EKS-MYL-00164

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00164

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	358.1	3.3E-107	69	331	263

Status

Unreviewed

Ensembl Protein

ENSMLUP00000004683

UniProt Accession

G1P418;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000005128	ENSMLUP00000004683	ENSMLUT00000005133

Organism

Myotis lucifugus

Functional Description

Protein Length

487

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEGE GEPEFSPADA CPLADLRTAA LEPAGHYEEV ELTETSVNPG 60

PERIGPHCFE LLRVLGKGGY GKVFQVRKVQ GTNLGKIYAM KVLRKAKIVR NAKDTAHTRA 120

ERNILESVKH PFIVELAYAF QTGGKLYLIL ECLSGGELFT HLEREGIFLE DTACFYLAEI 180

TLALGHHLHS HGIIYRDLKP ENIMLSSQGH IKLTDFGLCK ESIHEGVVTH TFCGTIEYMA 240

PEILVRSGHN RAVDWWSLGA LMYDMLTGSP PFTAENRKKT MDKIIKGKLT LPPYLTPDAR 300

DLVKKFLKRN PSQRIGGGPG DAADVQRHPF FRHINWDDLL ARRVDPPFRP CLQSEEDVSQ 360

FDTHFTRQTP VDSPDDTALS ESANQAFLGF TYVAPSVLDS IKEGFSFQPK RRSPRRLNSS 420

PRTPISPLKF SPFEGFRPSP GPPEPMEPPL PPLLPAPPPP PSSTVPLPIR PPSGKKKSKR 480

GRGHPGH 487

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TATTTGACTT GGACCTGGAG ACGGAGGAAG GCAGCGAGGG CGAGGGCGAG 60

GGCGAGCCAG AGTTCAGCCC TGCGGACGCG TGTCCCCTCG CCGACTTGAG GACGGCTGCC 120

CTGGAGCCCG CGGGCCACTA TGAGGAGGTG GAGCTGACGG AGACCAGTGT GAACCCCGGC 180

CCCGAGCGCA TTGGGCCCCA CTGCTTTGAG CTGCTGCGTG TGCTGGGCAA GGGGGGCTAT 240

GGCAAGGTGT TCCAGGTGCG AAAGGTGCAG GGCACCAACT TGGGCAAAAT ATATGCCATG 300

AAGGTCCTGA GGAAGGCCAA GATTGTGCGC AACGCCAAGG ACACGGCGCA CACCCGGGCT 360

GAACGAAACA TTCTGGAGTC AGTGAAGCAC CCCTTCATTG TGGAGCTGGC CTATGCCTTC 420

CAGACTGGTG GCAAGCTCTA CCTCATCCTC GAGTGCCTCA GTGGCGGCGA GCTCTTCACA 480

CACTTGGAGC GAGAGGGCAT CTTCCTGGAA GACACGGCCT GTTTCTACCT GGCAGAGATC 540

ACACTGGCCC TGGGCCACCA CCTCCACTCC CACGGCATCA TCTACCGGGA CCTCAAACCC 600

GAGAACATCA TGCTGAGCAG CCAGGGCCAC ATCAAACTGA CGGACTTCGG ACTCTGCAAG 660

GAGTCCATTC ATGAGGGTGT CGTCACCCAC ACCTTCTGTG GCACCATTGA GTACATGGCC 720

CCTGAGATTC TGGTGCGCAG CGGCCACAAC CGGGCGGTGG ACTGGTGGAG CCTGGGCGCC 780

CTGATGTACG ACATGCTCAC TGGATCGCCA CCCTTCACGG CAGAGAATCG GAAGAAAACC 840

ATGGACAAGA TCATCAAAGG GAAGCTGACG CTGCCCCCTT ACCTCACCCC GGATGCCCGG 900

GACCTCGTCA AAAAGTTTCT GAAGCGGAAT CCCAGCCAAC GGATCGGGGG TGGCCCAGGG 960

GACGCTGCTG ATGTACAGAG GCACCCCTTT TTCCGGCACA TTAATTGGGA TGATCTCCTG 1020

GCCCGCCGTG TGGACCCCCC TTTCAGGCCC TGTCTGCAGT CAGAAGAGGA CGTGAGCCAG 1080

TTTGACACCC ACTTCACGCG GCAGACACCA GTGGACAGTC CGGACGATAC GGCCCTCAGT 1140

GAGAGCGCCA ACCAGGCCTT CCTGGGCTTC ACGTACGTGG CGCCCTCCGT CCTGGACAGC 1200

ATCAAGGAGG GCTTCTCCTT CCAGCCCAAG CGGCGCTCCC CCAGGCGCCT CAACAGCAGC 1260

CCCCGGACCC CCATCAGCCC CCTGAAGTTC TCACCCTTTG AGGGGTTCCG GCCCAGCCCC 1320

GGCCCACCAG AGCCCATGGA GCCCCCTCTA CCTCCTCTCC TGCCAGCACC GCCACCACCA 1380

CCCTCGAGCA CTGTCCCCCT CCCCATCCGA CCCCCCTCAG GGAAAAAGAA GTCCAAGAGG 1440

GGCCGTGGGC ACCCTGGGCA CTAG 1464

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 69    FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  128

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlal.eyl  117

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal ++l

Q: 129   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALgHHL  188

         ********************************************************557*

S: 118   HskgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrk  177

         Hs+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+

Q: 189   HSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGVVTHTFCGTIEYMAPEILVRS  247

         **********************************9.9999999*****************

S: 178   gydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlv  237

         g+++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l+lp +  l+++a+dlv

Q: 248   GHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LTLPPY--LTPDARDLV  303

         *****************************************..******..*********

S: 238   kklLkkdpakRlga...taeeikehkfl  262

         kk+Lk++p++R+g    +a+++++h+f+

Q: 304   KKFLKRNPSQRIGGgpgDAADVQRHPFF  331

         ************99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHHL 120

HSHGIIYRDL KPENIMLSSQ GHIKLTDFGL CKESIHEGVV THTFCGTIEY MAPEILVRSG 180

HNRAVDWWSL GALMYDMLTG SPPFTAENRK KTMDKIIKGK LTLPPYLTPD ARDLVKKFLK 240

RNPSQRIGGG PGDAADVQRH PFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013