EKS-MYL-00452

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00452

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	504.7	6.2E-152	26	310	285

Status

Unreviewed

Ensembl Protein

ENSMLUP00000005579

UniProt Accession

G1P691;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000006103	ENSMLUP00000005579	ENSMLUT00000006111

Organism

Myotis lucifugus

Functional Description

Protein Length

1358

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

TLPLTSYKQE LEELKIRLHS AQNCLPFQKA AEKASEKAAM LFRQYVRDNL YDRISTRPFL 120

NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 180

ADFNYFFDTS RRRTCYIAPE RFVDGGLFAT ELEYMRDPST PLVDLNSNQR TRGELKRAMD 240

IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG QFFPEQVLNK IEDRSIRDLV TQMIHREPDK 300

RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGH 360

DLPEKAEGEP KENGLVILVS VITSCLQTLK YCDSKLAALE LILHLAPRLS VEILLDRITP 420

YLLHFSNDSV PRVRAEALRT LTKVLALVKE VPRNDINIYP EYILPGIAHL AQDDATIVRL 480

AYAENIALLA ETALRFLELV QLKNLNMEND PNSEEIDEVT HPNGNYDTEL QALHEMVQQK 540

VVTLLSDPEN IVKQTLMENG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS 600

IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALNALT CMCQLGLLQK PHVYEFASDI 660

APFLCHPNLW IRYGAVGFIT VVAHQINTAD VYCKLMPYLD PYITQPIIQI ERKLVLLSVL 720

KEPVSRSIFD YALRSKDITS LFRHLHMRQK KRNGSLPDCP PPEDPAIAQL LKKLLSQGMT 780

EEEEDKLLAL KDFMMKSNKA KANIVDQSHL HDSSQKGVID LAALGITGRQ VDLVKTKQEP 840

DDKRARKHVK QDSNVNEEWK SMFGSLEPPT IPQALPKGSD QEVIQTGKPS RSESSAGICV 900

PLSTSPQVPE VTHAQSRKPT IQVLSSTILP SPYQIRITTC KTELQQLIQQ KREQCNAERI 960

AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHSLFAT CSNDGTVKIW 1020

NSQKMEGKTT TTRSILTYSR IGGHVKTLTF CQGSHYLAIA SDNGAVQLLG IEASKLPKSP 1080

KIHPLQSRIL DPKEDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK 1140

SGLITSFAVD IHQCWLCIGT SSGTMACWDM RFQLPISSHC HPSRARIRRL SMHPRHQSWV 1200

IAAVQGNNEV SMWDMETGDR RFTLWASSAP PLSELQPSSH SVHGIYCSPA DGNPILLTAG 1260

SDMKIRFWDL AYPERSYVVA GSTSSPSVSY YRKIIEGTEV VQEIQNKQKV GPSDDTPRRG 1320

PESLPVGHHD IITDVATFQT TQGFIVTASR DGIVKVWK 1358

Nucleotide Sequence
(FASTA)

