EKS-MYL-00182

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00182

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	438.2	1.2E-131	328	597	270

Status

Unreviewed

Ensembl Protein

ENSMLUP00000005728

UniProt Accession

G1P6M6;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCI

Gene Synonyms/Alias

PRKCI;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000006267	ENSMLUP00000005728	ENSMLUT00000006273

Organism

Myotis lucifugus

Functional Description

Protein Length

671

Protein Sequence
(FASTA)

CWVPRRGRGG GGRGRWEEPR GSGCPGEATL GSAPRAGAQG EERRAAAPGR LRQPSPPARP 60

QPPRPPASRR GSQEMPTQRD STTMSHPIAG GGFGDHAHQV RVKAYYRGDI MITHFEPSIS 120

FEGLCNEVRD MCSFDNEQLF TMKWIDEEGE WCTKNSDLQL PEVWALEQLT KISEFKILLF 180

PCVPERPGMP CPGEDKSIYR RGARRWRKLY CANGHTFQAK RFNRRAHCAI CTDRIWGLGR 240

QGYKCINCKL LVHKKCHKLV TIECGRHSLP PEPMMPMDPS SMHSDHAQTV IPYNPSSHES 300

LDQVGEEKEA MNSRESGKAS SSLGLQDFDL LRVIGRGSYA KVLLVRLKKT DRIYAMKVVK 360

KELVNDDEDI DWVQTEKHVF EQASNHPFLV GLHSCFQTES RLFFVIEYVN GGDLMFHMQR 420

QRKLPEEHAR FYSAEISLAL NYLHERGIIY RDLKLDNVLL DSEGHIKLTD YGMCKKEGLR 480

PGDTTSTFCG TPNYIAPEIL RGEDYGFSVD WWALGVLMFE MMAGRSPFDI VGSSDNPDQN 540

TEDYLFQVIL EKQIRIPRSL SVKAASVLKS FLNKDPKERL GCHPQTGFAD IQGHPFFRNV 600

DWDMMEQKQV VPPFKPNISG EFGLDNFDSQ FTNEPVQLTP DDDDIVRKID QSEFEGFEYI 660

NPLLMSAEEC V 671

Nucleotide Sequence
(FASTA)

