EKS-MYL-00173

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00173

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	446.0	4.0E-134	411	671	261

Status

Unreviewed

Ensembl Protein

ENSMLUP00000005112

UniProt Accession

G1P546;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA5

Gene Synonyms/Alias

RPS6KA5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000005590	ENSMLUP00000005112	ENSMLUT00000005596

Organism

Myotis lucifugus

Functional Description

Protein Length

770

Protein Sequence
(FASTA)

LGLYADPFNC FFFLFVFLAN LTGHAEKVGI ENFELLKVLG TGAYGKVFLV RKISGHDAGK 60

LYAMKVLKKA TIVQKAKTTE HTRTERQVLE HIRQSPFLVT LHYAFQTETK LHLILDYING 120

GELFTHLSQR ERFTEHEVQI YIGEIVLALE HLHKLGIIYR DIKLENILLD SNGHVVLTDF 180

GLSKEFVADE AERAYSFCGT IEYMAPDIIR GGDSGHDKAV DWWSLGVLMY ELLTGASPFT 240

VDGEKNSQAE ISRRILKSEP PYPQDMSALA KDLIQRLLMK DPKKRLGCGP RDADEIKEHL 300

FFQKINWDDL AAKKVPAPFK PVIRDELDVS NFAEEFTEMD PTYSPAALPQ NSERLFQGYS 360

FVAPSILFKP NAAVVDPLQC HTGVERPGAT NVARSAMIKD SPFYQHYDLD LKDKPLGEGS 420

FSICRKCIHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE VFHDQLHTFL 480

VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK PENLLFTDEH 540

DNLEIKIIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNQ NGYDESCDLW SLGVILYTML 600

SGQVPFQSHD KSLTCTSAVE IMKKIKTGDF SFEGEAWKNV SQEAKDLIQG LLTVDPNKRL 660

KMSGLRYNEW LQDGSQLSSN PLMTPDILGS SGAAVHTCVK ATFHAFNKYK REGFCLQNVD 720

KAPLAKRRKM KKTSTSTETR SSSSESSHSS SSHSHGKTTP TKALQPSNPA 770

Nucleotide Sequence
(FASTA)

