EKS-MYL-00380

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00380

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	306.2	1.9E-91	17	261	245

Status

Unreviewed

Ensembl Protein

ENSMLUP00000006045

UniProt Accession

G1P7E8;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000006601	ENSMLUP00000006045	ENSMLUT00000006620

Organism

Myotis lucifugus

Functional Description

Protein Length

801

Protein Sequence
(FASTA)

MSSLGASFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI EKEAEILSVL 60

SHRNIIQFYG VVLEPPNYGI VTEYASLGSL YDYINSNRSE MDMEHIMTWA TDVAKEKGMH 120

YLHMEAPVKV IHRDLKSRNV VIAADGVLKI CDFGASRFHN HTTHMSLVGT FPWMAPEVIQ 180

SLPVSETCDT YSYGVVLWEM LTREVPFKGL EGLQVAWLVV EKNERLTIPS SCPRSFAELL 240

HQCWEADAKK RPSFKQIISI LESMSNDTNL PDQCNSFLHN KAEWRCEIEA TLERLKKLER 300

DLSFKEQELK ERERRLKMWE QKLTEQSNTP LLPSFEIGAW TEDDVYFWVQ QLVRKGDSSA 360

EMSVYASLFK ENNITGKRLL LLEEEDLKDM GIVSKGHIIH FKSAIEKLTH DYLNLFHFPP 420

LIKDSVGEPE ENEEKIVNLE LVFGFHLKPE TGPQDCKWKM YMEIDGDEIA ITYIKDVTFN 480

TNLPDAEILK MTKPPFVMEK WIVGITENQT VECTVTYESD VRTPKSTKHV HSIQWNRTKP 540

QDEVKAIQLA IQPLFPNSEG NLGSRSNSNA DCQWLDTLRM RQIASNTGLQ RSQSNPILGS 600

PFYPYFNDQD SYAAAVRRTQ VPIKYQQITP INQSRSSSPT QYGLPRNFSS LHLNSKDSGF 660

ASLTSDNSSE RAQYSGRSRN KYDRGCVSLS SSPRGRYSGK NSHSTPSRER YSGKFYRVHP 720

SALNAHQSPD FKRSPNDRHQ RRTIPGMPLN PETDSGAGEE ENKVSEGGWT KVEYRKKPHR 780

ASPAKTNRER ARGSYRGRRT F 801

Nucleotide Sequence
(FASTA)

