EKS-MYL-00377

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00377

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	320.2	9.9E-96	170	407	238

Status

Unreviewed

Ensembl Protein

ENSMLUP00000004314

UniProt Accession

G1P337;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K13

Gene Synonyms/Alias

MAP3K13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000004734	ENSMLUP00000004314	ENSMLUT00000004741

Organism

Myotis lucifugus

Functional Description

Protein Length

963

Protein Sequence
(FASTA)

MADPQEHLSC SSSPHLPLSE NKTFNGLQDE LPPMGSHPSP KLLTDQQDKG VVQTELTEGM 60

HSPITTTVLT SVSEDSRDQF ENSVLQLREQ DESEMAVSQG NSNTVDGESM SGTEDIKIQF 120

SRSGGGSGGF LEGLFGCLRP VWNIIGKAYS TDYKLQQQDT WEVPFEEISE LQWLGSGAQG 180

AVFLGKFRAE EVAIKKVREQ NETDIKHLRK LKHPNIIAFK GVCTQAPCYC IIMEYCAHGQ 240

LYEVLRAGRK ITPRLLVDWS TGIASGMNYL HLHKIIHRDL KSPNVLVTHT DAVKISDFGT 300

SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA 360

IIWGVGSNSL HLPVPSTCPD GFKILMKQTW QSKPRNRPSF RQTLMHLDIA SADVLATPQE 420

TYFKSQAEWR EEVKKHFEKI KSEGTCIHRL DEELIRRRRE ELRHALDIRE HYERKLERAN 480

NLYMELSAIM LQLEMREKEL IKREQAVEKK YPGTYKRHPV RPIIHPNAME KLMKRKGVPH 540

KPGVQTKRPD LLRSEGIPSV EVAPAASPLS GSPKMSTSGG KSRYRSKPRH RRGNSRGSHS 600

DFAAILKNQP APENSPHPTY LHEAQPQHPA LQQQYQQPPP ATSQSHHPRL NVHGQDIATC 660

ANNLRYFGPA AALRSPLSNH AQRQMPGSSP DLISTAVAAD GWRSSEPAQG QAGPWGCCQA 720

DPYDPCVQCR PEQCGPLDSP FAEPVGRSPD LFKSPAHNLL SENAQGSKKM EENEEFSGCR 780

SASSLGIPHH ITPPALPRKT RPLQKSGDES SEEEEGEVDS EVEFPRRQSS RPHRCIRSCQ 840

SYSTFSSENF SVSDGEEGNT SDHSNSPDEF ADKLEGRLAE RLDDLLSQTP EIPIEISSHS 900

DGLSDKECAV RRVKTQMSLG KLCVEQRGYE NPMQFEESDC DSSDGECSDA TVRTNKHYSS 960

ATW 963

Nucleotide Sequence
(FASTA)