ATGGGAAATC AGCTCGCTGG CATTGCTCCT TCCCAGATCC TTTCTGTGGA GAGTTATTTC 60

TCAGATATCC ATGACTTTGA ATATGATAAG AGCCTGGGGA GTACTCGTTT TTTTAAAGTT 120

GCCAGAGCGA AGCACCGAGA AGGCCTGGTG GTTGTGAAGG TCTTTGCAAT TCAGGATCCC 180

ACATTGCCTT TAACCAGCTA TAAACAAGAG CTGGAGGAAC TGAAAATCAG GCTTCATTCT 240

GCACAAAACT GTCTGCCTTT CCAGAAAGCA GCAGAAAAAG CATCTGAGAA AGCAGCCATG 300

CTCTTCAGGC AGTATGTGCG AGACAATCTC TATGATCGCA TAAGTACCCG TCCATTCTTA 360

AATAACATTG AAAAACGTTG GATTGCTTTC CAGATTCTGA CAGCTGTGGA CCAAGCGCAC 420

AAATCTGGAG TCCGTCATGG GGACATCAAG ACGGAGAATG TAATGGTCAC CAGTTGGAAC 480

TGGGTCCTCT TAACTGATTT TGCCAGTTTT AAACCCACTT ACCTTCCAGA AGACAACCCA 540

GCAGATTTCA ATTATTTCTT TGACACGTCA CGGAGGAGAA CTTGTTATAT TGCTCCCGAA 600

CGTTTTGTTG ATGGTGGGTT GTTTGCCACT GAGTTAGAAT ATATGAGAGA TCCTTCAACT 660

CCACTTGTAG ACTTAAATAG CAATCAGAGA ACAAGAGGAG AGTTGAAGCG AGCAATGGAC 720

ATCTTTTCGG CAGGTTGCGT GATAGCTGAG CTTTTTACAG AAGGTGTACC ATTATTTGAT 780

CTCTCTCAAC TTTTGGCTTA TAGAAATGGA CAGTTTTTCC CTGAACAAGT GCTAAATAAA 840

ATTGAAGATC GCAGTATCAG AGATTTGGTA ACTCAGATGA TTCACCGTGA GCCAGATAAA 900

CGATTAGAGG CAGAAGATTA CTTAAAGCAG CAGCGTGGCA ATGCCTTTCC TGAAATATTT 960

TACACTTTCC TTCAGCCCTA CATGGCCCAG TTTGCCAAGG AAACATTTCT TTCTGCAGAT 1020

GAGCGTATTC TGGTTATACG GAAGGATTTG GGCAACATTA TTCACAATCT CTGTGGACAT 1080

GATCTGCCAG AGAAAGCTGA AGGAGAGCCT AAGGAAAATG GGCTGGTTAT CTTGGTGTCT 1140

GTTATAACCT CCTGTCTACA GACCCTTAAA TACTGTGATT CTAAACTTGC TGCTTTGGAA 1200

CTTATTCTCC ATTTGGCTCC ACGATTAAGT GTAGAAATTC TTTTGGATCG TATTACTCCA 1260

TATCTTTTGC ACTTCAGCAA TGACTCTGTT CCTAGAGTGA GGGCTGAAGC CTTGAGGACA 1320

TTGACCAAAG TTCTAGCTCT TGTCAAAGAG GTTCCTCGCA ATGATATCAA TATCTATCCG 1380

GAATATATTC TGCCGGGCAT AGCCCACTTG GCCCAAGATG ATGCTACTAT TGTCAGACTA 1440

GCCTATGCTG AAAACATAGC TCTGCTGGCA GAAACAGCTT TGAGATTCCT GGAATTAGTA 1500

CAGTTAAAAA ATCTCAATAT GGAAAATGAC CCAAATAGTG AAGAAATAGA TGAAGTTACA 1560

CATCCCAATG GAAATTATGA CACAGAGCTC CAAGCCTTGC ATGAAATGGT CCAGCAGAAA 1620

GTTGTCACTT TGCTAAGTGA CCCTGAAAAT ATCGTGAAAC AAACCTTAAT GGAAAATGGA 1680

ATAACTCGGC TGTGTGTATT TTTTGGACGT CAAAAAGCCA ATGATGTTTT ATTGTCCCAC 1740

ATGATTACTT TCCTGAATGA TAAGAATGAT TGGCATCTGC GTGGAGCTTT TTTTGATAGT 1800

ATAGTTGGTG TTGCTGCCTA TGTTGGCTGG CAGAGCTCCT CAATTCTCAA ACCCCTGCTT 1860

CAACAAGGTC TTAGTGATGC TGAGGAATTT GTTATTGTGA AAGCTCTTAA TGCCCTTACC 1920

TGTATGTGCC AGTTAGGGCT GCTACAAAAA CCCCATGTCT ACGAATTTGC CAGTGATATT 1980

GCCCCATTTC TGTGTCATCC CAATCTATGG ATACGCTATG GTGCTGTGGG ATTTATCACA 2040

GTGGTAGCTC ATCAGATAAA CACAGCTGAT GTGTATTGTA AACTGATGCC TTACCTTGAC 2100

CCATATATTA CTCAACCAAT AATACAGATT GAAAGAAAAC TTGTTTTACT CAGTGTTTTA 2160

AAAGAGCCAG TAAGTCGTTC TATATTTGAT TATGCTTTGA GGTCTAAAGA TATTACTAGC 2220

TTGTTCAGAC ATCTTCACAT GCGTCAGAAA AAACGGAATG GGTCTCTTCC TGATTGCCCT 2280

CCACCTGAGG ATCCTGCCAT AGCACAGCTT TTGAAGAAAT TGCTCTCACA GGGAATGACA 2340

GAGGAAGAGG AAGACAAACT TTTGGCACTA AAAGACTTCA TGATGAAATC TAACAAAGCA 2400

AAGGCCAATA TAGTGGACCA GAGCCATCTT CATGATAGTA GTCAGAAGGG CGTAATTGAC 2460

TTGGCTGCCT TGGGCATAAC CGGGAGACAA GTAGATCTTG TTAAAACCAA ACAGGAACCA 2520

GATGACAAGC GAGCTAGAAA ACATGTGAAA CAAGACTCAA ATGTAAATGA AGAATGGAAA 2580

AGCATGTTTG GGTCACTGGA ACCACCGACC ATCCCTCAGG CCCTACCGAA AGGGAGTGAC 2640

CAGGAGGTGA TTCAGACTGG GAAGCCTTCT CGTTCCGAGT CCTCCGCTGG CATTTGCGTC 2700

CCCTTGTCAA CTTCTCCGCA GGTTCCAGAA GTGACACATG CCCAAAGTAG AAAACCAACA 2760

ATACAGGTTT TAAGTAGTAC AATTTTACCG TCCCCCTACC AGATTCGGAT CACGACTTGT 2820

