCAAAGGAAG CAATTAAGAA CAGCAGCCGC 1740

TAG 1743

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+vy+a ++ tg+ vaik++nl++q+k+e++++ei v+++ k+pniv+

Q: 304   YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN  363

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         yl+s+l+ +elw+vmeylagGsl+d+v+   ++ ++E qia+++re+l+aL++lHs++vi

Q: 364   YLDSYLVGDELWVVMEYLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALDFLHSNQVI  420

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++niLl ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 421   HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  478

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++++s  f++f+++cl+

Q: 479   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEM  538

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++++R sa+ell+h+Fl

Q: 539   DVDRRGSAKELLQHPFL  555

         ****************7

Domain Sequence
(FASTA)

YTRFEKIGQG ASGTVYTALD IATGQEVAIK QMNLQQQPKK ELIINEILVM RENKNPNIVN 60

YLDSYLVGDE LWVVMEYLAG GSLTDVVTET CMDEGQIAAV CRECLQALDF LHSNQVIHRD 120

IKSDNILLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPER LSAVFRDFLN RCLEMDVDRR 240

GSAKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013