EKS-MYL-00064

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00064

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	370.2	6.4E-111	729	1022	294

Status

Unreviewed

Ensembl Protein

ENSMLUP00000006077

UniProt Accession

G1P7H7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK12

Gene Synonyms/Alias

CDK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000006650	ENSMLUP00000006077	ENSMLUT00000006655

Organism

Myotis lucifugus

Functional Description

Protein Length

1492

Protein Sequence
(FASTA)

MPNPERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLAA KHKRHKSKHS KDMGLVTPEA 60

APLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GTDRSDRLHR HRHHQHRRSR 120

DLLKSKQTEK EKKQEVSSKS GSMKDRISGS SKRSNEENDD YGKAQISKSS SNKESRSSKL 180

HKEKTRKERE LKSGHKDRSK SHRKRETPKS YKTVDSPKRR SRSPHRKWSD SPKQDDSPSG 240

ASYGQDYDLS PPRSHTSSNY DSYKKSPGST SRRQSISPPY KEPSAYQSST RSPSPYSRRQ 300

RSVSPYSRRR SSSYERSGSY SGRSPSPYGR RRSSSPFTSK RSLSRSPLSS RKSMKSRSRS 360

PAYSRHSSSH SKKKRSGSRS RHSSISPVRL PLNSSLGAEL SRKKKERAAA AAAAKMDGKE 420

SKGSPIILTR KENSSVEAKD SGLESKKLPR VLKLEKSAPD TELVNVTHLN IEAKNSLDTG 480

KVKVDENSEK HPVLKDLKVQ GSRDTKPMAL KEEIVTPKDT ETTEKETLPP LPTVTSPPPP 540

LPTTTPPPQT PPLPPLPPLP AIPQQPPLPP PQPAFSQVPA SSPSTLPPST HLRTSTLSSQ 600

ANSQPSVQVS MKTQVSVTAA IPHLKTSTLP PLPLPPLLLG EDDMDSPKET LPSKPVKKEK 660

EQRPRHLLTD LPLPPELPGG DPSPPDSPEP KAITPPQQPY KKRPKICCPR YGERRQTESD 720

WGKRCVDKFD IIGIIGEGTY GQVYKAKDKD TGELVALKKV RLDNEKEGFP ITAIREIKIL 780

RQLIHRSVVN MKEIVTDKQD ALDFKKDKGA FYLVFEYMDH DLMGLLESGL VHFSEDHIKS 840

FMKQLMEGLD YCHKKNFLHR DIKCSNILLN NSGQIKLADF GLARLYNSEE SRPYTNKVIT 900

LWYRPPELLL GEERYTPAID VWSCGCILGE LFTKKPIFQA NLELAQLELI SRLCGSPCPA 960

VWPDVIKLPY FNTMKPKKQY RRRLREEFSF IPSAALDLLD HMLTLDPSRR CTAEQTLQSD 1020

FLKDVDPSKM DPPDLPHWQD CHELWSKKRR RQRQSGVVVE EPPPSKASRK ETTSGTGAEP 1080

VKNNSPAPPQ PAPVKVEPVA GDTIGLGDIT QQLNQSELAV LLNLLQSQTD LSIPQMVQLL 1140

NIHSNPEIQQ QLEALNQSIS ALTEATSQQQ DSEPMAPEES VKEAPPASVV QPSAEQKTPE 1200

ASSTPADMQN MLAVILSQLM KTQEPAGNLE ENNSDKNSGL QGPRRTPTMP QEEAAACPPH 1260

ILPPEKRPPE PPGPPPPPPP PPLVEGDLSS VPQELNPAVT AALLQLLSQP EAEPPGHLPH 1320

EHQALRPMEY STRPHPNRTY GNTDGPETGF SATDTDERNS GPALTESLAQ TLVKNRTFSG 1380

SVSHLGESSS YQGTGSVQFP GDQDLRFARV PLALHSVVGQ PFLKAEGSSN SVAHAETKLQ 1440

NFGELGPGTS GASSSGAGLN WGGPAQSSAY GKLYRGPTRV PPRGGRGRGV PY 1492

Nucleotide Sequence
(FASTA)