CTGGGCCTCT ATGCTGATCC CTTTAATTGT TTCTTTTTTC TCTTTGTTTT TTTAGCAAAT 60

TTAACAGGAC ATGCAGAGAA GGTGGGGATT GAAAATTTTG AGCTCCTGAA AGTCCTAGGA 120

ACTGGAGCAT ATGGAAAAGT ATTTCTAGTT CGTAAAATAA GTGGTCATGA TGCTGGAAAG 180

CTGTATGCCA TGAAGGTTTT GAAAAAGGCA ACAATAGTTC AAAAGGCCAA AACCACAGAG 240

CACACGCGGA CGGAGCGACA GGTCCTGGAG CACATCAGGC AGTCGCCGTT TTTGGTGACG 300

TTGCACTATG CCTTCCAGAC AGAAACCAAA CTTCATCTCA TTTTAGATTA TATAAATGGT 360

GGAGAACTTT TTACTCATCT TTCTCAAAGA GAGCGTTTCA CAGAGCACGA GGTGCAGATC 420

TATATTGGAG AGATTGTGCT CGCCCTCGAA CATCTCCACA AGTTGGGGAT TATATACCGT 480

GACATTAAGC TTGAGAATAT TCTGCTTGAT TCTAATGGCC ATGTGGTGCT GACAGATTTT 540

GGTCTGAGTA AGGAGTTTGT GGCTGATGAA GCTGAAAGAG CATATTCGTT TTGTGGCACT 600

ATTGAATACA TGGCACCAGA TATCATCAGA GGAGGAGATT CGGGACATGA CAAGGCAGTT 660

GACTGGTGGA GTTTAGGTGT CCTAATGTAT GAACTACTAA CTGGAGCATC TCCTTTCACT 720

GTGGATGGGG AGAAGAATTC CCAAGCTGAG ATCTCTAGGA GAATATTAAA AAGTGAGCCT 780

CCGTACCCCC AAGATATGAG TGCTTTAGCT AAAGACTTAA TTCAGCGTCT TCTGATGAAA 840

GATCCTAAGA AAAGATTGGG ATGTGGTCCG CGTGATGCAG ATGAAATCAA AGAGCATCTC 900

TTTTTTCAGA AAATAAATTG GGATGATTTA GCTGCCAAAA AAGTGCCCGC ACCATTTAAG 960

CCAGTCATCC GAGATGAATT AGATGTGAGT AACTTTGCAG AAGAGTTCAC AGAAATGGAT 1020

CCCACCTACT CCCCGGCAGC GCTGCCCCAG AACTCCGAGA GGCTGTTTCA GGGCTATTCC 1080

TTCGTTGCTC CTTCCATTCT CTTCAAGCCC AACGCAGCTG TTGTAGATCC TCTTCAGTGT 1140

CACACAGGAG TGGAACGTCC TGGGGCGACA AATGTTGCCA GGAGTGCAAT GATCAAGGAC 1200

TCTCCATTCT ATCAGCACTA TGACCTAGAT CTGAAAGACA AGCCACTGGG AGAAGGAAGT 1260

TTTTCAATTT GTCGAAAGTG CATACACAAA AAAAGTAACC AAGCATTTGC AGTCAAAATA 1320

ATCAGCAAAA GGATGGAAGC CAATACTCAG AAAGAAATAA CAGCACTGAA GCTCTGTGAA 1380

GGACACCCCA ATATCGTGAA ATTGCACGAA GTTTTTCATG ATCAGCTTCA CACTTTTCTA 1440

GTTATGGAAC TTCTGAACGG GGGAGAGCTG TTTGAACGCA TTAAGAAAAA GAAGCACTTC 1500

AGTGAGACCG AAGCCAGCTA CATCATGCGG AAGCTGGTTT CAGCTGTGAG CCACATGCAC 1560

GACGTCGGAG TGGTGCACAG AGACCTGAAG CCTGAGAATT TACTGTTCAC TGATGAACAT 1620

GACAACTTGG AAATTAAAAT AATTGACTTC GGGTTTGCGC GCTTAAAGCC GCCTGACAAT 1680

CAGCCTCTCA AGACCCCGTG CTTCACCCTC CACTACGCCG CCCCCGAGCT CTTGAACCAG 1740

AACGGCTACG ACGAGTCCTG CGACCTCTGG AGCCTGGGCG TCATTCTGTA TACAATGTTG 1800

TCTGGGCAAG TTCCATTCCA GTCTCATGAC AAAAGTTTGA CATGCACCAG TGCAGTGGAA 1860

ATCATGAAGA AAATCAAAAC GGGAGATTTC TCCTTTGAAG GAGAAGCTTG GAAGAATGTA 1920

TCCCAAGAGG CTAAAGATTT GATCCAAGGA CTTCTCACTG TTGATCCAAA TAAAAGGCTT 1980

AAAATGTCTG GCCTGAGATA CAATGAATGG CTCCAAGACG GCAGTCAGCT GTCCTCCAAC 2040

CCTCTGATGA CTCCCGACAT CCTGGGGTCT TCAGGAGCCG CCGTGCACAC CTGCGTGAAG 2100

GCCACCTTCC ACGCCTTTAA CAAGTACAAG AGAGAGGGGT TTTGCCTTCA GAATGTCGAC 2160

AAGGCCCCTC TGGCTAAGAG AAGGAAGATG AAGAAGACCA GCACCAGTAC GGAGACGCGC 2220

AGCAGCTCCA GCGAGAGCTC CCATTCTTCG TCCTCGCACT CCCACGGTAA AACCACCCCC 2280

ACAAAGGCAC TGCAGCCCAG CAACCCTGCC 2310

Domain Profile

S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60

         +++++lG+Gs+s+c++c+hk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++

Q: 411   LKDKPLGEGSFSICRKCIHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  470

         5789******************************9*************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         v++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk

Q: 471   VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  530

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         pen+l++de dn+e ikiidfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl

Q: 531   PENLLFTDEHDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL  589

         **************.*********************************************

S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236

         wslGv+lytml+G+vpf    +++++++a+ei++kik G+fs++Geaw++vs+eakdl++

Q: 590   WSLGVILYTMLSGQVPFqshdKSLTCTSAVEIMKKIKTGDFSFEGEAWKNVSQEAKDLIQ  649

         *****************98888899***********************************

S: 237   klltvdpakrlkleqllkhswl  258

         +lltvdp+krlk+++l++++wl

Q: 650   GLLTVDPNKRLKMSGLRYNEWL  671

         *********************7

Domain Sequence
(FASTA)

LKDKPLGEGS FSICRKCIHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60

VFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120

PENLLFTDEH DNLEIKIIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNQ NGYDESCDLW 180

SLGVILYTML SGQVPFQSHD KSLTCTSAVE IMKKIKTGDF SFEGEAWKNV SQEAKDLIQG 240

LLTVDPNKRL KMSGLRYNEW L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013