EKS-MYL-00258

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00258

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	247.1	1.7E-73	989	1241	253

Status

Unreviewed

Ensembl Protein

ENSMLUP00000005116

UniProt Accession

G1P549;

Protein Name

Protein Synonyms/Alias

Gene Name

PASK

Gene Synonyms/Alias

PASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000005589	ENSMLUP00000005116	ENSMLUT00000005600

Organism

Myotis lucifugus

Functional Description

Protein Length

1291

Protein Sequence
(FASTA)

MEDRGSPALE KDWRCLCGNP SSLAPSEGPA VQTSPQLSKS VSSAHRHLNR RNGLSKLCQS 60

RMALSEDRWS SYCLSSLAAQ NICTGKVQCT AMAEQADPAG FLGSMSCCSL LRGLSSGCST 120

PLLPAPAGNP NKAIFTVDAK TSEILVANDN ACRLLGYSSH DLIGLKLTQF FLKPDCDVVE 180

ALSEEHVEAD GHAAVVFGTV VDVVSRSSER IPVSVWMKRM KQEPRLCCVV VLEPVERVSA 240

WVSFQSDGTI TSCDSVFAHL HGYECGNEVA GQRITDLIPS VQLPAPGQPL PQNLKIQRSV 300

GRAKDGTTFP LSLKLKPKPN SKEAEAGQAA PEQGYSASIW VFSTISGLIT LLSDGTIYGI 360

NHSFALMLFG YGRTELLGKN ITFLIPGFYR CMDLVNEGSL PLPDLVSRLD MGNRSEPGET 420

TVDPLQGWST AEVGGRDPGI NVMLAVDHML PPDRTPKPAG SQEVVTGTQT QVDTGVRLPS 480

PLSSLPTLGF QDIPEGSPPA HRQLSSPEDQ QDTVLEKQEP TGTESLRQEL LRGSRSASVD 540

IRPFASCEDS EALTPAEDRS WGEVCGLSQA AQLECMGLST ANHQADAAGQ LAEVGLPVLH 600

PGYGAEWSTP QGSPATAASP SGPSGTARLS CSIPLEEQWL GAQDDREELQ TCLLKEQLSK 660

SSFGRPQDIS SIELVPAEHT AFSTPVSLCD LGGRDLYSGH SGSSSAYYAL ATDLPGVLDT 720

VEAPEADGNS FLWNLREVFY SRWTDRTSSN CSCASSELVG TASPSLAGSD VDVSTLHGHR 780

AEVLDDRELL LLTGTYFNLG EGRQFCETHL GLNQREPSDT SECEDVSGRE SPGCVLPRLE 840

SSPMDMCPLE EPRSSIQVTS TPVRGDSSAT SGTTSLQQEI QEGTYLGSCC HRDGSLLSVQ 900

FEVKRVELQG PAPLFCCWLV KNLLHGQQAS ATHTQLLLAS LPSSTHSACE HPGPSPGEML 960

RSRPWFEEPP KAGELEGLAA CEGAYSHKYS TLSPLGSGAF GFVWTALDRD QNKEVVVKFI 1020

KKEKVLEDCW IEDPTLGKVT LEISILSRVE HANIIKILDI FENQSFFQLV MEKHGSGLDL 1080

FAFIDHHPSL DEPLASYIFR QLVSAVGYLR SKSILHRDIK DENIVIAEDF TIKLIDFGSA 1140

AYLERGKLFY TFCGTIEYCA PEVLMGNPYK GPELEMWSLG VTLYTLIFEE NPFCELEETL 1200

EAAINPPYLV SEDLMNLMSG LLQPVPERRT TLEKLVTDPW VTQPVNLADY TWEEVCGINK 1260

PESRVMSTVS LEVESRSPSE VAQHPELAAP P 1291

Nucleotide Sequence
(FASTA)