AAAACTGAGC TTCAGCAACT CATACAACAA AAGCGGGAGC AGTGCAATGC TGAGAGAATA 2880

GCTAAGCAGA TGATGGAAAA CGCAGAGTGG GAGAGTAAAC CACCACCGCC TGGGTGGCGT 2940

CCTAAAGGGC TACTAGTTGC ACATCTTCAT GAACATAAAT CTGCTGTGAA TCGAATTAGA 3000

GTCTCTGATG AACACTCACT TTTTGCAACA TGTTCAAATG ATGGTACAGT GAAAATCTGG 3060

AACAGTCAAA AGATGGAGGG GAAGACCACT ACCACGAGAT CTATTCTTAC ATATAGCCGA 3120

ATTGGAGGAC ATGTCAAGAC TCTCACCTTC TGCCAGGGTT CCCACTACTT GGCCATAGCG 3180

TCTGATAATG GTGCTGTCCA GCTTCTTGGA ATCGAGGCTT CTAAGTTGCC CAAGTCTCCT 3240

AAAATTCATC CTCTACAAAG CAGGATTCTA GACCCCAAGG AGGATGGCTG TGTTGTGGAT 3300

ATGCATCACT TCAACTCTGG GGCACAGTCC GTTCTGGCCT ATGCCACTGT GAATGGCTCT 3360

CTGGTTGGCT GGGACCTCAG GTCTTCTAGC AACGCGTGGA CATTAAAGCA CGATTTGAAG 3420

TCAGGCCTCA TAACTTCCTT TGCTGTGGAC ATTCACCAGT GCTGGCTTTG CATTGGTACA 3480

AGCAGTGGTA CCATGGCTTG TTGGGACATG AGGTTCCAGT TGCCAATTTC CAGTCACTGC 3540

CATCCTTCCA GGGCTCGGAT CAGACGCCTC TCAATGCACC CCCGTCATCA GTCCTGGGTG 3600

ATTGCAGCTG TTCAGGGCAA CAATGAAGTG TCGATGTGGG ACATGGAGAC AGGCGACAGA 3660

AGATTCACTC TCTGGGCCAG TAGTGCACCA CCGCTTTCTG AGTTACAGCC TTCTTCTCAC 3720

AGTGTTCATG GTATCTACTG TAGTCCTGCA GATGGAAATC CTATTCTGCT GACAGCTGGT 3780

TCAGACATGA AAATAAGGTT TTGGGACTTG GCTTACCCAG AGAGGTCCTA TGTTGTTGCA 3840

GGAAGTACTA GTTCTCCATC AGTGTCCTAC TACAGGAAAA TAATTGAAGG CACCGAAGTT 3900

GTCCAGGAAA TTCAGAATAA GCAGAAGGTA GGACCTAGTG ATGACACCCC TCGGAGGGGC 3960

CCAGAGTCTC TGCCTGTGGG ACATCATGAT ATCATCACAG ATGTTGCCAC GTTCCAGACA 4020

ACACAGGGCT TCATTGTAAC TGCTTCTAGA GATGGGATTG TTAAGGTATG GAAATGA 4077

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG++vvkvf++qdptl+l+s+kq+leelk++l++aqncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCL  85

         68**********************************************************

S: 61    pfqkvlek..ekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvv  118

         pfqk++ek  ekaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+

Q: 86    PFQKAAEKasEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVR  145

         *******999**************************************************

S: 119   hGdiktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsa  178

         hGdiktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++

Q: 146   HGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDG  205

         ************************************************************

S: 179   lasdekl...rdgstelvdldsiqrlrgelkkamdifsaGcvilelftegrplfelsqll  235

         + ++++l   rd+st+lvdl+s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqll

Q: 206   GLFATELeymRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLL  265

         ******9999**************************************************

S: 236   ayrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         ayr+g+f++e+vl+kied+++r+lv+q+i++ep+kr++aed+lk+

Q: 266   AYRNGQFFPEQVLNKIEDRSIRDLVTQMIHREPDKRLEAEDYLKQ  310

         *******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGLVVVKVF AIQDPTLPLT SYKQELEELK IRLHSAQNCL 60

PFQKAAEKAS EKAAMLFRQY VRDNLYDRIS TRPFLNNIEK RWIAFQILTA VDQAHKSGVR 120

HGDIKTENVM VTSWNWVLLT DFASFKPTYL PEDNPADFNY FFDTSRRRTC YIAPERFVDG 180

GLFATELEYM RDPSTPLVDL NSNQRTRGEL KRAMDIFSAG CVIAELFTEG VPLFDLSQLL 240

AYRNGQFFPE QVLNKIEDRS IRDLVTQMIH REPDKRLEAE DYLKQ 285

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 6.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013