TGCTGGGTTC CGCGCCGCGG TAGAGGCGGT GGTGGCCGCG GGCGGTGGGA GGAGCCGCGT 60

GGTTCCGGCT GCCCGGGCGA GGCGACCCTT GGGTCCGCGC CGCGGGCAGG AGCGCAGGGA 120

GAGGAGCGGC GCGCCGCGGC TCCGGGGAGG CTCCGGCAGC CGAGTCCCCC CGCGCGCCCC 180

CAGCCCCCTC GGCCTCCGGC GTCGAGGCGG GGGAGCCAGG AGATGCCGAC CCAGAGGGAC 240

AGCACTACCA TGTCTCACCC GATCGCGGGC GGCGGCTTCG GGGACCATGC TCACCAGGTC 300

CGGGTGAAAG CCTACTACCG CGGGGATATC ATGATAACAC ACTTTGAACC TTCCATCTCC 360

TTTGAGGGCC TTTGCAATGA GGTTCGAGAC ATGTGTTCTT TTGACAATGA ACAGCTTTTT 420

ACCATGAAAT GGATCGATGA GGAAGGTGAG TGGTGCACCA AAAATTCTGA TCTTCAGCTG 480

CCTGAGGTTT GGGCACTGGA ACAGTTGACC AAGATATCTG AATTTAAAAT TCTATTATTT 540

CCTTGTGTAC CAGAACGTCC TGGAATGCCC TGTCCAGGAG AAGATAAGTC CATCTACCGC 600

AGAGGTGCAC GCCGCTGGAG AAAGCTTTAT TGTGCAAATG GCCACACTTT TCAAGCCAAG 660

CGTTTCAACA GGCGTGCCCA CTGTGCCATC TGTACTGACC GGATATGGGG ACTTGGACGC 720

CAGGGATATA AATGCATCAA CTGCAAACTC CTGGTTCATA AGAAGTGCCA CAAACTTGTC 780

ACAATTGAAT GTGGGCGACA TTCTTTACCA CCGGAACCAA TGATGCCCAT GGATCCATCA 840

TCCATGCACT CAGACCATGC ACAAACAGTC ATTCCATATA ATCCTTCAAG TCATGAGAGT 900

TTGGACCAAG TTGGTGAAGA AAAGGAGGCA ATGAACAGCA GGGAAAGTGG CAAAGCATCA 960

TCCAGTCTAG GTCTTCAGGA TTTTGATTTG CTCCGGGTAA TAGGAAGAGG AAGTTATGCC 1020

AAAGTACTGT TGGTGCGATT AAAAAAAACA GATCGTATCT ATGCAATGAA AGTTGTGAAA 1080

AAAGAGCTTG TCAATGATGA TGAGGATATT GACTGGGTAC AGACAGAGAA GCATGTTTTT 1140

GAGCAGGCAT CCAATCATCC TTTTCTTGTT GGGCTGCATT CTTGCTTTCA GACAGAAAGC 1200

AGATTGTTCT TTGTCATAGA GTATGTAAAT GGAGGAGATC TAATGTTTCA TATGCAGAGA 1260

CAAAGAAAAC TTCCTGAAGA ACATGCCAGA TTTTACTCTG CAGAAATCAG TCTAGCATTA 1320

AATTACCTTC ATGAACGAGG GATAATTTAT AGAGATTTGA AATTGGACAA TGTATTGCTG 1380

GACTCAGAAG GACACATTAA ACTCACTGAC TACGGCATGT GTAAGAAGGA AGGATTACGG 1440

CCAGGAGATA CAACAAGCAC TTTCTGTGGT ACTCCAAATT ACATTGCTCC TGAAATTTTA 1500

AGAGGAGAAG ATTATGGTTT CAGTGTTGAC TGGTGGGCTC TTGGAGTACT AATGTTTGAG 1560

ATGATGGCAG GAAGGTCTCC ATTTGATATC GTTGGGAGCT CTGATAACCC TGATCAAAAC 1620

ACAGAGGACT ATCTCTTCCA AGTTATTTTG GAAAAACAAA TTCGAATACC ACGTTCTCTG 1680

TCTGTAAAAG CTGCAAGTGT CCTGAAGAGT TTTCTCAACA AGGACCCAAA GGAACGATTG 1740

GGTTGTCATC CTCAAACAGG ATTTGCTGAT ATTCAGGGAC ACCCGTTCTT CCGAAATGTT 1800

GACTGGGATA TGATGGAGCA AAAGCAGGTG GTACCTCCCT TTAAACCAAA TATTTCTGGG 1860

GAATTTGGTT TGGACAACTT TGATTCTCAG TTTACTAATG AACCTGTCCA GCTCACTCCA 1920

GATGATGATG ATATTGTGAG GAAGATTGAT CAGTCTGAGT TTGAAGGCTT TGAGTACATC 1980

AATCCTCTTT TGATGTCTGC GGAAGAATGC GTCTGA 2016

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+ll+v+G+Gs++kvll++lkktd++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 328   FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  387

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g

Q: 388   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  447

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlck.eeilegkttstfcGtPdyiaPeilkeeeygk  179

         iiyrdlkldnvlld+eGhikl+d+G+ck e++  g+ttstfcGtP+yiaPeil++e+yg+

Q: 448   IIYRDLKLDNVLLDSEGHIKLTDYGMCKkEGLRPGDTTSTFCGTPNYIAPEILRGEDYGF  507

         ***************************73689****************************

S: 180   svdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeavei  230

         svdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+++

Q: 508   SVDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAASV  567

         ******************************99****************************

S: 231   lkglltkdpekrlGvk.eegeedikehaff  259

         lk++l+kdp++rlG++ ++g +di+ h+ff

Q: 568   LKSFLNKDPKERLGCHpQTGFADIQGHPFF  597

         ***************989***********9

Domain Sequence
(FASTA)

FDLLRVIGRG SYAKVLLVRL KKTDRIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKKE GLRPGDTTST FCGTPNYIAP EILRGEDYGF 180

SVDWWALGVL MFEMMAGRSP FDIVGSSDNP DQNTEDYLFQ VILEKQIRIP RSLSVKAASV 240

LKSFLNKDPK ERLGCHPQTG FADIQGHPFF 270

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00564	; PB1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00666	; PB1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013