ATGGAGGACA GAGGCTCACC CGCCTTGGAA AAGGACTGGA GGTGTCTGTG TGGGAACCCA 60

TCCTCGTTGG CACCCTCTGA GGGCCCTGCT GTGCAGACCT CCCCCCAGCT CAGCAAGTCT 120

GTGTCCTCGG CCCACAGACA CCTGAACAGA AGGAATGGGC TCTCGAAACT CTGCCAGAGC 180

AGGATGGCAC TCTCTGAAGA CAGATGGTCC TCCTATTGTC TCTCGTCATT GGCTGCCCAA 240

AACATCTGCA CAGGGAAAGT GCAGTGCACA GCCATGGCCG AGCAGGCGGA CCCAGCCGGG 300

TTCCTGGGCA GCATGTCCTG CTGCTCATTG CTGCGTGGCT TGTCCTCTGG GTGCTCCACA 360

CCCCTGCTCC CAGCCCCTGC GGGCAACCCC AACAAGGCCA TCTTCACGGT GGATGCCAAG 420

ACTTCAGAGA TCCTGGTTGC CAACGACAAT GCTTGCCGGC TCCTGGGGTA CAGCAGCCAC 480

GATCTCATCG GCCTGAAGCT CACGCAGTTC TTTCTGAAGC CAGACTGCGA TGTGGTGGAA 540

GCGCTCAGCG AGGAGCATGT GGAGGCTGAT GGCCATGCTG CCGTGGTGTT TGGCACAGTG 600

GTGGACGTTG TGAGCCGAAG CAGTGAGCGG ATCCCAGTGT CCGTGTGGAT GAAGAGGATG 660

AAGCAGGAGC CCCGCCTGTG CTGTGTGGTC GTGCTGGAGC CAGTGGAGAG GGTCTCAGCC 720

TGGGTCTCTT TCCAAAGTGA TGGAACGATC ACATCGTGTG ACAGTGTCTT TGCCCATCTG 780

CACGGCTACG AGTGTGGAAA CGAGGTGGCT GGGCAACGCA TCACAGACCT GATCCCTTCC 840

GTGCAGCTCC CTGCACCTGG CCAGCCTCTC CCACAGAATC TCAAGATTCA GAGGTCTGTC 900

GGAAGAGCCA AGGATGGTAC CACCTTCCCT CTGAGCTTAA AGCTGAAACC TAAGCCCAAT 960

AGCAAGGAGG CAGAAGCCGG CCAGGCGGCC CCTGAGCAAG GTTACTCGGC GTCCATCTGG 1020

GTGTTCTCCA CCATCAGCGG CCTTATCACC CTCCTGTCGG ATGGGACCAT CTATGGCATC 1080

AATCACAGCT TTGCACTGAT GCTGTTTGGT TATGGGAGGA CCGAGCTCCT GGGCAAGAAC 1140

ATCACTTTCC TGATCCCTGG TTTCTACCGT TGCATGGACC TTGTAAATGA GGGCTCCTTA 1200

CCACTGCCAG ACCTGGTCAG CCGCCTGGAC ATGGGAAACA GGAGTGAGCC TGGGGAAACG 1260

ACCGTGGACC CCCTGCAGGG CTGGAGCACG GCTGAGGTGG GCGGGCGGGA TCCAGGGATT 1320

AATGTCATGC TCGCTGTTGA CCACATGCTG CCCCCAGACA GGACCCCAAA GCCAGCGGGA 1380

AGCCAAGAAG TTGTCACAGG GACCCAGACC CAAGTGGACA CTGGAGTCCG GCTCCCTTCT 1440

CCCCTCTCAT CTCTGCCCAC TCTGGGGTTC CAGGACATCC CAGAAGGAAG CCCACCAGCC 1500

CATCGCCAGT TGTCATCACC TGAGGACCAG CAGGACACTG TCTTGGAGAA GCAGGAACCT 1560

ACAGGAACAG AGAGCCTCAG ACAGGAGCTT TTGAGGGGAA GCAGGTCTGC CTCAGTGGAC 1620

ATAAGACCCT TTGCTTCCTG TGAAGATTCT GAAGCTCTGA CCCCAGCTGA GGACAGGAGC 1680

TGGGGTGAAG TGTGTGGACT GTCCCAGGCA GCACAGCTGG AGTGCATGGG TTTGAGCACT 1740

GCCAACCATC AGGCTGATGC TGCGGGACAG CTAGCAGAGG TGGGCCTCCC AGTGCTGCAC 1800

