EKS-MYL-00121
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00121
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec489.41.8E-147406656251
StatusUnreviewed
Ensembl ProteinENSMLUP00000003954
UniProt AccessionG1P273;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000004336ENSMLUP00000003954ENSMLUT00000004346
OrganismMyotis lucifugus
Functional Description
Protein Length663
Protein Sequence
(FASTA)
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVQKLSYY EYDFERGRRG SKKGSIDVEK 60
ITCVETVVPE KNPPPERQIP PFSFRRGEES GEMEQISIIE RFPYPFQVVY DEGPLYVFSP 120
TEELRKRWIH QLKNVIRYNS DLVQKYHPCF WIDGQYLCCS QTAKNAMGCQ ILENRNGSLK 180
SGSSHRKTKK PLPPTPEEDQ ILKKPLPPEP TAAPVSTSEL KKVVALYDYM PMNANDLQLR 240
KGDEYFILEE SNLPWWRARD KNGQEGYIPS NYVTEAEDSI EMYEWYSKHM TRSQAEELLK 300
QEGKEGGFIV RDSSKAGKYT VSVFAKSTGD PQGVIRHYVV CSTPQSQYYL AEKHLFSTIP 360
ELINYHQHNS AGLISRLKYP VSQQNKNAPS TAGLGYGSWE IDPKDLTFLK ELGTGQFGVV 420
KYGKWRGQYD VAIKMIKEGS MSEDEFIEEA KVMMNLSHEK LVQLYGVCTK QRPIFIITEY 480
MANGCLLNYL REMRHHFQNQ QLLEMCKDVC EAMEYLESKQ FLHRDLAARN CLVNDQGVVK 540
VSDFGLSRYV LDDEYTSSVG SKFPVRWSPP EVLMYSKFSS KSDIWAFGVL MWEIYSLGKM 600
PYERFTNSET AEHIAQGLRL YRPHLASERV YTIMYSCWHE KADERPTFKV LLSNILDVMD 660
EES 663
Nucleotide Sequence
(FASTA)
ATGGCTGCAG TAATACTGGA GAGCATCTTT CTGAAGCGAT CCCAGCAGAA AAAGAAAACA 60
TCACCTTTAA ACTTCAAGAA GCGCCTTTTT CTTTTGACCG TGCAGAAACT TTCCTACTAT 120
GAGTATGATT TTGAACGTGG GAGAAGAGGC AGTAAGAAGG GTTCAATAGA TGTTGAGAAG 180
ATCACTTGTG TTGAAACAGT GGTTCCTGAA AAAAATCCTC CCCCTGAAAG ACAGATTCCG 240
CCATTCAGTT TCAGAAGGGG TGAAGAGTCT GGTGAAATGG AACAGATCTC AATCATTGAA 300
AGGTTCCCTT ACCCCTTCCA GGTTGTATAT GATGAAGGGC CTCTCTATGT CTTCTCCCCA 360
ACAGAAGAAT TGAGGAAGCG TTGGATTCAT CAGCTCAAAA ATGTAATCCG GTATAACAGT 420
GATCTGGTAC AGAAATACCA CCCTTGCTTC TGGATTGACG GGCAGTACCT CTGCTGCTCT 480
CAGACAGCCA AAAATGCTAT GGGCTGCCAA ATTTTGGAAA ACAGGAATGG AAGCTTAAAA 540
TCTGGGAGTT CTCACCGGAA GACAAAAAAG CCTCTTCCTC CCACACCTGA GGAGGACCAG 600
ATCTTGAAAA AGCCACTGCC CCCTGAGCCA ACAGCAGCAC CAGTTTCCAC AAGTGAACTG 660
AAAAAGGTTG TGGCCCTTTA TGACTACATG CCAATGAATG CAAATGACCT ACAGCTACGG 720
AAGGGTGATG AATATTTTAT CCTGGAAGAA AGCAACTTAC CCTGGTGGCG AGCACGAGAT 780
AAAAATGGGC AGGAAGGCTA CATCCCTAGT AACTATGTCA CTGAAGCAGA AGACTCCATA 840
GAAATGTATG AGTGGTATTC CAAACACATG ACTCGGAGTC AAGCTGAAGA ACTGCTAAAG 900
CAAGAGGGGA AGGAAGGAGG TTTCATTGTC AGAGACTCCA GCAAAGCTGG AAAATATACT 960
