EKS-MYL-00158

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00158

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	527.3	6.7E-159	466	742	277

Status

Unreviewed

Ensembl Protein

ENSMLUP00000005121

UniProt Accession

G1P553;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR4

Gene Synonyms/Alias

FGFR4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000005601	ENSMLUP00000005121	ENSMLUT00000005606

Organism

Myotis lucifugus

Functional Description

Protein Length

800

Protein Sequence
(FASTA)

MQLLLVLLGV LLRALWAPAL SFETSEEMEL EPCLAPSPEQ PEQELTVVLG QPVQLCCGKA 60

ERGGHWYKEG IRLAPAGRVR GWRGRLEIAS FLPEDVGHYL CLARGSMFVL HNVTLVMDDI 120

DSSTSSNGDE EHNGPSNRHV YPQHAPYWTH PQRMEKKLHA VPAGNTVKFR CPAAGNPTPT 180

IRWLKDGQDF HGEHRSIALE LRHQHWSLVM ESVVPSDRGT YTCLVENPVG SIHYSYLLDV 240

LERSPHRPIL QAGLPANTTA VVGSDVELLC KVYSDAQPHI QWLKHIVING SNFGADGFPY 300

VQVLKTTDIN SSEVEVLYLR NVSAEDAGEY TCLAGNSIGL SYQSAWLTVL PEEDLTWTAT 360

APDARYTDII LYTSGSLVLV VLLLLAGLYR RQVLHGRHSR QPASVQKLSR FPLARQFSLE 420

SGSSAKSSSS LVRGVRLSSS GPPLLAGLVS LDLPLDPQWE FPRDRLVLGK PLGEGCFGQV 480

VRAEALGMDP AQPDQASTVA VKMLKDNASD KDLADLVSEM EVMKLIGQHK NIINLLGVCT 540

QEGPLYVIVE CAAKGNLREF LRARRPPGPD LSPDGPRSSE GPLSFPALVS CAYQVARGMQ 600

YLESRKCIHR DLAARNVLVT EDNVMKIADF GLARGVHHID YYKKTSNGRL PVKWMAPEAL 660

FDRVYTHQSD VWSFGILLWE IFTLGGSPYP GIPVEELFSL LREGHRMDRP PNCPPELYGL 720

MRECWHAAPS QRPTFKQLVE ALDKVLLAIS EEYLDLRLTF GPYSPAGGDA SSTCSSSDSV 780

FSHDPLPLGP SSFPCPGVQT 800

Nucleotide Sequence
(FASTA)