CCTGGGTATG GGGCTGAGTG GAGCACACCC CAGGGGAGCC CAGCTACAGC CGCCAGTCCC 1860

TCGGGGCCCT CGGGGACAGC GCGACTCTCA TGTTCCATAC CTTTGGAGGA GCAGTGGCTG 1920

GGAGCGCAGG ATGACAGGGA GGAGCTGCAG ACTTGCTTAC TGAAGGAGCA GCTGTCCAAG 1980

TCGAGCTTTG GGAGACCTCA GGATATCTCC TCCATTGAGC TGGTCCCGGC GGAGCATACT 2040

GCCTTCTCCA CCCCTGTGTC GCTGTGTGAC CTGGGAGGCA GAGACCTGTA CAGCGGCCAC 2100

TCCGGCAGCT CCTCAGCCTA CTATGCCCTA GCCACAGACC TCCCCGGTGT CTTGGACACA 2160

GTGGAGGCCC CAGAGGCTGA TGGAAATTCC TTTTTATGGA ACCTCAGGGA AGTGTTTTAC 2220

AGCCGGTGGA CAGACCGAAC TTCTTCCAAC TGTTCCTGTG CCTCATCTGA GCTCGTGGGG 2280

ACAGCCTCCC CTTCACTGGC TGGCTCCGAT GTGGATGTGA GCACTTTGCA TGGGCACAGG 2340

GCAGAGGTTC TGGATGATAG GGAGCTGTTG TTGCTGACTG GCACCTATTT CAATCTTGGT 2400

GAAGGCCGGC AGTTCTGTGA GACCCATCTG GGCCTTAATC AGAGAGAACC ATCTGACACC 2460

TCAGAATGTG AAGACGTGAG TGGCAGAGAG AGCCCTGGCT GTGTCCTTCC CAGGTTGGAA 2520

TCCAGCCCCA TGGACATGTG CCCGTTAGAG GAGCCCAGGT CAAGCATCCA GGTCACCTCC 2580

ACGCCTGTGA GAGGGGATAG CTCGGCGACA TCCGGGACCA CTAGCCTGCA GCAGGAAATC 2640

CAGGAGGGCA CCTACTTGGG GAGCTGCTGC CACAGAGACG GCTCACTGCT GAGTGTTCAG 2700

TTTGAGGTGA AGCGGGTGGA GCTCCAAGGC CCTGCTCCCC TGTTCTGCTG CTGGCTGGTG 2760

AAAAACCTCC TGCACGGCCA ACAGGCCTCG GCCACTCATA CCCAACTGCT GCTGGCCAGC 2820

CTGCCCAGCT CCACGCACTC CGCGTGTGAG CATCCTGGAC CCAGCCCAGG GGAGATGCTC 2880

AGAAGCAGAC CGTGGTTTGA GGAGCCACCC AAGGCAGGGG AGTTGGAGGG GCTGGCAGCC 2940

TGTGAGGGTG CATACTCTCA CAAGTACAGT ACGCTGAGCC CACTGGGCAG TGGGGCCTTT 3000

GGCTTCGTGT GGACTGCTCT GGACAGGGAT CAGAATAAGG AGGTGGTGGT GAAGTTTATT 3060

AAGAAGGAGA AGGTTCTGGA GGATTGTTGG ATCGAGGATC CCACACTTGG AAAAGTTACG 3120

TTGGAGATAT CGATCCTGTC CAGGGTGGAG CACGCCAACA TCATAAAGAT CCTGGACATA 3180

TTCGAGAACC AGAGCTTCTT TCAGCTGGTG ATGGAGAAGC ATGGCTCTGG CCTGGACCTC 3240

TTTGCGTTCA TCGACCACCA CCCCAGCCTG GATGAGCCGT TGGCCAGTTA CATCTTCCGA 3300

CAGCTGGTGT CGGCAGTGGG GTATCTCCGC TCGAAGAGCA TCCTTCACCG GGACATCAAG 3360

GATGAGAACA TCGTCATTGC CGAGGACTTC ACCATTAAGC TCATAGACTT CGGCTCCGCT 3420

GCCTACTTGG AAAGGGGCAA ACTGTTCTAC ACCTTCTGTG GGACAATCGA GTACTGTGCG 3480

CCCGAAGTTC TCATGGGGAA TCCTTACAAG GGTCCGGAGC TAGAGATGTG GTCCCTGGGA 3540

GTCACGCTGT ACACGCTCAT CTTTGAGGAG AACCCCTTCT GCGAGCTGGA GGAGACCCTG 3600

