EKS-MYL-00368

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00368

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	433.9	1.7E-130	246	495	250

Status

Unreviewed

Ensembl Protein

ENSMLUP00000005919

UniProt Accession

G1P745;

Protein Name

Protein Synonyms/Alias

Gene Name

LCK

Gene Synonyms/Alias

LCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000006477	ENSMLUP00000005919	ENSMLUT00000006481

Organism

Myotis lucifugus

Functional Description

Protein Length

510

Protein Sequence
(FASTA)

MGCGCSSNPE DDWMENIDVC ENCHYPIVPL DGKATTRPAK LGSEVRDPLV TYQDTNPPAS 60

PLQDNLVIAL HSYEPSHDGD LGFEKGEQLR VLEQNGEWWK AQSLTTGQEG FIPFNFVAKA 120

NSLEPEPWFF KNLSRKDAER QLLAPGNTHG SFLIRESEST AGSFSLSVRD FDQNQGEVVK 180

HYKIRNLDKG GFYISPRITF PGLQELVRHY TNTPDGLCTR LSRPCQTQKP QKPWWEDEWE 240

VPRETLKLVE RLGAGQFGEV WMGYYNGHTK VAVKSLKQGS MSPDAFLAEA NLMKQLQHQR 300

LVRLYAVVTQ EPIYIITEYM ENGSLVDFLK TPAGIKLTIN KLLDMAAQIA EGMAFIEERN 360

YIHRDLRAAN ILVSDTLSCK IADFGLARLI EDNEYTAREG AKFPIKWTAP EAINYGTFTI 420

KSDVWSFGIL LTEIVTHGRI PYPGMTNPEV IQNLERGYRM VRPDNCPEEL YHLMMLCWKE 480

RPEDRPTFDY LRSVLDDFFT ATEGQYQPQP 510

Nucleotide Sequence
(FASTA)

ATGGGCTGTG GCTGCAGCTC AAACCCTGAA GATGACTGGA TGGAAAACAT CGATGTATGT 60

GAGAACTGCC ATTACCCCAT AGTCCCACTG GATGGCAAGG CCACGACCCG GCCGGCTAAG 120

CTGGGCTCTG AGGTGCGGGA CCCACTGGTC ACCTACCAGG ACACCAACCC CCCGGCTTCT 180

CCACTGCAAG ACAACCTGGT CATCGCCCTG CACAGCTATG AGCCCTCTCA CGATGGGGAC 240

CTGGGATTCG AAAAGGGTGA ACAGCTTCGT GTCCTGGAGC AGAACGGCGA GTGGTGGAAG 300

GCGCAGTCTC TGACCACCGG CCAGGAGGGT TTCATCCCCT TCAACTTCGT GGCCAAAGCG 360

AACAGCCTGG AGCCCGAACC CTGGTTCTTC AAAAACCTGA GCCGCAAGGA TGCTGAGCGG 420

CAGCTCCTGG CTCCCGGGAA CACGCACGGC TCCTTCCTGA TCCGGGAGAG CGAGAGCACC 480

GCGGGATCGT TTTCCCTGTC CGTTCGGGAC TTCGACCAGA ACCAAGGAGA GGTGGTGAAA 540

CATTACAAGA TCCGCAACCT GGACAAAGGA GGCTTCTACA TCTCCCCCCG CATCACTTTT 600

CCCGGCCTGC AGGAGCTGGT CCGCCATTAC ACCAACACTC CGGACGGGCT ATGCACGCGG 660

TTGAGCCGCC CCTGCCAGAC CCAGAAGCCC CAGAAGCCGT GGTGGGAGGA CGAGTGGGAG 720

GTTCCCAGGG AGACGCTGAA GCTGGTGGAG CGGCTGGGGG CTGGCCAGTT CGGGGAGGTG 780

TGGATGGGGT ACTACAATGG GCACACGAAG GTGGCAGTGA AGAGCCTGAA ACAGGGCAGC 840

ATGTCCCCCG ACGCCTTCCT GGCCGAGGCC AACCTCATGA AGCAGTTGCA GCATCAGCGG 900

CTGGTCCGGC TCTACGCGGT GGTCACCCAG GAGCCCATCT ACATCATCAC GGAATACATG 960

GAGAATGGGA GCCTGGTGGA TTTTCTCAAG ACCCCTGCAG GCATCAAGCT GACCATCAAC 1020

AAACTCTTGG ATATGGCAGC CCAAATTGCA GAGGGCATGG CATTTATTGA AGAGCGCAAT 1080

TATATCCACC GTGACCTGAG GGCCGCCAAC ATCCTGGTGT CTGACACCCT GAGCTGCAAG 1140

ATCGCAGACT TTGGCCTAGC ACGCCTCATT GAGGACAACG AGTACACCGC CAGGGAGGGG 1200

GCCAAGTTTC CCATTAAGTG GACAGCGCCA GAAGCCATTA ACTACGGGAC CTTCACCATC 1260

AAGTCGGACG TGTGGTCTTT CGGGATTCTG CTGACGGAGA TTGTCACCCA CGGTCGCATT 1320

CCTTACCCAG GGATGACCAA TCCTGAGGTG ATTCAGAACC TGGAGCGAGG TTACCGCATG 1380

GTGCGACCTG ACAACTGTCC AGAGGAGCTG TACCACCTCA TGATGCTGTG CTGGAAGGAG 1440

CGCCCAGAGG ACCGGCCCAC CTTTGACTAT CTGCGCAGCG TGCTGGACGA CTTCTTCACG 1500

GCCACGGAGG GCCAGTACCA GCCCCAGCCC TGA 1533

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklv++lG+GqfGevw+g+++g++kvavk+lk+g++sp+afl+ea+++k+l+h++lv+ly

Q: 246   LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY  305

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyi+te+m++Gsl+dflk+  g kl+++kl+d+aaq+aeGma++ee+n+ihr

Q: 306   AVVTQ-EPIYIITEYMENGSLVDFLKTPAGIKLTINKLLDMAAQIAEGMAFIEERNYIHR  364

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+++l +k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 365   DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  424

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillteivt+G++PypGmtn ev++++ergyr+ rp++cpeely+l++ cwk++pe+

Q: 425   WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPED  484

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++l++vl

Q: 485   RPTFDYLRSVL  495

         *******9876

Domain Sequence
(FASTA)

LKLVERLGAG QFGEVWMGYY NGHTKVAVKS LKQGSMSPDA FLAEANLMKQ LQHQRLVRLY 60

AVVTQEPIYI ITEYMENGSL VDFLKTPAGI KLTINKLLDM AAQIAEGMAF IEERNYIHRD 120

LRAANILVSD TLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180

SFGILLTEIV THGRIPYPGM TNPEVIQNLE RGYRMVRPDN CPEELYHLMM LCWKERPEDR 240

PTFDYLRSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013