EKS-MYL-00198

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00198

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	411.2	1.8E-123	61	308	248

Status

Unreviewed

Ensembl Protein

ENSMLUP00000005169

UniProt Accession

G1P594;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK2

Gene Synonyms/Alias

TESK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000005655	ENSMLUP00000005169	ENSMLUT00000005658

Organism

Myotis lucifugus

Functional Description

Protein Length

565

Protein Sequence
(FASTA)

MDRSKRNSIA GFPPRVERLE DFEGGVGNDG NVTQVGRVGT SSYRALISAF SRLTRLDDFT 60

CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANMLK EIQLMNRLSH PNILRFMGVC 120

VHQGQLHALT EYINAGNLEQ LLDSNLYLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 180

NCLIKRDENG YSAVVGDFGL AEKIPDVSMG REKLAVVGSP FWMAPEVLRD EPYNEKADVF 240

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 300

SFVETGKNLE EILNHLQEEE LQPTAKGLLE KGPGMKRLSS LDEKIPPKSP RPRRTIWLSR 360

SQSDIFSHKP PHTVNVLDPY YQPRGGAAST PKINPFSARQ DLKGGKVKFF DLPSKSVISL 420

VFDLDAPGPG TLPMADWQEP LAPPARRWHS LPGSPEFLHQ EACPFVGREE SLSDGPPPRL 480

SSLKYKVREI PPFRASALPA APAHEAMDCS SSQEENGFGP RPRGASPCLA GASEEMEVEE 540

RPRDSAPVPF SVSGRGLKTQ GEQDG 565

Nucleotide Sequence
(FASTA)

ATGGATCGGA GCAAACGGAA TTCAATTGCA GGATTTCCTC CACGTGTGGA GCGTCTTGAA 60

GATTTTGAAG GAGGTGTTGG AAACGATGGG AATGTGACCC AGGTGGGAAG AGTTGGGACA 120

TCTTCATATC GAGCTCTTAT AAGTGCCTTT TCCAGACTGA CACGTTTAGA TGACTTCACC 180

TGTGAAAAAA TAGGATCTGG CTTCTTTTCT GAAGTGTTCA AGGTGCGCCA CCGAGCTTCT 240

GGTCAGGTGA TGGCTCTTAA GATGAACACA TTGAGTAGTA ACCGGGCAAA CATGCTGAAG 300

GAAATCCAGC TTATGAATAG ACTCTCCCAC CCCAACATCC TTAGGTTCAT GGGTGTATGT 360

GTACATCAAG GACAATTGCA TGCACTTACA GAGTATATCA ACGCTGGAAA CCTGGAACAG 420

TTGCTAGACA GTAACCTGTA CTTGCCCTGG ACTGTGAGGG TGAAACTGGC CTATGACATA 480

GCAGTGGGCC TCAGCTATCT TCACTTCAAA GGCATTTTCC ATCGGGACCT CACATCTAAG 540

AACTGCCTGA TAAAGAGGGA TGAAAATGGT TACTCTGCGG TGGTAGGTGA CTTTGGCCTG 600

GCTGAGAAGA TCCCTGATGT CAGCATGGGG AGGGAAAAGC TGGCTGTGGT GGGCTCACCC 660

TTCTGGATGG CACCTGAAGT TCTCCGAGAT GAGCCCTACA ATGAGAAGGC GGACGTATTC 720

TCCTATGGTA TCATCCTCTG TGAGATCATC GCCCGTATCC AGGCTGATCC GGACTATCTT 780

CCCCGCACAG AGAACTTCGG GCTGGACTAT GACGCTTTCC AGCACATGGT GGGAGACTGT 840

CCCCCAGACT TTTTGCAGCT TACCTTCAAC TGCTGTAATA TGGACCCCAA ACTGCGCCCA 900

TCCTTTGTGG AGACTGGGAA GAACCTGGAG GAAATTCTGA ACCACCTACA GGAGGAAGAG 960

CTGCAGCCCA CTGCTAAGGG ACTCCTGGAG AAAGGACCTG GGATGAAGCG ACTGAGCTCA 1020

CTAGATGAGA AGATCCCTCC CAAGTCCCCA CGCCCAAGAC GTACCATCTG GCTGTCTCGT 1080

AGCCAGTCAG ACATCTTCTC CCATAAGCCC CCACATACAG TGAATGTCTT GGACCCCTAC 1140

TACCAGCCAC GAGGTGGTGC TGCCAGCACC CCCAAAATCA ACCCTTTCAG TGCTCGCCAG 1200

GACCTCAAGG GTGGCAAGGT CAAGTTCTTT GACCTGCCCA GCAAGTCTGT TATTTCCCTG 1260

GTATTTGACC TGGATGCACC AGGGCCTGGA ACTTTGCCTA TGGCTGACTG GCAGGAACCC 1320

CTGGCCCCAC CTGCTCGCCG GTGGCATTCT TTGCCTGGTT CACCAGAGTT CTTGCATCAA 1380

GAGGCCTGTC CATTTGTAGG CCGAGAAGAA TCACTGTCTG ATGGGCCCCC ACCACGTCTC 1440

AGTAGTCTCA AGTACAAAGT AAGAGAGATC CCGCCATTCC GAGCATCTGC CCTACCAGCT 1500

GCTCCAGCCC ATGAAGCCAT GGACTGCTCC AGTTCCCAGG AGGAAAATGG TTTTGGGCCC 1560

AGGCCTCGGG GGGCCAGTCC ATGCCTTGCA GGTGCCTCTG AAGAGATGGA GGTAGAAGAA 1620

AGGCCAAGAG ATTCGGCTCC AGTCCCCTTC TCTGTCTCAG GCAGAGGCCT GAAAACCCAG 1680

GGAGAGCAGG ATGGTTGA 1698

Domain Profile

S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63

          ek+G+Gffsevfkv+hrasG+vm+lk  ++++++nr+n+lke++l+++l+hpn+l+f+G

Q: 61    CEKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEIQLMNRLSHPNILRFMG  118

         59*************************..*******************************

S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123

         v+v++++lh+lteyi++G+l++ll+s+  lpwt+rv+la+dia+Glsylh+kgi+hrdl+

Q: 119   VCVHQGQLHALTEYINAGNLEQLLDSNLYLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT  178

         ************************************************************

S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180

         skncl+++   ++s+vv+dfGla          ek+++++++  +++l+vvGsP+wmaPe

Q: 179   SKNCLIKRdenGYSAVVGDFGLA----------EKIPDVSMG--REKLAVVGSPFWMAPE  226

         *******9887899*********..........9****9998..99**************

S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240

         vl+++ y+ek+dvfs+Gi+lceiiar++adPdylPrte+fgld++af++ +v+ dcP++f

Q: 227   VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQH-MVG-DCPPDF  284

         *************************************************.999.******

S: 241   lklavvccdldpesrpsfeelekk  264

         l+l+++cc++dp+ rpsf+e  k+

Q: 285   LQLTFNCCNMDPKLRPSFVETGKN  308

         *******************98776

Domain Sequence
(FASTA)

CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANMLK EIQLMNRLSH PNILRFMGVC 60

VHQGQLHALT EYINAGNLEQ LLDSNLYLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 120

NCLIKRDENG YSAVVGDFGL AEKIPDVSMG REKLAVVGSP FWMAPEVLRD EPYNEKADVF 180

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 240

SFVETGKN 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013