ATGTCGTCTC TCGGTGCCTC CTTTGTGCAA ATTAAATTTG ATGACTTGCA GTTTTTTGAA 60

AACTGCGGCG GAGGAAGTTT CGGGAGTGTT TATCGAGCCA AATGGATATC ACAGGACAAG 120

GAGGTGGCTG TGAAGAAGCT ACTCAAAATA GAGAAAGAGG CAGAAATACT CAGTGTCCTC 180

AGTCACAGAA ACATCATCCA GTTTTATGGA GTAGTTCTTG AACCTCCCAA CTATGGAATC 240

GTCACAGAAT ATGCTTCCCT GGGATCACTG TATGATTACA TTAACAGCAA CAGAAGTGAA 300

ATGGACATGG AACACATTAT GACCTGGGCC ACCGATGTAG CCAAAGAAAA AGGAATGCAC 360

TATTTACATA TGGAAGCTCC TGTCAAGGTG ATTCACAGAG ATCTCAAATC AAGAAACGTT 420

GTTATAGCTG CTGATGGGGT ATTGAAGATC TGCGATTTTG GTGCCTCTCG GTTCCATAAC 480

CATACAACAC ACATGTCCTT GGTTGGAACT TTCCCGTGGA TGGCTCCAGA AGTTATCCAA 540

AGTCTTCCTG TTTCTGAAAC ATGTGACACG TATTCCTATG GTGTGGTTCT CTGGGAGATG 600

CTAACAAGGG AGGTCCCCTT TAAAGGTTTG GAAGGATTAC AAGTAGCTTG GCTTGTAGTG 660

GAAAAAAACG AGAGATTAAC CATTCCAAGC AGTTGCCCCA GAAGTTTTGC TGAACTGTTA 720

CATCAGTGTT GGGAAGCTGA TGCCAAGAAA CGGCCGTCTT TCAAGCAAAT CATTTCAATT 780

CTGGAGTCCA TGTCAAATGA CACTAACCTT CCTGACCAGT GTAACTCATT CCTGCACAAC 840

AAGGCGGAGT GGAGGTGTGA AATTGAAGCA ACTCTTGAGA GGCTGAAGAA ACTAGAACGT 900

GACCTCAGCT TTAAAGAGCA GGAGCTCAAA GAACGAGAAA GACGTCTGAA GATGTGGGAG 960

CAAAAACTAA CCGAGCAGTC CAACACCCCG CTGCTGCCTT CCTTTGAGAT TGGCGCGTGG 1020

ACCGAGGATG ACGTGTATTT TTGGGTTCAG CAGCTCGTCA GAAAAGGTGA CTCTTCAGCA 1080

GAGATGAGCG TGTACGCGAG CTTGTTTAAG GAGAACAACA TCACGGGAAA GCGGCTGCTG 1140

CTCCTGGAGG AAGAAGACTT GAAGGACATG GGCATTGTCT CCAAGGGGCA CATCATTCAT 1200

TTCAAGTCAG CCATTGAGAA ATTAACCCAT GATTATCTAA ACTTGTTTCA CTTCCCACCA 1260

CTAATTAAGG ACTCAGTAGG TGAACCTGAA GAAAATGAGG AAAAAATAGT GAACCTTGAA 1320

CTTGTTTTTG GTTTTCACTT GAAGCCAGAA ACAGGCCCAC AGGACTGTAA GTGGAAAATG 1380

TATATGGAGA TAGATGGGGA TGAAATTGCA ATAACCTACA TCAAAGATGT GACATTCAAC 1440

ACCAACCTAC CTGATGCAGA GATTTTAAAG ATGACAAAGC CCCCATTTGT CATGGAAAAG 1500

TGGATTGTGG GAATAACAGA AAATCAGACT GTAGAATGTA CTGTCACATA TGAGAGTGAT 1560

GTTAGAACTC CCAAAAGCAC TAAACATGTT CATTCGATTC AGTGGAATAG AACGAAACCT 1620

CAGGATGAAG TGAAAGCCAT CCAACTTGCC ATTCAGCCAC TATTCCCCAA CTCAGAGGGC 1680

AACCTTGGAA GCAGATCTAA CTCAAATGCT GATTGCCAGT GGTTGGACAC CCTGCGCATG 1740

CGACAGATTG CCTCCAACAC TGGTTTACAA CGCTCCCAGA GCAACCCTAT CCTGGGGTCA 1800

CCCTTCTACC CCTACTTCAA CGACCAGGAT TCCTACGCCG CTGCTGTGAG GCGGACCCAG 1860

GTGCCCATTA AGTATCAACA GATTACACCC ATAAACCAGT CCAGGAGCTC CTCCCCCACC 1920

CAGTACGGGC TCCCCAGGAA CTTCTCTTCT CTGCACCTCA ACTCCAAGGA CAGCGGCTTT 1980

GCCAGTCTCA CGTCCGACAA CTCTTCGGAG AGGGCCCAGT ACTCGGGTAG AAGTCGGAAC 2040

AAATACGACC GCGGATGTGT GTCGCTCAGC TCGTCTCCTC GGGGAAGGTA CAGCGGGAAG 2100

AATTCGCACT CCACGCCTTC AAGAGAGAGA TACTCTGGGA AGTTCTACCG AGTTCATCCG 2160

TCTGCGCTCA ATGCGCATCA GTCGCCTGAC TTCAAGCGAA GCCCAAATGA CCGCCACCAA 2220

CGCCGGACCA TCCCAGGGAT GCCTTTGAAC CCCGAGACTG ACTCGGGAGC CGGCGAAGAG 2280

GAGAACAAAG TCAGCGAAGG AGGGTGGACG AAGGTGGAAT ATCGGAAGAA GCCCCACAGA 2340

GCGTCTCCTG CCAAGACGAA CAGAGAAAGA GCCCGAGGAA GCTACCGCGG GAGGAGAACC 2400

TTTTGA 2406

Domain Profile

S: 2     eleeligsgafgkvykakwrkke..vavKklreeaeekekleklereakllsklshpnii  59

         ++ e +g g+fg+vy+akw +++  vavKkl +          +e+ea++ls lsh+nii

Q: 17    QFFENCGGGSFGSVYRAKWISQDkeVAVKKLLK----------IEKEAEILSVLSHRNII  66

         67799**************665444****9987..........899**************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiA..rGmaYLhse  117

         +++Gv+le+pn+++v+ey++ gsL++++++ ++ e+d+e++++wa+++A  +Gm+YLh e

Q: 67    QFYGVVLEPPNYGIVTEYASLGSLYDYINS-NRSEMDMEHIMTWATDVAkeKGMHYLHME  125

         *****************************9.8899**************555********

S: 118   apkkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekv  177

         ap+k+ihrdLks+nv++ +++ +lkicdFG +r+++++t+ms  gt+ wmaPEv+++ +v

Q: 126   APVKVIHRDLKSRNVVI-AADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPV  184

         *****************.******************************************

S: 178   seksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecw  237

         se++D +SygvvLWe+ltrevP+k+l+ l++a+ v++k++rl+ipsscp+++++L+++cw

Q: 185   SETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCW  244

         ************************************************************

S: 238   nedpekRpsfseivksl  254

         ++d++kRpsf++i+++l

Q: 245   EADAKKRPSFKQIISIL  261

         *************9875

Domain Sequence
(FASTA)

QFFENCGGGS FGSVYRAKWI SQDKEVAVKK LLKIEKEAEI LSVLSHRNII QFYGVVLEPP 60

NYGIVTEYAS LGSLYDYINS NRSEMDMEHI MTWATDVAKE KGMHYLHMEA PVKVIHRDLK 120

SRNVVIAADG VLKICDFGAS RFHNHTTHMS LVGTFPWMAP EVIQSLPVSE TCDTYSYGVV 180

LWEMLTREVP FKGLEGLQVA WLVVEKNERL TIPSSCPRSF AELLHQCWEA DAKKRPSFKQ 240

IISIL 245

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00454

; SAM; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013