ATGGCCGACC CTCAGGAGCA CCTGAGCTGC TCCTCCTCCC CACACTTACC CTTGAGTGAA 60

AACAAAACCT TCAATGGACT GCAAGATGAA CTCCCGCCCA TGGGGAGCCA CCCTTCACCC 120

AAGCTCCTTA CGGACCAGCA GGACAAGGGG GTGGTGCAAA CCGAGCTAAC GGAGGGCATG 180

CACAGCCCCA TCACCACAAC AGTGTTGACA AGTGTGAGCG AGGATTCCAG GGACCAGTTT 240

GAGAACAGCG TTCTTCAGCT AAGGGAACAA GATGAATCGG AAATGGCCGT GTCTCAGGGG 300

AACAGCAACA CTGTAGATGG AGAGAGCATG AGTGGAACAG AAGACATCAA GATTCAGTTC 360

AGCAGGTCAG GCGGCGGCAG TGGTGGGTTT CTTGAAGGAC TATTTGGATG CTTAAGGCCT 420

GTATGGAATA TCATTGGGAA GGCGTATTCC ACTGATTACA AATTACAGCA GCAAGATACT 480

TGGGAAGTGC CATTTGAGGA GATCTCAGAG CTGCAGTGGC TGGGTAGCGG AGCCCAAGGA 540

GCTGTTTTTC TGGGCAAGTT CCGAGCGGAG GAGGTGGCCA TCAAGAAAGT GAGAGAACAG 600

AATGAGACGG ATATCAAGCA TTTGAGGAAG TTGAAGCATC CTAACATCAT CGCTTTCAAG 660

GGTGTTTGTA CTCAGGCCCC ATGTTATTGT ATCATCATGG AATACTGTGC CCATGGACAA 720

CTCTACGAGG TTTTGCGAGC GGGCAGGAAG ATCACGCCTC GATTGCTAGT AGACTGGTCC 780

ACAGGAATCG CAAGTGGAAT GAATTATCTG CACCTTCACA AAATTATTCA TCGTGATCTC 840

AAATCACCTA ATGTTTTAGT GACTCACACA GATGCAGTAA AAATTTCAGA TTTTGGTACC 900

TCTAAGGAAC TTAGCGATAA AAGTACCAAG ATGTCCTTTG CTGGCACAGT CGCGTGGATG 960

GCACCAGAAG TGATACGAAA TGAGCCTGTC TCTGAAAAAG TCGATATATG GTCCTTTGGT 1020

GTGGTGCTTT GGGAATTGCT GACAGGAGAG ATCCCTTATA AAGATGTAGA CTCTTCGGCC 1080

ATTATCTGGG GTGTTGGAAG CAATAGCCTA CATCTTCCAG TTCCTTCCAC TTGCCCTGAT 1140

GGATTCAAAA TCCTTATGAA ACAGACATGG CAAAGTAAAC CTCGCAACCG ACCTTCTTTC 1200

CGGCAGACAC TCATGCATTT GGACATCGCG TCTGCAGATG TTCTTGCCAC CCCACAAGAA 1260

ACTTACTTCA AGTCTCAGGC TGAATGGAGA GAAGAAGTGA AAAAACACTT TGAGAAGATC 1320

AAAAGTGAAG GGACGTGTAT ACACCGCTTG GATGAAGAGC TGATTAGAAG GCGGCGAGAA 1380

GAACTCAGGC ATGCTTTGGA CATTCGTGAA CACTACGAGA GAAAACTTGA GCGGGCTAAT 1440

AATTTATACA TGGAGCTGAG TGCCATCATG CTGCAGCTGG AAATGCGGGA GAAGGAGCTC 1500

ATTAAGCGTG AGCAAGCCGT GGAAAAGAAG TATCCTGGGA CCTACAAGCG ACACCCTGTC 1560

CGTCCAATAA TCCACCCCAA TGCCATGGAG AAGCTCATGA AAAGGAAGGG CGTGCCTCAC 1620

AAACCTGGGG TGCAGACCAA ACGGCCAGAT CTGCTGCGGT CAGAAGGCAT CCCCAGTGTG 1680

GAGGTGGCTC CCGCTGCATC CCCTTTGTCC GGAAGCCCCA AAATGTCCAC CTCAGGCGGC 1740

AAGAGCCGGT ACCGGAGCAA ACCACGCCAC CGCCGGGGCA ATAGCCGAGG CAGCCATAGT 1800

GACTTTGCAG CAATCTTGAA AAACCAGCCG GCCCCCGAAA ACTCACCCCA CCCCACGTAT 1860

CTACACGAGG CTCAACCCCA GCACCCTGCT CTGCAGCAGC AGTACCAGCA GCCCCCTCCC 1920

GCCACGTCTC AGAGTCACCA TCCCAGGCTC AATGTGCACG GCCAGGACAT TGCCACCTGC 1980

GCCAACAACC TGAGGTACTT TGGCCCCGCG GCTGCCCTGC GGAGCCCGCT CAGCAACCAC 2040

GCTCAGAGAC AGATGCCTGG CTCCAGCCCT GACCTCATCT CCACAGCCGT GGCAGCAGAT 2100

GGCTGGAGAA GTTCTGAGCC TGCCCAGGGC CAGGCCGGCC CCTGGGGCTG CTGCCAGGCT 2160

