EKS-MYL-00264

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00264

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	388.6	1.3E-116	12	265	254

Status

Unreviewed

Ensembl Protein

ENSMLUP00000004915

UniProt Accession

G1P4M4;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000005379	ENSMLUP00000004915	ENSMLUT00000005386

Organism

Myotis lucifugus

Functional Description

Protein Length

963

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMNRY LKNRRKPFSE NEARHFMHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDIWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLSGEAKD 240

LIHQLLRRNP ADRLSLSSVL DHPFMSRNSP TKSRDLGTSE DSIDSGHATI STAMTASSST 300

SISGSLFDRR RLLIGQPLPN KMTVFPKNKN SSDFSSSEDG SSFYTHWGNQ EQETINSGRG 360

RVIHDAEERP HSRYLRRAHS SDRSGTSNSQ SRANTCTMER CHSVEMLSKS KRSGGDENEE 420

RYSPTNSNVN IFHFKEKISN SSGSLERPAN NQALSNHLCP GKTPFPFPDQ TSQLEVVQQW 480

FGNLQKIAHL RETTEHKSLS SNRDFQDHSD LQDTSRNAWT DLRGKKSPGV SDNAHSAKQL 540

NTMKHITAFP NKPEIIPQES IFGLEPVSEQ SKTKDMEPPL GFQKRTLRSI TSPLTAYRLK 600

PIRQKTKKAV VSILDSEEVC VELLKEHSCQ EYVKEVLHVS SDGNMITIYY PNDGRGFPLA 660

DRPPSPTDNI SRYSFDNLPE KYWRKYQYAS RFVQLVRSKS PKITYFTKYA KCILMENSPC 720

ADFEVWFYDG TKIHKTEALI HVIEKTGKSY TLKGESEVNS LKEKIKVYMD HANEGHRICL 780

ALESIISEEE KKSGSAPFFP IIIGRKPSST SSPQGLSPPP MDPNYLMSKM IINSAASPEQ 840

APEYNSEMVT DEGLGGTVAA SGTNIPSSSL KDCFPKSAQP LKSVFVKNVG WPTQLTSGAV 900

WVQFNDGSQL VVQAGVSSIS YTSPDGQTTR YGENEKLPEY IKQKLQCLSS ILLMFSNPTH 960

SFH 963

Nucleotide Sequence
(FASTA)