ATGCAGTTGC TGCTGGTCCT GTTGGGGGTC CTCCTGAGAG CACTCTGGGC TCCAGCTTTG 60

TCCTTTGAGA CCTCTGAGGA AATGGAGCTG GAGCCCTGCC TGGCCCCCAG CCCGGAGCAG 120

CCAGAACAGG AGCTGACGGT GGTCCTTGGG CAGCCTGTGC AGTTATGCTG TGGGAAGGCT 180

GAGCGTGGTG GCCACTGGTA CAAGGAGGGC ATTCGCCTTG CACCTGCTGG CCGGGTACGA 240

GGCTGGAGGG GCCGCTTGGA GATCGCCAGC TTCCTACCCG AGGATGTTGG GCACTACCTC 300

TGCCTAGCAC GAGGCTCCAT GTTCGTCCTG CACAATGTCA CCTTGGTTAT GGATGACATA 360

GACTCCTCGA CCTCCAGCAA TGGTGATGAG GAACACAATG GCCCTTCAAA TAGGCATGTT 420

TACCCACAGC ATGCACCCTA CTGGACACAC CCCCAGCGCA TGGAGAAGAA ACTGCATGCA 480

GTGCCTGCTG GGAACACCGT CAAGTTCCGC TGTCCAGCGG CCGGAAACCC CACGCCCACC 540

ATCCGCTGGC TCAAAGACGG ACAGGACTTC CATGGGGAGC ATCGCAGCAT CGCATTGGAG 600

CTGCGCCATC AGCACTGGAG CCTGGTGATG GAAAGCGTGG TGCCCTCGGA TCGTGGCACA 660

TACACCTGCC TTGTGGAGAA TCCGGTGGGC AGCATCCACT ACAGCTATCT GCTGGACGTG 720

CTGGAGCGGT CCCCGCACCG GCCCATCCTG CAGGCAGGGC TCCCGGCCAA TACCACAGCG 780

GTAGTGGGCA GTGACGTGGA GCTGCTATGC AAGGTGTACA GTGACGCCCA GCCTCACATC 840

CAGTGGCTGA AGCACATTGT CATCAACGGC AGCAACTTCG GTGCCGACGG CTTTCCTTAT 900

GTGCAAGTCT TGAAGACAAC AGACATCAAC AGCTCAGAGG TAGAGGTCCT ATACCTTCGT 960

AACGTGTCGG CCGAGGACGC AGGCGAGTAC ACCTGTCTGG CAGGCAACTC CATTGGCCTC 1020

TCCTACCAGT CGGCCTGGCT CACTGTGCTG CCAGAGGAGG ACCTCACATG GACAGCAACG 1080

GCACCCGATG CCAGGTACAC AGACATCATC CTGTACACGT CGGGCTCTCT GGTGTTAGTG 1140

GTGCTCCTGC TGCTGGCCGG CCTGTATCGC CGACAGGTGC TCCACGGTCG GCACTCCCGG 1200

CAGCCCGCCT CGGTGCAGAA GCTGTCCCGC TTCCCTCTGG CCCGACAGTT CTCCCTGGAG 1260

TCAGGCTCCT CAGCCAAGTC AAGCTCGTCC CTGGTGCGGG GCGTCCGTCT TTCCTCCAGC 1320

GGCCCCCCCT TGCTTGCTGG CCTCGTGAGT CTAGACCTCC CTCTGGACCC GCAGTGGGAG 1380

TTCCCCCGGG ACAGGCTGGT GCTTGGGAAG CCCCTGGGCG AGGGCTGCTT TGGGCAGGTG 1440

GTGCGTGCAG AGGCCTTAGG CATGGACCCG GCCCAGCCTG ACCAAGCCAG CACCGTGGCC 1500

GTCAAGATGC TCAAGGACAA CGCCTCTGAC AAGGACTTGG CAGATCTGGT CTCTGAGATG 1560

GAAGTGATGA AGCTGATCGG TCAACACAAA AATATTATTA ACCTGCTGGG TGTCTGCACC 1620

CAAGAAGGCC CCCTGTACGT GATTGTGGAG TGTGCTGCCA AGGGAAACCT GCGGGAGTTC 1680

CTGCGGGCCC GGCGCCCCCC GGGCCCCGAT CTCAGCCCTG ATGGGCCTCG GAGCAGCGAG 1740

GGGCCACTCT CCTTCCCTGC CCTGGTCTCC TGCGCCTACC AGGTGGCCCG AGGCATGCAG 1800

TACCTGGAGT CTCGAAAGTG CATCCACCGA GACCTGGCTG CCCGTAACGT GCTGGTGACA 1860

GAGGACAATG TGATGAAGAT CGCTGACTTT GGACTGGCCC GAGGCGTCCA CCACATTGAC 1920

TACTACAAGA AAACCAGCAA CGGCCGCCTG CCTGTCAAGT GGATGGCACC GGAGGCCTTG 1980

TTTGACCGAG TCTACACACA CCAGAGTGAT GTGTGGTCAT TCGGGATCCT GCTGTGGGAG 2040

ATCTTCACCC TTGGGGGCTC CCCATACCCT GGCATCCCCG TGGAGGAACT GTTTTCACTG 2100

CTGCGGGAGG GGCATCGGAT GGACCGGCCC CCGAACTGCC CTCCAGAGCT GTATGGGCTG 2160

ATGCGTGAGT GCTGGCATGC GGCGCCCTCT CAGAGGCCCA CTTTCAAGCA GCTGGTGGAG 2220

GCACTGGACA AGGTCCTGCT GGCCATCTCT GAGGAGTACC TGGACCTCCG CCTGACCTTT 2280

GGACCCTACT CCCCAGCCGG TGGGGACGCC AGCAGCACCT GCTCCTCCAG TGACTCTGTC 2340

TTCAGCCATG ACCCCCTGCC ACTGGGGCCC AGTTCCTTCC CCTGTCCTGG GGTGCAGACT 2400

TGA 2403

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv+aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl

Q: 466   LVLGKPLGEGCFGQVVRAEALGMDPAQPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL  525

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d +++se  l++

Q: 526   IGQHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSF  585

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt

Q: 586   PALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT  645

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh

Q: 646   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  705

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm++p +c+ ely lmrecwha++s+rptfkqlve+l

Q: 706   RMDRPPNCPPELYGLMRECWHAAPSQRPTFKQLVEAL  742

         **********************************986

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVRAEA LGMDPAQPDQ ASTVAVKMLK DNASDKDLAD LVSEMEVMKL 60

IGQHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG PRSSEGPLSF 120

PALVSCAYQV ARGMQYLESR KCIHRDLAAR NVLVTEDNVM KIADFGLARG VHHIDYYKKT 180

SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240

RMDRPPNCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013