ATGCCCAATC CAGAGAGACA TGGGGGCAAG AAGGACGGGA GCGGAGGAGC TTCTGGAACT 60

TTGCAGCCGT CATCGGGAGG TGGCAGCTCC AACAGCAGAG AGCGTCACCG CTTGGCGGCG 120

AAGCACAAGC GGCACAAGTC CAAGCACTCC AAAGACATGG GTTTGGTGAC CCCCGAAGCA 180

GCACCTTTGG GGACAGTTAT CAAACCTTTG GTGGAGTATG ATGACATCAG CTCTGATTCA 240

GATACCTTCT CTGACGACAT GGCCTTCAAA TTAGATAGGA GGGAGAATGA TGAACGTCGT 300

GGAACTGATC GGAGTGACCG CTTGCACAGA CATCGTCACC ACCAGCACAG ACGTTCCCGG 360

GACTTACTAA AAAGTAAACA GACAGAAAAA GAAAAAAAAC AGGAAGTTTC CAGTAAGTCG 420

GGATCAATGA AGGACCGGAT ATCAGGAAGT TCAAAGCGTT CAAATGAGGA GAATGATGAC 480

TATGGGAAGG CACAGATCTC AAAAAGCAGC AGCAACAAGG AATCCAGGTC ATCCAAACTC 540

CACAAGGAGA AGACTCGGAA AGAACGTGAA TTGAAGTCTG GGCACAAAGA CCGGAGTAAA 600

AGTCATCGGA AAAGGGAAAC ACCCAAAAGT TACAAGACAG TGGACAGCCC CAAACGGAGA 660

TCCAGGAGTC CCCACAGGAA ATGGTCTGAC AGCCCCAAGC AAGATGATAG CCCCTCAGGA 720

GCTTCTTATG GCCAAGATTA TGACCTTAGT CCCCCAAGAT CTCACACCTC CAGCAATTAT 780

GACTCCTACA AGAAGAGTCC TGGAAGCACC TCAAGAAGGC AGTCTATTAG TCCACCTTAC 840

AAGGAGCCTT CCGCCTACCA GTCCAGCACC CGGTCACCCA GTCCCTACAG TAGACGACAG 900

AGATCTGTGA GTCCCTATAG CCGGAGACGT TCCTCAAGCT ATGAAAGGAG TGGCTCTTAC 960

AGTGGGAGAT CACCCAGTCC CTACGGTCGA AGGCGATCCA GCAGCCCTTT CACCAGCAAA 1020

CGGTCTCTGA GTCGGAGTCC GCTCTCCAGT AGGAAGTCCA TGAAGTCTAG AAGTAGAAGT 1080

CCTGCATATT CAAGACATTC ATCTTCGCAT AGTAAAAAGA AGAGATCCGG GTCACGTAGT 1140

CGACATTCCA GTATCTCACC TGTCCGACTT CCATTGAACT CCAGCTTGGG AGCTGAACTC 1200

AGTAGGAAAA AGAAGGAAAG AGCAGCTGCT GCAGCTGCAG CAAAAATGGA TGGAAAGGAA 1260

TCCAAGGGTT CACCTATTAT TTTGACTAGA AAAGAGAACA GTTCAGTAGA AGCTAAGGAT 1320

TCAGGTTTGG AGTCTAAAAA GTTACCCAGA GTTTTAAAAT TGGAAAAATC TGCCCCAGAT 1380

ACTGAACTAG TGAATGTAAC ACATCTAAAC ATAGAAGCCA AAAATTCTTT AGATACAGGG 1440

AAAGTAAAGG TGGATGAGAA CTCTGAAAAG CATCCTGTTC TTAAAGATTT GAAAGTACAG 1500

GGATCAAGAG ACACTAAACC CATGGCATTG AAGGAGGAGA TTGTTACTCC AAAAGATACA 1560

GAGACAACAG AAAAGGAGAC CCTTCCACCT CTCCCCACAG TTACTTCTCC TCCACCTCCT 1620

TTACCGACTA CTACCCCTCC ACCTCAAACC CCCCCCTTGC CACCTTTGCC TCCACTACCA 1680

GCTATTCCAC AGCAACCACC TCTGCCTCCT CCCCAGCCAG CATTTAGTCA GGTTCCTGCT 1740

TCTAGTCCTT CAACTTTGCC CCCTTCTACC CACTTAAGGA CGTCTACTCT GTCCTCTCAG 1800

