EKS-MYL-00279

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00279

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.4	3.7E-137	207	494	288

Status

Unreviewed

Ensembl Protein

ENSMLUP00000004085

UniProt Accession

G1P2J4;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000004487	ENSMLUP00000004085	ENSMLUT00000004489

Organism

Myotis lucifugus

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MAESAGASSF FPLVVLLLAG SSGSGPRGIQ ALLCTCTSCL QANYTCETDG ACMVSIFNLD 60

GVEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDF CNKIDLRVPS GHLKEPEHPS 120

MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 180

DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 240

ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 300

IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 360

DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 420

GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNIPNWW QSYEALRVMG KMMRECWYAN 480

GAARLTALRI KKTLSQLSVQ EDVKI 505

Nucleotide Sequence
(FASTA)

ATGGCGGAGT CGGCCGGAGC CTCCTCATTC TTCCCCCTCG TCGTCCTCCT GCTCGCCGGC 60

AGCAGCGGGT CCGGGCCCCG GGGAATCCAG GCTCTGCTGT GTACGTGCAC CAGCTGCCTA 120

CAGGCCAACT ACACGTGTGA AACAGATGGG GCCTGCATGG TTTCCATTTT CAACCTGGAT 180

GGGGTGGAGC ACCATGTGCG TACCTGCATC CCCAAAGTGG AGCTGGTCCC TGCTGGGAAG 240

CCCTTCTATT GCCTGAGCTC CGAGGACCTG CGTAACACCC ACTGCTGCTA TACTGACTTC 300

TGCAACAAGA TCGACCTGAG GGTGCCCAGT GGTCACCTTA AGGAGCCTGA GCACCCTTCC 360

ATGTGGGGCC CTGTGGAGCT GGTCGGCATC ATTGCCGGCC CAGTGTTCCT CCTGTTTCTC 420

ATCATCATCA TTGTTTTCCT TGTCATTAAC TATCACCAGC GTGTCTATCA CAACCGCCAG 480

AGGCTGGACA TGGAAGATCC CTCATGTGAG ATGTGCCTCT CCAAAGACAA GACGCTCCAA 540

GATCTTGTCT ACGATCTCTC CACATCAGGG TCTGGCTCAG GGTTACCACT GTTTGTCCAG 600

CGCACAGTGG CCCGAACCAT CGTTTTACAG GAGATTATTG GCAAGGGCCG GTTTGGAGAA 660

GTGTGGCGCG GCCGCTGGAG GGGTGGAGAT GTGGCTGTGA AAATTTTCTC TTCTCGTGAA 720

GAACGGTCTT GGTTCCGGGA AGCAGAGATA TACCAGACAG TCATGCTGCG CCACGAAAAC 780

ATCCTCGGAT TTATTGCTGC TGACAATAAA GATAATGGCA CCTGGACACA GCTGTGGCTC 840

GTCTCAGACT ACCATGAGCA TGGCTCCCTG TTCGATTATC TTAACCGGTA CACAGTGACG 900

ATCGAGGGGA TGATCAAGCT GGCCTTGTCT GCTGCCAGTG GGCTGGCACA CCTGCACATG 960

GAGATCGTGG GCACCCAAGG GAAGCCTGGA ATTGCTCATC GAGACTTAAA GTCGAAGAAC 1020

ATCCTAGTGA AGAAAAACGG CATGTGCGCC ATAGCAGACC TGGGCCTGGC CGTCCGTCAT 1080

GATGCAGTCA CAGACACCAT TGACATTGCC CCAAATCAGA GGGTGGGAAC CAAACGATAC 1140

ATGGCCCCTG AAGTGCTTGA TGAAACCATT AACATGAAGC ACTTTGACTC CTTTAAATGT 1200

GCTGATATCT ATGCCCTCGG GCTTGTATAT TGGGAGATTG CTCGAAGATG CAATTCTGGA 1260

GGAGTCCATG AAGAATATCA GCTGCCATAT TATGACTTAG TGCCCTCTGA CCCTTCCATT 1320

GAGGAAATGC GCAAGGTCGT ATGTGACCAG AAGCTGCGTC CCAACATCCC CAACTGGTGG 1380

CAGAGTTATG AGGCGTTACG CGTGATGGGG AAGATGATGC GAGAGTGCTG GTACGCCAAC 1440

GGCGCAGCCC GCCTGACTGC TCTGCGCATT AAGAAGACCC TCTCCCAGCT CAGCGTGCAG 1500

GAAGATGTGA AGATCTAA 1518

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 207   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  266

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 267   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  326

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 327   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  384

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 385   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  443

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 444   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  494

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013