GACCCCTATG ACCCCTGCGT GCAGTGCAGG CCGGAGCAGT GCGGGCCCCT GGACAGTCCC 2220

TTTGCTGAGC CGGTGGGGAG GAGCCCCGAC CTTTTCAAGT CACCAGCACA CAATCTCCTC 2280

TCAGAAAATG CCCAAGGTTC CAAGAAAATG GAAGAAAATG AAGAATTCAG TGGCTGTAGG 2340

TCTGCCTCGT CCCTTGGCAT CCCTCATCAC ATCACCCCAC CAGCGCTACC TCGAAAAACA 2400

AGGCCCCTTC AAAAGAGTGG AGATGAGTCC TCAGAAGAGG AAGAAGGGGA AGTAGATAGT 2460

GAAGTTGAAT TTCCACGAAG ACAGAGTTCT AGGCCCCATC GCTGCATCCG AAGTTGCCAG 2520

TCGTATTCAA CCTTTAGCTC TGAGAATTTC TCTGTGTCCG ATGGCGAGGA GGGAAATACC 2580

AGTGACCACT CAAACAGTCC TGATGAGTTT GCTGATAAAC TTGAAGGCCG CCTGGCAGAG 2640

AGGCTCGATG ACCTGCTGTC CCAGACGCCG GAGATTCCCA TCGAGATCTC CTCGCATTCA 2700

GATGGGCTCT CTGACAAGGA GTGTGCCGTG CGCCGCGTGA AGACGCAGAT GTCTCTGGGC 2760

AAGCTGTGTG TGGAGCAGCG TGGCTACGAG AATCCTATGC AGTTTGAAGA ATCAGACTGT 2820

GACTCTTCAG ATGGGGAGTG TTCTGATGCC ACAGTGAGGA CCAATAAACA CTACAGCTCT 2880

GCTACTTGGT AA 2892

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         + +++gsga+g+v+ +k+r++eva+Kk+re++e+         ++k+l+kl+hpnii+++

Q: 170   ELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET---------DIKHLRKLKHPNIIAFK  220

         6789**************************9999.........*****************

S: 63    GvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkki  122

         Gvc++ p+++++mey+++g+L++vl++   r+i+++ lv+w++ iA+Gm+YLh +   ki

Q: 221   GVCTQAPCYCIIMEYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLH---KI  275

         ***************************..99************************...9*

S: 123   ihrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseks  181

         ihrdLks+nvL+ ++++ +ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+

Q: 276   IHRDLKSPNVLV-THTDAVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKV  334

         ************.999***************99***************************

S: 182   DvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedp  241

         D+wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+ps+cp+ +k Lmk++w+++p

Q: 335   DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP  394

         ************************************************************

S: 242   ekRpsfseivksl  254

         ++Rpsf++ +++l

Q: 395   RNRPSFRQTLMHL  407

         *******998775

Domain Sequence
(FASTA)

ELQWLGSGAQ GAVFLGKFRA EEVAIKKVRE QNETDIKHLR KLKHPNIIAF KGVCTQAPCY 60

CIIMEYCAHG QLYEVLRAGR KITPRLLVDW STGIASGMNY LHLHKIIHRD LKSPNVLVTH 120

TDAVKISDFG TSKELSDKST KMSFAGTVAW MAPEVIRNEP VSEKVDIWSF GVVLWELLTG 180

EIPYKDVDSS AIIWGVGSNS LHLPVPSTCP DGFKILMKQT WQSKPRNRPS FRQTLMHL 238

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013