GCAAATTCTC AGCCCTCTGT ACAGGTTTCT ATGAAGACTC AAGTGTCTGT AACAGCTGCT 1860

ATTCCACACC TAAAAACGTC AACGTTGCCT CCTCTGCCCC TTCCACCCTT ATTACTTGGA 1920

GAAGATGACA TGGATAGTCC AAAAGAAACT CTGCCTTCAA AACCCGTAAA GAAAGAGAAG 1980

GAGCAAAGGC CACGTCACTT ACTCACGGAC CTCCCTCTCC CTCCAGAACT CCCTGGTGGG 2040

GATCCATCTC CACCTGACTC TCCAGAACCA AAGGCAATCA CACCACCTCA GCAACCATAT 2100

AAAAAGAGAC CAAAAATCTG TTGTCCTCGT TATGGAGAAA GAAGACAGAC AGAAAGTGAT 2160

TGGGGGAAAC GCTGTGTGGA CAAGTTTGAC ATTATTGGGA TTATTGGAGA GGGAACCTAT 2220

GGCCAAGTAT ATAAAGCCAA GGACAAAGAC ACAGGAGAGC TAGTGGCCCT GAAGAAGGTG 2280

AGACTAGACA ATGAGAAAGA AGGCTTCCCA ATCACAGCCA TTCGTGAGAT CAAAATCCTT 2340

CGGCAGCTAA TCCACCGAAG TGTTGTTAAC ATGAAGGAAA TTGTCACAGA TAAACAAGAT 2400

GCACTGGATT TCAAGAAGGA CAAAGGTGCC TTTTATCTTG TATTTGAGTA TATGGACCAT 2460

GACTTAATGG GACTGCTAGA ATCTGGTTTG GTGCACTTTT CTGAGGATCA TATCAAGTCA 2520

TTCATGAAAC AACTAATGGA AGGATTGGAT TACTGTCACA AAAAGAATTT CCTGCATCGG 2580

GATATTAAAT GTTCTAACAT TTTGCTGAAC AACAGTGGGC AAATCAAGCT AGCAGATTTT 2640

GGACTTGCTC GGCTCTATAA CTCTGAAGAG AGTCGCCCTT ATACAAACAA AGTCATTACT 2700

CTGTGGTACC GACCTCCAGA ACTTCTGCTG GGAGAGGAGC GTTACACACC AGCCATAGAT 2760

GTTTGGAGCT GTGGATGCAT CCTTGGGGAA CTGTTCACAA AGAAGCCTAT TTTTCAAGCT 2820

AATCTGGAGC TGGCGCAGCT AGAACTGATC AGTCGACTCT GTGGTAGCCC TTGTCCAGCT 2880

GTGTGGCCTG ATGTTATCAA GCTGCCTTAC TTCAATACCA TGAAACCGAA GAAGCAATAT 2940

AGAAGGCGTC TACGAGAAGA ATTCTCTTTC ATTCCTTCAG CAGCACTTGA TTTACTGGAC 3000

CACATGCTGA CACTAGATCC TAGCAGACGT TGCACAGCTG AGCAGACCCT ACAGAGTGAC 3060

TTCCTTAAAG ATGTCGACCC CAGCAAAATG GATCCTCCAG ACCTCCCCCA CTGGCAGGAT 3120

TGTCATGAAT TATGGAGTAA GAAACGGCGA CGGCAGCGAC AAAGTGGTGT TGTGGTAGAA 3180

GAGCCACCTC CATCCAAAGC CTCTCGAAAA GAAACTACCT CAGGGACAGG TGCTGAGCCT 3240

GTGAAGAACA ACAGCCCAGC ACCACCACAG CCTGCTCCTG TCAAGGTGGA GCCTGTGGCT 3300

GGGGATACAA TAGGCCTTGG TGACATCACA CAACAATTGA ATCAAAGTGA ATTGGCAGTA 3360

TTATTAAATC TGCTGCAGAG CCAAACTGAC CTGAGCATCC CTCAAATGGT ACAGCTGCTT 3420

AACATCCACT CCAACCCTGA GATACAGCAG CAGCTGGAGG CCCTGAACCA ATCTATCAGT 3480

GCCCTAACAG AAGCCACTTC CCAGCAGCAG GACTCAGAGC CCATGGCCCC AGAGGAATCT 3540