GAAGCTGCAA TAAACCCCCC GTACTTGGTG TCGGAAGATC TCATGAACCT CATGTCTGGG 3660

CTGCTGCAGC CTGTCCCCGA GCGGCGCACC ACCTTGGAGA AGCTGGTGAC AGACCCTTGG 3720

GTTACCCAGC CCGTGAACCT TGCAGACTAC ACCTGGGAGG AAGTGTGTGG AATAAACAAG 3780

CCAGAAAGTA GAGTCATGTC CACTGTGAGT CTGGAGGTGG AGAGCAGGAG CCCCAGTGAA 3840

GTGGCTCAGC ATCCGGAGCT GGCGGCGCCC CCT 3873

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl......seeslekikrEieilkk  54

         y++l+ lG+g+fg V +a +++++++v+vK+ikk+k+      ++ +l k++ Ei+il++

Q: 989   YSTLSPLGSGAFGFVWTALDRDQNKEVVVKFIKKEKVledcwiEDPTLGKVTLEISILSR  1048

         88999*******************************99999998888*************

S: 55    lkhpniikllevietkkklylvle.yasggeLfdyieekgrlkekearklfkqlvsavkY  113

         ++h niik+l+++e++++++lv+e + sg +Lf  i ++ +l+e  a+ +f+qlvsav Y

Q: 1049  VEHANIIKILDIFENQSFFQLVMEkHGSGLDLFAFIDHHPSLDEPLASYIFRQLVSAVGY  1108

         ************************888899******************************

S: 114   lhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkk  173

         l+sk+i HrD+K eN+++ ++ +ik++DFG a+++++gkl+ tfcG+++Y+aPe+l+g++

Q: 1109  LRSKSILHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNP  1168

         ************************************************************

S: 174   YegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklL  233

         Y+gp++++WslGv+Ly+l++++ Pf e       e++l+  ++ p+ +s++l++L++ lL

Q: 1169  YKGPELEMWSLGVTLYTLIFEENPFCEL------EETLEAAINPPYLVSEDLMNLMSGLL  1222

         *************************998......7888999999****************

S: 234   vvdpekRatieeilkhewl  252

         +  pe+R+t+e++++++w+

Q: 1223  QPVPERRTTLEKLVTDPWV  1241

         ******************7

Domain Sequence
(FASTA)

YSTLSPLGSG AFGFVWTALD RDQNKEVVVK FIKKEKVLED CWIEDPTLGK VTLEISILSR 60

VEHANIIKIL DIFENQSFFQ LVMEKHGSGL DLFAFIDHHP SLDEPLASYI FRQLVSAVGY 120

LRSKSILHRD IKDENIVIAE DFTIKLIDFG SAAYLERGKL FYTFCGTIEY CAPEVLMGNP 180

YKGPELEMWS LGVTLYTLIF EENPFCELEE TLEAAINPPY LVSEDLMNLM SGLLQPVPER 240

RTTLEKLVTD PWV 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000014	; PAS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00091	; PAS; 2.
SM00220	; S_TKc; 1.

Prosites

PS50112	; PAS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013