EKS-MYL-00367

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00367

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	444.2	1.3E-133	271	520	250

Status

Unreviewed

Ensembl Protein

ENSMLUP00000004080

UniProt Accession

G1Q0I2;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC

Gene Synonyms/Alias

SRC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000004480	ENSMLUP00000017214	ENSMLUT00000029596
ENSMLUG00000004480	ENSMLUP00000004080	ENSMLUT00000004483

Organism

Myotis lucifugus

Functional Description

Protein Length

537

Protein Sequence
(FASTA)

MGSNKSKPKD ASQRRRSLEP AENAHGGGGG GAFPTSQTPS KPASADGHRG SNTAFSPATA 60

EPKLFGGFNS SDTVTSPQRA GPLAGGVTTF VALYDYESRT ETDLSFKKGE RLQIVNNTEG 120

DWWLAHSLST GQTGYIPSNY VAPSDSIQAE EWYFGKITRR ESERLLLNAE NPRGTFLVRE 180

SETTKGAYCL SVSDFDNAKG LNVKHYKIRK LDSGGFYITS RTQFNSLQQL VAYYSKHADG 240

LCHRLTTVCP TSKPQTQGLA KDAWEIPRES LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT 300

LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY AVVSEEPIYI VTEYMSKGSL LDFLKGETGK 360

YLRLPQLVDM AAQIASGMAY VERMNYVHRD LRAANILVGE NLVCKVADFG LARLIEDNEY 420

TARQGGQVPI KWTAPEAALY GRFTIKSDVW SFGILLTELT TKGRVPYPGM VNREVLDQVE 480

RGYRMPCPPE CPESLHDLMC QCWRKEPEER PTFEYLQAFL EDYFTSTEPQ YQPGENL 537

Nucleotide Sequence
(FASTA)

ATGGGCAGCA ACAAGAGCAA GCCCAAGGAT GCCAGCCAGC GGCGCCGCAG CCTGGAGCCT 60

GCTGAGAACG CCCATGGTGG CGGCGGCGGG GGTGCCTTCC CCACCTCACA GACCCCCAGC 120

AAGCCGGCCT CCGCTGACGG CCACCGTGGC TCCAACACGG CCTTCTCCCC TGCCACCGCC 180

GAGCCCAAGC TGTTTGGAGG CTTCAACTCC TCGGACACAG TCACCTCCCC GCAGAGGGCG 240

GGGCCTCTGG CTGGTGGAGT GACCACCTTT GTGGCCCTCT ACGACTATGA GTCCCGGACA 300

GAGACTGATC TATCCTTCAA GAAAGGGGAG CGGCTGCAGA TTGTCAACAA CACAGAGGGA 360

GACTGGTGGC TGGCCCACTC GCTCAGCACG GGACAGACGG GCTACATCCC CAGCAACTAC 420

GTGGCGCCCT CCGACTCCAT CCAGGCTGAG GAGTGGTACT TTGGCAAGAT CACAAGACGG 480

GAGTCAGAGC GGTTATTGCT CAATGCAGAG AACCCGAGAG GGACCTTCCT AGTGCGAGAA 540

AGCGAGACCA CGAAAGGTGC CTACTGCCTC TCAGTGTCCG ACTTCGACAA CGCCAAGGGC 600

CTCAACGTGA AGCACTACAA GATCCGCAAG CTGGACAGCG GCGGCTTCTA CATCACCTCT 660

CGCACCCAGT TCAACAGTCT GCAGCAGCTC GTAGCCTACT ACTCCAAACA TGCTGATGGC 720

CTGTGCCACC GACTCACCAC TGTGTGCCCT ACGTCCAAGC CACAGACTCA GGGCCTGGCC 780

AAGGACGCTT GGGAGATCCC CCGGGAGTCA CTGCGGCTGG AGGTCAAGCT GGGCCAGGGC 840

TGCTTTGGAG AGGTGTGGAT GGGGACCTGG AACGGCACCA CCAGGGTGGC CATCAAAACC 900

CTGAAGCCAG GCACGATGTC TCCAGAGGCC TTCCTGCAGG AGGCCCAGGT CATGAAGAAA 960

CTGAGGCACG AGAAGCTGGT GCAGCTGTAC GCCGTGGTGT CTGAGGAGCC CATCTACATC 1020

GTCACGGAGT ACATGAGCAA GGGGAGTTTG CTGGACTTCC TCAAGGGGGA GACGGGCAAG 1080

TATCTGCGGC TGCCTCAGCT GGTGGACATG GCTGCTCAGA TCGCCTCAGG CATGGCGTAC 1140

GTGGAGCGGA TGAACTATGT CCACCGGGAT CTCCGTGCTG CCAACATCCT GGTTGGAGAG 1200

AATCTCGTGT GCAAAGTGGC CGACTTTGGC CTGGCTCGGC TCATCGAAGA CAACGAGTAC 1260

ACGGCCCGGC AAGGTGGGCA GGTCCCCATT AAGTGGACGG CTCCAGAAGC TGCCCTCTAC 1320

GGCCGGTTCA CCATCAAGTC AGACGTGTGG TCCTTTGGGA TCCTGCTGAC AGAGCTCACG 1380

ACAAAGGGCC GGGTGCCCTA CCCCGGAATG GTAAACCGTG AGGTGCTGGA CCAGGTGGAG 1440

CGAGGCTACC GGATGCCCTG CCCACCTGAG TGTCCCGAGT CCCTGCACGA CCTCATGTGC 1500

CAGTGCTGGC GGAAGGAGCC CGAGGAGCGG CCCACCTTCG AGTACCTGCA GGCCTTCCTG 1560

GAGGACTATT TCACGTCCAC TGAGCCCCAA TACCAGCCTG GAGAGAACCT ATAG 1614

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 271   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  330

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr

Q: 331   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  389

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+kvadfGlarlied+eyta++g ++PikWtaPea+ +g+ftiksdv

Q: 390   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGGQVPIKWTAPEAALYGRFTIKSDV  449

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee

Q: 450   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  509

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 510   RPTFEYLQAFL  520

         *******9876

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120

LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGGQVPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240

PTFEYLQAFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013