ATGGCGACTT GCATCGGGGA GAAGATCGAG GATTTTAAAG TTGGAAATCT GCTTGGTAAA 60

GGATCATTTG CTGGTGTCTA CAGAGCTGAG TCCATTCACA CGGGTTTGGA AGTTGCAATC 120

AAAATGATAG ATAAGAAAGC CATGTACAAA GCTGGAATGG TACAGAGAGT CCAAAATGAG 180

GTGAAAATAC ATTGCCAATT GAAACATCCT TCTATCTTGG AGCTGTATAA CTATTTTGAA 240

GATAGCAATT ATGTGTACCT GGTATTAGAA ATGTGCCATA ATGGAGAAAT GAACAGGTAT 300

CTAAAGAACA GAAGGAAACC ATTCTCAGAA AATGAAGCTC GACACTTTAT GCACCAGATC 360

ATCACAGGAA TGTTGTATCT CCATTCTCAT GGAATACTAC ACCGGGACCT CACACTTTCT 420

AATCTCTTAC TTACGCGTAA TATGAACATC AAGATTGCCG ATTTTGGGCT GGCAACTCAA 480

TTGAAAATGC CACATGAAAA GCACTATACG TTATGTGGAA CTCCTAATTA CATTTCACCA 540

GAAATTGCAA CTCGAAGTGC GCATGGACTT GAATCTGACA TTTGGTCATT GGGCTGTATG 600

TTTTATACAT TACTTATTGG GAGACCACCT TTTGACACTG ACACAGTCAA GAACACATTG 660

AATAAAGTAG TATTGGCAGA TTATGAAATG CCAACTTTTT TGTCAGGAGA GGCCAAGGAC 720

CTTATTCACC AGTTACTTCG TAGAAACCCA GCAGATCGTT TAAGCCTGTC TTCAGTATTA 780

GACCATCCTT TTATGTCCCG AAATTCTCCA ACAAAAAGTA GGGATTTAGG AACTTCAGAA 840

GATTCAATTG ATAGTGGACA TGCCACAATT TCTACTGCAA TGACAGCTTC CTCCAGTACC 900

AGTATAAGTG GTAGTTTGTT TGACAGAAGA AGACTTTTGA TTGGCCAGCC TCTCCCAAAT 960

AAAATGACTG TATTTCCAAA GAATAAAAAT TCAAGTGATT TTTCTTCTTC AGAAGATGGA 1020

AGCAGTTTTT ACACTCATTG GGGAAATCAA GAACAAGAAA CCATTAATAG TGGAAGGGGA 1080

AGAGTAATCC ATGATGCAGA AGAAAGGCCA CATTCTCGAT ACCTTCGTAG AGCCCATTCC 1140

TCTGATAGAT CTGGCACTTC TAATAGTCAA TCTCGAGCAA ACACATGTAC AATGGAACGA 1200

TGTCACTCGG TAGAAATGCT TTCAAAATCC AAAAGATCAG GAGGAGATGA AAATGAAGAA 1260

AGATACTCAC CCACAAATAG CAATGTCAAT ATTTTTCACT TTAAGGAAAA GATATCCAAT 1320

AGTTCTGGAT CTTTGGAAAG ACCTGCTAAC AATCAAGCAC TCTCAAATCA CCTTTGTCCA 1380

GGAAAAACTC CTTTTCCATT TCCAGACCAG ACATCTCAGC TTGAAGTGGT GCAACAGTGG 1440

TTTGGAAATC TGCAAAAAAT TGCTCATTTA AGAGAAACTA CTGAGCACAA AAGCCTTAGC 1500

TCAAACAGAG ATTTCCAGGA CCATTCAGAT TTGCAAGACA CGTCAAGAAA TGCCTGGACC 1560

GATTTAAGAG GCAAAAAGAG CCCTGGGGTT TCTGATAATG CACATTCTGC AAAACAGCTG 1620

AACACCATGA AACATATAAC TGCATTTCCT AATAAACCTG AGATAATTCC ACAAGAATCT 1680

ATTTTTGGCT TAGAACCTGT TTCTGAACAA AGCAAGACGA AGGATATGGA GCCACCATTG 1740

GGTTTTCAGA AACGTACATT ACGAAGCATT ACATCTCCTT TGACAGCTTA CAGATTAAAA 1800

CCAATCAGAC AGAAAACCAA AAAGGCTGTG GTGAGCATAC TTGATTCAGA GGAGGTATGT 1860

GTGGAGCTTC TAAAGGAGCA TTCATGTCAG GAATATGTGA AAGAAGTTCT TCATGTATCT 1920

AGTGATGGAA ATATGATCAC TATTTATTAT CCAAATGATG GAAGAGGTTT CCCTCTTGCT 1980

GATAGACCGC CTTCACCTAC TGATAATATC AGTAGGTACA GCTTTGACAA TTTACCAGAG 2040

AAGTACTGGC GAAAATATCA ATATGCTTCC AGATTTGTAC AGCTTGTAAG ATCTAAATCT 2100

CCAAAAATCA CTTATTTTAC AAAATATGCT AAATGCATCT TAATGGAGAA TTCTCCTTGT 2160

GCTGATTTTG AGGTTTGGTT TTATGATGGA ACAAAGATAC ATAAAACAGA AGCTTTAATT 2220

CATGTGATTG AAAAGACTGG AAAATCTTAC ACCTTAAAAG GTGAAAGTGA AGTTAATAGC 2280

TTGAAAGAGA AAATAAAAGT ATATATGGAC CATGCTAATG AGGGCCATCG TATTTGTTTA 2340

GCACTGGAAT CCATAATTTC AGAAGAGGAA AAGAAAAGTG GAAGTGCTCC CTTTTTCCCA 2400

ATAATTATAG GAAGAAAACC TAGTAGTACT AGCTCACCTC AGGGCTTGTC ACCTCCTCCT 2460

ATGGATCCAA ACTACCTGAT GAGTAAAATG ATCATAAATA GTGCTGCTTC TCCGGAACAG 2520

GCACCAGAAT ACAACAGTGA AATGGTTACA GATGAAGGAC TTGGCGGTAC TGTTGCAGCT 2580

TCTGGAACAA ACATCCCTTC TAGTAGTCTA AAAGATTGTT TTCCTAAATC AGCACAGCCT 2640

TTGAAATCTG TTTTTGTGAA AAATGTTGGT TGGCCTACAC AGTTAACTAG TGGAGCTGTG 2700

TGGGTTCAGT TTAATGATGG GTCCCAGCTG GTCGTGCAGG CAGGAGTATC TTCTATCAGT 2760

TACACATCAC CGGACGGTCA GACAACTAGA TATGGAGAAA ATGAAAAATT ACCAGAATAC 2820

ATCAAACAGA AATTACAGTG TCTTTCTTCC ATCCTTTTGA TGTTCTCTAA TCCAACTCAT 2880

AGTTTTCACT GA 2892

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++g++ylh++

Q: 72    ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRrKPFSENEARHFMHQIITGMLYLHSHG  131

         ******************************98879*************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +diWslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls eak+li++ll+++P+

Q: 192   SDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSGEAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl+++f+

Q: 252   DRLSLSSVLDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED SNYVYLVLEM CHNGEMNRYL KNRRKPFSEN EARHFMHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDIWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP TFLSGEAKDL IHQLLRRNPA 240

DRLSLSSVLD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013