GTGTCTGTAT TTGCTAAATC TACAGGGGAC CCTCAAGGGG TGATACGCCA TTATGTTGTG 1020
TGTTCCACAC CTCAGAGCCA ATATTACCTG GCTGAGAAGC ACCTTTTCAG CACCATCCCT 1080
GAGCTCATTA ACTACCATCA GCATAACTCT GCAGGACTCA TATCTAGGCT CAAATATCCA 1140
GTGTCTCAAC AAAACAAGAA TGCACCTTCT ACTGCAGGCC TGGGCTACGG ATCATGGGAA 1200
ATTGATCCAA AGGACCTGAC CTTCTTGAAG GAGCTGGGGA CTGGACAATT TGGGGTAGTG 1260
AAGTATGGGA AATGGAGAGG CCAGTATGAT GTGGCCATCA AGATGATCAA AGAAGGCTCC 1320
ATGTCTGAGG ATGAGTTCAT TGAAGAAGCC AAAGTCATGA TGAATCTTTC CCATGAGAAG 1380
CTGGTGCAGT TGTACGGTGT CTGCACCAAA CAGCGCCCCA TCTTTATCAT CACTGAGTAC 1440
ATGGCCAATG GCTGCCTCCT GAACTACCTG AGGGAGATGC GCCACCACTT CCAGAATCAG 1500
CAGCTGCTGG AGATGTGCAA GGATGTCTGC GAAGCCATGG AATACCTGGA GTCAAAGCAA 1560
TTCCTTCACA GAGACCTGGC GGCTCGAAAC TGTTTGGTAA ATGATCAAGG AGTTGTTAAA 1620
GTATCTGACT TCGGCCTGTC CAGGTATGTT CTGGATGATG AATACACAAG CTCAGTAGGC 1680
TCCAAATTTC CAGTCCGGTG GTCTCCACCA GAAGTCCTTA TGTACAGCAA GTTCAGCAGC 1740
AAATCTGACA TTTGGGCTTT TGGGGTTTTG ATGTGGGAAA TTTACTCTCT GGGGAAGATG 1800
CCATATGAGA GATTTACTAA CAGTGAAACT GCTGAACATA TTGCCCAAGG CTTACGTCTC 1860
TACAGGCCTC ATCTAGCTTC AGAAAGGGTA TATACCATCA TGTACAGCTG CTGGCATGAG 1920
AAAGCAGATG AACGTCCCAC TTTCAAAGTT CTTCTGAGCA ACATTCTAGA TGTCATGGAT 1980
GAAGAATCCT GA 1992
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+ikeg+mse++fieeakvmm+lsh+klvqly
Q: 406   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY  465
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd
Q: 466   GVCTKQRPIFIITEYMANGCLLNYLREMRHHFQNQQLLEMCKDVCEAMEYLESKQFLHRD  525
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w
Q: 526   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  585
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las++vy++m+scw+ek++er
Q: 586   AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADER  645
         ************************************************************
S: 241   ptfkellsale  251
         ptfk lls++ 
Q: 646   PTFKVLLSNIL  656
         ********996
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IKEGSMSEDE FIEEAKVMMN LSHEKLVQLY 60
GVCTKQRPIF IITEYMANGC LLNYLREMRH HFQNQQLLEM CKDVCEAMEY LESKQFLHRD 120
LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180
AFGVLMWEIY SLGKMPYERF TNSETAEHIA QGLRLYRPHL ASERVYTIMY SCWHEKADER 240
PTFKVLLSNI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-CIS-00119
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013