GTGAAGGAGG CACCCCCAGC TTCAGTGGTC CAGCCTTCAG CAGAACAGAA GACCCCTGAA 3600

GCTTCAAGCA CACCAGCTGA CATGCAGAAT ATGTTGGCAG TTATCTTGAG TCAGCTGATG 3660

AAAACCCAGG AGCCAGCAGG CAACCTGGAG GAAAACAACA GTGACAAGAA CAGTGGGCTA 3720

CAGGGGCCCC GAAGAACTCC CACAATGCCA CAGGAGGAGG CAGCAGCATG TCCTCCTCAC 3780

ATTCTTCCAC CAGAGAAGAG GCCCCCTGAG CCCCCTGGAC CTCCACCGCC GCCACCTCCA 3840

CCCCCTCTGG TTGAAGGCGA TCTTTCCAGC GTCCCCCAGG AGTTGAACCC AGCCGTGACA 3900

GCCGCCTTGC TGCAACTTTT ATCCCAGCCT GAAGCAGAGC CTCCTGGCCA CCTGCCACAT 3960

GAGCACCAGG CCTTGAGACC AATGGAATAC TCTACCCGAC CCCATCCCAA CAGGACTTAC 4020

GGAAACACTG ATGGGCCTGA AACAGGGTTC AGTGCCACTG ACACTGATGA ACGCAACTCT 4080

GGTCCAGCCT TGACAGAATC CTTGGCCCAG ACCCTGGTGA AGAACAGGAC CTTCTCAGGC 4140

TCTGTGAGCC ACCTTGGGGA GTCCAGCAGT TACCAGGGTA CAGGGTCAGT GCAGTTTCCA 4200

GGGGACCAGG ACCTCCGTTT TGCCAGGGTC CCCTTAGCAT TACACTCAGT GGTCGGGCAA 4260

CCATTCCTGA AGGCCGAGGG AAGCAGCAAC TCTGTGGCAC ATGCAGAGAC CAAATTGCAA 4320

AACTTTGGGG AGCTGGGGCC AGGAACCAGT GGAGCCAGCA GCTCAGGAGC AGGCCTTAAC 4380

TGGGGGGGCC CAGCTCAGTC TTCTGCTTAT GGAAAACTCT ATCGGGGGCC TACAAGAGTC 4440

CCGCCAAGAG GGGGAAGAGG GAGAGGAGTT CCTTACTAA 4479

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +

Q: 729   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  788

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e

Q: 789   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  847

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe

Q: 848   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  907

         ***************************************7766527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p  +vwp+v k

Q: 908   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK  967

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp +++  pkk+++ +l+e+++ + ++aldll+++l+ldp++R++a+++lq++++

Q: 968   LPYFNTMKPKKQYRrRLREEFSFIPSAALDLLDHMLTLDPSRRCTAEQTLQSDFL  1022

         *****7777777777******9999**************************9985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRRLREEF SFIPSAALDL LDHMLTLDPS RRCTAEQTLQ SDFL 294

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013